1. Home
  2. Gene Locus
  3. human-ACHE

human-ACHE

Homo sapiens (Human) acetylcholinesterase

Comment

Acetylcholinesterase (ACHE\; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. (H322N)

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Homo sapiens

Molecular evidence

No mutation

Acetylthiocholine_WT_human-ACHE Acetylthiocholine_W286A_human-ACHE Acetylthiocholine_Y337A_human-ACHE Acetylthiocholine_F338A_human-ACHE Acetylthiocholine_W86A_human-ACHE 3,3-dimethylbutylthioacetate_WT_human-ACHE 3,3-dimethylbutylthioacetate_W286A_human-ACHE 3,3-dimethylbutylthioacetate_Y337A_human-ACHE 3,3-dimethylbutylthioacetate_F338A_human-ACHE 3,3-dimethylbutylthioacetate_W86A_human-ACHE S-N-Propylthioacetate_WT_human-ACHE S-N-Propylthioacetate_W286A_human-ACHE S-N-Propylthioacetate_Y337A_human-ACHE S-N-Propylthioacetate_F338A_human-ACHE S-N-Propylthioacetate_W86A_human-ACHE Paranitrophenylacetate_WT_human-ACHE Paranitrophenylacetate_W286A_human-ACHE Paranitrophenylacetate_Y337A_human-ACHE Paranitrophenylacetate_F338A_human-ACHE Paranitrophenylacetate_W86A_human-ACHE Edrophonium_WT_human-ACHE Edrophonium_W286A_human-ACHE Edrophonium_Y337A_human-ACHE Edrophonium_F338A_human-ACHE Edrophonium_W86A_human-ACHE Acetylthiocholine_E84Q_human-ACHE Acetylthiocholine_E292A_human-ACHE Acetylthiocholine_E285A_human-ACHE Acetylthiocholine_D349N_human-ACHE Acetylthiocholine_E358Q_human-ACHE Acetylthiocholine_E389Q_human-ACHE Acetylthiocholine_D390N_human-ACHE Acetylthiocholine_E84Q\/E292A_human-ACHE Acetylthiocholine_D349N\/E358Q_human-ACHE Acetylthiocholine_E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/D349N\/E358Q_human-ACHE Acetylthiocholine_E292A\/D349N\/E358Q_human-ACHE Acetylthiocholine_E292A\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/E292A\/D349N\/E358Q_human-ACHE Acetylthiocholine_D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE Acetylthiocholine_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q_human-ACHE 3,3-dimethylbutylthioacetate_E292A_human-ACHE 3,3-dimethylbutylthioacetate_E285A_human-ACHE 3,3-dimethylbutylthioacetate_D349N_human-ACHE 3,3-dimethylbutylthioacetate_E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E389Q_human-ACHE 3,3-dimethylbutylthioacetate_D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E292A_human-ACHE 3,3-dimethylbutylthioacetate_D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E292A\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E292A\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E292A\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q_human-ACHE Edrophonium_E292A_human-ACHE Edrophonium_E285A_human-ACHE Edrophonium_D349N_human-ACHE Edrophonium_E358Q_human-ACHE Edrophonium_E389Q_human-ACHE Edrophonium_D390N_human-ACHE Edrophonium_E84Q\/E292A_human-ACHE Edrophonium_D349N\/E358Q_human-ACHE Edrophonium_E389Q\/D390N_human-ACHE Edrophonium_E84Q\/D349N\/E358Q_human-ACHE Edrophonium_E292A\/D349N\/E358Q_human-ACHE Edrophonium_E292A\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/E292A\/D349N\/E358Q_human-ACHE Edrophonium_D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE Edrophonium_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_Y72A_human-ACHE Acetylthiocholine_D74N_human-ACHE Acetylthiocholine_Y124A_human-ACHE Acetylthiocholine_Y341A_human-ACHE Acetylthiocholine_Y72A\/Y124A_human-ACHE Acetylthiocholine_Y72A\/E285A_human-ACHE Acetylthiocholine_Y72A\/W286A_human-ACHE Acetylthiocholine_E285A\/W286A_human-ACHE Acetylthiocholine_Y72A\/E285A\/W286A_human-ACHE Acetylthiocholine_Y124A\/E285A\/W286A_human-ACHE Acetylthiocholine_F295A_human-ACHE Acetylthiocholine_F297A_human-ACHE Acetylthiocholine_Y337F_human-ACHE Hexamethonium_WT_human-ACHE BW284C51_WT_human-ACHE Propidium_WT_human-ACHE Decamethonium_WT_human-ACHE Edrophonium_Y72A_human-ACHE