human-DPP8

Homo sapiens (Human) dipeptidyl peptidase 8 (DPP8)

Comment

DPP8 and DPP9 are cytosolic peptidases. Have dpp activity similar to dpp4. The first identified endogenous DPP9 substrate is the tumor epitope RU13442 (VPYGSFKHV). Inhibition or silencing of DPP9, but not DPP8, led to increased presentation of this antigen on MHC class I alleles to cytotoxic T-cells, linking DPP9 to the MHC class I antigen presentation pathway. Small ubiquitin-like protein modifier SUMO1 acts as an allosteric activator of DPP9. By binding to an armlike motif in DPP9\; DPP9 functions as an endogenous inhibitor of NLRP1 inflammasome. DPP9 interacts with a unique autoproteolytic domain (Function to Find Domain (FIIND)) found in NLRP1 and CARD8. Previously called DRP1 Qi et al || . Has dpp activity as dpp4 || . Q7Z4D3 mstp135 very short sequence with some diff in N-term ?!! Q7Z4C8 mstp141 Q7Z4E1 mstp097

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Homo sapiens

Sequence

Peptide

MAAAMETEQL GVEIFETADC EENIESQDRP KLEPFYVERY SWSQLKKLLA DTRKYHGYMM AKAPHDFMFV KRNDPDGPHS DRIYYLAMSG ENRENTLFYS EIPKTINRAA VLMLSWKPLL DLFQATLDYG MYSREEELLR ERKRIGTVGI ASYDYHQGSG TFLFQAGSGI YHVKDGGPQG FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNIVTREE RRLTYVHNEL ANMEEDARSA GVATFVLQEE FDRYSGYWWC PKAETTPSGG KILRILYEEN DESEVEIIHV TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIMIDAEGRI IDVIDKELIQ PFEILFEGVE YIARAGWTPE GKYAWSILLD RSQTRLQIVL ISPELFIPVE DDVMERQRLI ESVPDSVTPL IIYEETTDIW INIHDIFHVF PQSHEEEIEF IFASECKTGF RHLYKITSIL KESKYKRSSG GLPAPSDFKC PIKEEIAITS GEWEVLGRHG SNIQVDEVRR LVYFEGTKDS PLEHHLYVVS YVNPGEVTRL TDRGYSHSCC ISQHCDFFIS KYSNQKNPHC VSLYKLSSPE DDPTCKTKEF WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL QPGKKYPTVL FIYGGPQVQL VNNRFKGVKY FRLNTLASLG YVVVVIDNRG SCHRGLKFEG AFKYKMGQIE IDDQVEGLQY LASRYDFIDL DRVGIHGWSY GGYLSLMALM QRSDIFRVAI AGAPVTLWIF YDTGYTERYM GHPDQNEQGY YLGSVAMQAE KFPSEPNRLL LLHGFLDENV HFAHTSILLS FLVRAGKPYD LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI

References

Title : Non-Specific Inhibition of Dipeptidyl Peptidases 8\/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation - Torrecillas-Baena_2023_J.Clin.Med_12_4632
Author(s) : Torrecillas-Baena B , Camacho-Cardenosa M , Quesada-Gomez JM , Moreno-Moreno P , Dorado G , Galvez-Moreno M , Casado-Diaz A
Ref : J Clin Med , 12 :4632 , 2023
Abstract : Torrecillas-Baena_2023_J.Clin.Med_12_4632
ESTHER : Torrecillas-Baena_2023_J.Clin.Med_12_4632
PubMedSearch : Torrecillas-Baena_2023_J.Clin.Med_12_4632
PubMedID: 37510747
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells - Moore_2022_ACS.Chem.Biol_17_2595
Author(s) : Moore KP , Schwaid AG , Tudor M , Park S , Beshore DC , Converso A , Shipe WD , Anand R , Lan P , Moningka R , Rothman DM , Sun W , Chi A , Cornella-Taracido I , Adam GC , Bahnck-Teets C , Carroll SS , Fay JF , Goh SL , Lusen J , Quan S , Rodriguez S , Xu M , Andrews CL , Song C , Filzen T , Li J , Hollenstein K , Klein DJ , Lammens A , Lim UM , Fang Z , McHale C , Li Y , Lu M , Diamond TL , Howell BJ , Zuck P , Balibar CJ
Ref : ACS Chemical Biology , 17 :2595 , 2022
Abstract : Moore_2022_ACS.Chem.Biol_17_2595
ESTHER : Moore_2022_ACS.Chem.Biol_17_2595
PubMedSearch : Moore_2022_ACS.Chem.Biol_17_2595
PubMedID: 36044633
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498
Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R
Ref : Angew Chem Int Ed Engl , : , 2022
Abstract : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498
ESTHER : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498
PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498
PubMedID: 36089535
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors - Cui_2022_Front.Pharmacol_13_1002871
Author(s) : Cui C , Tian X , Wei L , Wang Y , Wang K , Fu R
Ref : Front Pharmacol , 13 :1002871 , 2022
Abstract : Cui_2022_Front.Pharmacol_13_1002871
ESTHER : Cui_2022_Front.Pharmacol_13_1002871
PubMedSearch : Cui_2022_Front.Pharmacol_13_1002871
PubMedID: 36172198
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair - Bolgi_2022_EMBO.Rep__e54136
Author(s) : Bolgi O , Silva-Garcia M , Ross B , Pilla E , Kari V , Killisch M , Spitzner M , Stark N , Lenz C , Weiss K , Donzelli L , Gorrell MD , Grade M , Riemer J , Urlaub H , Dobbelstein M , Huber R , Geiss-Friedlander R
Ref : EMBO Rep , :e54136 , 2022
Abstract : Bolgi_2022_EMBO.Rep__e54136
ESTHER : Bolgi_2022_EMBO.Rep__e54136
PubMedSearch : Bolgi_2022_EMBO.Rep__e54136
PubMedID: 35912982
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Aerosol-based ligand soaking of reservoir-free protein crystals - Ross_2021_J.Appl.Crystallogr_54_895
Author(s) : Ross B , Krapp S , Geiss-Friedlander R , Littmann W , Huber R , Kiefersauer R
Ref : J Appl Crystallogr , 54 :895 , 2021
Abstract : Ross_2021_J.Appl.Crystallogr_54_895
ESTHER : Ross_2021_J.Appl.Crystallogr_54_895
PubMedSearch : Ross_2021_J.Appl.Crystallogr_54_895
PubMedID: 34188616
Gene_locus related to this paper: human-DPP8

Title : Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells - Zhang_2021_Pharmacol.Res_169_105630
Author(s) : Zhang Y , Li K , Li Y , Zhao W , Wang L , Chen Z , Ma X , Yao T , Wang J , Dong W , Li X , Tian X , Fu R
Ref : Pharmacol Res , 169 :105630 , 2021
Abstract : Zhang_2021_Pharmacol.Res_169_105630
ESTHER : Zhang_2021_Pharmacol.Res_169_105630
PubMedSearch : Zhang_2021_Pharmacol.Res_169_105630
PubMedID: 33932609
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair - Silva-Garcia_2020_Biorxiv__
Author(s) : Silva-Garcia M , Bolgi O , Ross B , Pilla E , Kari V , Killisch M , Stark N , Lenz C , Spitzner M , Gorrell MD , Grade M , Urlaub H , Dobbelstein M , Huber R , Geiss-Friedlander R
Ref : Biorxiv , : , 2020
Abstract : Silva-Garcia_2020_Biorxiv__
ESTHER : Silva-Garcia_2020_Biorxiv__
PubMedSearch : Silva-Garcia_2020_Biorxiv__
PubMedID:
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Activation of the CARD8 Inflammasome Requires a Disordered Region - Chui_2020_Cell.Rep_33_108264
Author(s) : Chui AJ , Griswold AR , Taabazuing CY , Orth EL , Gai K , Rao SD , Ball DP , Hsiao JC , Bachovchin DA
Ref : Cell Rep , 33 :108264 , 2020
Abstract : Chui_2020_Cell.Rep_33_108264
ESTHER : Chui_2020_Cell.Rep_33_108264
PubMedSearch : Chui_2020_Cell.Rep_33_108264
PubMedID: 33053349
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : DPP8 is a novel therapeutic target for multiple myeloma - Sato_2019_Sci.Rep_9_18094
Author(s) : Sato T , Tatekoshi A , Takada K , Iyama S , Kamihara Y , Jawaid P , Rehman MU , Noguchi K , Kondo T , Kajikawa S , Arita K , Wada A , Murakami J , Arai M , Yasuda I , Dang NH , Hatano R , Iwao N , Ohnuma K , Morimoto C
Ref : Sci Rep , 9 :18094 , 2019
Abstract : Sato_2019_Sci.Rep_9_18094
ESTHER : Sato_2019_Sci.Rep_9_18094
PubMedSearch : Sato_2019_Sci.Rep_9_18094
PubMedID: 31792328
Gene_locus related to this paper: human-DPP8

