ESTHER Database

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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....
9alte-a3jf54   	-------------------------------------------------------------------------------------M-------ARTSSLVVIGGWGVSAAMLEPVY----RYWQG---V-VQVVSLTDDGLSS-------------CNS------PAHAAA---IL---LQRYPQ-P---AVWLGWSLGAQVAMAAA------------QA----NPH-----SVNKVVTLGGFPQFVAS---Q------------NWPWGVSPA----IFRRFERYFEREPQACRASFFAQMIDGSEHQAEQVRAIKAWLKQGLP-----------EP-IEPLAKGVRWLRHCCQLHTWQQ---C--PVPTL--HLRGSCDAVVPPWAQHLAMPV---HS-R--A--------LTIDGMGHWPGE----------------FYGPECWQAIHDFLTSSHDVCH-----------------------------------------------------     =====>
9alte-a6f3i0   	-------------------------------------------------------------------------------M---NAV-------ESRIPLVVVGGWGVDAAMLLPLF----DRWPG---E-IHLISLNDALMSR-------------CDS------VTEVAD---YL---LERYPC-P---SVWAGWSQGAQVVMAAA------------SR----SFA-----QVSKAITLAGFPRFVAG---P------------QWPAGMAVD----SFEAFRGQVSQNAGLAWRRFQQLLIHGCPDGSQARQELRPWLARGPS-----------VS-DLNLARGLEWLGSEDQRSLWSA---L--AVPTL--HLQASEDVVVQCWEHTFDPSQ---VA-K--V--------VTVPGMTHWPRG----------------QSLSRCQDEILRFVFGKEVQWTL----------------------------------------------------     =====>
9aqui-a8uy41   	---------------------------------------------------------------------------------------------MELLSPVFIHGWAFSSRVFNRCR----------------GIKVELPGHGRNTEPYK---------N------LESVVE---SL---ALSLPG-R---HDIVGWSLGGTLALMLA------------MK----YPA-----KVNRLFLIGTSPYFGG-----------------AWS----ER----NLRAFKLRIKREGV---GAFR-----------------KMAYPKSFE-------DR--LS-EETALRMLEDFIKTDLRCRLPL---L--RKKTL--IVHGERDVITPVKEALKL----------YNL---VKGSKLIILPGGHFPAE----------------DETGLLSTLLKVGRDL-----------------------------------------------------------     =====>
9aqui-a8uzu7   	-------------------------------------------------------------------------------------------------MNVFLHGWGFSKEIWKDFY----NLD--------NSIFLDLPFHGELKKFSTEN-------I------LENYIE---YINAF---VKE-P---SVFIGWSLGASVSILFY------------LK----YPE-----KVKKLILIGFSPKFKSE---S-----------LGHP----PK----YVKAFLLSLRKDFENTVYNFR-----------------VLSSDKKFE-------NIPLPE-KKGATKILNEYINLDLTDDLKK---I--TVPAV--IIHGKKDKVVNYKVSYFV----------NQK---IKNSELFLYPYNHSPFY----------------NNPDIIVNCI-----------------------------------------------------------------     =====>
9aqui-c4fm14   	------------------------------------------------------------------------------------------------MKTVFIHGWGFSKEIFKDYY----YLD--------NSLFLDLPFHGDFKDFEKNN-------I------FEDYVN---YVSNL---INE-K---TTLIGWSLGGSVAFLTA------------LK----NP------FIEKLVLIGFSPKFNDS---V-----------LGSD----PK----VIKAFMLNLNNDFENTVYQFR-----------------KTATGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9bact-q3ymm4   	-------------------------------------------------------------MHAEAERIAIGG--LRLRH---WPG-------QGRP-RVFVHGWAMHGGLFAELI----DALD----P-RPAYALDLPGHGDNRDSAVPLE-------------PDAVAA---A----LAPL-G-T---ADWIGWSLGGLFALAAA-------------S----AG------QASGVALIASLPRFVAG---A------------DWPHGMPEA----TFAGFAADLARDWHGTVDRFLALEALGDADERALMQRLRLQ-VYAH--------GE--PD-PAALSAGLDLLHTRDARATLAEVAAS--GVPIR--LIGGRRDRLVSPAALAATAAL---HP-A------IR--SQIIPGAAHAPFM----------------THVAEVAAALG----------------------------------------------------------------     =====>
9bact-q6a3q9   	---------------------------------------------------------------------MPQNTGNLSIN---VQG-------SGPA-LVLLHGWGLNQAIWHPIQ----AKLAA----HFTVYCVDLPGFGDSSW---------LPGNESFHHACTRVAE---QL---IRRIGH-S---FALAGWSMGGLIATQIA------------LD----FPT-----YVQRLITIASSPCFIAH---EG----------EQWP-GIKPT----TLETFRYQLTTDYRKTLERFLAVQALGSPAARDEIKAMRVL-LSE----------RAEPQ-PEALVAGLRWLAQVDMRKQLMA---L--EVPLL--RLYGKRDSLVPIATQEAIRPL---LPHH------LQDTVVTFQGSAHAPFF----------------TEPEQFVAALL----------------------------------------------------------------     =====>
9delt-q1nt00   	---------------------------------------------------------------------------MLTPE---PPA-------EDGPPLLFVPGWGFDGQVRELRP----ELV-------------PCPAP---TDFYDPFT------L------ADELAA---WL---DRRNIP-T---CRLLGWSLGGLVALDFA------------RR----YPQ-----RLEGLTLLGVRAHWPAA---E-----------LETS----R-----------RELRRQPADFLRSFYRKVFLGYQ---AAYRRFQHQLEADYL-------DRALAG-LDLLDRGLA-FLATPATTLLPA---A--GGRLR--CWHGRRDLLAPPAQRLQI----------------PGTPCQVLEHGGHALFL----------------EPDIPLPQPHLRTNPRASPQPRPRASPRATVQQR-----------------------------------------     =====>
