Homo sapiens (Human) (EC 3.3.2.3) Abhydrolase domain-containing protein 11 williams-beuren syndrome critical region protein 21
No amidase\/protease, phosphatase, sulfatase, phospholipase C or phosphodiesterase activity. No activity of hABHD11 towards mono- or diacylglycerols. ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al.<\/A> published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis. ABHD11-AS1 is An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies
MRAGQQLASM LRWTRAWRLP REGLGPHGPS FARVPVAPSS SSGGRGGAEP RLLDGEAALP AVVFLHGLFG SKTNFNSIAK ILAQQTGRRV LTVDARNHGD SPHSPDMSYE IMSQDLQDLL PQLGLVPCVV VGHSMGGKTA MLLALQRPEL VERLIAVDIS PVESTGVSHF ATYVAAMRAI NIADELPRSR ARKLADEQLS SVIQDMAVRQ HLLTNLVEVD GRFVWRVNLD ALTQHLDKIL AFPQRQESYL GPTLFLLGGN SQFVHPSHHP EIMRLFPRAQ MQTVPNAGHW IHADRPQDFI AAIRGFLV
Title : ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies - Golla_2022_Noncoding.RNA_8_21 |
Author(s) : Golla U , Sesham K , Dallavalasa S , Manda NK , Unnam S , Sanapala AK , Nalla S , Kondam S , Kumar R |
Ref : Noncoding RNA , 8 : , 2022 |
Abstract : Golla_2022_Noncoding.RNA_8_21 |
ESTHER : Golla_2022_Noncoding.RNA_8_21 |
PubMedSearch : Golla_2022_Noncoding.RNA_8_21 |
PubMedID: 35314614 |
Gene_locus related to this paper: human-ABHD11 |
Title : LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1\/EGFR signaling pathway - Lu_2022_Clin.Transl.Oncol_24_1124 |
Author(s) : Lu H , Zhu C , Chen Y , Ruan Y , Fan L , Chen Q , Wei Q |
Ref : Clin Transl Oncol , 24 :1124 , 2022 |
Abstract : Lu_2022_Clin.Transl.Oncol_24_1124 |
ESTHER : Lu_2022_Clin.Transl.Oncol_24_1124 |
PubMedSearch : Lu_2022_Clin.Transl.Oncol_24_1124 |
PubMedID: 35098448 |
Gene_locus related to this paper: human-ABHD11 |
Title : Pancreatic Cancer Cell-Derived Exosomes Promote Lymphangiogenesis by Downregulating ABHD11-AS1 Expression - Zhou_2022_Cancers.(Basel)_14_ |
Author(s) : Zhou X , Zhong F , Yan Y , Wu S , Wang H , Liu J , Li F , Cui D , Xu M |
Ref : Cancers (Basel) , 14 : , 2022 |
Abstract : Zhou_2022_Cancers.(Basel)_14_ |
ESTHER : Zhou_2022_Cancers.(Basel)_14_ |
PubMedSearch : Zhou_2022_Cancers.(Basel)_14_ |
PubMedID: 36230535 |
Gene_locus related to this paper: human-ABHD11 |
Title : LncRNA ABHD11-AS1 Participates in the Progression of Cervical Carcinoma by Targeting miR-1254 and Is the Key to the Diagnosis and Treatment of Cervical Carcinoma in the Future - Zhu_2022_J.Healthc.Eng_2022_8387458 |
Author(s) : Zhu D , Hao Q , Qian M , Hu Y , Wu F |
Ref : J Healthc Eng , 2022 :8387458 , 2022 |
Abstract : Zhu_2022_J.Healthc.Eng_2022_8387458 |
ESTHER : Zhu_2022_J.Healthc.Eng_2022_8387458 |
PubMedSearch : Zhu_2022_J.Healthc.Eng_2022_8387458 |
PubMedID: 35186240 |
Gene_locus related to this paper: human-ABHD11 |
Title : A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes - Karottki_2021_Metab.Eng_66_114 |
Author(s) : Karottki KJC , Hefzi H , Li S , Pedersen LE , Spahn PN , Joshi C , Ruckerbauer D , Bort JAH , Thomas A , Lee JS , Borth N , Lee GM , Kildegaard HF , Lewis NE |
Ref : Metab Eng , 66 :114 , 2021 |
Abstract : Karottki_2021_Metab.Eng_66_114 |
ESTHER : Karottki_2021_Metab.Eng_66_114 |
PubMedSearch : Karottki_2021_Metab.Eng_66_114 |
PubMedID: 33813034 |
