(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Platyhelminthes: NE > Trematoda: NE > Digenea: NE > Strigeidida: NE > Schistosomatoidea: NE > Schistosomatidae: NE > Schistosoma: NE > Schistosoma japonicum: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MTSATCVNGSDPCLTEDLTMRRNLVNRLFLFIRPIHSQFSYWLMSPKSLC SLINFNKSLHVSGLFILFVFGVPVSSSLNYIVLPLSLLISVLLLMLALWF CFLYLEQTLVYACNEPLSSRLLYTNPSSFGFFTWELVKLHPNGKTGPTII GFLLLQPNLYQRKSCPVVLLLHGNAGNSTSRLPMCQILKNRFECNIFIID YRGYGHSTGKPSEEGLYADCKCALDYLYTRNDLNDRKIFVLGRSLGGALA IYLAGDPVSSRKICGVIIENTFTSITDAASHILNIPCKLPSRLFINQYPS LAKLQSCCKSRKSSSAFPPMLLISGELDNIIPPTMMWKLAEAYENIVTKQ QIQNDHSSNIYDDSSKGGSLSQKPDTFINSGTDGLVSFPDGHHNDTWFCN QWSDVILRFIEQSSLRPKSTINENDLDISV
Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region. Knowledge of the genome of this parasite should improve understanding of schistosome-host interactions, biomedical aspects of schistosomiasis and invertebrate evolution. We assigned 43,707 expressed sequence tags (ESTs) derived from adult S. japonicum and their eggs to 13,131 gene clusters. Of these, 35% shared no similarity with known genes and 75% had not been reported previously in schistosomes. Notably, S. japonicum encoded mammalian-like receptors for insulin, progesterone, cytokines and neuropeptides, suggesting that host hormones, or endogenous parasite homologs, could orchestrate schistosome development and maturation and that schistosomes modulate anti-parasite immune responses through inhibitors, molecular mimicry and other evasion strategies.
