Gene_locus Report for: fusof-f9f6v2

Other strains: Fusarium oxysporum (Fo5176; FOSC 3-a; Fo47; f. sp. (lycopersici (4287 / CBS 123668 / FGS 9935 / NRRL 34936; MN25); f. sp. cubense (strain race 4; race 1; tropical race 4 54006); pisi HDV247; melonis 26406; raphani 54005; radicis-lycopersici 26381; conglutinans race 2 54008; vasinfectum 25433) (Fusarium vascular wilt of tomato) Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) Fusarium fujikuroi

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > sordariomyceta: N E > Sordariomycetes: N E > Hypocreomycetidae: N E > Hypocreales: N E > Nectriaceae: N E > Fusarium: N E > Fusarium oxysporum species complex: N E > Fusarium oxysporum: N E

ABHD11-Acetyl_transferase : fusof-f9f774Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt). Uncharacterized protein.
Acetylxylan_esterase : fusof-f9fgw0Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9fgw1Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9fcz8Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9f800Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9gak5Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9f4k6Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein.
Arb2_domain : fusox-w9hvf0Fusarium oxysporum; Fusarium sp.. Arb2_domain.
Canar_LipB : fusof-f9g6q0Fusarium oxysporum (Fusarium vascular wilt) (Panama disease fungus) Lipase B.
Carb_B_Bacteria : fusof-f9f4n3Fusarium oxysporum (Panama disease fungus) (contaminant from bacteria?) Putative uncharacterized protein, fusof-f9fn88Fusarium oxysporum (strain Fo5176; Fo47) (Panama disease fungus) (bacterial contaminant ?) Putative uncharacterized protein.
Cutinase : fusof-f9ftm6Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9fji8Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9f3d9Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9fsi0Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusof-f9f4m7Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein, fusox-CUT Fusarium oxysporum (Fusarium vascular wilt) Cutinase FoCut5A, fusof-f9fvf1Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) Uncharacterized protein.
FaeC : fuso4-a0a0c4diy4Fusarium oxysporum f. (Fusarium vascular wilt of tomato); Fusarium fujikuroi, Mango malformation disease fungus, Orchid endophyte fungus, Fusarium vascular wilt, Fusarium nygamai, Fusarium proliferatum, Fusarium verticillioides, Panama disease fungus). Abhydrolase_2 domain-containing protein.
Fungal_carboxylesterase_lipase : fusof-f9f2k2Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9f3l6Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9f6t8Fusarium oxysporum (Panama disease fungus), Gibberella fujikuroi (Bakanae and foot rot disease fungus); Gibberella moniliformis, Putative uncharacterized protein, fusof-f9f132Fusarium oxysporum (Panama disease fungus), Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi), Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides), Putative uncharacterized protein, fusof-f9f781Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fd72Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fd90Fusarium oxysporum (Panama disease fungus); Gibberella fujikuroi; Gibberella moniliformis; Putative uncharacterized protein, fusof-f9fem0Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fhk2Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fiu4Fusarium oxysporum (strain Fo5176) (Panama disease fungus) Putative uncharacterized protein, fusof-f9fj19Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fj20Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fki8Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fmx2Fusarium oxysporum (Panama disease fungus), Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi), Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides) Putative uncharacterized protein, fusof-f9fnt4Fusarium oxysporum (Panama disease fungus) (Fusarium vascular wilt of tomato) Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi), Gibberella moniliformis Putative uncharacterized protein, fusof-f9fpy4Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fvs6Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fwu0Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fxz4Fusarium oxysporum (Panama disease fungus), Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum), Gibberella moniliformis, Putative uncharacterized protein, fusof-f9fzw0Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9fzy5Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9g2a2Fusarium oxysporum (Panama disease fungus) Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) Putative uncharacterized protein, fusof-f9g3b1Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9g5h7Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9g5z8Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9g6e6Fusarium oxysporum (Panama disease fungus); Gibberella moniliformis Putative uncharacterized protein, fusof-f9g6y7Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9g7b0Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusof-f9g797Fusarium oxysporum (Panama disease fungus) Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) Putative uncharacterized protein, fusof-f9g972Fusarium oxysporum (strain Fo5176) (Panama disease fungus) Putative uncharacterized protein, fusof-f9ga50Fusarium oxysporum (Panama disease fungus), Gibberella fujikuroi, Gibberella moniliformis, Putative uncharacterized protein, fusof-f9gck4Fusarium oxysporum (Panama disease fungus) Gibberella fujikuroi (Fusarium fujikuroi) (Fusarium vascular wilt of tomato), Gibberella moniliformis Putative uncharacterized protein, fusof-f9gd15Fusarium oxysporum (Panama disease fungus) Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) Putative uncharacterized protein, fusof-f9gd77Fusarium oxysporum (Panama disease fungus) Putative uncharacterized protein, fusc4-n1s9p6Fusarium oxysporum (Panama disease fungus) Lipase 1, fusox-w9iyc7Fusarium oxysporum. Uncharacterized protein, fusox-w9hez6Fusarium oxysporum (Panama disease fungus). Uncharacterized protein, fuso4-a0a0j9vhl8Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) Uncharacterized protein, fuso4-a0a0j9wuq4Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) Uncharacterized protein.
HOD-cofactorfree-dioxygenase : fusox-x0bme4Fusarium oxysporum. Uncharacterized protein.
Hormone-sensitive_lipase_like : fusof-f9gf05Fusarium oxysporum (Fusarium vascular wilt). Uncharacterized protein, fusof-f9fg31Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt). Uncharacterized protein.
Kynurenine-formamidase : fusof-f9fnm6Fusarium oxysporum (Fusarium vascular wilt). N-formylkynurenine formamidase, fusof-f9gfd3Fusarium oxysporum (Fusarium vascular wilt). N-formylkynurenine formamidase.
Tannase : fusox-a0a1d3s5h0 Fusarium oxysporum (Fusarium vascular wilt) type C feruloyl esterase FoFaeC; Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi); Gibberella moniliformis; (Maize ear and stalk rot fungus); Fusarium mangiferae. SF2 faeC Feruloyl esterase

Title: Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites
Wiemann P, Sieber CM, von Bargen KW, Studt L, Niehaus EM, Espino JJ, Huss K, Michielse CB, Albermann S and Tudzynski B <18 more author(s)> Wiemann P, Sieber CM, von Bargen KW, Studt L, Niehaus EM, Espino JJ, Huss K, Michielse CB, Albermann S, Wagner D, Bergner SV, Connolly LR, Fischer A, Reuter G, Kleigrewe K, Bald T, Wingfield BD, Ophir R, Freeman S, Hippler M, Smith KM, Brown DW, Proctor RH, Munsterkotter M, Freitag M, Humpf HU, Guldener U, Tudzynski B (- 18)
Ref: PLoS Pathog, 9:e1003475, 2013 : PubMed
Abstract


ESTHER: Wiemann_2013_PLoS.Pathog_9_E1003475
PubMedSearch: Wiemann 2013 PLoS.Pathog 9 E1003475
PubMedID: 23825955
Gene_locus related to this paper: fusox-a0a1d3s5h0, fusof-f9f6t8, fusof-f9f6v2, fusof-f9f132, fusof-f9fd90, fusof-f9fmx2, fusof-f9fnt4, fusof-f9g2a2, fusof-f9g797, fusof-f9ga50, fusof-f9gck4, fusof-f9gd15, gibf5-s0ea65, gibf5-s0enx6, gibf5-s0epd5, gibf5-s0dwm1, gibf5-s0egd1, gibf5-s0duw7, gibf5-s0ekf7, gibf5-s0e2n9, gibf5-s0en31, gibf5-s0e7t9, gibf5-s0eim9, gibf5-s0drv8, gibf5-s0e9e0, gibf5-s0e3u9, gibf5-s0dzu5, gibf5-s0dqr2, gibf5-s0ecj3, gibf5-s0ekc4, gibf5-s0ejq7, gibf5-s0eli0, gibf5-s0dz40, gibf5-s0ehu3, gibf5-fuj3, gibf5-fub5, gibf5-fus5, gibf5-bik1

Abstract

The fungus Fusarium fujikuroi causes "bakanae" disease of rice due to its ability to produce gibberellins (GAs), but it is also known for producing harmful mycotoxins. However, the genetic capacity for the whole arsenal of natural compounds and their role in the fungus' interaction with rice remained unknown. Here, we present a high-quality genome sequence of F. fujikuroi that was assembled into 12 scaffolds corresponding to the 12 chromosomes described for the fungus. We used the genome sequence along with ChIP-seq, transcriptome, proteome, and HPLC-FTMS-based metabolome analyses to identify the potential secondary metabolite biosynthetic gene clusters and to examine their regulation in response to nitrogen availability and plant signals. The results indicate that expression of most but not all gene clusters correlate with proteome and ChIP-seq data. Comparison of the F. fujikuroi genome to those of six other fusaria revealed that only a small number of gene clusters are conserved among these species, thus providing new insights into the divergence of secondary metabolism in the genus Fusarium. Noteworthy, GA biosynthetic genes are present in some related species, but GA biosynthesis is limited to F. fujikuroi, suggesting that this provides a selective advantage during infection of the preferred host plant rice. Among the genome sequences analyzed, one cluster that includes a polyketide synthase gene (PKS19) and another that includes a non-ribosomal peptide synthetase gene (NRPS31) are unique to F. fujikuroi. The metabolites derived from these clusters were identified by HPLC-FTMS-based analyses of engineered F. fujikuroi strains overexpressing cluster genes. In planta expression studies suggest a specific role for the PKS19-derived product during rice infection. Thus, our results indicate that combined comparative genomics and genome-wide experimental analyses identified novel genes and secondary metabolites that contribute to the evolutionary success of F. fujikuroi as a rice pathogen.



        

Title: A highly conserved effector in Fusarium oxysporum is required for full virulence on Arabidopsis
Thatcher LF, Gardiner DM, Kazan K, Manners JM
Ref: Mol Plant Microbe Interact, 25:180, 2012 : PubMed
Abstract


ESTHER: Thatcher_2012_Mol.Plant.Microbe.Interact_25_180
PubMedSearch: Thatcher 2012 Mol.Plant.Microbe.Interact 25 180
PubMedID: 21942452
Gene_locus related to this paper: fusox-a0a1d3s5h0, fusof-f9f2k2, fusof-f9f3l6, fusof-f9f4n3, fusof-f9f6t8, fusof-f9f6v2, fusof-f9f132, fusof-f9f781, fusof-f9fd72, fusof-f9fd90, fusof-f9fem0, fusof-f9fhk2, fusof-f9fiu4, fusof-f9fj19, fusof-f9fj20, fusof-f9fki8, fusof-f9fmx2, fusof-f9fn88, fusof-f9fnt4, fusof-f9fpy4, fusof-f9fvs6, fusof-f9fwu0, fusof-f9fxz4, fusof-f9fzw0, fusof-f9fzy5, fusof-f9g2a2, fusof-f9g3b1, fusof-f9g5h7, fusof-f9g5z8, fusof-f9g6e6, fusof-f9g6y7, fusof-f9g7b0, fusof-f9g797, fusof-f9g972, fusof-f9ga50, fusof-f9gck4, fusof-f9gd15, fusof-f9gd77, fusof-f9fgw0, fusof-f9ftm6, fusof-f9fji8, fusof-f9fgw1, fusof-f9fcz8, fusof-f9f800, fusof-f9f3d9, fusof-f9gak5, fusof-f9fsi0, fusof-f9f4k6, fusof-f9f4m7, fusox-CUT, fusof-f9fvf1, fusc4-n1s9p6, fusof-f9g6q0, fusox-x0h323, fusox-x0bme4, fusof-f9fnm6, fusof-f9gfd3, fusof-f9gf05, fusof-f9fg31, fusof-f9f774, fusox-w9hvf0

Abstract

Secreted-in-xylem (SIX) proteins of the vascular wilt pathogen Fusarium oxysporum f. sp. lycopersici are secreted during infection of tomato and function in virulence or avirulence. F. oxysporum formae speciales have specific host ranges but the roles of SIX proteins in diverse hosts are unknown. We identified homologs of F. oxysporum f. sp. lycopersici SIX1, SIX4, SIX8, and SIX9 in the genome of Arabidopsis infecting isolate Fo5176. A SIX4 homolog (termed Fo5176-SIX4) differed from that of F. oxysporum f. sp. lycopersici (Fol-SIX4) by only two amino acids, and its expression was induced during infection of Arabidopsis. Transgenic Arabidopsis plants constitutively expressing Fo5176-SIX4 had increased disease symptoms with Fo5176. Conversely, Fo5176-SIX4 gene knock-out mutants (Deltasix4) had significantly reduced virulence on Arabidopsis, and this was associated with reduced fungal biomass and host jasmonate-mediated gene expression, the latter known to be essential for host symptom development. Full virulence was restored by complementation of Deltasix4 mutants with either Fo5176-SIX4 or Fol-SIX4. Thus, Fo5176-SIX4 contributes quantitatively to virulence on Arabidopsis whereas, in tomato, Fol-SIX4 acts in host specificity as both an avirulence protein and a suppressor of other race-specific resistances. The strong sequence conservation for SIX4 in F. oxysporum f. sp. lycopersici and Fo5176 suggests a recent common origin.



        

Title: Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Ma LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Di Pietro A, Dufresne M, Freitag M, Grabherr M and Rep M <53 more author(s)> Ma LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Di Pietro A, Dufresne M, Freitag M, Grabherr M, Henrissat B, Houterman PM, Kang S, Shim WB, Woloshuk C, Xie X, Xu JR, Antoniw J, Baker SE, Bluhm BH, Breakspear A, Brown DW, Butchko RA, Chapman S, Coulson R, Coutinho PM, Danchin EG, Diener A, Gale LR, Gardiner DM, Goff S, Hammond-Kosack KE, Hilburn K, Hua-Van A, Jonkers W, Kazan K, Kodira CD, Koehrsen M, Kumar L, Lee YH, Li L, Manners JM, Miranda-Saavedra D, Mukherjee M, Park G, Park J, Park SY, Proctor RH, Regev A, Ruiz-Roldan MC, Sain D, Sakthikumar S, Sykes S, Schwartz DC, Turgeon BG, Wapinski I, Yoder O, Young S, Zeng Q, Zhou S, Galagan J, Cuomo CA, Kistler HC, Rep M (- 53)
Ref: Nature, 464:367, 2010 : PubMed
Abstract


ESTHER: Ma_2010_Nature_464_367
PubMedSearch: Ma 2010 Nature 464 367
PubMedID: 20237561
Gene_locus related to this paper: fusox-a0a1d3s5h0, gibf5-fus2, fusof-f9f2k2, fusof-f9f3l6, fusof-f9f6t8, fusof-f9f6v2, fusof-f9f132, fusof-f9f781, fusof-f9fd72, fusof-f9fd90, fusof-f9fem0, fusof-f9fhk2, fusof-f9fj19, fusof-f9fj20, fusof-f9fki8, fusof-f9fmx2, fusof-f9fnt4, fusof-f9fpy4, fusof-f9fvs6, fusof-f9fwu0, fusof-f9fxz4, fusof-f9fzy5, fusof-f9g2a2, fusof-f9g3b1, fusof-f9g5h7, fusof-f9g6e6, fusof-f9g6y7, fusof-f9g7b0, fusof-f9g797, fusof-f9g972, fusof-f9ga50, fusof-f9gck4, fusof-f9gd15, gibze-a8w610, gibze-b1pdn0, gibze-i1r9e6, gibze-i1rda9, gibze-i1rdk7, gibze-i1rec8, gibze-i1rgs0, gibze-i1rgy0, gibze-i1rh52, gibze-i1rhi8, gibze-i1rig9, gibze-i1rip5, gibze-i1rpg6, gibze-i1rsg2, gibze-i1rv36, gibze-i1rxm5, gibze-i1rxp8, gibze-i1rxv5, gibze-i1s1u3, gibze-i1s3j9, gibze-i1s6l7, gibze-i1s8i8, gibze-i1s9x4, gibze-q4huy1, gibze-i1rg17, fuso4-j9mvr9, fuso4-j9ngs6, fuso4-j9niq8, fuso4-j9nqm2, gibze-i1rb76, gibze-i1s1m7, gibze-i1s3z6, gibze-i1rd78, gibze-i1rgl9, gibze-i1rjp7, gibze-i1s1q6, gibze-i1ri35, gibze-i1rf76, gibze-i1rhp3, fusc1-n4uj11, fusc4-n1s9p6, gibf5-s0dqr2, gibm7-w7n1b5, fusof-f9g6q0, gibm7-w7n497, fusox-x0bme4, gibm7-w7mcf8, gibm7-w7mak5, fusox-x0a2c5, gibm7-w7mum7, fusox-w9iyc7, gibm7-w7maw6, gibm7-w7msi0, gibm7-w7luf0, gibm7-w7msa3, gibm7-w7mna8, gibm7-w7n8b7, gibm7-w7n564, fusox-w9jpi0, gibm7-w7ngc3, gibm7-w7m4v6, gibm7-w7m4v2, gibm7-w7lt61, gibm7-w7mly6, gibm7-w7ncn3, fusox-w9ibd7, fusof-f9fnm6, gibm7-w7n526, gibza-a0a016pda4, gibza-a0a016pl96, gibm7-w7muq1, fusof-f9gfd3, gibm7-w7mt52, gibze-i1rjb5, gibf5-s0ehu3, fusox-w9hvf0, gibze-i1rkc4, gibm7-w7mv30, gibze-a0a1c3ylb1, fuso4-a0a0c4diy4, gibm7-w7n4n0, gibze-gra11, gibze-fsl2, gibf5-fub4, gibf5-fub5, gibf5-fus5, gibm7-dlh1

Abstract

Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.