Gene_locus related to this paper: human-ABHD11 |
Title : Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5\/focal adhesion kinase\/phosphoinositide 3 kinase\/Akt signaling pathway - Luo_2021_Aging.(Albany.NY)_13_20179 |
Author(s) : Luo J , Jiang Y , Wu L , Zhuo D , Zhang S , Jiang X , Sun Y , Huang Y |
Ref : Aging (Albany NY) , 13 :20179 , 2021 |
Abstract : Luo_2021_Aging.(Albany.NY)_13_20179 |
ESTHER : Luo_2021_Aging.(Albany.NY)_13_20179 |
PubMedSearch : Luo_2021_Aging.(Albany.NY)_13_20179 |
PubMedID: 34375304 |
Gene_locus related to this paper: human-ABHD11 |
Title : Single-Nucleotide Polymorphisms Promote Dysregulation Activation by Essential Gene Mediated Bio-Molecular Interaction in Breast Cancer - Wang_2021_Front.Oncol_11_791943 |
Author(s) : Wang X , Zhao Z , Han X , Zhang Y , Li F , Li H |
Ref : Front Oncol , 11 :791943 , 2021 |
Abstract : Wang_2021_Front.Oncol_11_791943 |
ESTHER : Wang_2021_Front.Oncol_11_791943 |
PubMedSearch : Wang_2021_Front.Oncol_11_791943 |
PubMedID: 34926308 |
Gene_locus related to this paper: human-ABHD11 |
Title : m(6) A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer - Xue_2021_J.Cell.Physiol_236_2649 |
Author(s) : Xue L , Li J , Lin Y , Liu D , Yang Q , Jian J , Peng J |
Ref : Journal of Cellular Physiology , 236 :2649 , 2021 |
Abstract : Xue_2021_J.Cell.Physiol_236_2649 |
ESTHER : Xue_2021_J.Cell.Physiol_236_2649 |
PubMedSearch : Xue_2021_J.Cell.Physiol_236_2649 |
PubMedID: 32892348 |
Gene_locus related to this paper: human-ABHD11 |
Title : EZH2-mediated lncRNA ABHD11-AS1 promoter regulates the progression of ovarian cancer by targeting miR-133a-3p - Zhang_2021_Anticancer.Drugs_32_269 |
Author(s) : Zhang W , Huang X , Shi J |
Ref : Anticancer Drugs , 32 :269 , 2021 |
Abstract : Zhang_2021_Anticancer.Drugs_32_269 |
ESTHER : Zhang_2021_Anticancer.Drugs_32_269 |
PubMedSearch : Zhang_2021_Anticancer.Drugs_32_269 |
PubMedID: 33491971 |
Gene_locus related to this paper: human-ABHD11 |
Title : ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex - Bailey_2020_Nat.Commun_11_4046 |
Author(s) : Bailey PSJ , Ortmann BM , Martinelli AW , Houghton JW , Costa ASH , Burr SP , Antrobus R , Frezza C , Nathan JA |
Ref : Nat Commun , 11 :4046 , 2020 |
Abstract : Bailey_2020_Nat.Commun_11_4046 |
ESTHER : Bailey_2020_Nat.Commun_11_4046 |
PubMedSearch : Bailey_2020_Nat.Commun_11_4046 |
PubMedID: 32792488 |
Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
Title : ABHD11, a new diacylglycerol lipase involved in weight gain regulation - Escoubet_2020_PLoS.One_15_e0234780 |
Author(s) : Escoubet J , Kenigsberg M , Derock M , Yaligara V , Bock MD , Roche S , Massey F , de Foucauld H , Bettembourg C , Olivier A , Berthemy A , Capdevielle J , Legoux R , Perret E , Buzy A , Chardenot P , Destelle V , Leroy A , Cahours C , Teixeira S , Juvet P , Gauthier P , Leguet M , Rocheteau-Beaujouan L , Chatoux MA , Deshayes W , Clement M , Kabiri M , Orsini C , Mikol V , Didier M , Guillemot JC |
Ref : PLoS ONE , 15 :e0234780 , 2020 |
Abstract : Escoubet_2020_PLoS.One_15_e0234780 |
ESTHER : Escoubet_2020_PLoS.One_15_e0234780 |
PubMedSearch : Escoubet_2020_PLoS.One_15_e0234780 |
PubMedID: 32579589 |
