1. Home
  2. Gene Locus
  3. human-NOTUM

human-NOTUM

Homo sapiens (Human) Protein notum homolog

Comment

In animals Notum acts to modify heparan sulfate proteoglycans and thereby alters the extracellular gradient of Wg\/Wnt protein. Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase (Kakugawa et al.). Notum also deacylates octanoylated Ghrelin

Relationship

Family : Pectinacetylesterase-Notum

Block : X

Position in NCBI Life Tree : Homo sapiens

Molecular evidence

No mutation

No kinetic

No disease

ARUK3004048 ARUK3004903 ARUK3004308 ARUK3004558 ARUK3004470 ARUK3004552 ARUK3004556 ARUK3005522 ARUK3005518 ARUK3004876 ARUK3004877 ARUK3006560 ARUK3006561 ARUK3006562 ARUK3003778 ARUK3000438 CHEMBL57478 ARUK3001043 ARUK3002697 ARUK3003934 Fragment-828 Fragment-810 Fragment-872 Fragment-863 Fragment-791 Fragment-772 Fragment-784 Fragment-792 Fragment-705 Fragment-722 Fragment-714 Fragment-658 Fragment-690 Fragment-923 Fragment-924 Fragment-900 Fragment-916 Fragment-934 Fragment-955 Fragment-927 ARUK3000223 Fragment-886 Fragment-067 Fragment-074 Fragment-077 Fragment-065 Fragment-154 Fragment-159 Felbinac Fragment-174 Fragment-173 Fragment-110 Sulfapyridine Fragment-147 Fragment-297 Fragment-290 Fragment-201 Fragment-210 Fragment-283 Fragment-282 Fragment-277 Fragment-276 Fragment-197 Fragment-193 Fragment-199 Fragment-588 Fragment-609 Fragment-634 Fragment-646 Fragment-830 2-N-pyridin-2-ylbenzene-1,2-diamine 1-Naphthalenepentanoic-acid 2-(1,2-Dihydroacenaphthylen-5-ylsulfanyl)acetic-acid N-methyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamide 3-(Quinazolin-4-ylthio)propanoic-acid 4,5-Dihydronaphtho[1,2-b]thiophene-2-carboxylic-acid (Isoquinolin-1-ylsulfanyl)-acetic-acid Cotinine Riluzole ARUK3003710 (4-fluoroanilino)thiourea Methyl-4H-thieno[3,2-c]chromene-2-carboxylic-acid 4H-thieno[3,2-c]chromene-2-carboxylic-acid Piperine Maybridge_18 Maybridge_4 Maybridge_56 TDZD8 PPOH Bepridil ARUK3003902 ARUK3003909 ARUK3003776 ARUK3003775 ARUK3003748 Fragment-063-notum-screen Fragment-064-notum-screen Fragment-049-notum-screen SCHEMBL21776992 4F-329S Caffeine Pyrrole-5-6YUY Pyrrole-6-6YV4 Pyrrole-7-6YUW Pyrrolidine-8-6YV2 Pyrrolidine-10-6YV0 Pyrrole-20i-6YXI Pyrrole-26-6YSK M9N LP-914822 N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide N-acetylserotonin Melatonin Theophylline Isoquinoline-45-JV8 Benzotriazole-39-JV5 JVB CHEMBL4539054 LP-922056 Heparin-disaccharide Palmitoleic-acid LP-935001 Myristoleic-acid Sucrose-octasulfate Octanoate Decanoate Myristic-acid Laurate ARUK3003718 ARUK3003907 ARUK3003910 ARUK3002704 ARUK3003906 ARUK3001185 ABC99 Nicotine PMSF

Database

Sequence

Peptide

MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH LTGQPVQEGL RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV QVKGTSLPRA LHCWDRSLHD SHKASKTPLK GCPVHLVDSC PWPHCNPSCP TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP QGLEPSELLG MLSNGS

