Homo sapiens (Human) carboxylesterase hCE-2,iCE, hiCE, CES2 gene cDNA FLJ76104 Cocaine esterase
human carboxylesterase iCE gene intestine and liver, Q8IUP4 (Strausberg R.) contains 65 extra amino acid in N-term
MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK ALPQKIQELE EPEERHTEL
| Title : Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation - Kailass_2024_J.Med.Chem__ |
| Author(s) : Kailass K , Casalena D , Jenane L , McEdwards G , Auld DS , Sadovski O , Kaye EG , Hudson E , Nettleton D , Currie MA , Beharry AA |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : Kailass_2024_J.Med.Chem__ |
| ESTHER : Kailass_2024_J.Med.Chem__ |
| PubMedSearch : Kailass_2024_J.Med.Chem__ |
| PubMedID: 38265364 |
| Gene_locus related to this paper: human-CES2 |
| Title : Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology - Nagaoka_2024_Biochem.Pharmacol__116128 |
| Author(s) : Nagaoka M , Sakai Y , Nakajima M , Fukami T |
| Ref : Biochemical Pharmacology , :116128 , 2024 |
| Abstract : Nagaoka_2024_Biochem.Pharmacol__116128 |
| ESTHER : Nagaoka_2024_Biochem.Pharmacol__116128 |
| PubMedSearch : Nagaoka_2024_Biochem.Pharmacol__116128 |
| PubMedID: 38492781 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening - Fan_2023_Anal.Chem_95_15665 |
| Author(s) : Fan Y , Zhang T , Song Y , Sang Z , Zeng H , Liu P , Wang P , Ge G |
| Ref : Analytical Chemistry , 95 :15665-15672 , 2023 |
| Abstract : Fan_2023_Anal.Chem_95_15665 |
| ESTHER : Fan_2023_Anal.Chem_95_15665 |
| PubMedSearch : Fan_2023_Anal.Chem_95_15665 |
| PubMedID: 37782032 |
| Gene_locus related to this paper: human-CES2 |
| Title : Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea - Yang_2023_Bioorg.Chem_138_106625 |
| Author(s) : Yang Z , Cao Z , Wang W , Chen Y , Huang W , Jiao S , Chen S , Chen L , Liu Y , Mao J , Zhang L , Li Z |
| Ref : Bioorg Chem , 138 :106625 , 2023 |
| Abstract : Yang_2023_Bioorg.Chem_138_106625 |
| ESTHER : Yang_2023_Bioorg.Chem_138_106625 |
| PubMedSearch : Yang_2023_Bioorg.Chem_138_106625 |
| PubMedID: 37300962 |
| Gene_locus related to this paper: human-CES2 |
| Title : A molecular imaging tool for monitoring carboxylesterase 2 during early diagnosis of liver-related diseases - Li_2023_Sens.Actuators.B.Chem_377_133122 |
| Author(s) : Li J , Cao J , Wu W , Xu L , Zhang S , Ma P , Wu Q , Song D |
| Ref : Sensors and Actuators B: Chemical , 377 :133122 , 2023 |
| Abstract : Li_2023_Sens.Actuators.B.Chem_377_133122 |
| ESTHER : Li_2023_Sens.Actuators.B.Chem_377_133122 |
| PubMedSearch : Li_2023_Sens.Actuators.B.Chem_377_133122 |
| PubMedID: |
| Gene_locus related to this paper: human-CES2 |
| Title : Prognostic and Immunological Roles of CES2 in Breast Cancer and Potential Application of CES2-Targeted Fluorescent Probe DDAB in Breast Surgery - Qu_2023_Int.J.Gen.Med_16_1567 |
| Author(s) : Qu W , Yao Y , Liu Y , Jo H , Zhang Q , Zhao H |
| Ref : Int J Gen Med , 16 :1567 , 2023 |
| Abstract : Qu_2023_Int.J.Gen.Med_16_1567 |
| ESTHER : Qu_2023_Int.J.Gen.Med_16_1567 |
| PubMedSearch : Qu_2023_Int.J.Gen.Med_16_1567 |
| PubMedID: 37139258 |
| Gene_locus related to this paper: human-CES2 |
| Title : Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease - Chalhoub_2021_J.Lipid.Res__100075 |