Title : DPP8\/9 inhibitors are universal activators of functional NLRP1 alleles - Gai_2019_Cell.Death.Dis_10_587
Author(s) : Gai K , Okondo MC , Rao SD , Chui AJ , Ball DP , Johnson DC , Bachovchin DA
Ref : Cell Death Dis , 10 :587 , 2019
Abstract : Gai_2019_Cell.Death.Dis_10_587
ESTHER : Gai_2019_Cell.Death.Dis_10_587
PubMedSearch : Gai_2019_Cell.Death.Dis_10_587
PubMedID: 31383852
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : DPP8\/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages - de Vasconcelos_2019_Life.Sci.Alliance_2_
Author(s) : de Vasconcelos NM , Vliegen G , Goncalves A , De Hert E , Martin-Perez R , Van Opdenbosch N , Jallapally A , Geiss-Friedlander R , Lambeir AM , Augustyns K , Van der Veken P , De Meester I , Lamkanfi M
Ref : Life Sciences Alliance , 2 : , 2019
Abstract : de Vasconcelos_2019_Life.Sci.Alliance_2_
ESTHER : de Vasconcelos_2019_Life.Sci.Alliance_2_
PubMedSearch : de Vasconcelos_2019_Life.Sci.Alliance_2_
PubMedID: 30718379
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma - Brunetti_2019_Virchows.Arch_474_177
Author(s) : Brunetti M , Holth A , Panagopoulos I , Staff AC , Micci F , Davidson B
Ref : Virchows Arch , 474 :177 , 2019
Abstract : Brunetti_2019_Virchows.Arch_474_177
ESTHER : Brunetti_2019_Virchows.Arch_474_177
PubMedSearch : Brunetti_2019_Virchows.Arch_474_177
PubMedID: 30467600
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer - Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437
Author(s) : Ross B , Krapp S , Augustin M , Kierfersauer R , Arciniega M , Geiss-Friedlander R , Huber R
Ref : Proc Natl Acad Sci U S A , 115 :E1437 , 2018
Abstract : Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437
ESTHER : Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437
PubMedSearch : Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437
PubMedID: 29382749
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : DPP8\/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia - Johnson_2018_Nat.Med_24_1151
Author(s) : Johnson DC , Taabazuing CY , Okondo MC , Chui AJ , Rao SD , Brown FC , Reed C , Peguero E , de Stanchina E , Kentsis A , Bachovchin DA
Ref : Nat Med , 24 :1151 , 2018
Abstract : Johnson_2018_Nat.Med_24_1151
ESTHER : Johnson_2018_Nat.Med_24_1151
PubMedSearch : Johnson_2018_Nat.Med_24_1151
PubMedID: 29967349
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Inhibition of Dpp8\/9 Activates the Nlrp1b Inflammasome - Okondo_2018_Cell.Chem.Biol_25_262
Author(s) : Okondo MC , Rao SD , Taabazuing CY , Chui AJ , Poplawski SE , Johnson DC , Bachovchin DA
Ref : Cell Chemical Biology , 25 :262 , 2018
Abstract : Okondo_2018_Cell.Chem.Biol_25_262
ESTHER : Okondo_2018_Cell.Chem.Biol_25_262
PubMedSearch : Okondo_2018_Cell.Chem.Biol_25_262
PubMedID: 29396289
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages - Taabazuing_2017_Cell.Chem.Biol_24_507
Author(s) : Taabazuing CY , Okondo MC , Bachovchin DA
Ref : Cell Chemical Biology , 24 :507 , 2017
Abstract : Taabazuing_2017_Cell.Chem.Biol_24_507
ESTHER : Taabazuing_2017_Cell.Chem.Biol_24_507
PubMedSearch : Taabazuing_2017_Cell.Chem.Biol_24_507
PubMedID: 28392147
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis - Okondo_2017_Nat.Chem.Biol_13_46
Author(s) : Okondo MC , Johnson DC , Sridharan R , Go EB , Chui AJ , Wang MS , Poplawski SE , Wu W , Liu Y , Lai JH , Sanford DG , Arciprete MO , Golub TR , Bachovchin WW , Bachovchin DA
Ref : Nat Chemical Biology , 13 :46 , 2017
Abstract : Okondo_2017_Nat.Chem.Biol_13_46
ESTHER : Okondo_2017_Nat.Chem.Biol_13_46
PubMedSearch : Okondo_2017_Nat.Chem.Biol_13_46
PubMedID: 27820798
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : The SUMO1-E67 Interacting Loop Peptide Is an Allosteric Inhibitor of the Dipeptidyl Peptidases 8 and 9 - Pilla_2013_J.Biol.Chem_288_32787
Author(s) : Pilla E , Kilisch M , Lenz C , Urlaub H , Geiss-Friedlander R
Ref : Journal of Biological Chemistry , 288 :32787 , 2013
Abstract : Pilla_2013_J.Biol.Chem_288_32787
ESTHER : Pilla_2013_J.Biol.Chem_288_32787
PubMedSearch : Pilla_2013_J.Biol.Chem_288_32787
PubMedID: 24072711
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? - Van Goethem_2011_J.Med.Chem_54_5737
Author(s) : Van Goethem S , Matheeussen V , Joossens J , Lambeir AM , Chen X , De Meester I , Haemers A , Augustyns K , Van der Veken P
Ref : Journal of Medicinal Chemistry , 54 :5737 , 2011
Abstract : Van Goethem_2011_J.Med.Chem_54_5737
ESTHER : Van Goethem_2011_J.Med.Chem_54_5737
PubMedSearch : Van Goethem_2011_J.Med.Chem_54_5737
PubMedID: 21711053
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Hydrophilic residues surrounding the S1 and S2 pockets contribute to dimerisation and catalysis in human dipeptidyl peptidase 8 (DP8) - Pitman_2010_Biol.Chem_391_959
Author(s) : Pitman MR , Menz RI , Abbott CA
Ref : Biol Chem , 391 :959 , 2010
Abstract : Pitman_2010_Biol.Chem_391_959
ESTHER : Pitman_2010_Biol.Chem_391_959
PubMedSearch : Pitman_2010_Biol.Chem_391_959
PubMedID: 20536396
Gene_locus related to this paper: human-DPP8

Title : The in vivo expression of dipeptidyl peptidases 8 and 9 - Yu_2009_J.Histochem.Cytochem_57_1025
Author(s) : Yu DM , Ajami K , Gall MG , Park J , Lee CS , Evans KA , McLaughlin EA , Pitman MR , Abbott CA , McCaughan GW , Gorrell MD
Ref : Journal of Histochemistry & Cytochemistry , 57 :1025 , 2009
Abstract : Yu_2009_J.Histochem.Cytochem_57_1025
ESTHER : Yu_2009_J.Histochem.Cytochem_57_1025
PubMedSearch : Yu_2009_J.Histochem.Cytochem_57_1025
PubMedID: 19581630
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis -
Author(s) : Yu DM , Wang XM , Ajami K , McCaughan GW , Gorrell MD
Ref : Advances in Experimental Medicine & Biology , 575 :63 , 2006
PubMedID: 16700509
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis - Yu_2006_FEBS.J_273_2447
Author(s) : Yu DM , Wang XM , McCaughan GW , Gorrell MD
Ref : Febs J , 273 :2447 , 2006
Abstract : Yu_2006_FEBS.J_273_2447
ESTHER : Yu_2006_FEBS.J_273_2447
PubMedSearch : Yu_2006_FEBS.J_273_2447
PubMedID: 16704418
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8 - Lee_2006_J.Biol.Chem_281_38653
Author(s) : Lee HJ , Chen YS , Chou CY , Chien CH , Lin CH , Chang GG , Chen X
Ref : Journal of Biological Chemistry , 281 :38653 , 2006
Abstract : Lee_2006_J.Biol.Chem_281_38653
ESTHER : Lee_2006_J.Biol.Chem_281_38653
PubMedSearch : Lee_2006_J.Biol.Chem_281_38653
PubMedID: 17040910
Gene_locus related to this paper: human-DPP8