Gene_locus related to this paper: human-ABHD11 |
Title : ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis - Liu_2020_Front.Cell.Dev.Biol_8_570 |
Author(s) : Liu G , Ruan Y , Zhang J , Wang X , Wu W , He P , Wang J , Xiong J , Cheng Y , Liu L , Yang Y , Tian Y , Jian R |
Ref : Front Cell Developmental Biology , 8 :570 , 2020 |
Abstract : Liu_2020_Front.Cell.Dev.Biol_8_570 |
ESTHER : Liu_2020_Front.Cell.Dev.Biol_8_570 |
PubMedSearch : Liu_2020_Front.Cell.Dev.Biol_8_570 |
PubMedID: 32733886 |
Gene_locus related to this paper: human-ABHD11 |
Title : Long non-coding RNA ABHD11-AS1 boosts gastric cancer development by regulating miR-361-3p\/PDPK1 signalling - Xin_2020_J.Biochem_168_465 |
Author(s) : Xin H , Yan Z , Cao J |
Ref : J Biochem , 168 :465 , 2020 |
Abstract : Xin_2020_J.Biochem_168_465 |
ESTHER : Xin_2020_J.Biochem_168_465 |
PubMedSearch : Xin_2020_J.Biochem_168_465 |
PubMedID: 32678870 |
Gene_locus related to this paper: human-ABHD11 |
Title : Long noncoding RNA ABHD11-AS1 promote cells proliferation and invasion of colorectal cancer via regulating the miR-1254-WNT11 pathway - He_2019_J.Cell.Physiol_234_12070 |
Author(s) : He D , Yue Z , Liu L , Fang X , Chen L , Han H |
Ref : Journal of Cellular Physiology , 234 :12070 , 2019 |
Abstract : He_2019_J.Cell.Physiol_234_12070 |
ESTHER : He_2019_J.Cell.Physiol_234_12070 |
PubMedSearch : He_2019_J.Cell.Physiol_234_12070 |
PubMedID: 30537177 |
Gene_locus related to this paper: human-ABHD11 |
Title : Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice - Park_2019_Neurosci.Res_147_58 |
Author(s) : Park H , Miyazaki H , Yamanaka T , Nukina N |
Ref : Neurosci Res , 147 :58 , 2019 |
Abstract : Park_2019_Neurosci.Res_147_58 |
ESTHER : Park_2019_Neurosci.Res_147_58 |
PubMedSearch : Park_2019_Neurosci.Res_147_58 |
PubMedID: 30391555 |
Gene_locus related to this paper: human-ABHD11 |
Title : Circulating lncRNA ABHD11-AS1 serves as a biomarker for early pancreatic cancer diagnosis - Liu_2019_J.Cancer_10_3746 |
Author(s) : Liu Y , Feng W , Liu W , Kong X , Li L , He J , Wang D , Zhang M , Zhou G , Xu W , Chen W , Gong A , Xu M |
Ref : J Cancer , 10 :3746 , 2019 |
Abstract : Liu_2019_J.Cancer_10_3746 |
ESTHER : Liu_2019_J.Cancer_10_3746 |
PubMedSearch : Liu_2019_J.Cancer_10_3746 |
PubMedID: 31333792 |
Gene_locus related to this paper: human-ABHD11 |
Title : STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p\/STAT3 axis and PI3K\/AKT signalling pathway - Wen_2019_Cell.Prolif_52_e12569 |
Author(s) : Wen J , Wang H , Dong T , Gan P , Fang H , Wu S , Li J , Zhang Y , Du R , Zhu Q |
Ref : Cell Prolif , 52 :e12569 , 2019 |
Abstract : Wen_2019_Cell.Prolif_52_e12569 |
ESTHER : Wen_2019_Cell.Prolif_52_e12569 |
PubMedSearch : Wen_2019_Cell.Prolif_52_e12569 |
PubMedID: 30657221 |
Gene_locus related to this paper: human-ABHD11 |
Title : lncRNA ABHD11-AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2 - Zeng_2019_Cancer.Med_8_7074 |
Author(s) : Zeng XY , Jiang XY , Yong JH , Xie H , Yuan J , Zeng D , Dou YY , Xiao SS |
Ref : Cancer Med , 8 :7074 , 2019 |
Abstract : Zeng_2019_Cancer.Med_8_7074 |
ESTHER : Zeng_2019_Cancer.Med_8_7074 |
PubMedSearch : Zeng_2019_Cancer.Med_8_7074 |
PubMedID: 31568657 |
Gene_locus related to this paper: human-ABHD11 |
Title : Long noncoding RNA ABHD11-AS1 functions as a competing endogenous RNA to regulate papillary thyroid cancer progression by miR-199a-5p\/SLC1A5 axis - Zhuang_2019_Cell.Death.Dis_10_620 |
Author(s) : Zhuang X , Tong H , Ding Y , Wu L , Cai J , Si Y , Zhang H , Shen M |
Ref : Cell Death Dis , 10 :620 , 2019 |
Abstract : Zhuang_2019_Cell.Death.Dis_10_620 |
ESTHER : Zhuang_2019_Cell.Death.Dis_10_620 |
PubMedSearch : Zhuang_2019_Cell.Death.Dis_10_620 |
PubMedID: 31409775 |
Gene_locus related to this paper: human-ABHD11 |
Title : Long non-coding RNA ABHD11-AS1 promotes colorectal cancer development through regulation of miR-133a\/SOX4 axis - Lei_2018_Biosci.Rep_38_ |
Author(s) : Lei X , Li L , Duan X |
Ref : Bioscience Reports , 38 : , 2018 |
Abstract : Lei_2018_Biosci.Rep_38_ |
ESTHER : Lei_2018_Biosci.Rep_38_ |
PubMedSearch : Lei_2018_Biosci.Rep_38_ |
PubMedID: 30429229 |
Gene_locus related to this paper: human-ABHD11 |
Title : LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1 - Liu_2018_J.Cell.Mol.Med_22_3955 |
Author(s) : Liu Y , Wang LL , Chen S , Zong ZH , Guan X , Zhao Y |
Ref : J Cell Mol Med , 22 :3955 , 2018 |
Abstract : Liu_2018_J.Cell.Mol.Med_22_3955 |
ESTHER : Liu_2018_J.Cell.Mol.Med_22_3955 |
PubMedSearch : Liu_2018_J.Cell.Mol.Med_22_3955 |
PubMedID: 29799152 |
Gene_locus related to this paper: human-ABHD11 |
Title : Long noncoding RNA ABHD11-AS1 predicts the prognosis of pancreatic cancer patients and serves as a promoter by activating the PI3K-AKT pathway - Qiao_2018_Eur.Rev.Med.Pharmacol.Sci_22_8630 |
Author(s) : Qiao X , Lv SX , Qiao Y , Li QP , Ye B , Wang CC , Miao L |
Ref : Eur Rev Med Pharmacol Sci , 22 :8630 , 2018 |
Abstract : Qiao_2018_Eur.Rev.Med.Pharmacol.Sci_22_8630 |
ESTHER : Qiao_2018_Eur.Rev.Med.Pharmacol.Sci_22_8630 |
PubMedSearch : Qiao_2018_Eur.Rev.Med.Pharmacol.Sci_22_8630 |
PubMedID: 30575903 |
Gene_locus related to this paper: human-ABHD11 |
Title : Human alpha beta hydrolase domain containing protein 11 and its yeast homolog are lipid hydrolases - Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
Author(s) : Arya M , Srinivasan M , Rajasekharan R |
Ref : Biochemical & Biophysical Research Communications , 487 :875 , 2017 |
Abstract : Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
ESTHER : Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
PubMedSearch : Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
PubMedID: 28465236 |
Gene_locus related to this paper: human-ABHD11 |
Title : Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer - Chen_2017_Oncotarget_8_28176 |
Author(s) : Chen M , Li J , Zhuang C , Cai Z |
Ref : Oncotarget , 8 :28176 , 2017 |
Abstract : Chen_2017_Oncotarget_8_28176 |
ESTHER : Chen_2017_Oncotarget_8_28176 |
PubMedSearch : Chen_2017_Oncotarget_8_28176 |
PubMedID: 28157695 |
Gene_locus related to this paper: human-ABHD11 |
Title : Role of the lncRNA ABHD11-AS(1) in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC - Wu_2017_Mol.Cancer_16_138 |
Author(s) : Wu DD , Chen X , Sun KX , Wang LL , Chen S , Zhao Y |
Ref : Mol Cancer , 16 :138 , 2017 |
Abstract : Wu_2017_Mol.Cancer_16_138 |
ESTHER : Wu_2017_Mol.Cancer_16_138 |
