(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Protostomia: NE > Ecdysozoa: NE > Panarthropoda: NE > Arthropoda: NE > Mandibulata: NE > Pancrustacea: NE > Hexapoda: NE > Insecta: NE > Dicondylia: NE > Pterygota: NE > Neoptera: NE > Paraneoptera: NE > Psocodea: NE > Phthiraptera: NE > Anoplura: NE > Pediculidae: NE > Pediculus: NE > Pediculus humanus: NE > Pediculus humanus capitis: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA GGGASVQTQSAHFVEHDSLKFSERNNLGLGEGNMHLNRKDRSEFGAQNKD LKNDYRFVDEKKNDPLIVSTTKGKVRGVTLQAANGKYVDAWLGIPYAQKP IGNLRFRHPRPIEKWDPEIFNATKPPNSCVQILDTVFGDFPGATMWNPNT PLSEDCLYINVVVPKPRPRKSAVMVWIFGGGFYSGTATLDVYDPKTLVSE ENVIVVSMQYRIASLGFLYFGTPDVPGNAGLFDQLMALQWVHDNIRSFGG NPYNVTLFGESAGAVSVSTHLLSPLSRNLFSQAIMESGSPTAPWAIIPTE ESILRGLRLAEAVNCPHDRFQLSAVVECLRNTNASLLVNNEWGTLGICEF PFVPVIDGAFLDELPELALANKNFKKTNILMGSNTEEGYYFIIYYLTELL RKEENVYVNRDEFIKAVRELNPYINNIARQAIIFEYTDWLNPDDPARNRD ALDKMVGDYHFTCSVNEFAHRYAETGNKVYMYYFTHRSAGNPWPSWTGVM HGDEINYIFGEPLNPLKNYQVEEQELSRRIMRYWANFAKTGNPSMSEDGT WTPVVWPEHTAHGREYLTLAVNNTSTGRGPRLKQCAFWKKYLPQLLALTK NIKSNNQIQNCQSKGSKSTFLHFSHFIPPYFNLLLLLLLSLGKIF
Two cDNA sequences encoding Drosophila Ace-orthologous and -paralogous acetylcholinesterase precursors (AO- and AP-AChE precursors, respectively), were identified from the body louse, Pediculus humanus humanus L. In vitro inhibition studies with an insecticide-susceptible body louse strain exhibited a simplex inhibitory response of AChE. The I50 values of fenitroxon and carbaryl were estimated to be 2.2 and 1.9 microM for the susceptible lice, respectively. The mRNA level of AP-AChE gene was 3.1- and 9.3-fold higher than that of AO-AChE gene in the abdomen and the combined parts of the head and thorax, respectively, suggesting, due to its abundance, the potential significance of the AP-AChE isoform in Pediculus human lice in association with the efficacy of AChE-targeting pediculicides.