9entr-b0m0h6   	-------------------------------------------------------------------------MSALYWQ---TIG-------EGDRDLVLLHGWGLNAEVWHCMI----ERLTP----HFRLHLVDLPGYGRSLGFG--------PMS------LEQMAE---TV---MAAAPA-K---AWWLGWSLGGLVASQIA------------LL----QPQ-----RVSGLITVASSPCFAAQ---------------DDWP-GIRPE----VLSGFQHQLGQDFQRTVERFLALQTLGTQSARQDARLLKSVVLN-----------QPMPS-VEVLNGGLEILRTADLRQPLAK---L--PLPLL--RVYGYLDGLVPRKVAGLLDVS---WP-N--------SPSIIIAKAAHAPFI----------------SQPDEFAEIIGTFVAENGI--------------------------------------------------------     =====>
9entr-b6xh89   	-------------------------------------------------------MKNDNEID----RKESVIMATLYWQ---TVG-------EGKQDIVLLHGWGLNAEVWQTII----PRVAS----QFRIHLVDLPGYGRSRDFS--------PMS------VQSMAD---IL---WEQAPK-N---AIWLGWSLGGLVASRIA------------LD----HSD-----EVKALITVASSPCFRAH---------------EEWQ-GIKPE----VLLNFEKMLSENFQRTVERFLALQTLGTESAREDARTLKSVVLA-----------LPMPT-VEVLNMGLESLRTEDLREELTH---L--TVPFL--RIYGYLDGLVPRKIVSKLDAL---YP-H--------SSSIVMRHCAHAPFV----------------SHPDEFSEYLIEFFTQLDK--------------------------------------------------------     =====>
9entr-c0auc8   	-------------------------------------------------------------------------MNKLYWQ---TIG-------EGKTDLVLLHGWGLNAEVWQSLI----PRLSS----HFTLHLVDLPGYGRSQGFP--------ALT------LKEMAE---IV---FTKAPA-N---AIWLGWSLGGLVASRVV------------LD----NPN-----NVQALITVASSPCFGAH---------------DDWP-GIKPE----VLRGFEQQLNENFHRTVERFLALQTLGTQSAREDMKALKSVVLE-----------QPLPS-VEVLNGGLEILRTEDLREELKM---L--SCPFI--RFYGYLDGLVPRKVAGLLDAI---YP-Q--------SPSVIFRNAAHAPFI----------------SHPDEFSDALIHACKE-----------------------------------------------------------     =====>
9entr-d1p0w3   	-------------------------------------------------------------------------MAQLYWQ---TVG-------DGKQDLVLLHGWGLNAQVWQTLI----PRIAS----QFRIHLVDLPGYGRSQNFS--------PMN------IQSMAE---TL---WAQAPK-N---AIWLGWSLGGLVASRIA------------LD----HSK-----EVKGLITVASSPCFGAE---------------DNWA-GIKPD----VLLNFEKQLSADFQRTVERFLALQTLGTESARDDARTLKSVVLA-----------QPIPT-VDVLNAGLESLRTEDLREELKN---L--AIPFL--RIYGYLDGLVPRKIVGILDEM---YP-E--------SKSVMIRQSAHAPFI----------------SHPDEFSKYLIEFSNQLDKP-------------------------------------------------------     =====>
9entr-d2u2z8   	---------------------------------------------------------------------------------------------------MLLHGWGLNAEVWRTIE----VGCGS----HFRLHLVDLPGYGRSHLFP--------PMS------LQQMAE---VI---WQKAPK-Q---AIWLGWSLGGLIASIIA------------LN----HQV-----EIAGLITVASTPCFSQQ---------------ENWP-GIKPM----VLTGFEQQLQANFHRTVERFLALQTLGTKTAHEDIRLLKTVLLK-----------QPLPS-VAVLNAGLEILRTTDLRQSLLT---L--NKPFL--RIYGDLDGLVPRKVVPIIDGW---LP-N--------SPSVIIKHAAHAPFI----------------SHPKQFIQLLVNFSSQLEK--------------------------------------------------------     =====>
9gamm-a0y490   	---------------------------------------------------------------------------------------------MQKE-LVLLHGWGMNQGVWQLIQ----PELEN--LYAGEVRSLDLPGFGNSATTL--P----TPYN------LHDAAM---QL---SQQLKP-H---SILMGWSLGGLFALYIA------------KH----WPE-----KVAKVILVASTPYFAEQ---------------GEWP-GISEK----VLTQFKDQLVNHREKTIERFLAIQAMGSESARDDIKQLKQL-LNQ----------YSAPN-SEALTAGLDILQNDDLRDLFAT---C--PVKIM--GVFGRLDALVPYKAIAKMSVL---NT-E------FE--YQVIDKASHAPFI----------------SHKNEFLSIVKSML-------------------------------------------------------------     =====>
9gamm-a3wj22   	--------------------------------------------------------------------------MSIAIT---RQG-------QGED-LVVLHGWGMNRHVWSLIK----DELSK----HFNIWLVDLPGFGDSHEET-------LSNS------VDSIAD---QL---LSSLPQ-R---FHILGWSMGGLIATSLA------------TR----HCQ-----RVDKLITVASSPYFLE---------------SSDWP-GIKPR----LMTQLETDLQNDFRKTVERFLSLQAMGSKNAKQQVKQLKQW-LFE----------SPLAS-EETLLTGLKLLEKTDLRNTLKH---I--QAPML--RMYGRLDGLVPISACQAIEPL---VP-Q------ST--SYVFNDSAHAPFI----------------TEPELFIERLISFIKG-----------------------------------------------------------     =====>
9gamm-a3y9c0   	--------------------------------------------------------------------------MRYKLEQVSFGD-------PANQAIFLLPGWAMPKECFYELA----HKLS----QQYYVVLVNLPGISTDVELI-KGAKTGPNYD------IDALTE---QL---ILAAPK-D---AWWLGWSLGGMIASYVA------------AH----RAS-----CVKGLITIASNPSFVRS---E------------GWQWGMSLG----DFEAFEDLIKHDPVVGLKRFIALQSKGSRAATEVRKQLSHW-VEP-----------DACL-PLALEAGLHLLKNLDVRRELEI---L--DMPSL--HLLGEKDVLVDSNWPKAIINN---CV-P------IE--YKVFENCAHQPFI----------------EDLDQLYPHIENFLNAQ----------------------------------------------------------     =====>
