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Gene_locus Report for: fashe-a0a4e0rpg5

Fasciola hepatica (Liver fluke) Acetylcholinesterase 2

Comment
Other strains: Fasciola hepatica (Liver fluke); Fasciola gigantica (Giant liver fluke). Both sequences incomplete


Relationship
Family|ACHE
Block| C
Position in NCBI Life Tree|Fasciola hepatica
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Platyhelminthes: N E > Trematoda: N E > Digenea: N E > Plagiorchiida: N E > Echinostomata: N E > Echinostomatoidea: N E > Fasciolidae: N E > Fasciola: N E > Fasciola hepatica: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
Sequence
Graphical view for this peptide sequence: fashe-a0a4e0rpg5
Colored MSA for ACHE (raw)
MLSCATNLWLLILISEIIRETNSSAPAPTITLSHGGRVRGATEEVIFRDQ
KKNVDYFLGIPFAKPPVKELRFASPENHKGWEGIRDAVNLPPTCWQYIFT
GFDIANNGARMWVNNTEMSEDCLYLNVWMPSGKINANLPVMVWIYGGGYT
SGTSTLDVYNGKFLAAKHDLIVVSMQYRLGAFGFLRIDPKPTRFNRESEG
STKLALGNMGLKDQLLALEWVQKEIKNFGGNPRQVTVFGESSGAVSVTAL
WTSPKTKALFRRAIVQSGSIFARWGLHDLKVANHRAVVFSKACNCPDPTV
DPSTSIKCLQDVDPMVLVNTLDAVIEDDAVQRNNTMWENFFHKLSASEIG
NGPFPGWATSSRRYFEVPFAAVIDGDFLPNHPRNVLKSPNYTRESPELLI
GVNQNEAIYFILYGLAMQETMFLKEDGNIVLPESIKKAGLREPRKSDGQK
ADFRWITALEFLDKSFLIPGLAAAPATFYGLPVSFNTTQEYAYPYDIKLA
GEEVMKRISDLASDADFICPTLEFAEMASRQSNAKVYLYYFQQMSSRLPW
PTWVGAMHGYEIPFVFGIPYSKEFIKEFYGFTLEETEFGDKMQQLWVNFA
KYGDPNLPVTDQYSAKWPLYKSNAISEKQPDQWDHYILDVNMRPGSRLRE
KECGFWLHFMDAYQREVLAGAMAIYPANRTGLVLLWICIFRIAVLLY
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MLSCATNLWLLILISEIIRETNSSAPAPTITLSHGGRVRGATEEVIFRDQ
KKNVDYFLGIPFAKPPVKELRFASPENHKGWEGIRDAVNLPPTCWQYIFT
GFDIANNGARMWVNNTEMSEDCLYLNVWMPSGKINANLPVMVWIYGGGYT
SGTSTLDVYNGKFLAAKHDLIVVSMQYRLGAFGFLRIDPKPTRFNRESEG
STKLALGNMGLKDQLLALEWVQKEIKNFGGNPRQVTVFGESSGAVSVTAL
WTSPKTKALFRRAIVQSGSIFARWGLHDLKVANHRAVVFSKACNCPDPTV
DPSTSIKCLQDVDPMVLVNTLDAVIEDDAVQRNNTMWENFFHKLSASEIG
NGPFPGWATSSRRYFEVPFAAVIDGDFLPNHPRNVLKSPNYTRESPELLI
GVNQNEAIYFILYGLAMQETMFLKEDGNIVLPESIKKAGLREPRKSDGQK
ADFRWITALEFLDKSFLIPGLAAAPATFYGLPVSFNTTQEYAYPYDIKLA
GEEVMKRISDLASDADFICPTLEFAEMASRQSNAKVYLYYFQQMSSRLPW
PTWVGAMHGYEIPFVFGIPYSKEFIKEFYGFTLEETEFGDKMQQLWVNFA
KYGDPNLPVTDQYSAKWPLYKSNAISEKQPDQWDHYILDVNMRPGSRLRE
KECGFWLHFMDAYQREVLAGAMAIYPANRTGLVLLWICIFRIAVLLY


Reference
    Title: Transcriptome-Based Identification of a Functional Fasciola hepatica Carboxylesterase B
    Pedroza-Gomez YJ, Cossio-Bayugar R, Aguilar-Diaz H, Scarcella S, Reynaud E, Sanchez-Carbente MDR, Narvaez-Padilla V, Miranda-Miranda E
    Ref: Pathogens, 10:1454, 2021 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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