| Author(s) : Chalhoub G , Kolleritsch S , Maresch LK , Taschler U , Pajed L , Tilp A , Natmessnig H , Rosina P , Kien B , Radner FPW , Schicho R , Oberer M , Schoiswohl G , Haemmerle G |
| Ref : J Lipid Res , :100075 , 2021 |
| Abstract : Chalhoub_2021_J.Lipid.Res__100075 |
| ESTHER : Chalhoub_2021_J.Lipid.Res__100075 |
| PubMedSearch : Chalhoub_2021_J.Lipid.Res__100075 |
| PubMedID: 33872605 |
| Gene_locus related to this paper: human-CES2 , mouse-Ces2a , mouse-Ces2b , mouse-Ces2c |
| Title : Determination of carboxylesterase 2 by fluorescence probe to guide pancreatic adenocarcinoma profiling - Zhang_2021_Chem.Phys.Lett_785_139143 |
| Author(s) : Zhang MM , Li P , Hai F , Jia Y |
| Ref : Chem Phys Lett , 785 :139143 , 2021 |
| Abstract : Zhang_2021_Chem.Phys.Lett_785_139143 |
| ESTHER : Zhang_2021_Chem.Phys.Lett_785_139143 |
| PubMedSearch : Zhang_2021_Chem.Phys.Lett_785_139143 |
| PubMedID: |
| Gene_locus related to this paper: human-CES2 |
| Title : Rapalogues as hCES2A Inhibitors: In Vitro and In Silico Investigations - Shi_2021_Eur.J.Drug.Metab.Pharmacokinet_46_129 |
| Author(s) : Shi CC , Song YQ , He RJ , Guan XQ , Song LL , Chen ST , Sun MR , Ge GB , Zhang LR |
| Ref : Eur J Drug Metab Pharmacokinet , 46 :129 , 2021 |
| Abstract : Shi_2021_Eur.J.Drug.Metab.Pharmacokinet_46_129 |
| ESTHER : Shi_2021_Eur.J.Drug.Metab.Pharmacokinet_46_129 |
| PubMedSearch : Shi_2021_Eur.J.Drug.Metab.Pharmacokinet_46_129 |
| PubMedID: 33140264 |
| Gene_locus related to this paper: human-CES2 |
| Title : Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions - Shen_2021_Fundam.Clin.Pharmacol_35_432 |
| Author(s) : Shen Y , Eades W , Yan B |
| Ref : Fundamental & Clinical Toxicology , 35 :432 , 2021 |
| Abstract : Shen_2021_Fundam.Clin.Pharmacol_35_432 |
| ESTHER : Shen_2021_Fundam.Clin.Pharmacol_35_432 |
| PubMedSearch : Shen_2021_Fundam.Clin.Pharmacol_35_432 |
| PubMedID: 33369768 |
| Gene_locus related to this paper: human-CES2 |
| Title : Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2 - Song_2021_Front.Pharmacol_12_655659 |
| Author(s) : Song YQ , He RJ , Pu D , Guan XQ , Shi JH , Li YG , Hou J , Jia SN , Qin WW , Fang SQ , Ge GB |
| Ref : Front Pharmacol , 12 :655659 , 2021 |
| Abstract : Song_2021_Front.Pharmacol_12_655659 |
| ESTHER : Song_2021_Front.Pharmacol_12_655659 |
| PubMedSearch : Song_2021_Front.Pharmacol_12_655659 |
| PubMedID: 34084136 |
| Gene_locus related to this paper: human-CES2 |
| Title : Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway - Zhang_2020_Exp.Cell.Res__111856 |
| Author(s) : Zhang Y , Sun L , Sun Y , Chen Y , Wang X , Xu M , Chi P , Xu Z , Lu X |
| Ref : Experimental Cell Research , :111856 , 2020 |
| Abstract : Zhang_2020_Exp.Cell.Res__111856 |
| ESTHER : Zhang_2020_Exp.Cell.Res__111856 |
| PubMedSearch : Zhang_2020_Exp.Cell.Res__111856 |
| PubMedID: 31981591 |
| Gene_locus related to this paper: human-CES2 |
| Title : Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma - Goeppert_2019_Sci.Rep_9_4338 |
| Author(s) : Goeppert B , Renner M , Singer S , Albrecht T , Zhang Q , Mehrabi A , Pathil A , Springfeld C , Kohler B , Rupp C , Weiss KH , Kuhl AA , Arsenic R , Pape UF , Vogel A , Schirmacher P , Roessler S , Utku N |
