Gene_Locus Report

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Gene_locus Report for: helro-ACHE1

Helobdella robusta (Californian leech)Annelide acetylcholinesterase 1

Comment
Helobdella robusta Leeches are distinguished from other annelids by anterior and posterior suckers used for locomotion and feeding on blood or soft body parts of other animals. jgi|Helro1|76935 this is strange gene H exon linked to 4th exon in a single exon a duplicate of exon 3 in the middle


Relationship
Family|ACHE
Block| C
Position in NCBI Life Tree|Helobdella robusta
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Lophotrochozoa: N E > Annelida: N E > Clitellata: N E > Hirudinea: N E > Rhynchobdellida: N E > Glossiphoniidae: N E > Helobdella: N E > Helobdella robusta: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
1 Genbank : KB096275
1 UniProt : T1G2R7
1 UniProt : T1G2R7
1 Interpro : T1G2R7
1 Pfam : T1G2R7
1 PIRSF : T1G2R7
1 SUPERFAM : T1G2R7
Sequence
Graphical view for this peptide sequence: helro-ACHE1
Colored MSA for ACHE (raw)
MKFLNNLKVALQIGYFKIELVIVLIVFSAIGCHQLHKIRSHGDLIVNTES
GLVRGHRFHIPSVISPIDAYLGIPFAKPPVKKLRFRHPQPYGKWEGVYNA
TRLPNSCFQMPDTVFGADFPGSSAWNPTTKLSEDCLYLNIWVPKTTPKLR
KSAVMVWIYGGGFYSGTTTLNVYDGKILAANSSIIVVSVAYRVGAFGFLT
LNHPSAPGNAGLFDQLMALEWIQRNIKYFGGDPENITLFGESAGAVSISM
HLLSPLSHSKFQRAILQSGVANMPWAFTTMEQAKRRGIDFAIATMSCNYT
DIEVLVDCLREVPDYILAEHQYITRGIMQFPFIPVIDGSFLPEHPKEILK
KGNFKHCPILLGSNKNEATFFLIYELTDWLNLTSIKMTKTDYLESMNRLF
FTHPHPNRVTYPFVMESIQFQYANWLDEDNYVLNTQALDAAVSEYHFICP
VNQFAQLYASLGENVYMYYFTQRYSTNPWPAWMGVLHGDEIMFVFGEALK
SLANYSEDDKKLSRIMTEYWVNFAKTGDPNQIPGVRTTQDWPLYTPNMKE
YLELNSKFLDDPDSTKAVGRGPRIKECAFWDEYIPQLNAVIGSLVHPFTK
CRLSILIFTLIFFTTN
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MKFLNNLKVALQIGYFKIELVIVLIVFSAIGCHQLHKIRSHGDLIVNTES
GLVRGHRFHIPSVISPIDAYLGIPFAKPPVKKLRFRHPQPYGKWEGVYNA
TRLPNSCFQMPDTVFGADFPGSSAWNPTTKLSEDCLYLNIWVPKTTPKLR
KSAVMVWIYGGGFYSGTTTLNVYDGKILAANSSIIVVSVAYRVGAFGFLT
LNHPSAPGNAGLFDQLMALEWIQRNIKYFGGDPENITLFGESAGAVSISM
HLLSPLSHSKFQRAILQSGVANMPWAFTTMEQAKRRGIDFAIATMSCNYT
DIEVLVDCLREVPDYILAEHQYITRGIMQFPFIPVIDGSFLPEHPKEILK
KGNFKHCPILLGSNKNEATFFLIYELTDWLNLTSIKMTKTDYLESMNRLF
FTHPHPNRVTYPFVMESIQFQYANWLDEDNYVLNTQALDAAVSEYHFICP
VNQFAQLYASLGENVYMYYFTQRYSTNPWPAWMGVLHGDEIMFVFGEALK
SLANYSEDDKKLSRIMTEYWVNFAKTGDPNQIPGVRTTQDWPLYTPNMKE
YLELNSKFLDDPDSTKAVGRGPRIKECAFWDEYIPQLNAVIGSLVHPFTK
CRLSILIFTLIFFTTN


Reference
    Title: Insights into bilaterian evolution from three spiralian genomes
    Simakov O, Marletaz F, Cho SJ, Edsinger-Gonzales E, Havlak P, Hellsten U, Kuo DH, Larsson T, Lv J and Rokhsar DS <16 more author(s)>
    Ref: Nature, 493:526, 2013 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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