9gamm-a4ceu8   	-----------------------------------------------------------------------MGVKTIILE---SINHGKGEIKMQKQ-CVLLHGWGMNSNVWQQVL----PQLHH-DIPQVNFKALDLAGFGDNK-AL--P----SPYS------LETIAA---QI---AQQLAP-K---TILMGWSLGGLVAIYIA------------KH----WPE-----KVAKVVLVASTPLFSEQ---------------HDWP-GIKVK----VLENFTEQLQQNSTRTIERFLSIQALGSESAKDDIKALKIA-LAQ----------SNPAD-EIALKQGLAMLLNDDLREDFAS---L--TQPVA--GIFGRLDALVPIKAEQQMRAL---NS-H------FS--TVVIEKASHAPFI----------------SHKAEFTSALETLL-------------------------------------------------------------     =====>
9gamm-a6fg15   	-----------------------------------------------------------MSEIVVTESKNVSPCTTLYVD---IVG-------DGPD-LVLLHGWGLNGACWQSIV----PLLSQ----HYRLHLVDLPGFGFSHDSH--V----ASGT------LADITD---AL---IKVAPA-N---AVWLGWSLGGLCATDFA------------LQ----YPH-----RVSALVTVASSPKFMAA---SKV------DDSATWP-GIAEQ----VLAQFQQQLQQDLSQTINRFLAIQGMGSATAKQDIKQLKLL-LAA----------RPQPH-EQALSNGLTLLSTVDLRAQLAT---L--TMPFY--RCYGRLDSLVPQATVAWMDNY---LP-Q------SP--SWIFKASSHAPFI----------------SEPTLFVNKLQAFINHSL---------------------------------------------------------     =====>
9gamm-a9cy57   	---------------------------------------------------------------------------------------------------------------------------------------MDLPGFGYSSA---------IAGD------IYDWLE---AL---ITRLPD-K---AIWVGWSLGGLLATLAA------------LN----YPG-----RVRGLVTIASSPCFMAR---EE----------EKWP-GIPPQ----VLSQFGESLHKDLGKTIERFLAIQAMGSTTAKADIKQLKNL-LLS----------RPLPD-SRALVQGLNMLECVDLRPKLDK---I--NLPWL--RIWGRLDRLVPRRVPPLMPLN---DT-I------YQ--DIILPKASHAPFI----------------SHKDEFLAGFVTWIEEISN--------------------------------------------------------     =====>
9gamm-b4wya3   	-------------------------------------------------------MPKLIPFHNTYKA---TG------V---NDD-------EAQD-IVLIHGWGLHAIVFDDIV----PALL----ERFRVTVVDLPGMGQSPMPNGDYT-------------LDFLAD---EV---LAIMPE-R---AHVLGWSLGGLVALAMA------------GK----AAQ-----RVQSVVTVATSPRFTTG---E------------GWDTAMKPD----ILGKFAEMFDEDHEGTLVRFLALNCKGSAAMREDTARLKEI-LYFC--------GL--PA-PKALRSGLDILREADMRTVLPA---L--DMPVL--MVFGENDHIVPAAAMAASEPL---IH-H------GR--TALIEQVAHVAFL----------------SAPETFTRAVYDFYREYRLVA------------------------------------------------------     =====>
9gamm-b5jtu3   	----------------------------------------------------------------------------------------------------------MDVACWQSVQ----AALQA---D-FDVLPLALPELPSLST-----G--DTECL------LDAWLQ---DL---LARVPR-R---AYWLGWSLGGMLVMALS------------RR----YPD-----RLLGAAVVAAAPRFVED---E------------GWP-GVPRS----VVEGFERQLCEAPEQLRRQFLALVAHGDRAARRAL-------------------KPAVDG-EVSLRQGLHLLKSMDLR---GA---W--NSPLLSGVLLSEVDGVLPPTLIAPMMSE---CG-E--K-------IRL-TAACHAPMV----------------SAPEIVAEFVRDCFCR-----------------------------------------------------------     =====>
9gamm-b7s223   	------------------------------------------------------------------------------------------------------------------ML----PALR----SWANITLLDLPCLAPGLASA-PVS-------------LNSLLE---GI---FTHSPE-R---AVYMGWSLGGQLALELA------------TM----QPD-----RVAALVTLCSTPCFLEQ---D------------GWP-GMPAP----TLQQFSEAFVADPPAGLRRFDSLQAAGAARPRSLMRSLHAL-RND-------------QS-SGYLEAGLDWLACLDQRSCCSE---L--TQPQL--HLYGDNDDLLAADLAQSMAKLLESVP-R------AV--VGFIEGASHVAPL----------------EQGRAISDSLFHFLQNA----------------------------------------------------------     =====>
9gamm-c0n6r0   	----------------------------------------------------------------------------------------------------------MHSGVWHELA----EGLA----ERFTLHLVDLPGHGQSDWQEGQFE-------------LPLLLS---EL---EQKLPD-N---AVWLGWSLGGLICLAMQ------------QR----YPK-----KVRKLSLMATTPKFVGC---E------------TWPCAMAPS----VFESFASNLHVDQQQTLQRFLMLQAKGAVQSREIIRELSEQ-LATQ--------HT--PQ-PEALRQGLALLLQTDMRDALSQ---A--TCPLQ--LILGERDTLIPASMPDYAKKL---NP-A------LD--VTMIDGVGHAPFI----------------AQPQRCQELIELFIDG-----------------------------------------------------------     =====>
9gamm-c6mzw5   	--------------------------------------------------------------------------MNIHIK---TYG-------CG-FPLVFFHGWGFDSQVWMPLV----SQLA----GNYQLILVDLPGFGHSFMMD-----------------WSSFKT---QL---LNQLPP-Q---FALVGWSMGGLFATRLA------------LE----KPE-----RVTHLINITSSPRFLLD---N------------DWP-GVSQE----VFTTFYQNLLKDSRATLEEFIALQVSKH----------NFELAL-----------GHLPS-SAGLASGLDILGTWDFRQQLKQ---F--ERPVC--YMFGRLDPIVPVKTMKAMQEH---YP-G------FK--YVYFNRAAHMPFL----------------SHMDLFTSEMQEFIK------------------------------------------------------------     =====>