| Ref : Sci Rep , 9 :4338 , 2019 |
| Abstract : Goeppert_2019_Sci.Rep_9_4338 |
| ESTHER : Goeppert_2019_Sci.Rep_9_4338 |
| PubMedSearch : Goeppert_2019_Sci.Rep_9_4338 |
| PubMedID: 30867471 |
| Gene_locus related to this paper: human-CES2 |
| Title : Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury - Tian_2019_Anal.Chem_91_15840 |
| Author(s) : Tian X , Yan F , Zheng J , Cui X , Feng L , Li S , Jin L , James TD , Ma X |
| Ref : Analytical Chemistry , 91 :15840 , 2019 |
| Abstract : Tian_2019_Anal.Chem_91_15840 |
| ESTHER : Tian_2019_Anal.Chem_91_15840 |
| PubMedSearch : Tian_2019_Anal.Chem_91_15840 |
| PubMedID: 31713417 |
| Gene_locus related to this paper: human-CES2 |
| Title : Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor - Kailass_2019_Chem.Sci_10_8428 |
| Author(s) : Kailass K , Sadovski O , Capello M , Kang Y , Fleming JB , Hanash SM , Beharry AA |
| Ref : Chem Sci , 10 :8428 , 2019 |
| Abstract : Kailass_2019_Chem.Sci_10_8428 |
| ESTHER : Kailass_2019_Chem.Sci_10_8428 |
| PubMedSearch : Kailass_2019_Chem.Sci_10_8428 |
| PubMedID: 31803422 |
| Gene_locus related to this paper: human-CES2 |
| Title : Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza (Danshen) - Hatfield_2018_J.Nat.Prod_81_2410 |
| Author(s) : Hatfield MJ , Binder RJ , Gannon R , Fratt EM , Bowling J , Potter PM |
| Ref : Journal of Natural Products , 81 :2410 , 2018 |
| Abstract : Hatfield_2018_J.Nat.Prod_81_2410 |
| ESTHER : Hatfield_2018_J.Nat.Prod_81_2410 |
| PubMedSearch : Hatfield_2018_J.Nat.Prod_81_2410 |
| PubMedID: 30351923 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Clinical implications of genetic variation in carboxylesterase drug metabolism - Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131 |
| Author(s) : Chen F , Zhang B , Parker RB , Laizure SC |
| Ref : Expert Opin Drug Metab Toxicol , 14 :131 , 2018 |
| Abstract : Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131 |
| ESTHER : Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131 |
| PubMedSearch : Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131 |
| PubMedID: 29264996 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS\/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants - Boberg_2017_Drug.Metab.Dispos_45_216 |
| Author(s) : Boberg M , Vrana M , Mehrotra A , Pearce RE , Gaedigk A , Bhatt DK , Leeder JS , Prasad B |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :216 , 2017 |
| Abstract : Boberg_2017_Drug.Metab.Dispos_45_216 |
| ESTHER : Boberg_2017_Drug.Metab.Dispos_45_216 |
| PubMedSearch : Boberg_2017_Drug.Metab.Dispos_45_216 |
| PubMedID: 27895113 |
| Gene_locus related to this paper: human-CES2 |
| Title : Identification of Tissue-Restricted Bioreaction Suitable for in Vivo Targeting by Fluorescent Substrate Library-Based Enzyme Discovery - Yoshioka_2015_J.Am.Chem.Soc_137_12187 |
| Author(s) : Yoshioka K , Komatsu T , Nakada A , Onagi J , Kuriki Y , Kawaguchi M , Terai T , Ueno T , Hanaoka K , Nagano T , Urano Y |
| Ref : Journal of the American Chemical Society , 137 :12187 , 2015 |
| Abstract : Yoshioka_2015_J.Am.Chem.Soc_137_12187 |