PubMedSearch : Wu_2017_Mol.Cancer_16_138 |
PubMedID: 28818073 |
Gene_locus related to this paper: human-ABHD11 |
Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR |
Ref : Eur J Pharm Sci , 93 :253 , 2016 |
Abstract : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
ESTHER : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
PubMedSearch : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
PubMedID: 27544863 |
Gene_locus related to this paper: human-ABHD11 |
Title : Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer - Yang_2016_Tumour.Biol_37_1183 |
Author(s) : Yang Y , Shao Y , Zhu M , Li Q , Yang F , Lu X , Xu C , Xiao B , Sun Y , Guo J |
Ref : Tumour Biol , 37 :1183 , 2016 |
Abstract : Yang_2016_Tumour.Biol_37_1183 |
ESTHER : Yang_2016_Tumour.Biol_37_1183 |
PubMedSearch : Yang_2016_Tumour.Biol_37_1183 |
PubMedID: 26280398 |
Gene_locus related to this paper: human-ABHD11 |
Title : Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo - Francelle_2015_Neurobiol.Aging_36_1601.e7 |
Author(s) : Francelle L , Galvan L , Gaillard MC , Petit F , Bernay B , Guillermier M , Bonvento G , Dufour N , Elalouf JM , Hantraye P , Deglon N , de Chaldee M , Brouillet E |
Ref : Neurobiology of Aging , 36 :1601 e7 , 2015 |
Abstract : Francelle_2015_Neurobiol.Aging_36_1601.e7 |
ESTHER : Francelle_2015_Neurobiol.Aging_36_1601.e7 |
PubMedSearch : Francelle_2015_Neurobiol.Aging_36_1601.e7 |
PubMedID: 25619660 |
Gene_locus related to this paper: human-ABHD11 |
Title : Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance - Lin_2014_Med.Oncol_31_42 |
Author(s) : Lin X , Yang M , Xia T , Guo J |
Ref : Med Oncol , 31 :42 , 2014 |
Abstract : Lin_2014_Med.Oncol_31_42 |
ESTHER : Lin_2014_Med.Oncol_31_42 |
PubMedSearch : Lin_2014_Med.Oncol_31_42 |
PubMedID: 24984296 |
Gene_locus related to this paper: human-ABHD11 |
Title : Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes - Bachovchin_2009_Nat.Biotechnol_27_387 |
Author(s) : Bachovchin DA , Brown SJ , Rosen H , Cravatt BF |
Ref : Nat Biotechnol , 27 :387 , 2009 |
Abstract : Bachovchin_2009_Nat.Biotechnol_27_387 |
ESTHER : Bachovchin_2009_Nat.Biotechnol_27_387 |
PubMedSearch : Bachovchin_2009_Nat.Biotechnol_27_387 |
PubMedID: 19329999 |
Gene_locus related to this paper: human-ABHD11 |
Title : Effects of rosiglitazone and high fat diet on lipase\/esterase expression in adipose tissue - Shen_2007_Biochim.Biophys.Acta_1771_177 |
Author(s) : Shen WJ , Patel S , Yu Z , Jue D , Kraemer FB |
Ref : Biochimica & Biophysica Acta , 1771 :177 , 2007 |
Abstract : Shen_2007_Biochim.Biophys.Acta_1771_177 |
ESTHER : Shen_2007_Biochim.Biophys.Acta_1771_177 |
PubMedSearch : Shen_2007_Biochim.Biophys.Acta_1771_177 |
PubMedID: 17215164 |
Gene_locus related to this paper: human-ABHD11 |
Title : Identification of additional transcripts in the Williams-Beuren syndrome critical region - Merla_2002_Hum.Genet_110_429 |
Author(s) : Merla G , Ucla C , Guipponi M , Reymond A |
Ref : Hum Genet , 110 :429 , 2002 |
Abstract : Merla_2002_Hum.Genet_110_429 |
ESTHER : Merla_2002_Hum.Genet_110_429 |
PubMedSearch : Merla_2002_Hum.Genet_110_429 |
PubMedID: 12073013 |
Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |