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mouse-RISC

Mus musculus RISC retinoid-inducible serine carboxypeptidase HSCP1 (serine carboxypeptidase 1)

Comment

Trembl Q99J29 is one aa diff from AK014680 cdna 4833411k15 || Trembl Q920A5 (RISC) Mus musculus (Mouse) retinoid-inducible serine carboxypeptidase in smouth muscle aorta and kidney || Kollmann et al. (2009) showed that the 55-kD mouse Scpep1 precursor protein was processed into a 35-kD N-terminal fragment and an 18-kD C-terminal fragment. Processing was mediated by a lysosomal serine proteinase and took place in the endosomal-lysosomal compartment. All 5 putative N-glycosylation sites of Scpep1 were N-glycosylated in mouse embryonic fibroblasts. Lee et al. (2009) showed that Scpep1 expression promoted growth and migration of mouse or rat smooth muscle cells (SMCs). Mutation analysis revealed that the stimulatory effects of Scpep1 on SMC growth and migration required the Scpep1 catalytic triad, but not cleavage of Scpep1. Immunohistochemical analysis of injured mouse and rat carotid arteries demonstrated increased Scpep1 expression in vessel walls where modulated SMCs were proliferative and migratory. By analyzing cultured mouse aortic vascular SMCs (AVSMCs), Pan et al. (2014) showed that Scpep1 had carboxypeptidase activity towards ET1 (EDN1), complementing the serine carboxypeptidase activity of CathA (CTSA). Analysis with purified recombinant protein confirmed that Scpep1 cleaved the C-terminal trp residue from ET1.

Relationship

Family : Carboxypeptidase_S10

Block : X

Position in NCBI Life Tree : Mus musculus

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MELSRRICLV RLWLLLLSFL LGFSAGSAID WREPEGKEVW DYVTVRKDAH MFWWLYYATN PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTQLKP RNTTWLQWAS LLFVDNPVGT GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF DCHKEFQTVP FYIFSESYGG KMAAGISVEL YKAVQQGTIK CNFSGVALGD SWISPVDSVL SWGPYLYSMS LLDNQGLAEV SDIAEQVLDA VNKGFYKEAT QLWGKAEMII EKNTDGVNFY NILTKSSPEK AMESSLEFLR SPLVRLCQRH VRHLQGDALS QLMNGPIKKK LKIIPEDISW GAQASYVFLS MEGDFMKPAI DVVDKLLAAG VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSKFNQLKWK ALYTDPKSSE TAAFVKSYEN LAFYWILKAG HMVPSDQGEM ALKMMKLVTK QE

References

Title : Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 - Pan_2014_PLoS.Genet_10_e1004146
Author(s) : Pan X , Grigoryeva L , Seyrantepe V , Peng J , Kollmann K , Tremblay J , Lavoie JL , Hinek A , Lubke T , Pshezhetsky AV
Ref : PLoS Genet , 10 :e1004146 , 2014
Abstract : Pan_2014_PLoS.Genet_10_e1004146
ESTHER : Pan_2014_PLoS.Genet_10_e1004146
PubMedSearch : Pan_2014_PLoS.Genet_10_e1004146
PubMedID: 24586188
Gene_locus related to this paper: human-SCPEP1 , mouse-RISC

Title : Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1 - Kollmann_2009_Febs.j_276_1356
Author(s) : Kollmann K , Damme M , Deuschl F , Kahle J , D'Hooge R , Lullmann-Rauch R , Lubke T
Ref : Febs J , 276 :1356 , 2009
Abstract : Kollmann_2009_Febs.j_276_1356
ESTHER : Kollmann_2009_Febs.j_276_1356
PubMedSearch : Kollmann_2009_Febs.j_276_1356
PubMedID: 19187242
Gene_locus related to this paper: human-SCPEP1 , mouse-RISC

Title : Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells - Lee_2009_Circ.Res_105_271
Author(s) : Lee TH , Chen J , Miano JM
Ref : Circulation Research , 105 :271 , 2009
Abstract : Lee_2009_Circ.Res_105_271
ESTHER : Lee_2009_Circ.Res_105_271
PubMedSearch : Lee_2009_Circ.Res_105_271
PubMedID: 19574551
Gene_locus related to this paper: human-SCPEP1 , mouse-RISC