| ESTHER : Yoshioka_2015_J.Am.Chem.Soc_137_12187 |
| PubMedSearch : Yoshioka_2015_J.Am.Chem.Soc_137_12187 |
| PubMedID: 26360463 |
| Gene_locus related to this paper: human-CES2 |
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| Abstract : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| ESTHER : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications - Feng_2014_Chem.Commun.(Camb)_50_14519 |
| Author(s) : Feng L , Liu ZM , Xu L , Lv X , Ning J , Hou J , Ge GB , Cui JN , Yang L |
| Ref : Chem Commun (Camb) , 50 :14519 , 2014 |
| Abstract : Feng_2014_Chem.Commun.(Camb)_50_14519 |
| ESTHER : Feng_2014_Chem.Commun.(Camb)_50_14519 |
| PubMedSearch : Feng_2014_Chem.Commun.(Camb)_50_14519 |
| PubMedID: 25303144 |
| Gene_locus related to this paper: human-CES2 |
| Title : The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect - Merali_2014_Drug.Metabol.Drug.Interact_29_143 |
| Author(s) : Merali Z , Ross S , Pare G |
| Ref : Drug Metabol Drug Interact , 29 :143 , 2014 |
| Abstract : Merali_2014_Drug.Metabol.Drug.Interact_29_143 |
| ESTHER : Merali_2014_Drug.Metabol.Drug.Interact_29_143 |
| PubMedSearch : Merali_2014_Drug.Metabol.Drug.Interact_29_143 |
| PubMedID: 24988246 |
| Gene_locus related to this paper: human-CES2 |
| Title : Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase - Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| Author(s) : Shimizu M , Fukami T , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1103 , 2014 |
| Abstract : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| ESTHER : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| PubMedSearch : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| PubMedID: 24751575 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs - Xiao_2013_Biochem.Pharmacol_85_439 |
| Author(s) : Xiao D , Shi D , Yang D , Barthel B , Koch TH , Yan B |
| Ref : Biochemical Pharmacology , 85 :439 , 2013 |
| Abstract : Xiao_2013_Biochem.Pharmacol_85_439 |
| ESTHER : Xiao_2013_Biochem.Pharmacol_85_439 |
| PubMedSearch : Xiao_2013_Biochem.Pharmacol_85_439 |
| PubMedID: 23228697 |
| Gene_locus related to this paper: human-CES2 |
| Title : Relationship between CES2 genetic variations and rifampicin metabolism - Song_2013_J.Antimicrob.Chemother_68_1281 |
| Author(s) : Song SH , Chang HE , Jun SH , Park KU , Lee JH , Lee EM , Song YH , Song J |
| Ref : J Antimicrob Chemother , 68 :1281 , 2013 |
| Abstract : Song_2013_J.Antimicrob.Chemother_68_1281 |
| ESTHER : Song_2013_J.Antimicrob.Chemother_68_1281 |
| PubMedSearch : Song_2013_J.Antimicrob.Chemother_68_1281 |
| PubMedID: 23471941 |
| Gene_locus related to this paper: human-CES2 |
| Title : Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2 - Wang_2011_Drug.Metab.Dispos_39_1329 |
| Author(s) : Wang J , Williams ET , Bourgea J , Wong YN , Patten CJ |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 39 :1329 , 2011 |
| Abstract : Wang_2011_Drug.Metab.Dispos_39_1329 |
| ESTHER : Wang_2011_Drug.Metab.Dispos_39_1329 |
| PubMedSearch : Wang_2011_Drug.Metab.Dispos_39_1329 |
| PubMedID: 21540359 |
| Gene_locus related to this paper: human-CES2 |
| Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427 |
| Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ |
| Ref : Mamm Genome , 21 :427 , 2010 |
| Abstract : Holmes_2010_Mamm.Genome_21_427 |
| ESTHER : Holmes_2010_Mamm.Genome_21_427 |
| PubMedSearch : Holmes_2010_Mamm.Genome_21_427 |
| PubMedID: 20931200 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
| Title : Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin - Yang_2009_Biochem.Pharmacol_77_238 |
| Author(s) : Yang D , Pearce RE , Wang X , Gaedigk R , Wan YJ , Yan B |
| Ref : Biochemical Pharmacology , 77 :238 , 2009 |
| Abstract : Yang_2009_Biochem.Pharmacol_77_238 |
| ESTHER : Yang_2009_Biochem.Pharmacol_77_238 |
| PubMedSearch : Yang_2009_Biochem.Pharmacol_77_238 |
| PubMedID: 18983829 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Human carboxylesterases: an update on CES1, CES2 and CES3 - Sanghani_2009_Protein.Pept.Lett_16_1207 |
| Author(s) : Sanghani SP , Sanghani PC , Schiel MA , Bosron WF |
| Ref : Protein Pept Lett , 16 :1207 , 2009 |
| Abstract : Sanghani_2009_Protein.Pept.Lett_16_1207 |
| ESTHER : Sanghani_2009_Protein.Pept.Lett_16_1207 |
| PubMedSearch : Sanghani_2009_Protein.Pept.Lett_16_1207 |
| PubMedID: 19508181 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 |
| Title : Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene - Bellott_2008_Cancer.Chemother.Pharmacol_61_481 |
| Author(s) : Bellott R , Le Morvan V , Charasson V , Laurand A , Colotte M , Zanger UM , Klein K , Smith D , Bonnet J , Robert J |
| Ref : Cancer Chemother Pharmacol , 61 :481 , 2008 |
| Abstract : Bellott_2008_Cancer.Chemother.Pharmacol_61_481 |
| ESTHER : Bellott_2008_Cancer.Chemother.Pharmacol_61_481 |
| PubMedSearch : Bellott_2008_Cancer.Chemother.Pharmacol_61_481 |
| PubMedID: 17483951 |
| Gene_locus related to this paper: human-CES2 |
| Title : Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes - Hosokawa_2007_Drug.Metab.Rev_39_1 |
| Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Koyano N , Fujii A , Nagahara Y , Satoh T , Chiba K |
| Ref : Drug Metabolism Reviews , 39 :1 , 2007 |
| Abstract : Hosokawa_2007_Drug.Metab.Rev_39_1 |
| ESTHER : Hosokawa_2007_Drug.Metab.Rev_39_1 |
| PubMedSearch : Hosokawa_2007_Drug.Metab.Rev_39_1 |
| PubMedID: 17364878 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
| Title : Haplotypes and a novel defective allele of CES2 found in a Japanese population - Kim_2007_Drug.Metab.Dispos_35_1865 |
| Author(s) : Kim SR , Sai K , Tanaka-Kagawa T , Jinno H , Ozawa S , Kaniwa N , Saito Y , Akasawa A , Matsumoto K , Saito H , Kamatani N , Shirao K , Yamamoto N , Yoshida T , Minami H , Ohtsu A , Saijo N , Sawada J |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :1865 , 2007 |
| Abstract : Kim_2007_Drug.Metab.Dispos_35_1865 |
| ESTHER : Kim_2007_Drug.Metab.Dispos_35_1865 |
| PubMedSearch : Kim_2007_Drug.Metab.Dispos_35_1865 |
| PubMedID: 17640957 |
| Gene_locus related to this paper: human-CES2 |
| Title : Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2 - Yang_2007_Mol.Pharmacol_72_686 |
| Author(s) : Yang J , Shi D , Yang D , Song X , Yan B |
| Ref : Molecular Pharmacology , 72 :686 , 2007 |
| Abstract : Yang_2007_Mol.Pharmacol_72_686 |
| ESTHER : Yang_2007_Mol.Pharmacol_72_686 |
| PubMedSearch : Yang_2007_Mol.Pharmacol_72_686 |
| PubMedID: 17537833 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2 - Nishi_2006_Arch.Biochem.Biophys_445_115 |
| Author(s) : Nishi K , Huang H , Kamita SG , Kim IH , Morisseau C , Hammock BD |
| Ref : Archives of Biochemistry & Biophysics , 445 :115 , 2006 |
| Abstract : Nishi_2006_Arch.Biochem.Biophys_445_115 |
| ESTHER : Nishi_2006_Arch.Biochem.Biophys_445_115 |
| PubMedSearch : Nishi_2006_Arch.Biochem.Biophys_445_115 |
| PubMedID: 16359636 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine - Imai_2006_Drug.Metab.Dispos_34_1734 |
| Author(s) : Imai T , Taketani M , Shii M , Hosokawa M , Chiba K |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 34 :1734 , 2006 |
| Abstract : Imai_2006_Drug.Metab.Dispos_34_1734 |
| ESTHER : Imai_2006_Drug.Metab.Dispos_34_1734 |
| PubMedSearch : Imai_2006_Drug.Metab.Dispos_34_1734 |
| PubMedID: 16837570 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide - Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
| Author(s) : Quinney SK , Sanghani SP , Davis WI , Hurley TD , Sun Z , Murry DJ , Bosron WF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :1011 , 2005 |
| Abstract : Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
| ESTHER : Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
| PubMedSearch : Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
| PubMedID: 15687373 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 |
| Title : Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3 - Sanghani_2004_Drug.Metab.Dispos_32_505 |
| Author(s) : Sanghani SP , Quinney SK , Fredenburg TB , Davis WI , Murry DJ , Bosron WF |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 32 :505 , 2004 |
| Abstract : Sanghani_2004_Drug.Metab.Dispos_32_505 |
| ESTHER : Sanghani_2004_Drug.Metab.Dispos_32_505 |
| PubMedSearch : Sanghani_2004_Drug.Metab.Dispos_32_505 |
| PubMedID: 15100172 |
| Gene_locus related to this paper: human-CES2 , human-CES3 |
| Title : Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene - Wu_2004_Pharmacogenet_14_595 |
| Author(s) : Wu MH , Chen P , Wu X , Liu W , Strom S , Das S , Cook EH, Jr. , Rosner GL , Dolan ME |
| Ref : Pharmacogenetics , 14 :595 , 2004 |
| Abstract : Wu_2004_Pharmacogenet_14_595 |
| ESTHER : Wu_2004_Pharmacogenet_14_595 |
| PubMedSearch : Wu_2004_Pharmacogenet_14_595 |
| PubMedID: 15475733 |
| Gene_locus related to this paper: human-CES2 |
| Title : Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38 - Charasson_2004_Clin.Pharmacol.Ther_76_528 |
| Author(s) : Charasson V , Bellott R , Meynard D , Longy M , Gorry P , Robert J |
| Ref : Clinical Pharmacology & Therapeutics , 76 :528 , 2004 |
| Abstract : Charasson_2004_Clin.Pharmacol.Ther_76_528 |
| ESTHER : Charasson_2004_Clin.Pharmacol.Ther_76_528 |
| PubMedSearch : Charasson_2004_Clin.Pharmacol.Ther_76_528 |
| PubMedID: 15592324 |
| Gene_locus related to this paper: human-CES2 |
| Title : Pharmacogenomic assessment of carboxylesterases 1 and 2 - Marsh_2004_Genomics_84_661 |
| Author(s) : Marsh S , Xiao M , Yu J , Ahluwalia R , Minton M , Freimuth RR , Kwok PY , McLeod HL |
| Ref : Genomics , 84 :661 , 2004 |
| Abstract : Marsh_2004_Genomics_84_661 |
| ESTHER : Marsh_2004_Genomics_84_661 |
| PubMedSearch : Marsh_2004_Genomics_84_661 |
| PubMedID: 15475243 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Characterization of multiple promoters in the human carboxylesterase 2 gene - Wu_2003_Pharmacogenet_13_425 |
| Author(s) : Wu MH , Chen P , Remo BF , Cook EH, Jr. , Das S , Dolan ME |
| Ref : Pharmacogenetics , 13 :425 , 2003 |
| Abstract : Wu_2003_Pharmacogenet_13_425 |
| ESTHER : Wu_2003_Pharmacogenet_13_425 |
| PubMedSearch : Wu_2003_Pharmacogenet_13_425 |
| PubMedID: 12835618 |
| Gene_locus related to this paper: human-CES2 |
| Title : Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2) - Kim_2003_Drug.Metab.Pharmacokinet_18_327 |
| Author(s) : Kim SR , Nakamura T , Saito Y , Sai K , Nakajima T , Saito H , Shirao K , Minami H , Ohtsu A , Yoshida T , Saijo N , Ozawa S , Sawada J |
| Ref : Drug Metab Pharmacokinet , 18 :327 , 2003 |
| Abstract : Kim_2003_Drug.Metab.Pharmacokinet_18_327 |
| ESTHER : Kim_2003_Drug.Metab.Pharmacokinet_18_327 |
| PubMedSearch : Kim_2003_Drug.Metab.Pharmacokinet_18_327 |
| PubMedID: 15618752 |
| Gene_locus related to this paper: human-CES2 |
| Title : Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population - Saito_2003_J.Hum.Genet_48_249 |
| Author(s) : Saito S , Iida A , Sekine A , Kawauchi S , Higuchi S , Ogawa C , Nakamura Y |
| Ref : J Hum Genet , 48 :249 , 2003 |
| Abstract : Saito_2003_J.Hum.Genet_48_249 |
| ESTHER : Saito_2003_J.Hum.Genet_48_249 |
| PubMedSearch : Saito_2003_J.Hum.Genet_48_249 |
| PubMedID: 12721789 |
| Gene_locus related to this paper: human-CES2 , human-ESD |
| Title : Irinotecan pathway genotype analysis to predict pharmacokinetics - Mathijssen_2003_Clin.Cancer.Res_9_3246 |
| Author(s) : Mathijssen RH , Marsh S , Karlsson MO , Xie R , Baker SD , Verweij J , Sparreboom A , McLeod HL |
| Ref : Clin Cancer Research , 9 :3246 , 2003 |
| Abstract : Mathijssen_2003_Clin.Cancer.Res_9_3246 |
| ESTHER : Mathijssen_2003_Clin.Cancer.Res_9_3246 |
| PubMedSearch : Mathijssen_2003_Clin.Cancer.Res_9_3246 |
| PubMedID: 12960109 |
| Gene_locus related to this paper: human-CES2 |
| Title : Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver - Schwer_1997_Biochem.Biophys.Res.Commun_233_117 |
| Author(s) : Schwer H , Langmann T , Daig R , Becker A , Aslanidis C , Schmitz G |
| Ref : Biochemical & Biophysical Research Communications , 233 :117 , 1997 |
| Abstract : Schwer_1997_Biochem.Biophys.Res.Commun_233_117 |
| ESTHER : Schwer_1997_Biochem.Biophys.Res.Commun_233_117 |
| PubMedSearch : Schwer_1997_Biochem.Biophys.Res.Commun_233_117 |
| PubMedID: 9144407 |
| Gene_locus related to this paper: human-CES2 |
| Title : Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin - Pindel_1997_J.Biol.Chem_272_14769 |
| Author(s) : Pindel EV , Kedishvili NY , Abraham TL , Brzezinski MR , Zhang J , Dean RA , Bosron WF |
| Ref : Journal of Biological Chemistry , 272 :14769 , 1997 |
| Abstract : Pindel_1997_J.Biol.Chem_272_14769 |
| ESTHER : Pindel_1997_J.Biol.Chem_272_14769 |
| PubMedSearch : Pindel_1997_J.Biol.Chem_272_14769 |
| PubMedID: 9169443 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |