maggr-pyie

Magnaporthe grisea (Crabgrass-specific blast fungus) (Pyricularia grisea) Hydrolase pyiE

Comment

Pyrichalasin H biosynthesis cluster protein E || . Hydrolyase\; part of the gene cluster that mediates the biosynthesis of the mycotoxin pyrichalasin H, a tyrosine-derived cytochalasan that inhibits the growth of rice seedlings, but also inhibits lymphocyte capping and actin polymerization and alters cell morphology. After PyiS PyiC and before PyiF. FUS2 hydrolase family

Relationship

Family : Duf_1100-S

Block : X

Position in NCBI Life Tree : Magnaporthe grisea

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MHKFFPRSGF FDFETVRILG TACYGGADVA EVLEAVGEIK SDDAASWEEA WRRQSWWAEA LADQAREGGD REAARRAYLR ASNYARASGY MYVSDLGAEG GNAPPTQDPR ALPVAEKVGR LFRKALALME GEVRALSIPC GAQALPGLLY LPPPGKRIPG RDKIPVLVFL GGADSCQEEL YYLYPAAGPG LGYAVLTFDG PGQGIVLRKH GLRVRPDWEV VTSSVLDYLE AYSAQHPGLE LDMKAIAVSG ASMGGYYALR SAVDRRVKAC VSIDPFYDMW DFGTAHVSPL FISAWTSGII SSGFVDKLMT VVSRLWFQMK WEIALTGTLF GLSSPSQILL NMKNYTLSGK SDGSRANGKK SHSPTDGGGV ESDSFLSEVR CPVFLSGAGK SLYLDVDSHT RRCYDGLTGV AAKDKELWVP ESEGQGSLQA KMGALALCNQ KTFQFLDKVL GVQRVPLDVS AHI

References

Title : Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans - Zhang_2021_Chemistry_10_3106
Author(s) : Zhang H , Hantke V , Bruhnke P , Skellam E , Cox RJ
Ref : Chemistry , 10 :3106 , 2021
Abstract : Zhang_2021_Chemistry_10_3106
ESTHER : Zhang_2021_Chemistry_10_3106
PubMedSearch : Zhang_2021_Chemistry_10_3106
PubMedID: 33146923
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB , maggr-pyie

Title : Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis - Wang_2019_Org.Lett_21_8756
Author(s) : Wang C , Becker K , Pfutze S , Kuhnert E , Stadler M , Cox RJ , Skellam E
Ref : Org Lett , 21 :8756 , 2019
Abstract : Wang_2019_Org.Lett_21_8756
ESTHER : Wang_2019_Org.Lett_21_8756
PubMedSearch : Wang_2019_Org.Lett_21_8756
PubMedID: 31644300
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB , maggr-pyie

Title : Targeted Gene Inactivations Expose Silent Cytochalasans in Magnaporthe grisea NI980 - Wang_2019_Org.Lett_21_4163
Author(s) : Wang C , Hantke V , Cox RJ , Skellam E
Ref : Org Lett , 21 :4163 , 2019
Abstract : Wang_2019_Org.Lett_21_4163
ESTHER : Wang_2019_Org.Lett_21_4163
PubMedSearch : Wang_2019_Org.Lett_21_4163
PubMedID: 31099577
Gene_locus related to this paper: maggr-pyie