Hexamethonium_Y72A_human-ACHE BW284C51_Y72A_human-ACHE Propidium_Y72A_human-ACHE Decamethonium_Y72A_human-ACHE Edrophonium_D74N_human-ACHE Hexamethonium_D74N_human-ACHE BW284C51_D74N_human-ACHE Propidium_D74N_human-ACHE Decamethonium_D74N_human-ACHE Edrophonium_Y124A_human-ACHE Hexamethonium_Y124A_human-ACHE BW284C51_Y124A_human-ACHE Propidium_Y124A_human-ACHE Decamethonium_Y124A_human-ACHE Hexamethonium_E285A_human-ACHE BW284C51_E285A_human-ACHE Propidium_E285A_human-ACHE Decamethonium_E285A_human-ACHE Hexamethonium_W286A_human-ACHE BW284C51_W286A_human-ACHE Propidium_W286A_human-ACHE Decamethonium_W286A_human-ACHE Edrophonium_Y341A_human-ACHE Hexamethonium_Y341A_human-ACHE BW284C51_Y341A_human-ACHE Propidium_Y341A_human-ACHE Decamethonium_Y341A_human-ACHE Edrophonium_Y72A\/Y124A_human-ACHE Hexamethonium_Y72A\/Y124A_human-ACHE BW284C51_Y72A\/Y124A_human-ACHE Propidium_Y72A\/Y124A_human-ACHE Decamethonium_Y72A\/Y124A_human-ACHE Edrophonium_Y72A\/E285A_human-ACHE Hexamethonium_Y72A\/E285A_human-ACHE BW284C51_Y72A\/E285A_human-ACHE Propidium_Y72A\/E285A_human-ACHE Decamethonium_Y72A\/E285A_human-ACHE Edrophonium_Y72A\/W286A_human-ACHE Hexamethonium_Y72A\/W286A_human-ACHE BW284C51_Y72A\/W286A_human-ACHE Propidium_Y72A\/W286A_human-ACHE Decamethonium_Y72A\/W286A_human-ACHE Edrophonium_E285A\/W286A_human-ACHE Hexamethonium_E285A\/W286A_human-ACHE BW284C51_E285A\/W286A_human-ACHE Propidium_E285A\/W286A_human-ACHE Decamethonium_E285A\/W286A_human-ACHE Edrophonium_Y72A\/E285A\/W286A_human-ACHE Hexamethonium_Y72A\/E285A\/W286A_human-ACHE BW284C51_Y72A\/E285A\/W286A_human-ACHE Propidium_Y72A\/E285A\/W286A_human-ACHE Decamethonium_Y72A\/E285A\/W286A_human-ACHE Edrophonium_Y124A\/E285A\/W286A_human-ACHE Hexamethonium_Y124A\/E285A\/W286A_human-ACHE BW284C51_Y124A\/E285A\/W286A_human-ACHE Propidium_Y124A\/E285A\/W286A_human-ACHE Decamethonium_Y124A\/E285A\/W286A_human-ACHE Hexamethonium_W86A_human-ACHE BW284C51_W86A_human-ACHE Propidium_W86A_human-ACHE Decamethonium_W86A_human-ACHE Edrophonium_F295A_human-ACHE Hexamethonium_F295A_human-ACHE BW284C51_F295A_human-ACHE Propidium_F295A_human-ACHE Decamethonium_F295A_human-ACHE Edrophonium_F297A_human-ACHE Hexamethonium_F297A_human-ACHE BW284C51_F297A_human-ACHE Propidium_F297A_human-ACHE Decamethonium_F297A_human-ACHE Edrophonium_Y337F_human-ACHE Hexamethonium_Y337F_human-ACHE BW284C51_Y337F_human-ACHE Propidium_Y337F_human-ACHE Decamethonium_Y337F_human-ACHE Hexamethonium_Y337A_human-ACHE BW284C51_Y337A_human-ACHE Propidium_Y337A_human-ACHE Decamethonium_Y337A_human-ACHE Hexamethonium_F338A_human-ACHE BW284C51_F338A_human-ACHE Propidium_F338A_human-ACHE Decamethonium_F338A_human-ACHE 3,3-dimethylbutylthioacetate_D131N_human-ACHE 3,3-dimethylbutylthioacetate_V132A_human-ACHE 3,3-dimethylbutylthioacetate_V132K_human-ACHE Acetylthiocholine_D131N_human-ACHE Acetylthiocholine_V132A_human-ACHE Acetylthiocholine_V132K_human-ACHE Edrophonium_D131N_human-ACHE Edrophonium_V132A_human-ACHE Edrophonium_V132K_human-ACHE Acetylthiocholine_W86F_human-ACHE Acetylthiocholine_W86E_human-ACHE Acetylthiocholine_Y133F_human-ACHE Acetylthiocholine_Y133A_human-ACHE Acetylthiocholine_E202Q_human-ACHE 3,3-dimethylbutylthioacetate_W86F_human-ACHE 3,3-dimethylbutylthioacetate_W86E_human-ACHE 3,3-dimethylbutylthioacetate_Y133F_human-ACHE 3,3-dimethylbutylthioacetate_Y133A_human-ACHE 3,3-dimethylbutylthioacetate_Y337F_human-ACHE 3,3-dimethylbutylthioacetate_E202Q_human-ACHE Edrophonium_W86F_human-ACHE Edrophonium_W86E_human-ACHE Edrophonium_Y133F_human-ACHE Edrophonium_Y133A_human-ACHE Edrophonium_E202Q_human-ACHE Propidium_W86F_human-ACHE Propidium_W86E_human-ACHE Propidium_Y133F_human-ACHE Propidium_Y133A_human-ACHE Propidium_E202Q_human-ACHE Decamethonium_W86F_human-ACHE Decamethonium_W86E_human-ACHE Decamethonium_Y133F_human-ACHE Decamethonium_Y133A_human-ACHE Decamethonium_E202Q_human-ACHE Acetylthiocholine_D74E_human-ACHE Acetylthiocholine_D74G_human-ACHE Acetylthiocholine_D74K_human-ACHE Acetylthiocholine_E202D_human-ACHE Acetylthiocholine_E202A_human-ACHE Edrophonium_D74E_human-ACHE Edrophonium_D74G_human-ACHE Edrophonium_D74K_human-ACHE Edrophonium_E202D_human-ACHE Edrophonium_E202A_human-ACHE Propidium_D74E_human-ACHE Propidium_D74G_human-ACHE Propidium_D74K_human-ACHE Propidium_E202D_human-ACHE Propidium_E202A_human-ACHE Decamethonium_D74E_human-ACHE Decamethonium_D74G_human-ACHE Decamethonium_D74K_human-ACHE Decamethonium_E202D_human-ACHE Decamethonium_E202A_human-ACHE BW284C51_D74E_human-ACHE BW284C51_D74G_human-ACHE BW284C51_D74K_human-ACHE BW284C51_E202Q_human-ACHE BW284C51_E202D_human-ACHE BW284C51_E202A_human-ACHE Bambuterol_WT_human-ACHE Tacrine_WT_human-ACHE Tacrine_W86F_human-ACHE Tacrine_W86A_human-ACHE Tacrine_Y133A_human-ACHE Tacrine_Y337A_human-ACHE Tacrine_Y337F_human-ACHE Tacrine_F338A_human-ACHE Tacrine_Y133F_human-ACHE Tacrine_E202A_human-ACHE Tacrine_E202Q_human-ACHE Tacrine_E450A_human-ACHE Tacrine_F295A_human-ACHE Tacrine_F297A_human-ACHE Tacrine_D74N_human-ACHE Tacrine_Y124A_human-ACHE Tacrine_W286A_human-ACHE Tacrine_Y341A_human-ACHE HuperzineA_WT_human-ACHE HuperzineA_W86F_human-ACHE HuperzineA_W86A_human-ACHE HuperzineA_Y133A_human-ACHE HuperzineA_Y337A_human-ACHE HuperzineA_Y337F_human-ACHE HuperzineA_F338A_human-ACHE HuperzineA_Y133F_human-ACHE HuperzineA_E202A_human-ACHE HuperzineA_E202Q_human-ACHE HuperzineA_E450A_human-ACHE HuperzineA_F295A_human-ACHE HuperzineA_F297A_human-ACHE HuperzineA_D74N_human-ACHE HuperzineA_Y124A_human-ACHE HuperzineA_W286A_human-ACHE HuperzineA_Y341A_human-ACHE Butyrylthiocholine_WT_human-ACHE Succinylcholine~Suxamethonium_WT_human-ACHE Dibucaine_WT_human-ACHE Cocaine_WT_human-ACHE Acetylthiocholine_C580A_human-ACHE Acetylthiocholine_Y72N_human-ACHE Acetylthiocholine_Y124Q_human-ACHE Acetylthiocholine_F295L_human-ACHE Acetylthiocholine_F297V_human-ACHE Acetylthiocholine_Y72N\/Y124Q_human-ACHE Acetylthiocholine_F295L\/F297V_human-ACHE Acetylthiocholine_Y72N\/Y124Q\/W286A_human-ACHE Acetylthiocholine_F295L\/F297V\/Y337A_human-ACHE Acetylthiocholine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Butyrylthiocholine_Y72N_human-ACHE Butyrylthiocholine_Y124Q_human-ACHE Butyrylthiocholine_W286A_human-ACHE Butyrylthiocholine_F295L_human-ACHE Butyrylthiocholine_F297V_human-ACHE Butyrylthiocholine_Y337A_human-ACHE Butyrylthiocholine_Y72N\/Y124Q_human-ACHE Butyrylthiocholine_F295L\/F297V_human-ACHE Butyrylthiocholine_Y72N\/Y124Q\/W286A_human-ACHE Butyrylthiocholine_F295L\/F297V\/Y337A_human-ACHE Butyrylthiocholine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Edrophonium_Y72N\/Y124Q_human-ACHE Edrophonium_F295L\/F297V_human-ACHE Edrophonium_Y72N\/Y124Q\/W286A_human-ACHE Edrophonium_F295L\/F297V\/Y337A_human-ACHE Edrophonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE HuperzineA_Y72N\/Y124Q_human-ACHE HuperzineA_F295L\/F297V_human-ACHE HuperzineA_Y72N\/Y124Q\/W286A_human-ACHE HuperzineA_F295L\/F297V\/Y337A_human-ACHE HuperzineA_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Tacrine_Y72N\/Y124Q_human-ACHE Tacrine_F295L\/F297V_human-ACHE Tacrine_Y72N\/Y124Q\/W286A_human-ACHE Tacrine_F295L\/F297V\/Y337A_human-ACHE Tacrine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Decamethonium_Y72N\/Y124Q_human-ACHE Decamethonium_F295L\/F297V_human-ACHE Decamethonium_Y72N\/Y124Q\/W286A_human-ACHE Decamethonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE BW284C51_Y72N\/Y124Q_human-ACHE BW284C51_F295L\/F297V_human-ACHE BW284C51_Y72N\/Y124Q\/W286A_human-ACHE BW284C51_F295L\/F297V\/Y337A_human-ACHE BW284C51_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE

No disease

Aryl-carboxamide-benzoxazole-cpd36 CHEMBL459756 FUB833 Piperidine-4-carboxamide-alkyl-tacrine-cpd16 N,N-diethyl-4,5-dimethoxy-2-methylbenzenesulfonamide Aurone-Donepezil-Cpd5g Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b Tacrine-Sibiriline-Cpd7 Tacrine-selegiline-8g Tacrine-selegiline-7d Di-tert-butyl-phenol-octylamino-acridine-17d Indole-piperidine-amide-cpd23a SB-1448 3-(Dimethylamino)-N-propanamide-Tryptanthrin CHEMBL4207101 CHEMBL5206601 8AEV-LWU Genistein-O-alkylbenzylamine-25d tacrine-isatin-Cpd7k Lycocasuarine-C Lycocasuarinine-D N-demethylhuperzinine Caffeic-acid-phenethyl-ester Propargyl-Tacrine-15 3,5-dihydroxybenzamido-huprine-hybrid-11 Phenothiazine-Tacrine-1dC Diclofenac-derivative-39 M30D Tacrine-pentylmethylene-tolylsulfonamide N-10-Phenothiazine-isopropyl-carbamate Bivalent-4-Aminopyridine-12i Coumarin-Pyridine-3f K-1234 Tetrabenzyl-D-glucosamine-oxadiazole-6i Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 4-aminopyridine-1,3,4-oxadiazole-9 N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t 5-pyrid-3-yl-1,3,4-oxadiazole-5e Fluoropezil Salicylamide-8-Tacrine 3-butyl-6-benzyloxyphthalide-Mannich-base-7d TPPU-6-Chlorotacrine-12c MT-031 7P1P-4IX T-1123 Tetracyclic-triterpene-1 Tetracyclic-triterpene-36e CHEMBL3585776 DTE-bis8-Tacrine BisQ AzoTHA H0L-7D9O H1R-7D9Q H0R-7D9P PE154 Hypaphorine ZINC11996936 ZINC11709541 ACHE-GSK-3-27g Chelerythrine 8-Hydroxydihydrochelerythrine N-alkyl-quinuclidine-cpd14 6o-5-HT3 6ZWE-Cpd3 Tilorone VXS GD29 GT15 Lipocrine TAK-802 Tanshinone-IIA DL0410 Novichok-5~A-230 A-234-Nerve-agent A-230-Nerve-agent A-232-Nerve-agent Novichok-C01-A039 Novichok-C01-A035 A-262-Nerve-agent A-242-Nerve-agent NTMGMP Novichok-5~A-232 VX-Biotin (-)-phenethylcymserine Aricept~Donepezil~E2020 Quinolinetrione-tacrine-Cpd3 BW284C51 DFP Edrophonium Fasciculin2 Sanguinine Galanthamine HuperzineA HuprineW EMPA IMP-pNP IMP-pNP-F NEMP Paraoxon Toluidine-Blue Pyridostigmine Sarin Tacrine TerritremB Dihydrotanshinone-I VX

Database

Sequence

Peptide

MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ VSDLAAEAVV LHYTDWLHPE DPARLREALS DVVGDHNVVC PVAQLAGRLA AQGARVYAYV FEHRASTLSW PLWMGVPHGY EIEFIFGIPL DPSRNYTAEE KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ YVSLDLRPLE VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN QFDHYSKQDR CSDL

References

Title : A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning - Da Silva_2022_J.Med.Chem_65_4649
Author(s) : Da Silva O , Probst N , Landry C , Hanak AS , Warnault P , Coisne C , Calas AG , Gosselet F , Courageux C , Gastellier AJ , Trancart M , Baati R , Dehouck MP , Jean L , Nachon F , Renard PY , Dias J
Ref : Journal of Medicinal Chemistry , 65 :4649 , 2022
Abstract : Da Silva_2022_J.Med.Chem_65_4649
ESTHER : Da Silva_2022_J.Med.Chem_65_4649
PubMedSearch : Da Silva_2022_J.Med.Chem_65_4649
PubMedID: 35255209
Gene_locus related to this paper: human-ACHE

Title : Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery - Dileep_2022_Int.J.Biol.Macromol_210_172
Author(s) : Dileep KV , Ihara K , Mishima-Tsumagari C , Kukimoto-Niino M , Yonemochi M , Hanada K , Shirouzu M , Zhang KYJ
Ref : Int J Biol Macromol , 210 :172 , 2022
Abstract : Dileep_2022_Int.J.Biol.Macromol_210_172
ESTHER : Dileep_2022_Int.J.Biol.Macromol_210_172
PubMedSearch : Dileep_2022_Int.J.Biol.Macromol_210_172
PubMedID: 35526766
Gene_locus related to this paper: human-ACHE

Title : Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering - Gerlits_2022_Structure_30_1538
Author(s) : Gerlits O , Fajer M , Cheng X , Blumenthal DK , Radic Z , Kovalevsky A
Ref : Structure , 30 :1538 , 2022
Abstract : Gerlits_2022_Structure_30_1538
ESTHER : Gerlits_2022_Structure_30_1538
PubMedSearch : Gerlits_2022_Structure_30_1538
PubMedID: 36265484
Gene_locus related to this paper: human-ACHE

Title : Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases - Chavarria_2021_Antioxidants.(Basel)_10_329
Author(s) : Chavarria D , Da Silva O , Benfeito S , Barreiro S , Garrido J , Cagide F , Soares P , Remiao F , Brazzolotto X , Nachon F , Oliveira PJ , Dias J , Borges F
Ref : Antioxidants (Basel) , 10 :329 , 2021
Abstract : Chavarria_2021_Antioxidants.(Basel)_10_329
ESTHER : Chavarria_2021_Antioxidants.(Basel)_10_329
PubMedSearch : Chavarria_2021_Antioxidants.(Basel)_10_329
PubMedID: 33672269
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6 - McGuire_2021_Chem.Res.Toxicol_34_804
Author(s) : McGuire JR , Bester SM , Guelta MA , Cheung J , Langley C , Winemiller MD , Bae SY , Funk V , Myslinski JM , Pegan SD , Height JJ
Ref : Chemical Research in Toxicology , 34 :804 , 2021
Abstract : McGuire_2021_Chem.Res.Toxicol_34_804
ESTHER : McGuire_2021_Chem.Res.Toxicol_34_804
PubMedSearch : McGuire_2021_Chem.Res.Toxicol_34_804
PubMedID: 33538594
Gene_locus related to this paper: human-ACHE

Title : Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects - Blumenthal_2021_J.Biol.Chem__
Author(s) : Blumenthal DK , Cheng X , Fajer M , Ho KY , Rohrer J , Gerlits O , Taylor P , Juneja P , Kovalevsky A , Radic Z
Ref : Journal of Biological Chemistry , :101007 , 2021
Abstract : Blumenthal_2021_J.Biol.Chem__
ESTHER : Blumenthal_2021_J.Biol.Chem__
PubMedSearch : Blumenthal_2021_J.Biol.Chem__
PubMedID: 34324828
Gene_locus related to this paper: human-ACHE

Title : Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate - Zhou_2021_J.Med.Chem_64_1844
Author(s) : Zhou Y , Fu Y , Yin W , Li J , Wang W , Bai F , Xu S , Gong Q , Peng T , Hong Y , Zhang D , Liu Q , Xu Y , Xu HE , Zhang H , Jiang H , Liu H
Ref : Journal of Medicinal Chemistry , 64 :1844 , 2021
Abstract : Zhou_2021_J.Med.Chem_64_1844
ESTHER : Zhou_2021_J.Med.Chem_64_1844
PubMedSearch : Zhou_2021_J.Med.Chem_64_1844
PubMedID: 33570950
Gene_locus related to this paper: human-ACHE

Title : Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure - Gerlits_2021_Curr.Res.Struct.Biol_3_206
Author(s) : Gerlits O , Blakeley MP , Keen DA , Radic Z , Kovalevsky A
Ref : Current Research in Structural Biology , 3 :206 , 2021
Abstract : Gerlits_2021_Curr.Res.Struct.Biol_3_206
ESTHER : Gerlits_2021_Curr.Res.Struct.Biol_3_206
PubMedSearch : Gerlits_2021_Curr.Res.Struct.Biol_3_206
PubMedID: 34541552
Gene_locus related to this paper: human-ACHE

Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812
Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 64 :812 , 2021
Abstract : Viayna_2021_J.Med.Chem_64_812
ESTHER : Viayna_2021_J.Med.Chem_64_812
PubMedSearch : Viayna_2021_J.Med.Chem_64_812
PubMedID: 33356266
Gene_locus related to this paper: human-ACHE

Title : Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase - Gorecki_2020_J.Biol.Chem_295_4079
Author(s) : Gorecki L , Gerlits O , Kong X , Cheng X , Blumenthal DK , Taylor P , Ballatore C , Kovalevsky A , Radic Z
Ref : Journal of Biological Chemistry , 295 :4079 , 2020
Abstract : Gorecki_2020_J.Biol.Chem_295_4079
ESTHER : Gorecki_2020_J.Biol.Chem_295_4079
PubMedSearch : Gorecki_2020_J.Biol.Chem_295_4079
PubMedID: 32019865
Gene_locus related to this paper: human-ACHE

