(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Platyhelminthes: NE > Rhabditophora: NE > Seriata: NE > Tricladida: NE > Continenticola: NE > Geoplanoidea: NE > Dugesiidae: NE > Schmidtea: NE > Schmidtea mediterranea: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MKSYLILNTLLLSLLKINGFSKSSWFSSKTSLIFDRINKLNDPQSSNSIH SRKYQYFQLKKFPNSTNVRCNDGSIPGYYTRPSTTNCSKKWLIFLEGGWY CFNNNTCESRRRTHYDLFSSEFWSSERQLGGILSNNERINPNFHDYNSVY IPYCSSDLWSGKQLEKTNGLYFHGSRILDTVVDDLTQNQHFKKVHEVAFV GSSAGGIGVLLNIDRLKRRLKKKLKRKVFIHGIVDSAWFLDYPAYRQSNC THIYECPPENALRNGMKLWNPRIPRRCKKFQGRGREWKCFMGPVIYRHLK NPTFIIQSLFDDAQLQMSKVPILEGGSNKKFSYIQQLGGFAAQTLRQAKG VFAHSCVDHEILTKSNWAYVSVNNQRLHETLNYWQAYLEGEKKKIKKKVQ KNPKLIKTGKSPCKNLRKPKFSGNIDQSKYQLIDSCHISQITSYKIQLPH NRTLSRCANAIPLIPLCNPTCSPLSHPISGLSMSFIDLLELYNVRINLIA KSLGISMEQLRKMNTQQQISLLYCSSR
Reference
Title: Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration Petersen CP, Reddien PW Ref: Science, 332:852, 2011 : PubMed
Regeneration requires initiation of programs tailored to the identity of missing parts. Head-versus-tail regeneration in planarians presents a paradigm for study of this phenomenon. After injury, Wnt signaling promotes tail regeneration. We report that wounding elicits expression of the Wnt inhibitor notum preferentially at anterior-facing wounds. This expression asymmetry occurs at essentially any wound, even if the anterior pole is intact. Inhibition of notum with RNA interference (RNAi) causes regeneration of an anterior-facing tail instead of a head, and double-RNAi experiments indicate that notum inhibits Wnt signaling to promote head regeneration. notum expression is itself controlled by Wnt signaling, suggesting that regulation of feedback inhibition controls the binary head-tail regeneration outcome. We conclude that local detection of wound orientation with respect to tissue axes results in distinct signaling environments that initiate appropriate regeneration responses.
