Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) hormone-sensitive lipase (EC 3.1.1.79) (HSL)
(from Uniprot) Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs. Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. There are two entries ((PTL) mRNA clone 7G5 pancreatic )differing only by four amino acid
Family : Hormone-sensitive_lipase_like
Block : H
Position in NCBI Life Tree : Spermophilus tridecemlineatus
MDLRTMTQSL VTLAEDNMAF FSSQGPGETA RRLSNVFAGV REQALGLEPA LGSLLSVAHL FDLDPETPAN GYRSLVHTAR CCLAHLLHKS RYVASNRRSI FFRTSHNLAE LEAYLAALTQ LRALAYYAQR LLATNRPGGL FFEGDEGLTA DFLREYVTLH KGCFYGRCLG FQFTPSIRPF LQTISIGLVS FGEHYKRNES GLGVTASSLF TSGRFAIDPE LRGAEFERIT QNLDVHFWKA FWNITEIEVL SSLANMASAT VRVSRLISLP PEAFEMPLTS DPKLTVTISP PLAHTGPGPV LIRLISYDLR EGQDSEELNS MVKSEGPRIL ELRPRPQQTS RSRSLVVXFH GGGFVAQTSK SHEPYLKSWA QELGAPIISI DYSLAPEAPF PRALEECFFA YCWAVKHCAL LGSTGERICL AGDSAGGNLC FTVALRAAAY GVRVPDGIMA AYPATMLQSA ASPSRLLSLM DPLLPLSVLS KCVSAYAGAE TEEHPNSDEK ALGMMGLVRR DTSLLLRDLR LGASSWLNSF LEFSGQKSQK TSAPTVESMR RSVSEAALAQ PEGPVGTDSL KILTLKDLNL KSSSETSETP EMSLSVETLG PSTPSDVNFF LRPEDAREEA EAKEGLSAKD GSSRVSNAFP EGFHPRRTSQ GATQMPLYSS PIVKNPFMSP LLAPDNMLKT LPPVHIVACA LDPMLDDSXM FARRLRALGQ PVTLRVVEDL PHGFLSLASL CRETRQAAEL CVERIRLILT PPAAAAAAAP PPL
No reference