Title : New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease - Zueva_2019_Neuropharmacol_155_131
Author(s) : Zueva IV , Dias J , Lushchekina SV , Semenov VE , Mukhamedyarov MA , Pashirova TN , Babaev VM , Nachon F , Petrova N , Nurullin LF , Zakharova LY , Ilyin VI , Masson P , Petrov KA
Ref : Neuropharmacology , 155 :131 , 2019
Abstract : Zueva_2019_Neuropharmacol_155_131
ESTHER : Zueva_2019_Neuropharmacol_155_131
PubMedSearch : Zueva_2019_Neuropharmacol_155_131
PubMedID: 31132435
Gene_locus related to this paper: human-ACHE

Title : The structural and biochemical impacts of monomerizing human acetylcholinesterase - Bester_2019_Protein.Sci_28_1106
Author(s) : Bester SM , Adipietro KA , Funk VL , Myslinski JM , Keul ND , Cheung J , Wilder PT , Wood ZA , Weber DJ , Height JJ , Pegan SD
Ref : Protein Science , 28 :1106 , 2019
Abstract : Bester_2019_Protein.Sci_28_1106
ESTHER : Bester_2019_Protein.Sci_28_1106
PubMedSearch : Bester_2019_Protein.Sci_28_1106
PubMedID: 30993792
Gene_locus related to this paper: human-ACHE

Title : A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies - Gerlits_2019_Chem.Biol.Interact_13ChEPon_
Author(s) : Gerlits O , Ho KY , Cheng X , Blumenthal D , Taylor P , Kovalevsky A , Radic Z
Ref : Chemico-Biological Interactions , : , 2019
Abstract : Gerlits_2019_Chem.Biol.Interact_13ChEPon_
ESTHER : Gerlits_2019_Chem.Biol.Interact_13ChEPon_
PubMedSearch : Gerlits_2019_Chem.Biol.Interact_13ChEPon_
PubMedID: 31176713
Gene_locus related to this paper: human-ACHE

Title : Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase - Gerlits_2019_J.Biol.Chem_294_10607
Author(s) : Gerlits O , Kong X , Cheng X , Wymore T , Blumenthal DK , Taylor P , Radic Z , Kovalevsky A
Ref : Journal of Biological Chemistry , 294 :10607 , 2019
Abstract : Gerlits_2019_J.Biol.Chem_294_10607
ESTHER : Gerlits_2019_J.Biol.Chem_294_10607
PubMedSearch : Gerlits_2019_J.Biol.Chem_294_10607
PubMedID: 31138650
Gene_locus related to this paper: human-ACHE

Title : Synthesis and Molecular Properties of Nerve Agent Reactivator HLo-7 Dimethanesulfonate - Hsu_2019_ACS.Med.Chem.Lett_10_761
Author(s) : Hsu FL , Bae SY , McGuire J , Anderson DR , Bester SM , Height JJ , Pegan SD , Walz AJ
Ref : ACS Med Chem Lett , 10 :761 , 2019
Abstract : Hsu_2019_ACS.Med.Chem.Lett_10_761
ESTHER : Hsu_2019_ACS.Med.Chem.Lett_10_761
PubMedSearch : Hsu_2019_ACS.Med.Chem.Lett_10_761
PubMedID: 31097996
Gene_locus related to this paper: human-ACHE

Title : Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase - Kovarik_2019_Toxicol.Appl.Pharmacol_372_40
Author(s) : Kovarik Z , Macek Hrvat N , Kalisiak J , Katalinic M , Sit RK , Zorbaz T , Radic Z , Fokin VV , Sharpless KB , Taylor P
Ref : Toxicol Appl Pharmacol , 372 :40 , 2019
Abstract : Kovarik_2019_Toxicol.Appl.Pharmacol_372_40
ESTHER : Kovarik_2019_Toxicol.Appl.Pharmacol_372_40
PubMedSearch : Kovarik_2019_Toxicol.Appl.Pharmacol_372_40
PubMedID: 30978400
Gene_locus related to this paper: human-ACHE

Title : Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6 - Bester_2018_Chem.Res.Toxicol_31_1405
Author(s) : Bester SM , Guelta MA , Cheung J , Winemiller MD , Bae SY , Myslinski J , Pegan SD , Height JJ
Ref : Chemical Research in Toxicology , 31 :1405 , 2018
Abstract : Bester_2018_Chem.Res.Toxicol_31_1405
ESTHER : Bester_2018_Chem.Res.Toxicol_31_1405
PubMedSearch : Bester_2018_Chem.Res.Toxicol_31_1405
PubMedID: 30462502
Gene_locus related to this paper: human-ACHE

Title : Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface - Franklin_2016_Proteins_84_1246
Author(s) : Franklin MC , Rudolph MJ , Ginter C , Cassidy MS , Cheung J
Ref : Proteins , 84 :1246 , 2016
Abstract : Franklin_2016_Proteins_84_1246
ESTHER : Franklin_2016_Proteins_84_1246
PubMedSearch : Franklin_2016_Proteins_84_1246
PubMedID: 27191504
Gene_locus related to this paper: human-ACHE

Title : Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 - Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
Author(s) : Allgardsson A , Berg L , Akfur C , Hornberg A , Worek F , Linusson A , Ekstrom F
Ref : Proc Natl Acad Sci U S A , 113 :5514 , 2016
Abstract : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
ESTHER : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
PubMedSearch : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
PubMedID: 27140636
Gene_locus related to this paper: human-ACHE

Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability - Goldenzweig_2016_Mol.Cell_63_337
Author(s) : Goldenzweig A , Goldsmith M , Hill SE , Gertman O , Laurino P , Ashani Y , Dym O , Unger T , Albeck S , Prilusky J , Lieberman RL , Aharoni A , Silman I , Sussman JL , Tawfik DS , Fleishman SJ
Ref : Mol Cell , 63 :337 , 2016
Abstract : Goldenzweig_2016_Mol.Cell_63_337
ESTHER : Goldenzweig_2016_Mol.Cell_63_337
PubMedSearch : Goldenzweig_2016_Mol.Cell_63_337
PubMedID: 27425410
Gene_locus related to this paper: human-ACHE

Title : HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants - Macek Hrvat_2016_Chem.Biol.Interact_259_148
Author(s) : Macek Hrvat N , Zunec S , Taylor P , Radic Z , Kovarik Z
Ref : Chemico-Biological Interactions , 259 :148 , 2016
Abstract : Macek Hrvat_2016_Chem.Biol.Interact_259_148
ESTHER : Macek Hrvat_2016_Chem.Biol.Interact_259_148
PubMedSearch : Macek Hrvat_2016_Chem.Biol.Interact_259_148
PubMedID: 27083141
Gene_locus related to this paper: human-ACHE

Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393
Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY
Ref : Biochemical Journal , 453 :393 , 2013
Abstract : Nachon_2013_Biochem.J_453_393
ESTHER : Nachon_2013_Biochem.J_453_393
PubMedSearch : Nachon_2013_Biochem.J_453_393
PubMedID: 23679855
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility - Cheung_2013_ACS.Med.Chem.Lett_4_1091
Author(s) : Cheung J , Gary EN , Shiomi K , Rosenberry TL
Ref : ACS Med Chem Lett , 4 :1091 , 2013
Abstract : Cheung_2013_ACS.Med.Chem.Lett_4_1091
ESTHER : Cheung_2013_ACS.Med.Chem.Lett_4_1091
PubMedSearch : Cheung_2013_ACS.Med.Chem.Lett_4_1091
PubMedID: 24900610
Gene_locus related to this paper: human-ACHE

Title : Structures of human acetylcholinesterase in complex with pharmacologically important ligands - Cheung_2012_J.Med.Chem_55_10282
Author(s) : Cheung J , Rudolph MJ , Burshteyn F , Cassidy MS , Gary EN , Love J , Franklin MC , Height JJ
Ref : Journal of Medicinal Chemistry , 55 :10282 , 2012
Abstract : Cheung_2012_J.Med.Chem_55_10282
ESTHER : Cheung_2012_J.Med.Chem_55_10282
PubMedSearch : Cheung_2012_J.Med.Chem_55_10282
PubMedID: 23035744
Gene_locus related to this paper: human-ACHE

Title : Acetylcholinesterase: from 3D structure to function - Dvir_2010_Chem.Biol.Interact_187_10
Author(s) : Dvir H , Silman I , Harel M , Rosenberry TL , Sussman JL
Ref : Chemico-Biological Interactions , 187 :10 , 2010
Abstract : Dvir_2010_Chem.Biol.Interact_187_10
ESTHER : Dvir_2010_Chem.Biol.Interact_187_10
PubMedSearch : Dvir_2010_Chem.Biol.Interact_187_10
PubMedID: 20138030
Gene_locus related to this paper: human-ACHE

Title : Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation - Carletti_2010_J.Med.Chem_53_4002
Author(s) : Carletti E , Colletier JP , Dupeux F , Trovaslet M , Masson P , Nachon F
Ref : Journal of Medicinal Chemistry , 53 :4002 , 2010
Abstract : Carletti_2010_J.Med.Chem_53_4002
ESTHER : Carletti_2010_J.Med.Chem_53_4002
PubMedSearch : Carletti_2010_J.Med.Chem_53_4002
PubMedID: 20408548
Gene_locus related to this paper: human-ACHE

Title : The DNA sequence of human chromosome 7 - Hillier_2003_Nature_424_157
Author(s) : Hillier LW , Fulton RS , Fulton LA , Graves TA , Pepin KH , Wagner-McPherson C , Layman D , Maas J , Jaeger S , Walker R , Wylie K , Sekhon M , Becker MC , O'Laughlin MD , Schaller ME , Fewell GA , Delehaunty KD , Miner TL , Nash WE , Cordes M , Du H , Sun H , Edwards J , Bradshaw-Cordum H , Ali J , Andrews S , Isak A , Vanbrunt A , Nguyen C , Du F , Lamar B , Courtney L , Kalicki J , Ozersky P , Bielicki L , Scott K , Holmes A , Harkins R , Harris A , Strong CM , Hou S , Tomlinson C , Dauphin-Kohlberg S , Kozlowicz-Reilly A , Leonard S , Rohlfing T , Rock SM , Tin-Wollam AM , Abbott A , Minx P , Maupin R , Strowmatt C , Latreille P , Miller N , Johnson D , Murray J , Woessner JP , Wendl MC , Yang SP , Schultz BR , Wallis JW , Spieth J , Bieri TA , Nelson JO , Berkowicz N , Wohldmann PE , Cook LL , Hickenbotham MT , Eldred J , Williams D , Bedell JA , Mardis ER , Clifton SW , Chissoe SL , Marra MA , Raymond C , Haugen E , Gillett W , Zhou Y , James R , Phelps K , Iadanoto S , Bubb K , Simms E , Levy R , Clendenning J , Kaul R , Kent WJ , Furey TS , Baertsch RA , Brent MR , Keibler E , Flicek P , Bork P , Suyama M , Bailey JA , Portnoy ME , Torrents D , Chinwalla AT , Gish WR , Eddy SR , McPherson JD , Olson MV , Eichler EE , Green ED , Waterston RH , Wilson RK
Ref : Nature , 424 :157 , 2003
Abstract : Hillier_2003_Nature_424_157
ESTHER : Hillier_2003_Nature_424_157
PubMedSearch : Hillier_2003_Nature_424_157
PubMedID: 12853948
Gene_locus related to this paper: human-ABHD11 , human-ACHE , human-CPVL , human-DPP6 , human-MEST

Title : Comparative analysis of the gene-dense ACHE\/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 - Wilson_2001_Nucleic.Acids.Res_29_1352
Author(s) : Wilson MD , Riemer C , Martindale DW , Schnupf P , Boright AP , Cheung TL , Hardy DM , Schwartz S , Scherer SW , Tsui LC , Miller W , Koop BF
Ref : Nucleic Acids Research , 29 :1352 , 2001
Abstract : Wilson_2001_Nucleic.Acids.Res_29_1352
ESTHER : Wilson_2001_Nucleic.Acids.Res_29_1352
PubMedSearch : Wilson_2001_Nucleic.Acids.Res_29_1352
PubMedID: 11239002
Gene_locus related to this paper: human-ACHE , mouse-ACHE

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
Abstract : Venter_2001_Science_291_1304
ESTHER : Venter_2001_Science_291_1304
PubMedSearch : Venter_2001_Science_291_1304
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases - Shapira_2000_Hum.Mol.Genet_9_1273
Author(s) : Shapira M , Tur-Kaspa I , Bosgraaf L , Livni N , Grant AD , Grisaru D , Korner M , Ebstein RP , Soreq H
Ref : Hum Mol Genet , 9 :1273 , 2000
Abstract : Shapira_2000_Hum.Mol.Genet_9_1273
ESTHER : Shapira_2000_Hum.Mol.Genet_9_1273
PubMedSearch : Shapira_2000_Hum.Mol.Genet_9_1273
PubMedID: 10814709
Gene_locus related to this paper: human-ACHE

Title : Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II - Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
Author(s) : Kryger G , Harel M , Giles K , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL
Ref : Acta Crystallographica D Biol Crystallogr , 56 :1385 , 2000
Abstract : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
ESTHER : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
PubMedSearch : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
PubMedID: 11053835
Gene_locus related to this paper: human-ACHE

Title : Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase - Ashani_1994_Mol.Pharmacol_45_555
Author(s) : Ashani Y , Grunwald J , Kronman C , Velan B , Shafferman A
Ref : Molecular Pharmacology , 45 :555 , 1994
Abstract : Ashani_1994_Mol.Pharmacol_45_555
ESTHER : Ashani_1994_Mol.Pharmacol_45_555
PubMedSearch : Ashani_1994_Mol.Pharmacol_45_555
PubMedID: 8145739
Gene_locus related to this paper: human-ACHE

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
Abstract : Ordentlich_1993_J.Biol.Chem_268_17083
ESTHER : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure - Soreq_1990_Proc.Natl.Acad.Sci.U.S.A_87_9688
Author(s) : Soreq H , Ben-Aziz R , Prody CA , Seidman S , Gnatt A , Neville LF , Lieman-Hurwitz J , Lev-Lehman E , Ginzberg D , Lipidot-Lifson Y
Ref : Proceedings of the National Academy of Sciences of the United States of America , 87 :9688 , 1990
Abstract : Soreq_1990_Proc.Natl.Acad.Sci.U.S.A_87_9688
ESTHER : Soreq_1990_Proc.Natl.Acad.Sci.U.S.A_87_9688
PubMedSearch : Soreq_1990_Proc.Natl.Acad.Sci.U.S.A_87_9688
PubMedID: 2263619
Gene_locus related to this paper: human-ACHE

Title : Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase - Chhajlani_1989_FEBS.Lett_247_279
Author(s) : Chhajlani V , Derr D , Earles B , Schmell ED , August T
Ref : FEBS Letters , 247 :279 , 1989
Abstract : Chhajlani_1989_FEBS.Lett_247_279
ESTHER : Chhajlani_1989_FEBS.Lett_247_279
PubMedSearch : Chhajlani_1989_FEBS.Lett_247_279
PubMedID: 2714437
Gene_locus related to this paper: human-ACHE