Title : Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8 - Jiaang_2005_Bioorg.Med.Chem.Lett_15_687
Author(s) : Jiaang WT , Chen YS , Hsu T , Wu SH , Chien CH , Chang CN , Chang SP , Lee SJ , Chen X
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :687 , 2005
Abstract : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687
ESTHER : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687
PubMedSearch : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687
PubMedID: 15664838
Gene_locus related to this paper: human-DPP8

Title : Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells - Chen_2004_Protein.Expr.Purif_35_142
Author(s) : Chen YS , Chien CH , Goparaju CM , Hsu JT , Liang PH , Chen X
Ref : Protein Expr Purif , 35 :142 , 2004
Abstract : Chen_2004_Protein.Expr.Purif_35_142
ESTHER : Chen_2004_Protein.Expr.Purif_35_142
PubMedSearch : Chen_2004_Protein.Expr.Purif_35_142
PubMedID: 15039077
Gene_locus related to this paper: human-DPP8

Title : Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases - Qi_2003_Biochem.J_373_179
Author(s) : Qi SY , Riviere PJ , Trojnar J , Junien JL , Akinsanya KO
Ref : Biochemical Journal , 373 :179 , 2003
Abstract : Qi_2003_Biochem.J_373_179
ESTHER : Qi_2003_Biochem.J_373_179
PubMedSearch : Qi_2003_Biochem.J_373_179
PubMedID: 12662155
Gene_locus related to this paper: human-DPP8 , human-DPP9 , human-DPP10 , mouse-dpp9 , mouse-dpp10

Title : Structural requirements for catalysis, expression, and dimerization in the CD26\/DPIV gene family - Ajami_2003_Biochemistry_42_694
Author(s) : Ajami K , Abbott CA , Obradovic M , Gysbers V , Kahne T , McCaughan GW , Gorrell MD
Ref : Biochemistry , 42 :694 , 2003
Abstract : Ajami_2003_Biochemistry_42_694
ESTHER : Ajami_2003_Biochemistry_42_694
PubMedSearch : Ajami_2003_Biochemistry_42_694
PubMedID: 12534281
Gene_locus related to this paper: human-DPP8 , human-DPP9

Title : Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8 - Abbott_2000_Eur.J.Biochem_267_6140
Author(s) : Abbott CA , Yu DM , Woollatt E , Sutherland GR , McCaughan GW , Gorrell MD
Ref : European Journal of Biochemistry , 267 :6140 , 2000
Abstract : Abbott_2000_Eur.J.Biochem_267_6140
ESTHER : Abbott_2000_Eur.J.Biochem_267_6140
PubMedSearch : Abbott_2000_Eur.J.Biochem_267_6140
PubMedID: 11012666
Gene_locus related to this paper: human-DPP8