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mouse-Abhd16b

Mus musculus (Mouse) similar to chromosome 20 open reading frame 135

Comment

Shan et al.<\/A> identified a nonsense mutation in the bovine Abhydrolase domain containing 16B gene ABHD16B (SNP rs468948776 AC_000170 g.54429815G>A) associated with male subfertility in Holstein cattle. The mutation causes a premature stop codon at amino acid position Glu 218, resulting in a truncation of 235 C-terminal amino acids. ABHD16B is involved in lipid biosynthesis in testis and is crucial for fertilization

Relationship

Family : ABHD16

Block : X

Position in NCBI Life Tree : Mus musculus

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MCVICFVKAL VHVFKIYLTA NYSYNFRSWP VDFRWDDLHA PSTGNSSQRA LTCAAAAAGV WLLHDAALGG DTLTRPPRGA RSQVQCLLQQ IRELPSQLAS YALAHSLGRW LVYPGSMFLM TRALMPLLQQ GQERLVDRYR GRRAKLVACD GNEIDTMFMD RRQHPGSHGR GLCLVICCEG NAGFYEMGCL SAPLEAGYSV LGWNHPGFGG STGAPFPQHD ANAMDVVVKY ALHRLNFPPA HVVVYGWSIG GFTATWATMT YPELGALVLD ATFDDLVPLA LKVMPQSWKG LVVRTVREHF NLNVAEQLCC YPGPVLLLRR TQDDVVSTSN HIPSMPSCQV EGDVEGNRGN ELLLRLLQHR YPSVMAREGR TVVTRWLRAS NLAQETALYA RYRVDDEWCL ATLRSYRERC QKELDDAEAW GPHGLSFPWF VGQGLSARRR RQLALFLARR HLKNLEATHC SPLEPEDFQL PWRL

References

Title : Association of alpha\/beta-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition - Shan_2020_Int.J.Mol.Sci_21_
Author(s) : Shan S , Xu F , Bleyer M , Becker S , Melbaum T , Wemheuer W , Hirschfeld M , Wacker C , Zhao S , Schutz E , Brenig B
Ref : Int J Mol Sci , 21 : , 2020
Abstract : Shan_2020_Int.J.Mol.Sci_21_
ESTHER : Shan_2020_Int.J.Mol.Sci_21_
PubMedSearch : Shan_2020_Int.J.Mol.Sci_21_
PubMedID: 31963602
Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B , mouse-Abhd16b