Gene_locus Report for: teth8-Q5SI36

Putative uncharacterized protein TTHA1544

The adjacent gene TTHA1545 is complementary (C-term) to this sequence but not in the same frame and not in the right order

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Deinococcus-Thermus: N E > Deinococci: N E > Thermales: N E > Thermaceae: N E > Thermus: N E > Thermus thermophilus: N E

6_AlphaBeta_hydrolase : thet2-q72kf4Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) putative hydrolase, thet2-q72kp8Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) putative hydrolase, thet2-q746k7Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (and strain HB8 / ATCC 27634 / DSM 579) hypothetical protein.
A85-IroE-IroD-Fes-Yiel : thet2-q72jm3Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (strain HB8 / ATCC 27634 / DSM 579) ferric enterobactin esterase-related protein.
ACPH_Peptidase_S9 : thet2-q72i91Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (strain HB8 / ATCC 27634 / DSM 579) acylamino-acid-releasing enzyme (EC 3.4.19.1).
AlphaBeta_hydrolase : theth-TT1662 Thermus thermophilus TT1662 TTC1275 TTHA1638 (strain HB27/ATCC BAA-163/DSM 7039 and HB8); uncultured bacterium.
CarbLipBact_2 : thet2-q72hz1Thermus thermophilus carboxylesterase (EC 3.1.1.1).
Carbon-carbon_bond_hydrolase : thet8-q53vu2Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 2-hydroxymuconic semialdehyde hydrolase.
Carb_B_Bacteria : theth-TTC1787Thermus thermophilus carboxylesterase (EC 3.1.1.3).
Epoxide_hydrolase : thet2-q72hv6Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (strain HB8 / ATCC 27634 / DSM 579) 3-oxoadipate enol-lactonase (EC 3.1.1.24).
Pectinacetylesterase-Notum : thet2-q72j75Thermus thermophilus hyper-thermoalkalophilic esterase E34Tt KLEST-3S estC55-38 estC76-179 estC76-218.
Proline_iminopeptidase : thet2-q72hm9 Thermus thermophilus proline iminopeptidase (EC 3.4.11.5) (no catalytic serine).
Prolyl_oligopeptidase_S9 : thet2-q72jk9Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (strain HB8 / ATCC 27634 / DSM 579) putative hydrolase.
TTHA1544-like : thetg-f6ddv5Thermus thermophilus (strain SG0.5JP17-16). Uncharacterized protein

Title: Structure of the minimized alpha/beta-hydrolase fold protein from Thermus thermophilus HB8
Xie Y, Takemoto C, Kishishita S, Uchikubo-Kamo T, Murayama K, Chen L, Liu ZJ, Wang BC, Manzoku M and Yokoyama S <3 more author(s)> Xie Y, Takemoto C, Kishishita S, Uchikubo-Kamo T, Murayama K, Chen L, Liu ZJ, Wang BC, Manzoku M, Ebihara A, Kuramitsu S, Shirouzu M, Yokoyama S (- 3)
Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 63:993, 2007 : PubMed
Abstract


ESTHER: Xie_2007_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_63_993
PubMedSearch: Xie 2007 Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun 63 993
PubMedID: 18084077
Gene_locus related to this paper: teth8-Q5SI36

Abstract

The gene encoding TTHA1544 is a singleton found in the Thermus thermophilus HB8 genome and encodes a 131-amino-acid protein. The crystal structure of TTHA1544 has been determined at 2.0 A resolution by the single-wavelength anomalous dispersion method in order to elucidate its function. There are two molecules in the asymmetric unit. Each molecule consists of four alpha-helices and six beta-strands, with the beta-strands composing a central beta-sheet. A structural homology search revealed that the overall structure of TTHA1544 resembles the alpha/beta-hydrolase fold, although TTHA1544 lacks the catalytic residues of a hydrolase. These results suggest that TTHA1544 represents the minimized alpha/beta-hydrolase fold and that an additional component would be required for its activity.