9gamm-c6nyz5   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQR---P------------DWSCALPEA----ILAEFATRLRSDAHATRQRFVALQVLGDPGARVRL-PDTRQ-WPA-------------PD-HGCLEDGLNLLATQDLRPSLRP---L--DYPVT--ILQGGRDRIVPPAAGAHLSAA----L-G------AE--YRLLAEAGHAPFL----------------SDPATCGRCLLEALT------------------------------------------------------------     =====>
9gamm-d1kc19   	---------------------------------------------------------------------------MLYSS---TTG-------IGQD-LVLLHGWGFNSELFNDLI----DRYK----NQYRITKIDLPGHGRSDEVN--GG-------------LNEWCD---EI---IKILPN-N---PTLLGWSLGGLLAINIA------------NK----V-------SISKLILVASTPNFVRT---D------------NWEFGIGAN----NFEQFSDSLQLNLSKGLKRFVSLQTKDKTQIKHLNQTIDNY--------------P--AT-TQALNQGLNILLKTNLIKTLES---L--SVEKE--VILGKNDTLVPNKIAKWYQQN---NI-K-----------TQLLNTGHLPFL----------------CDDFLL---------------------------------------------------------------------     =====>
9gamm-q1mzv8   	--------------------------------------------------------------MQIQHDEF------HIRE---FGN-------PDNPSLFCIHGWASNSHVFEPLA----KLFK----DHFHFVCVDLPGFGESKCED-AQ----QSYQ------LPYLIE---GL---LSVAPE-K---SAWLGWSLGGMLAVQAA------------AKLQLEKSD-----RIEALVSMNANAKFIAH---K------------SWKSGVPQP----LFDGFMESIA-DVKTTLRRFAALTVVGEQKDMLQSLKWLQQ-NTQ----------VPAPT-SDVLNASLKLLAQLDNRATLKQ---L--TLPTL--HLLSTDDAIVPNGVSQELNKL---NP-M------HP--VSFVPNGSHASLV----------------AQPQSVANGILTFLEGLNA--------------------------------------------------------     =====>
9gamm-q1yr00   	------------------------------------------------MNAF---IAAPSPVLSSNNPAL----TDYPCT---GMR-------LYTQPLVLLHGWGMDSQIWAQLP----QQLR----QFADVMTLDLPGFAQSPT----V----QNYS------SAGLYQ---WM---AELLPE-R---CYLIGLSLGGMLSCGFA------------AR----YPQ-----RVAGLVTLSSNSHFVAS---E------------ANPTALDKA----LYLGFLDNYNQNEDQCLKRFAALQAQGDKQQRQLIRQLRS----M----------QVCLD-SHSGVQLLTLLGDIDNQSGLTQ---L--QCPAL--MLLGQGDALVPVASGARIASL---NS-K------IE--VNIIAGAGHLPHL----------------TQPETVIEKIKNFLARQLYALD-----------------------------------------------------     =====>
9gamm-q1zel6   	----------------------------------------------------------------------MSIEKVVACR---ISG-------VGED-LVLLHGWGTNSAIWQGVE----TSLAQ----YFRVYCIDLPGFGKSSE----L----STYT------LTSMLE---AI---IEVLPD-H---AIWCGWSLGGLLATYAS------------YA----YPH-----KVRKLIQVCSALKFVSE---------------DPLY-GVEGA----VFENFKENLKTDKNKTLKRFISLQAQGPISSKKDIVVIKKS-LQN----------SFIAS-DEALLSGLDLLQHTDLIECFAT---I--KQPCL--SIFGAYDALIPEQGRLQMQAI---LK-H------SQ--QVVFEQSAHAPFI----------------SERDRFCHLIKMF--------------------------------------------------------------     =====>
9gamm-q2bk53   	--------------------------------------------------------------------------MGLHVER--VGG-------EGKPELVMLHGWGMNSSIWSGVV----ENLA----SNYSITLIDLPGLGRSVSYPEPYT-------------SDGVIQ---ML---ADAAPE-K---ASWIGWSMGGQLAIQFA------------DR----YPE-----RVERLVTIASNPCFVQK---P------------DWRSAMDEE----THNAFEISLSENVAKTLSRFAMLQTQGAEAARDTLKQLKAA-LKV-------------AE-PSAPVESLGLL-REDVRSQLSA---L--KMPLL--QMFGEKDLLVPVSAALECDAL----T-S------RA--SIVYPGAGHLPFI----------------SHQAELVSDLTRFLQEPLA--------------------------------------------------------     =====>
9gamm-q2byf3   	------------------------------------------------------------------------MAVMLDWH---NKG-------QG-SDLVLIHGWGMNGAVWQDVI----PVLAE----HFTVHWCDLPGYGYSGDVT--------AES------LVEITQ---AV---LARAP-QK---AAWLGWSLGGLVATQAA------------LL----APE-----RVTQLMTVASSPSFMAR---------------EGWR-GIKPD----VLKNFQSQLASDFSLTVERFLALQAMGSPTARQDIKNLKQAVLE-----------RPTPQ-PSALTLGLTLLETVDQRTELSL---L--TQPWL--RMYGRLDGLVPVKTETAIAKL---CP-Q--------SLSYVFQSASHAPFI----------------SHPDEFIDVVRQFISEDAVVS------------------------------------------------------     =====>
9neis-b9z5l8   	--------------------------------------------------------------------------MSLYIE---SLG-------RGPD-VVMLHGWGLHGGVFSRVA----ERLD----GRYCLHLVDLPGHGASASRH-PFD-------------ADDIAD---LL---AAQLPW-P---VHVVGWSLGGLLAQHWA------------AR----HPE-----QVKSLALIASSPRFVKQ---D------------GWPHAQEKK----AIEGVGASLDSAFELTLERFLALQMLGAPGARDTLKALREE-LFA---------H---GR-PQGLLPALELLLMADARALAPR---I--HCPVG--LFFGAKDAITPIGAGRWLAET---LA-D------AT--LYEFPQASHAPFL----------------SHEEEFVARLAAHLDQHA---------------------------------------------------------     =====>
9prot-q0evs9   	----------------------------------------------------------------------------------------------MTP-LVFLHGWAQSRQIWYQQQ----RAFP----Q-AHF--LNLPGHGGAMAAP-ADA-------------WLD------LL---VAQLPD---EPCALIGWSLGGMLALEIA------------HR----FPE-----RIAALGLIATTPRFRTG---D------------AWSCGCDEA----TFAAFHEAVASASPRALNRFFALMLHGDDLPRSRYNELARHAVDRQ--------N-PAT--SSALSAGLALLASLDLRQSLAL---A--DMPVL--LMHGEQDAIVPVAAGRWLAEQ---LP-G------AQ--AHYADACGHAPFL----------------SQPERFNTILKEWWQQ-----------------------------------------------------------     =====>
9vibr-a6d4h9   	-----------------------------------------------------------MNSV----GDNVSSASKVHWH---SEG-------QG-PDIVLLHGWGMNGAVWSKCS----AELAQ----SFTVHSVDLPGYGFSHDVE--------YQS------LEQFCE---LL---LADAP-DQ---AIWLGWSLGGLVATHIA------------HY----YPQ-----RISQLVTLASSPKFSEG---------------EQWR-GIKKD----VLAAFTEQLTENFKLTIERFMALQAMGSPSARQDVKQLKEAVLS-----------RPMPS-QEALMLGLNWLDSLDLRQQLGE---L--SMPVH--RWYGRLDGLVPVRVAKQLDEL---TS-G--------HQSHVFKDSSHAPFI----------------TEQSGFIDKVQALVR------------------------------------------------------------     =====>
9vibr-c9nll8   	-----------------------------------------------------------MENV----AQNEIKPTTPYWQ---STG-------QG-DDLVLVHGWGMNGAVWHQAV----EQLSQ----HFRVHVVDLPGFGHSHQLH--------FET------MEELAQ---QV---LHSAP-DN---AIWLGWSLGGLVATHIA------------IH----HPE-----RITKLITVASSPKFSAE---------------KRWR-GIQPQ----VLSAFTEQLVDDFRVTIERFMALQAMGSPSARQDVKTLKQAVLS-----------RPEPN-PQSLLAGLQLLADVDYRQALLD---V--SVPTL--RLYGRLDGLVPAKVATDVDTL---MP-T--------SESYMFGASSHAPFM----------------TELNEFCQQVTRFSAGR----------------------------------------------------------     =====>
9vibr-q1zka4   	------------------------------------------------------------------------MAVMLDWH---CKG-------QG-SDLVLIHGWGMNGAVWQDVI----PALAE----HFTVHWCDLPGYGYSGDVT--------AES------LVEITQ---AV---LARAP-QK---AAWLGWSLGGLVATQAA------------LL----APE-----RVTQLMTLASSPSFMAR---------------EEWR-GIKPD----VLRNFQSQLASDFNLTVDRFLALQAMGSPTARQDIKNLKQAVLE-----------RPTPQ-PSALALGLTLLETVDQRAELSS---L--TQPWL--RMYGRLDGLVPVKTEAAITEL---CP-Q--------SLSYVFQSASHAPFI----------------SHPDEFIAAVRQFISEDAVVS------------------------------------------------------     =====>
accpu-c7rnx0   	------------------------------------------------------------------------------MTR--VVG-------EGPD-LALIHGWGLGSAVWEPLR----PALS----AHARVHLIDLPGYGEAADDS--G-------D------FTATAQ---TL---IDALPN-P---VVLCGWSLGGMLAVRAA------------VL----APE-----RVNGLVLVGATASFTQR---G------------DWRAAQAPA----VVDSFSASVRLQPEQTLQRFVTLLSQGDNQARAITRELLASLNR-----------APGPQ-IEALGRGLDWLREIDLRPLLPA---V--TARCL--LVHGENDPLNPLAAARYLAET---IA-N------AR--LEVFGGAGHAPFL----------------NDRERFVRLLDDFCHVRPAP-------------------------------------------------------     =====>
acif2-b7j3y8   	--------------------------------------------------------------------------MNWARQ---VSG-------RGRP-LVLLHGWGMESRVFASWR----SLLD----THFTCISYDLPGHGQTPCAP-SGLA------------WSASLE---SL---RQMLAQ-EAPKPLLLGWSLGGLLALGIA------------LQ----HPE-----LLAGLVLVSSSPAFCQR---P------------DWSPAIPAA----TLEDFAQRLRVDPQGTRRRFLALQVLNDPQGRRVLEGLSTS-WPM-------------PD-QACLADGLGLLREVDLRSQLSR---V--PMPVH--IVHGRQDRIVPVGAGEYLHQH---LT-G------SR--FTLLEQAGHAPFL----------------SHPEACANALLETWG------------------------------------------------------------     =====>
aerhh-a0kf11   	--------------------------------------------------------------------------MSVSVE---RFG-------QG-PDLVLLHGWGMNGAVWHGIV----PALAS----RYRVHLVDLPGFGNSPLAGE------VEYS------LPWLAE---EV---AAILPE-Q---CHLLGWSLGGLVASQLA------------LS----HPE-----RLHSLITVASSPCFMAR---------------DEWP-GIAPK----VLAGFNQMLAGDFKQTIERFLAIQAMGSEHARDDIRQLRHWLAE-----------RPAPQ-LAALEAGLGLLAEVDLRDELTP---L--SLPWL--RVYGRLDSLVPKASIPLLDER---YP-S--------SRSVVLEKASHAPFI----------------SHPQQFIEIIEHFVG------------------------------------------------------------     =====>
aers4-bioh     	--------------------------------------------------------------------------MSVSVE---RFG-------QG-PDLVLLHGWGMNGAVWHGIA----QQLAA----HYRLHLVDLPGFGNSPLREG------SDYS------LPWLAE---QI---AIVLPQ-K---CHLLGWSLGGLVASQLA------------LT----QPE-----RLHSLITVASSPCFMAR---------------DEWP-GIAPK----VLTGFNQMLAGDFRQTIERFLAIQAMGSEHARDDIRQLRHWLAE-----------RPAPQ-FAALEAGLGLLADVDLRDELLQ---L--SLPWL--RVYGRLDSLVPKASIALLDER---YP-A--------SHSVVLEKASHAPFI----------------SHPQQFVEIVRYFVG------------------------------------------------------------     =====>
alcbs-q0vmd2   	-----------------------------------------------------------MPRL-----IPFHNTYRATGV---DDA-------QAQD-IVLIHGWGLHAIVFDDIV----PALLA----HFRVTVVDLPGMGQSPL-P--N----DDYS------LDFLAE---QV---LAIMPQ-K---AHLLGWSLGGLVALAMA------------EK----APE-----RVQSVVTVATSPRFTAA---D------------DWAPAMKPE----ILAKFAEMFNEDNEGTLVRFLALNCKGSAAMREDTARLKQI-LYF----------CGLPA-PRALRGGLNILRDSDLRESLTA---L--SMPVL--MVFGEHDHIVPAAVMAAVEPL---IG-N------GR--TALIEQVAHVPFL----------------STPDTFTQAVYDFYRDYQLVR------------------------------------------------------     =====>
alheh-q0a5w3   	---------------------------------------------------------------------------MMRAV---TEG-------RGPEGLVLVHGWGFDHRVFDPWL----PRLT----QRWRVTRTDLPGHGGSAPLP-ADAG------------LEAWAD---AV---RLAVPE-D---AIWVGWSLGALPLLAAA------------AR-----GA-----RPRALLLLAATPCFCQR---D------------GWPYGLLRE----ELDAMIGGLAEDARRTLRGFHALLGRAGAGDREALRPWRRR-------------GP--GP-ATALEPGLSLLRDTDLRGRLAA---I--DRPTT--WLAGGRDPLVPDGAAKEAARA---MP-R------AR--MAYHPEAGHLPFL----------------THPEWVAGHLHLLSQQCRP--------------------------------------------------------     =====>
alisl-bioh     	------------------------------------------------------------------------MTTSLYWQ---TEG-------EG-SDLVLIHGWGMNGAVWQPIV----EKLSS----QYRVHTVDLSGYGYSAELG--------SAD------FDEMVA---QV---LAQAP-EK---SAWLGWSLGGLIATQAA------------LT----APD-----RVSQLITVASSPRFAAE---------------KGWR-GIKSA----VLSQFTEQLKEDFTLTVERFMTLQAMGSPNAKQDIKQVKRAVLS-----------RPAPN-PSALATGLTILADIDLRESLSQ---L--TMPVC--RMYGRLDGLVPIKVAHDMDAF---IP-H--------STKVVFEQASHAPFI----------------SHSDEFITELHRFLQPEDEFLI-----------------------------------------------------     =====>
allvd-d3rnx1   	---------------------------------------------------------------------MSNQSAPPHTP---TPE-------TTAD-LVLLHGWGMNSAIWNGVP----EPTWN----GLTQHRIDLPGHGDSPF-P--T----GRDD------LWGWAE---AC---LDAAPE-R---AVWVGWSLGGLIALAAA------------LH----APK-----RVAGLILLTATPRFTQA---T------------DWTPAMPEA----TLAQFHDGLLADPSGTLNRFLALQTRGSDTARETLRTLKQE-LAA----------RPEPK-PAALALGLDLLREEDLRPQLPD---I--RCPTL--WLFGQHDTLVPARVAERIELL---MP-E------AR--VETIAGAAHAPHI----------------SHPHETGRAIRTFLDAL----------------------------------------------------------     =====>
anad2-b8j7l6   	-----------------------------------------------------------MPLLVTDSG------VRLAYA---DRG-------AGAP-LVLVHGWSLSSAAFDDLA----VRLP----G-RRLVTPDLRGHGGSGAAP--FA-------------LEDLGRDLALL---LDRLDL---RGAVLAGWSLGAQAALAAL------------PA----VRA-----RLAGLVLISGTPRFTLC---D------------GWPHGLPAQ----ALEVLAHRVRREPARAAARFFDGMFAPGELDPAARART---GALRA--------AIPSPG-SAAALAGLDVLAAADLRPTLAG---V--GVPAL--VIHGTADPICPPGAGRALAAG---IP-G------AR--LALLPGAGHAPHL----------------TRPDEVAALLQAFPAGAGAVAA-----------------------------------------------------     =====>
anofw-b7ghw8   	------------------------------------------------------------------------------------------------MNILLLPGWGMKGDVFSPLI----HALQP-----SHVTVVAWEH----------MH--DVNHF------LAKAKD---AL-------TV-P---SIVIGWSLGSLVALQLA------------------MHE-----HVQALVCIGGTSRFTMT---D------------DYPIGWHAR----VVERMKTQLMRQPEKTIQSFIDMLWGEEEAQPF---------------------HYMHHH-IPDLLLGLDYLLTTDVRDQLQQ---I--DVPLL--LIHGERDRICPPQAARYIYER---TN-RCTFTLMPNV--------GHAPHV----------------TQPSTCAHYIQTWLGGREND-------------------------------------------------------     =====>
aquae-aq2138   	----------------------------------------------------------------------------------------------MLKNPLFIHGWAFSSKVFNDFH----------------GIKYDLPGHGKNKNPYE---------S------IEKVVE---EI---GKIATS-K---HDVVGWSLGGSLALLFA------------YR----YPE-----KVNRLILIGTTPHFKG-----------------AWS----EK----NIRAMKLLIKKKGI---KAFR-----------------ELAYGK-FE-------DF--FD-EEQGMRFLEDYVNLNLYTVLPY---I--KKEVY--LIHGVSDRIVPYSEAYKL----------HRA---LKCSKLILLGGGHFPVR----------------NEEHLRKAILKGY--------------------------------------------------------------     =====>
azosb-a1k6q2   	-----------------------------------------------------------------------------MVEI--GMP-------SLPP-LVLLHGWGMTPAVWDGLA----PALR----ERFAVSAPPLPCHPGSEVTT--G-------A------LPAWAD---AI---AGGLPD-D---ALVCGWSLGAQLAMTLA------------LR----HPH-----KVRRLLLVGATPCFVAA---P------------GWGAALDAA----TVTAFVEGFRASPAPTLRRFLSLQVQGEARRKPVLQALGATAVAAD--------ALEAGD-AAALAAALDVLVSTDLRALAGR---I--TAPTL--LVHGDGDALMPLDAAHWLAEA---LP-H------AR--LEVFADSGHAPFL----------------SDPERFVALLGALGDA-----------------------------------------------------------     =====>