References

Title : Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity - Atkinson_2023_Eur.J.Med.Chem_251_115132
Author(s) : Atkinson BN , Willis NJ , Zhao Y , Patel C , Frew S , Costelloe K , Magno L , Svensson F , Jones EY , Fish PV
Ref : Eur Journal of Medicinal Chemistry , 251 :115132 , 2023
Abstract : Atkinson_2023_Eur.J.Med.Chem_251_115132
ESTHER : Atkinson_2023_Eur.J.Med.Chem_251_115132
PubMedSearch : Atkinson_2023_Eur.J.Med.Chem_251_115132
PubMedID: 36934521
Gene_locus related to this paper: human-NOTUM

Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060
Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY
Ref : ACS Chem Neurosci , 13 :2060 , 2022
Abstract : Zhao_2022_ACS.Chem.Neurosci_13_2060
ESTHER : Zhao_2022_ACS.Chem.Neurosci_13_2060
PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060
PubMedID: 35731924
Gene_locus related to this paper: human-NOTUM

Title : Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity - Steadman_2022_J.Med.Chem_65_562
Author(s) : Steadman D , Atkinson BN , Zhao Y , Willis NJ , Frew S , Monaghan A , Patel C , Armstrong E , Costelloe K , Magno L , Bictash M , Jones EY , Fish PV , Svensson F
Ref : Journal of Medicinal Chemistry , 65 :562 , 2022
Abstract : Steadman_2022_J.Med.Chem_65_562
ESTHER : Steadman_2022_J.Med.Chem_65_562
PubMedSearch : Steadman_2022_J.Med.Chem_65_562
PubMedID: 34939789
Gene_locus related to this paper: human-NOTUM

Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212
Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV
Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022
Abstract : Willis_2022_J.Med.Chem_65_7212
ESTHER : Willis_2022_J.Med.Chem_65_7212
PubMedSearch : Willis_2022_J.Med.Chem_65_7212
PubMedID: 35536179
Gene_locus related to this paper: human-NOTUM

Title : Structural Insights into Notum Covalent Inhibition - Zhao_2021_J.Med.Chem_64_11354
Author(s) : Zhao Y , Svensson F , Steadman D , Frew S , Monaghan A , Bictash M , Moreira T , Chalk R , Lu W , Fish PV , Jones EY
Ref : Journal of Medicinal Chemistry , 64 :11354 , 2021
Abstract : Zhao_2021_J.Med.Chem_64_11354
ESTHER : Zhao_2021_J.Med.Chem_64_11354
PubMedSearch : Zhao_2021_J.Med.Chem_64_11354
PubMedID: 34292747
Gene_locus related to this paper: human-NOTUM

Title : Notum deletion from late-stage skeletal cells increases cortical bone formation and potentiates skeletal effects of sclerostin inhibition - Choi_2021_J.Bone.Miner.Res__
Author(s) : Choi RB , Bullock WA , Hoggatt AM , Horan DJ , Pemberton EZ , Hong JM , Zhang X , He X , Robling AG
Ref : J Bone Miner Res , : , 2021
Abstract : Choi_2021_J.Bone.Miner.Res__
ESTHER : Choi_2021_J.Bone.Miner.Res__
PubMedSearch : Choi_2021_J.Bone.Miner.Res__
PubMedID: 34223673
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : NOTUM from Apc-mutant cells biases clonal competition to initiate cancer - Flanagan_2021_Nature__
Author(s) : Flanagan DJ , Pentinmikko N , Luopajarvi K , Willis NJ , Gilroy K , Raven AP , McGarry L , Englund JI , Webb AT , Scharaw S , Nasreddin N , Hodder MC , Ridgway RA , Minnee E , Sphyris N , Gilchrist E , Najumudeen AK , Romagnolo B , Perret C , Williams AC , Clevers H , Nummela P , Lahde M , Alitalo K , Hietakangas V , Hedley A , Clark W , Nixon C , Kirschner K , Jones EY , Ristimaki A , Leedham SJ , Fish PV , Vincent JP , Katajisto P , Sansom OJ
Ref : Nature , : , 2021
Abstract : Flanagan_2021_Nature__
ESTHER : Flanagan_2021_Nature__
PubMedSearch : Flanagan_2021_Nature__
PubMedID: 34079124
Gene_locus related to this paper: human-NOTUM