Title : Tissue expression of the novel serine carboxypeptidase Scpep1 - Lee_2006_J.Histochem.Cytochem_54_701
Author(s) : Lee TH , Streb JW , Georger MA , Miano JM
Ref : Journal of Histochemistry & Cytochemistry , 54 :701 , 2006
Abstract : Lee_2006_J.Histochem.Cytochem_54_701
ESTHER : Lee_2006_J.Histochem.Cytochem_54_701
PubMedSearch : Lee_2006_J.Histochem.Cytochem_54_701
PubMedID: 16461364
Gene_locus related to this paper: human-SCPEP1 , mouse-RISC

Title : Functional annotation of a full-length mouse cDNA collection - Kawai_2001_Nature_409_685
Author(s) : Kawai J , Shinagawa A , Shibata K , Yoshino M , Itoh M , Ishii Y , Arakawa T , Hara A , Fukunishi Y , Konno H , Adachi J , Fukuda S , Aizawa K , Izawa M , Nishi K , Kiyosawa H , Kondo S , Yamanaka I , Saito T , Okazaki Y , Gojobori T , Bono H , Kasukawa T , Saito R , Kadota K , Matsuda H , Ashburner M , Batalov S , Casavant T , Fleischmann W , Gaasterland T , Gissi C , King B , Kochiwa H , Kuehl P , Lewis S , Matsuo Y , Nikaido I , Pesole G , Quackenbush J , Schriml LM , Staubli F , Suzuki R , Tomita M , Wagner L , Washio T , Sakai K , Okido T , Furuno M , Aono H , Baldarelli R , Barsh G , Blake J , Boffelli D , Bojunga N , Carninci P , de Bonaldo MF , Brownstein MJ , Bult C , Fletcher C , Fujita M , Gariboldi M , Gustincich S , Hill D , Hofmann M , Hume DA , Kamiya M , Lee NH , Lyons P , Marchionni L , Mashima J , Mazzarelli J , Mombaerts P , Nordone P , Ring B , Ringwald M , Rodriguez I , Sakamoto N , Sasaki H , Sato K , Schonbach C , Seya T , Shibata Y , Storch KF , Suzuki H , Toyo-oka K , Wang KH , Weitz C , Whittaker C , Wilming L , Wynshaw-Boris A , Yoshida K , Hasegawa Y , Kawaji H , Kohtsuki S , Hayashizaki Y
Ref : Nature , 409 :685 , 2001
Abstract : Kawai_2001_Nature_409_685
ESTHER : Kawai_2001_Nature_409_685
PubMedSearch : Kawai_2001_Nature_409_685
PubMedID: 11217851
Gene_locus related to this paper: mouse-1lipg , mouse-1plip , mouse-1plrp , mouse-ABH15 , mouse-abhd5 , mouse-ABHD6 , mouse-Abhd8 , mouse-aryla , mouse-bphl , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-EPHX1 , mouse-ES10 , mouse-hslip , mouse-hyes , mouse-ABHD2 , mouse-lcat , mouse-lipli , mouse-LIPN , mouse-lypla1 , mouse-lypla2 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-Ppgb , mouse-PPME1 , mouse-ppt , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-RISC , mouse-SERHL , mouse-SPG21 , mouse-Tex30

Title : Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells - Chen_2001_J.Biol.Chem_276_34175
Author(s) : Chen J , Streb JW , Maltby KM , Kitchen CM , Miano JM
Ref : Journal of Biological Chemistry , 276 :34175 , 2001
Abstract : Chen_2001_J.Biol.Chem_276_34175
ESTHER : Chen_2001_J.Biol.Chem_276_34175
PubMedSearch : Chen_2001_J.Biol.Chem_276_34175
PubMedID: 11447226
Gene_locus related to this paper: human-SCPEP1 , mouse-RISC , ratno-RISC

Title : Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes - Carninci_2000_Genome.Res_10_1617
Author(s) : Carninci P , Shibata Y , Hayatsu N , Sugahara Y , Shibata K , Itoh M , Konno H , Okazaki Y , Muramatsu M , Hayashizaki Y
Ref : Genome Res , 10 :1617 , 2000
Abstract : Carninci_2000_Genome.Res_10_1617
ESTHER : Carninci_2000_Genome.Res_10_1617
PubMedSearch : Carninci_2000_Genome.Res_10_1617
PubMedID: 11042159
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-hyes , mouse-lipli , mouse-LIPN , mouse-pafa , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC

Title : High-efficiency full-length cDNA cloning -
Author(s) : Carninci P , Hayashizaki Y
Ref : Methods Enzymol , 303 :19 , 1999
PubMedID: 10349636
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-lipli , mouse-LIPN , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC