Sus scrofa (Pig) hormone-sensitive lipase (LIPE gene) (EC 3.1.1.79) (hsl)
(from Uniprot) Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs. Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
MDLRTMTQSL VTLAEDNMAF FSGQGPGETA RRLSGVFAGI REQALGLEPA LGRLLSVAHL FDLDAETPAN GYRSLVHTAR CCLAHLLHKS RYVASNRRSI FFRTSHNLAE LEAYLAALTQ LRALAYYAHR LLAINRPGKL FFEGDEGVTA DFLREYVTLH KGCFYGRCLG FQFTPAIRPF LQTISIGLVS FGEHYKRNET GLSVTASSLF TSGRFAIDPE LRGAEFERII QNLDVHFWKA FWNITEIEVL SSLANMASAT VRVSRLLSLP PKAFEMPLTA DPKLTVTISP PLAHTAPGPV LVRLISYDLR EGQDSEELSS LVRSEGPRSL ELRPRPQQAP RSRSLVVHIH GGGFVAQTSK SHEPYLKSWA QELGVPILSI DYSLAPEAPF PRALEECFYA YCWAVKHCGL LGSTGERICL AGDSAGGNLC FTVSLRAAAY GVRVPDGIMA AYPATMLQSA ASPSRLLSLM DPLLPLSVLS KCVSAYAGGE MEDHSDSDQK ALGMMGLVRR DTALLFRDLR LGASSWLNSF LELSGHKSRP NLVPTEEPMR RSVSEAALAQ PEGPLGTDSL KYLTLHDLSL SSETQDTPEL SLSAETLGPT TPSAVNFLFR PEDAPEEAEA RDEISTKEEK VYSVRAAFPE GFHPRRSSQG AIQMPLYSAP IVKNPFMSPL LAPDSMLQTL PPVHIVACAL DPMLDDSVMF ARRLQLGQPV TLHVVEDLPH RFLSLAALCR ETRQAAALCV DRIRFILNPP GPATPAGPTT PPV
| Title : The porcine hormone-sensitive lipase gene: sequence, structure, polymorphism and linkage mapping - Harbitz_1999_Anim.Genet_30_10 |
| Author(s) : Harbitz I , Langset M , Ege AG , Hoyheim B , Davies W |
| Ref : Anim Genet , 30 :1 , 1999 |
| Abstract : Harbitz_1999_Anim.Genet_30_10 |
| ESTHER : Harbitz_1999_Anim.Genet_30_10 |
| PubMedSearch : Harbitz_1999_Anim.Genet_30_10 |
| PubMedID: 10050278 |
| Gene_locus related to this paper: pig-hslip |