Title : Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__
Author(s) : Zhao Y , Jolly S , Benvegnu S , Jones EY , Fish PV
Ref : Future Med Chem , : , 2021
Abstract : Zhao_2021_Future.Med.Chem__
ESTHER : Zhao_2021_Future.Med.Chem__
PubMedSearch : Zhao_2021_Future.Med.Chem__
PubMedID: 33882714
Gene_locus related to this paper: human-NOTUM

Title : Notum Deacylates Octanoylated Ghrelin - Zhao_2021_Mol.Metab__101201
Author(s) : Zhao Y , Schuhmacher LN , Roberts M , Kakugawa S , Bineva-Todd G , Howell S , O'Reilly N , Perret C , Snijders AP , Vincent JP , Jones EY
Ref : Mol Metab , :101201 , 2021
Abstract : Zhao_2021_Mol.Metab__101201
ESTHER : Zhao_2021_Mol.Metab__101201
PubMedSearch : Zhao_2021_Mol.Metab__101201
PubMedID: 33647468
Gene_locus related to this paper: human-NOTUM

Title : Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling - Bayle_2021_J.Med.Chem__
Author(s) : Bayle ED , Svensson F , Atkinson BN , Steadman D , Willis NJ , Woodward HL , Whiting P , Vincent JP , Fish PV
Ref : Journal of Medicinal Chemistry , : , 2021
Abstract : Bayle_2021_J.Med.Chem__
ESTHER : Bayle_2021_J.Med.Chem__
PubMedSearch : Bayle_2021_J.Med.Chem__
PubMedID: 33783220
Gene_locus related to this paper: human-NOTUM

Title : Osteocyte- and late Osteoblast-derived NOTUM Reduces Cortical Bone Mass in Mice - Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__
Author(s) : Nilsson KH , Henning P , El Shahawy M , Wu J , Koskela A , Tuukkanen J , Perret C , Lerner UH , Ohlsson C , Moverare-Skrtic S
Ref : American Journal of Physiology Endocrinol Metab , : , 2021
Abstract : Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__
ESTHER : Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__
PubMedSearch : Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__
PubMedID: 33749332
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit - Mahy_2020_J.Med.Chem_63_12942
Author(s) : Mahy W , Willis NJ , Zhao Y , Woodward HL , Svensson F , Sipthorp J , Vecchia L , Ruza RR , Hillier J , Kjr S , Frew S , Monaghan A , Bictash M , Salinas PC , Whiting P , Vincent JP , Jones EY , Fish PV
Ref : Journal of Medicinal Chemistry , 63 :12942 , 2020
Abstract : Mahy_2020_J.Med.Chem_63_12942
ESTHER : Mahy_2020_J.Med.Chem_63_12942
PubMedSearch : Mahy_2020_J.Med.Chem_63_12942
PubMedID: 33124429
Gene_locus related to this paper: human-NOTUM

Title : Caffeine inhibits Notum activity by binding at the catalytic pocket - Zhao_2020_Commun.Biol_3_555
Author(s) : Zhao Y , Ren J , Hillier J , Lu W , Jones EY
Ref : Commun Biol , 3 :555 , 2020
Abstract : Zhao_2020_Commun.Biol_3_555
ESTHER : Zhao_2020_Commun.Biol_3_555
PubMedSearch : Zhao_2020_Commun.Biol_3_555
PubMedID: 33033363
Gene_locus related to this paper: human-NOTUM

Title : Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity - Mahy_2020_J.Med.Chem_63_9464
Author(s) : Mahy W , Patel M , Steadman D , Woodward HL , Atkinson BN , Svensson F , Willis NJ , Flint A , Papatheodorou D , Zhao Y , Vecchia L , Ruza RR , Hillier J , Frew S , Monaghan A , Costa A , Bictash M , Walter MW , Jones EY , Fish PV
Ref : Journal of Medicinal Chemistry , 63 :9464 , 2020
Abstract : Mahy_2020_J.Med.Chem_63_9464
ESTHER : Mahy_2020_J.Med.Chem_63_9464
PubMedSearch : Mahy_2020_J.Med.Chem_63_9464
PubMedID: 32787107
Gene_locus related to this paper: human-NOTUM

Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805
Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA
Ref : Cell Rep , 31 :107805 , 2020
Abstract : Mizrak_2020_Cell.Rep_31_107805
ESTHER : Mizrak_2020_Cell.Rep_31_107805
PubMedSearch : Mizrak_2020_Cell.Rep_31_107805
PubMedID: 32579931
Gene_locus related to this paper: human-NOTUM

Title : Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen - Atkinson_2019_Medchemcomm_10_1361
Author(s) : Atkinson BN , Steadman D , Zhao YG , Sipthorp J , Vecchia L , Ruza RR , Jeganathan F , Lines G , Frew S , Monaghan A , Kjaer S , Bictash M , Jones Y , Fish PV , Zhao Y , Jones EY
Ref : Medchemcomm , 10 :1361 , 2019
Abstract : Atkinson_2019_Medchemcomm_10_1361
ESTHER : Atkinson_2019_Medchemcomm_10_1361
PubMedSearch : Atkinson_2019_Medchemcomm_10_1361
PubMedID: 31534655
Gene_locus related to this paper: human-NOTUM

Title : Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum - Zhao_2019_J.Pineal.Res__e12630
Author(s) : Zhao Y , Ren J , Hillier J , Jones M , Lu W , Jones EY
Ref : J Pineal Res , :e12630 , 2019
Abstract : Zhao_2019_J.Pineal.Res__e12630
ESTHER : Zhao_2019_J.Pineal.Res__e12630
PubMedSearch : Zhao_2019_J.Pineal.Res__e12630
PubMedID: 31876313
Gene_locus related to this paper: human-NOTUM

Title : Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways - Li_2019_Biol.Res_52_10
Author(s) : Li W , Yu X , Zhu C , Wang Z , Zhao Z , Li Y , Zhang Y
Ref : Biol Res , 52 :10 , 2019
Abstract : Li_2019_Biol.Res_52_10
ESTHER : Li_2019_Biol.Res_52_10
PubMedSearch : Li_2019_Biol.Res_52_10
PubMedID: 30871618
Gene_locus related to this paper: human-NOTUM

Title : NOTUM inhibition increases endocortical bone formation and bone strength - Brommage_2019_Bone.Res_7_2
Author(s) : Brommage R , Liu J , Vogel P , Mseeh F , Thompson AY , Potter DG , Shadoan MK , Hansen GM , Jeter-Jones S , Cui J , Bright D , Bardenhagen JP , Doree DD , Moverare-Skrtic S , Nilsson KH , Henning P , Lerner UH , Ohlsson C , Sands AT , Tarver JE , Powell DR , Zambrowicz B , Liu Q
Ref : Bone Res , 7 :2 , 2019
Abstract : Brommage_2019_Bone.Res_7_2
ESTHER : Brommage_2019_Bone.Res_7_2
PubMedSearch : Brommage_2019_Bone.Res_7_2
PubMedID: 30622831
Gene_locus related to this paper: human-NOTUM

Title : An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent - Willis_2019_Beilstein.J.Org.Chem_15_2790
Author(s) : Willis NJ , Bayle ED , Papageorgiou G , Steadman D , Atkinson BN , Mahy W , Fish PV
Ref : Beilstein J Org Chem , 15 :2790 , 2019
Abstract : Willis_2019_Beilstein.J.Org.Chem_15_2790
ESTHER : Willis_2019_Beilstein.J.Org.Chem_15_2790
PubMedSearch : Willis_2019_Beilstein.J.Org.Chem_15_2790
PubMedID: 31807213
Gene_locus related to this paper: human-NOTUM

Title : Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors - Atkinson_2019_Bioorg.Med.Chem.Lett__126751
Author(s) : Atkinson BN , Steadman D , Mahy W , Zhao Y , Sipthorp J , Bayle ED , Svensson F , Papageorgiou G , Jeganathan F , Frew S , Monaghan A , Bictash M , Jones EY , Fish PV
Ref : Bioorganic & Medicinal Chemistry Lett , :126751 , 2019
Abstract : Atkinson_2019_Bioorg.Med.Chem.Lett__126751
ESTHER : Atkinson_2019_Bioorg.Med.Chem.Lett__126751
PubMedSearch : Atkinson_2019_Bioorg.Med.Chem.Lett__126751
PubMedID: 31862412
Gene_locus related to this paper: human-NOTUM

Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398
Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P
Ref : Nature , 571 :398 , 2019
Abstract : Pentinmikko_2019_Nature_571_398
ESTHER : Pentinmikko_2019_Nature_571_398
PubMedSearch : Pentinmikko_2019_Nature_571_398
PubMedID: 31292548
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans - Moverare-Skrtic_2019_FASEB.J__fj201900707R
Author(s) : Moverare-Skrtic S , Nilsson KH , Henning P , Funck-Brentano T , Nethander M , Rivadeneira F , Coletto Nunes G , Koskela A , Tuukkanen J , Tuckermann J , Perret C , Souza PPC , Lerner UH , Ohlsson C
Ref : FASEB Journal , :fj201900707R , 2019
Abstract : Moverare-Skrtic_2019_FASEB.J__fj201900707R
ESTHER : Moverare-Skrtic_2019_FASEB.J__fj201900707R
PubMedSearch : Moverare-Skrtic_2019_FASEB.J__fj201900707R
PubMedID: 31307226
Gene_locus related to this paper: human-NOTUM

Title : Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling - Suciu_2018_ACS.Med.Chem.Lett_9_563
Author(s) : Suciu RM , Cognetta AB, 3rd , Potter ZE , Cravatt BF
Ref : ACS Med Chem Lett , 9 :563 , 2018
Abstract : Suciu_2018_ACS.Med.Chem.Lett_9_563
ESTHER : Suciu_2018_ACS.Med.Chem.Lett_9_563
PubMedSearch : Suciu_2018_ACS.Med.Chem.Lett_9_563
PubMedID: 29937983
Gene_locus related to this paper: human-NOTUM

Title : NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition - Madan_2016_Oncotarget_7_12386
Author(s) : Madan B , Ke Z , Lei ZD , Oliver FA , Oshima M , Lee MA , Rozen S , Virshup DM
Ref : Oncotarget , 7 :12386 , 2016
Abstract : Madan_2016_Oncotarget_7_12386
ESTHER : Madan_2016_Oncotarget_7_12386
PubMedSearch : Madan_2016_Oncotarget_7_12386
PubMedID: 26848981
Gene_locus related to this paper: human-NOTUM

Title : Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase - Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
Author(s) : Tarver JE, Jr. , Pabba PK , Barbosa J , Han Q , Gardyan MW , Brommage R , Thompson AY , Schmidt JM , Wilson AG , He W , Lombardo VK , Carson KG , Wilson AGE
Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1525 , 2016
Abstract : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
ESTHER : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
PubMedSearch : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
PubMedID: 26897593
Gene_locus related to this paper: human-NOTUM

Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187
Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP
Ref : Nature , 519 :187 , 2015
Abstract : Kakugawa_2015_Nature_519_187
ESTHER : Kakugawa_2015_Nature_519_187
PubMedSearch : Kakugawa_2015_Nature_519_187
PubMedID: 25731175
Gene_locus related to this paper: drome-q9vux3 , human-NOTUM

Title : Novel insights into Notum and glypicans regulation in colorectal cancer - De Robertis_2015_Oncotarget_6_41237
Author(s) : De Robertis M , Arigoni M , Loiacono L , Riccardo F , Calogero RA , Feodorova Y , Tashkova D , Belovejdov V , Sarafian V , Cavallo F , Signori E
Ref : Oncotarget , 6 :41237 , 2015
Abstract : De Robertis_2015_Oncotarget_6_41237
ESTHER : De Robertis_2015_Oncotarget_6_41237
PubMedSearch : De Robertis_2015_Oncotarget_6_41237
PubMedID: 26517809
Gene_locus related to this paper: human-NOTUM

Title : Genetic Approaches To Identifying Novel Osteoporosis Drug Targets - Brommage_2015_J.Cell.Biochem_116_2139
Author(s) : Brommage R
Ref : Journal of Cellular Biochemistry , 116 :2139 , 2015
Abstract : Brommage_2015_J.Cell.Biochem_116_2139
ESTHER : Brommage_2015_J.Cell.Biochem_116_2139
PubMedSearch : Brommage_2015_J.Cell.Biochem_116_2139
PubMedID: 25833316
Gene_locus related to this paper: human-NOTUM

Title : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) - Gerhard_2004_Genome.Res_14_2121
Author(s) : Gerhard DS , Wagner L , Feingold EA , Shenmen CM , Grouse LH , Schuler G , Klein SL , Old S , Rasooly R , Good P , Guyer M , Peck AM , Derge JG , Lipman D , Collins FS , Jang W , Sherry S , Feolo M , Misquitta L , Lee E , Rotmistrovsky K , Greenhut SF , Schaefer CF , Buetow K , Bonner TI , Haussler D , Kent J , Kiekhaus M , Furey T , Brent M , Prange C , Schreiber K , Shapiro N , Bhat NK , Hopkins RF , Hsie F , Driscoll T , Soares MB , Casavant TL , Scheetz TE , Brown-stein MJ , Usdin TB , Toshiyuki S , Carninci P , Piao Y , Dudekula DB , Ko MS , Kawakami K , Suzuki Y , Sugano S , Gruber CE , Smith MR , Simmons B , Moore T , Waterman R , Johnson SL , Ruan Y , Wei CL , Mathavan S , Gunaratne PH , Wu J , Garcia AM , Hulyk SW , Fuh E , Yuan Y , Sneed A , Kowis C , Hodgson A , Muzny DM , McPherson J , Gibbs RA , Fahey J , Helton E , Ketteman M , Madan A , Rodrigues S , Sanchez A , Whiting M , Madari A , Young AC , Wetherby KD , Granite SJ , Kwong PN , Brinkley CP , Pearson RL , Bouffard GG , Blakesly RW , Green ED , Dickson MC , Rodriguez AC , Grimwood J , Schmutz J , Myers RM , Butterfield YS , Griffith M , Griffith OL , Krzywinski MI , Liao N , Morin R , Palmquist D , Petrescu AS , Skalska U , Smailus DE , Stott JM , Schnerch A , Schein JE , Jones SJ , Holt RA , Baross A , Marra MA , Clifton S , Makowski KA , Bosak S , Malek J
Ref : Genome Res , 14 :2121 , 2004
Abstract : Gerhard_2004_Genome.Res_14_2121
ESTHER : Gerhard_2004_Genome.Res_14_2121
PubMedSearch : Gerhard_2004_Genome.Res_14_2121
PubMedID: 15489334
Gene_locus related to this paper: human-AFMID , human-CES4A , human-CES5A , human-NOTUM , human-SERAC1 , human-SERHL2 , human-TMEM53 , mouse-acot1 , mouse-adcl4 , mouse-Ces2f , mouse-Ces4a , mouse-notum , mouse-q6wqj1 , mouse-Q9DAI6 , mouse-rbbp9 , mouse-SERHL , mouse-srac1 , mouse-tmm53 , rat-abhd6 , rat-abhda , rat-abhea , rat-abheb , rat-Ldah , rat-cd029 , rat-estd , rat-Kansl3 , rat-nceh1 , ratno-acph , ratno-CMBL , mouse-b2rwd2 , rat-b5den3 , rat-ab17c

Title : HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient - Giraldez_2002_Dev.Cell_2_667
Author(s) : Giraldez AJ , Copley RR , Cohen SM
Ref : Dev Cell , 2 :667 , 2002
Abstract : Giraldez_2002_Dev.Cell_2_667
ESTHER : Giraldez_2002_Dev.Cell_2_667
PubMedSearch : Giraldez_2002_Dev.Cell_2_667
PubMedID: 12015973
Gene_locus related to this paper: drome-q9vux3 , human-NOTUM