Gene_locus Report for: pteal-l5kvh1.1

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Chiroptera: N E > Megachiroptera: N E > Pteropodidae: N E > Pteropodinae: N E > Pteropus: N E > Pteropus alecto: N E

Title: Comparative analysis of bat genomes provides insight into the evolution of flight and immunity
Zhang G, Cowled C, Shi Z, Huang Z, Bishop-Lilly KA, Fang X, Wynne JW, Xiong Z, Baker ML and Wang J <18 more author(s)> Zhang G, Cowled C, Shi Z, Huang Z, Bishop-Lilly KA, Fang X, Wynne JW, Xiong Z, Baker ML, Zhao W, Tachedjian M, Zhu Y, Zhou P, Jiang X, Ng J, Yang L, Wu L, Xiao J, Feng Y, Chen Y, Sun X, Zhang Y, Marsh GA, Crameri G, Broder CC, Frey KG, Wang LF, Wang J (- 18)
Ref: Science, 339:456, 2013 : PubMed
Abstract


ESTHER: Zhang_2013_Science_339_456
PubMedSearch: Zhang 2013 Science 339 456
PubMedID: 23258410
Gene_locus related to this paper: myods-l5mij9, pteal-l5k8f5, pteal-l5kjy3, pteal-l5k6f0, pteal-l5kxe2, myods-l5m0a8, myods-l5lvb4, pteal-l5k7h7, myods-l5lm42, pteal-l5jz73, pteal-l5kvh1.1, pteal-l5kvh1.2, pteal-l5kw21, myods-l5lug5, pteal-l5kv18, myods-l5lbf8, pteal-l5kwh0, myods-l5lfh8, myods-l5lfr7, myods-l5lu20, pteal-l5jzi4, pteal-l5kib7, pteal-l5kyq5, myods-l5lf36, myods-l5lnh7, myods-l5lu25, pteal-l5k0u1, pteal-l5k2g6, pteal-l5l3r3, myods-l5mdx5, pteal-l5k220, myolu-g1pdp2, pteal-l5l5n3, pteal-l5k1s7, myolu-g1nth4, pteal-l5l7w7, pteal-l5l537, myods-l5lwe4, pteal-l5klr9, pteal-l5k670, pteal-l5jr94, pteal-l5kvb4, myolu-g1q4e3, pteal-l5jrl1

Abstract

Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kappaB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.