mycle-ML0314

Comment

ML0314c showed preference for short carbon chain substrates with maximum activity for pNP-acetate. Secreted carboxyl esterase that could modulate the immune response in leprosy patients. Inhibited by Eserine, DEPC and Orlistat

Relationship

Family : Hormone-sensitive_lipase_like

Block : H

Position in NCBI Life Tree : Mycobacterium leprae

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

AL035159 AL583918

Q9ZBM4 Q7AQJ7

Sequence

Peptide

MAISAGAPVE IVESGPSIAA RLASLTSRLT IRPILAVGSY VPQLPWPFGL IDHAARVLLP VTNAARAEVN LSNTSAQLVR AAGVRPADGS GRIVLYLHGG AFLGCGANSH RRLVETLSKL ADSPILVVNY RLLPKHSIGM ALDDCHDGYQ WLRRLGYDPE QIVLAGDSAG GYLALALAQR LQDVGEEPAA LVAISPLLQL AKKGKQAHPN AKTDAMFPPK AFDALGRLVA SSAAKNKVDD KPEELYEPLD HIAPGLPRTL IHVSGSEVLL HDAQLAATKL AAVGVPAEIR VWPGQVHVFQ AAAPMVPEAT LSLRQISQYI REATASKASR DRQSL

References

Title : Characterization of ML0314c of Mycobacterium leprae and deciphering its role in the immune response in leprosy patients - Kaur_2018_Gene_643_26

Author(s) : Kaur G , Sharma A , Narang T , Dogra S , Kaur J

Ref : Gene , 643 :26 , 2018

Abstract : Kaur_2018_Gene_643_26

ESTHER : Kaur_2018_Gene_643_26

PubMedSearch : Kaur_2018_Gene_643_26

PubMedID: 29208413

Gene_locus related to this paper: mycle-ML0314

Title : Massive gene decay in the leprosy bacillus - Cole_2001_Nature_409_1007

Author(s) : Cole ST , Eiglmeier K , Parkhill J , James KD , Thomson NR , Wheeler PR , Honore N , Garnier T , Churcher C , Harris D , Mungall K , Basham D , Brown D , Chillingworth T , Connor R , Davies RM , Devlin K , Duthoy S , Feltwell T , Fraser A , Hamlin N , Holroyd S , Hornsby T , Jagels K , Lacroix C , Maclean J , Moule S , Murphy L , Oliver K , Quail MA , Rajandream MA , Rutherford KM , Rutter S , Seeger K , Simon S , Simmonds M , Skelton J , Squares R , Squares S , Stevens K , Taylor K , Whitehead S , Woodward JR , Barrell BG

Ref : Nature , 409 :1007 , 2001

Abstract : Cole_2001_Nature_409_1007

ESTHER : Cole_2001_Nature_409_1007

PubMedSearch : Cole_2001_Nature_409_1007

PubMedID: 11234002

Gene_locus related to this paper: mycle-a85a , mycle-a85b , mycle-a85c , mycle-lipG , mycle-LPQC , mycle-metx , mycle-ML0314 , mycle-ML0370 , mycle-ML0376 , mycle-ML1339 , mycle-ML1444 , mycle-ML1632 , mycle-ML1633 , mycle-ML1921 , mycle-ML2269 , mycle-ML2297 , mycle-ML2359 , mycle-ML2603 , mycle-mpt5 , mycle-PKS13 , mycle-PTRB , mycle-q9cc62 , mycle-q9cdb3

mycle-ML0314

Comment

Relationship

Molecular evidence

Mutation (0)

Structure (0)

Kinetic (0)

Disease (0)

Substrate (0)

Inhibitor (0)

Database

Genbank (2)

Interpro (2)

Pfam (2)

UniProt (2)

PIRSF (2)

SUPERFAM (2)

Sequence

Peptide

References

Characterization of ML0314c of Mycobacterium leprae and deciphering its role in the immune response in leprosy patients

Massive gene decay in the leprosy bacillus