azose-q5nzf6   	-------------------------------------------------------------------------------------M-------NRPD-LVLLHGWGLGPQVWSALT----PYLP----AGLRVRTPALPGHGGTPARG--P-------T------LEAWSD---AL---LPELPD-D---AVVCGWSLGGLVALDLA------------RR----HPH-----KVARLVLIGTSPCFVTR---PEN-------AAAPWPYGLAAS----TVTGFIDDFAHDPAATLRRFVALQALGDARRRTVSNALNAAL---A--------NLEQCR-PAALGAGLELLADTDWRAALDD---V--RQPVQ--LIHGAGDALMPLAAAEWLATR---LP-D------AR--LARFDDCGHAPFL----------------SHPEDCAVLIEDVVRG-----------------------------------------------------------     =====>
azovd-c1dkj0   	-----------------------------------------------------------------------------------------------MTRLILLPGWGLGRAALEPLA----GALR----ER--GLDVGLA---GLPA----L----DESD------PEAWLA---EL---DARLPQ-G---AWLGGWSLGGMLATALA------------AR----RGE-----GCRGLLTLASNARFVAG---A------------DWPHAMPPD----IFAVFRNGCAQDSVAILKRFALLCCQGCTEARSLSRQLNQ----G----------IPAEE-TAQRLAGLEVLAALDNRAALVA---F--AGLQL--HLLAEADALVPVAAAEPLQAL---LS-R------GV--VERVAGTGHAFVL----------------ERPQALAARLAAFIREAGDD-------------------------------------------------------     =====>
bacan-BA4338   	---------------------------------------------------------------------------------------------MKELKIIFIPGWGMEENIWDLVL-----PHFK---G-YSVQCIDWRN----------VK--EQSEF------AGRIID---VA------KDE-N---VILVGWSLGALAAIQAY------------K------KI-----KAKGIVLIGGTAKFTNA---S------------DYSNGWNTL----HVERLKRNLARRKEDTLKRFYENMFTKDELKENK---SFED--IVK--------HFKGDS-IQSLQFGLDYLIETDMREALKE---I--NVPIL--LIHGERDVICPLSAACSMAEN---ET-A--KLK-------VVSEAGHALCV----------------TNFEYCVNEIIQFVEGIRHDQQNV--TTKTV--------------------------------------------     =====>
bacc1-q731i0   	---------------------------------------------------------------------------------------------MKELKIIFIPGWGMEEGVWTLVL-----PYFK---E-YSVQCINWRN----------VK--EQSEF------AGRIID---VA------KDE-N---VILVGWSLGALAAVQAH------------K------KI-----QTKGIVLIGGTPKFTNT---S------------DYTSGWNAL----HVERLKKNVARKKEDTLKRFYENMFTKDELKENT---SFEE--IAL--------NFKGDS-IQSLQLGLDYLIETDMRNELID---V--KVPLL--LLHGEQDVICPLSAAHSMTEN---AN-A--KLK-------VVSEAGHALCV----------------TNFEYCANEIIQFVEGIRHDQQNV--TTKTI--------------------------------------------     =====>
bacce-BC4116   	---------------------------------------------------------------------------------------------MNELKIIFIPGWGMEENIWDLVL-----PYFK---G-YSVQCIDWRN----------VK--ERSEF------AERIID---VA------HND-N---VILVGWSLGALAAVEAY------------K------KI-----QAKGIVLIGGTAKFTNT---S------------DYSNGWNAL----HVERLKRNLARRKEDTLKRFYENMFTKDELKENK---NFED--IVD--------RFKGDS-IQSLQLGLDYLIETDMREELKE---I--KVPIL--LIHGEQDVICPLSAARSMTEN---SS-S--ELK-------VVSEAGHALCV----------------MNFEYCANEIIQFVEGIRHDQQNV--TTKTV--------------------------------------------     =====>
bacce-c2pjt4   	----------------------------------------------------------------------------------------------------------MEEGVWTLVL-----PYFK---G-YSVQCINWRN----------VK--EQSEF------AGRIID---VA------KDE-N---VILVGWSLGALAAVQAH------------K------KV-----KAKGIVLIGGTAKFTST---N------------DYTSGWNTL----HVERLKKNLVRKKEDTLKRFYENMFTKDELKENK---RFED--MIK--------RFKGDS-IQSLQLGLEYLIEADMREELKE---I--KVPIL--LIHGEQDVICPLSAARSMAEN---ET-A--TLK-------VVSEAGHALCV----------------TNFEYCGNEIIQFVEGIRHDQQNV--TSKTV--------------------------------------------     =====>
bacce-c2qxu3   	----------------------------------------------------------------------------------------------------------MEGDIWDLVL-----PHLK---E-YPVQCIDWRN----------VK--EQSEF------ADRIID---VA------QDD-N---VILVGWSLGALAAIQAY------------K------KI-----KAKGIVLIGGTAKFTNA---S------------DYSNGWNAL----HVERLKKNVARKKEDTLKRFYENMFTKNELKENK---RFED--MIK--------RFKGDS-IQSLLLGLDYLIETDMREELKE---V--KGPIL--LIHGERDVICPLSAARSIAVN---ET-A--MLK-------VVSEAGHALCV----------------TNFEYCANEIIQFVEGIRHDQQNV--TTKTV--------------------------------------------     =====>
bacce-c2u276   	----------------------------------------------------------------------------------------------------------MEENVWDLVL-----PYFK---E-YPVQCIDWRN----------VK--EIGEF------AERIID---VA------HDE-N---VILVGWSLGALAAIQAY------------K------KI-----KAKGIVLIGGTAKFTNT---S------------DYTSGWNSL----HVERLKKNLVRKKEDTLKRFYENMFTKDELKENK---CFED--IVK--------HFKGDS-IQSLQLGLDYLIETDMRGELKE---I--QAPIL--LIHGEQDVICPLSAAHSMADN---TN-V--TLK-------VVSEAGHALCI----------------MNLEYCANEVIQFVEGIRHDQQNV--TAKTV--------------------------------------------     =====>
