Mus musculus (Mouse) (EC 3.1.2.2) very-long-chain Acyl-CoA thioesterase (MTE-I) ACOT2
Q9QYR9 Q6P2K2 few aa different || The mouse ACOT gene cluster comprises six genes with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6). The corresponding human gene cluster contains only three genes (ACOT1, ACOT2, and ACOT4) coding for full-length thioesterase proteins only ACOT4 is peroxisomal
MVASSFAVLR ASRLCQQDWK SWARLFVPPP LSTGGRTTWA RTNATLSVEP EGRSCWDEPL SIAVRGLAPE QPVTLRSALR DEKGALFRAH ARYRADAGGE LNLARAPALG GSFSGLEPMG LLWAMEPERP LWRLIKRDVQ TPFLVELEVL DGHEPDGGQR LAHAVHERHF LAPGVRRVPV REGRVRATLF LPPEPGPFPG IIDLFGVGGG LLEYRASLLA GKGFAVMALA YYNYDDLPKS IETMHMEYFE EAVNYLRSHP EVKGPGIGLL GISKGGELGL AMASFLKGIT AAVVINGSVA AVGNTISYKD ETIPPVSLVR NQVKMTKDGL LDVVEALQSP LVDKKSFIPV ERSDTTFLFL VGQDDHNWKS EFYADEISKR LQAHGKEKPQ IICYPAAGHY IEPPYFPLCS AGMHLLVGAN ITFGGEPRAH AVAQVDAWQQ LQTFFHKQLG SKS
| Title : Acyl-CoA thioesterase-2 facilitates beta-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner - Bekeova_2023_bioRxiv__ |
| Author(s) : Bekeova C , Han JI , Xu H , Kerr E , Blackburne B , Lynch SC , Mesaros C , Murgia M , Vadigepalli R , Beld J , Leonardi R , Snyder NW , Seifert EL |
| Ref : Biorxiv , : , 2023 |
| Abstract : Bekeova_2023_bioRxiv__ |
| ESTHER : Bekeova_2023_bioRxiv__ |
| PubMedSearch : Bekeova_2023_bioRxiv__ |
| PubMedID: 37425757 |
| Gene_locus related to this paper: mouse-acot2 |
| Title : Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs - Hunt_2006_FASEB.J_20_1855 |
| Author(s) : Hunt MC , Rautanen A , Westin MA , Svensson LT , Alexson SE |
| Ref : FASEB Journal , 20 :1855 , 2006 |
| Abstract : Hunt_2006_FASEB.J_20_1855 |
| ESTHER : Hunt_2006_FASEB.J_20_1855 |
| PubMedSearch : Hunt_2006_FASEB.J_20_1855 |
| PubMedID: 16940157 |
| Gene_locus related to this paper: human-ACOT1 , human-ACOT2 , human-ACOT4 , human-ACOT6 , mouse-acot1 , mouse-acot2 , mouse-acot3 , mouse-acot4 , mouse-acot5 , mouse-ACOT6 |
| Title : Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism - Hunt_2000_Cell.Biochem.Biophys_32 Spring_317 |
| Author(s) : Hunt MC , Lindquist PJ , Nousiainen S , Huttunen M , Orii K , Svensson TL , Aoyama T , Hashimoto T , Diczfalusy U , Alexson SE |
| Ref : Cell Biochem Biophys , 32 Spring :317 , 2000 |
| Abstract : Hunt_2000_Cell.Biochem.Biophys_32 Spring_317 |
| ESTHER : Hunt_2000_Cell.Biochem.Biophys_32 Spring_317 |
| PubMedSearch : Hunt_2000_Cell.Biochem.Biophys_32 Spring_317 |
| PubMedID: 11330065 |
| Gene_locus related to this paper: mouse-acot1 , mouse-acot2 |
| Title : Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism - Hunt_1999_J.Biol.Chem_274_34317 |
| Author(s) : Hunt MC , Nousiainen SE , Huttunen MK , Orii KE , Svensson LT , Alexson SE |
| Ref : Journal of Biological Chemistry , 274 :34317 , 1999 |
| Abstract : Hunt_1999_J.Biol.Chem_274_34317 |
| ESTHER : Hunt_1999_J.Biol.Chem_274_34317 |
| PubMedSearch : Hunt_1999_J.Biol.Chem_274_34317 |
| PubMedID: 10567408 |
| Gene_locus related to this paper: mouse-acot1 , mouse-acot2 , mouse-acot3 , mouse-acot4 |