bacce-c2wbq5   	----------------------------------------------------------------------------------------------------------MEKQVWDPLL-----PYFQ---E-YSVRHVEWRD----------VK--EITDF------AKRIEE---AA------KGK-E---VVLIGWSLGALAALQVC------------D------RV-----RTKGMVLIGSTAKFTVD---E------------NYESGWKSP----FVERMKRSLVKRKDDTLERFYKSMFTKQELKESE---QFEG--IVA--------RFQGDS-IESLQLGLDYLIEMDMRSQLQD---V--KTPIL--LLHGEQDTICPLSAARYIQEN---TI-G--TLK-------VRNGAGHALCV----------------TDFEYCANEIIRFVEGIQNDQQNV--ITKTI--------------------------------------------     =====>
bacce-c2yw57   	----------------------------------------------------------------------------------------------------------MEEGVWTLVL-----PYFK---G-YSVQCINWRN----------VR--EQSEF------AGRIID---VA------KDE-N---VILVGWSLGALAAVQVH------------K------KI-----KAKGIVLIGGTAKFTNT---S------------DYTSGWNAL----HVERLKKNVARKKKDTLKRFYENMFTKDELKENK---RFED--MIK--------RFKGDS-IQSLQLGLEYLIEADMREELKE---V--KVPIL--LIHGEQDVICPLSAARSMAEN---ET-A--TLK-------VVSEAGHALCV----------------TNFEYCGNEIIQFVEGIRNDQQNV--TTKTV--------------------------------------------     =====>
bacce-c2zcf9   	----------------------------------------------------------------------------------------------------------MEEGVWTLVL-----PYFK---G-YSVQCIDWRN----------VK--EQSEF------AGRIID---VA------QDE-N---VILVGWSLGALAAVQAY------------K------KV-----KAKGMVLIGGTAKFTNT---S------------DYTSGWNSL----HVERMKKNLTRKKEDTLKRFYENMFTKSELKENT---NFEE--IAL--------KFKGDS-IQSLQLGLDYLIGTDMRNELTS---V--KVPLL--LLHGEQDVICPLSAAHSMTEN---TN-A--TLK-------VVSEAGHALCV----------------TNFEYCANEIIQFVEGIRHDQQNV--TAKTV--------------------------------------------     =====>
baccn-a7gse0   	---------------------------------------------------------------------------------------------MKQLKLIFIPGWGMEKQVWSPIL-----SLLQ---E-SFAEYIEWHD----------VK--EINEF------AKRVEK---AA------EGY-D---VILIGWSLGALVALEVC------------N------NV-----KTKGMILISSTAKFTVD---E------------RYKHGWKPS----FVERMKRNIKKRKNETLSRFYISMFAEEESAVKE---SFEN--MIK--------EFQGDS-TESLQTGLDYLMRADMRERLKD---V--NVPML--LLHGEQDSICPLPAAHYIKEK---TN-A--TLK-------VIHQAGHAICI----------------TNFEYCANEINKFIEGIRNDQ------------------------------------------------------     =====>
bacha-BH3908   	------------------------------------------------------------------------------------------------MNVLWIPGWSIPFDRWKELC----SPFQK---AELEGMFIDFRA----------CQ--RREDF------LQLVLD---TI---D-GHQG-E---WLLAGWSMGSMIAIEAA------------TL----RKA-----RVKGLFLLSSGLQFSQS---D------------HHPGGIPLA----VIRHMSRQLKRNRTDTLTSFYEQMFSESEKSHGLDQAFLQTLEAGD--------PFYHWQ-NESLIAGLDYLANVQLLQGWPT---V--SVPIT--WIHGSDDTICPSPASGLF---------------SPSKRLIIVEGAGHVPFY----------------TQDSVVINAWEELLGNVY---------------------------------------------------------     =====>
bacmy-c3aq75   	---------------------------------------------------------------------------------------------MKQPELIFIPGWGMEKQVWDLLL-----PYFQ---E-YSVWHVEWRG----------VK--ELSEF------AERVAE---AA------RGQ-D---VILIGWSLGALAALQAC------------D------RV-----WVKGMILIGGTAKFTVD---E------------NYESGWKLP----FVERMKRSLVKRKDHTLERFYKSMFTKQEIKDSE---QFED--IAE--------RFQGDF-IESLQLGLDYLIEMDMRSQLKH---V--KMPVL--LLHGEQDAICPLSAARYIQEN---TN-G--ALK-------VINGAGHALCV----------------TDSEYCANEIIQFVEGIQNDQQNV--ITKTI--------------------------------------------     =====>
bactu-c3c7d6   	----------------------------------------------------------------------------------------------------------MEENIWDLVL-----PHLK---E-YPVQCIDWRN----------VK--EQSEF------ADRIID---VA------QDD-N---VILVGWSLGALAAIQAY------------K------KI-----KAKGIVLIGGTAKFTNA---S------------DYSNGWNAL----HVERLKKNVARKKEDTLKRFYENMFTKNELKENK---RFED--MIK--------RFKGDS-IQSLLLGLDYLIETDMREELKE---V--KVPIL--LIHGERDVICPLSAARSMAVN---ET-A--MLK-------VVSEAGHALCV----------------TNFEYCANEIIQFVEGIRHDQQNV--TTKTV--------------------------------------------     =====>
bacwk-a9vg55   	---------------------------------------------------------------------------------------------MKELKLIFIPGWGMEEGVWTLVL-----PYFK---G-YSVQCIDWRN----------VK--EQSEF------AGRIID---VA------QDE-N---VILVGWSLGALAAVQAY------------K------KI-----KTQGMVLIGGTAKFTNT---S------------DYTSGWNSL----HVERMKKNLTRKKEDTLKRFYENM