Gene_locus Report for: drome-CG18815

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > melanogaster group: N E > melanogaster subgroup: N E > Drosophila melanogaster: N E

6_AlphaBeta_hydrolase : drome-CG14717Drosophila melanogaster (Fruit fly) cg14717 protein.
A85-EsteraseD-FGH : drome-CG4390Drosophila melanogaster (Fruit fly) cg4390 protein.
ABHD11-Acetyl_transferase : drome-CG2059Drosophila melanogaster (Fruit fly) cg2059 protein.
ABHD12-PHARC : drome-CG15111Drosophila melanogaster (Fruit fly) cg15111 protein re26090p.
ABHD13-BEM46 : drome-BEM46Drosophila melanogaster (Fruit fly); Drosophila ficusphila bem46 CG18642 protein.
ABHD16 : drome-CG1309Drosophila melanogaster (Fruit fly) cg1309 protein (gh07444p).
ABHD17-depalmitoylase : drome-CG11935Drosophila melanogaster (Fruit fly) cg11935 protein or CG33096.
ABHD18 : drome-CG10982Drosophila melanogaster (Fruit fly) rh36554p CG32112, isoform A isoform B isoform C.
abh_upf0017 : drome-abhd2Drosophila melanogaster (Fruit fly) CG3488 Abhydrolase domain-containing protein 2, Hydr2,anon-23D, anon-23Da, drome-CG8058Drosophila melanogaster (Fruit fly) cg8058 protein gm08242p.
ACHE : drome-ACHE Drosophila melanogaster (Fruit fly) acetylcholinesterase H subunit.
Acidic_Lipase : drome-CG2772Drosophila melanogaster (Fruit fly) cg2772 protein, drome-CG5932Drosophila melanogaster (Fruit fly) cg5932 protein, drome-CG6113Drosophila melanogaster (Fruit fly) cg6113 protein Lip4 (dLip4, dlip4, DmelCG6113, lip4), drome-CG6753Drosophila melanogaster (Fruit fly) rh07667p cg6753 protein, drome-CG7329Drosophila melanogaster (Fruit fly) cg7329 protein, drome-CG8093Drosophila melanogaster (Fruit fly) cg8093 protein, drome-CG11406Drosophila melanogaster (Fruit fly) cg11406 lp23252p protein, drome-CG11598Drosophila melanogaster (Fruit fly) male accessory gland protein. cg11598 protein, drome-CG11600Drosophila melanogaster (Fruit fly) cg11600 protein, drome-CG11608Drosophila melanogaster (Fruit fly) cg11608 protein, drome-CG17097Drosophila melanogaster (Fruit fly) male accessory gland protein. cg17097 ip15216p protein, drome-CG17099Drosophila melanogaster (Fruit fly) cg17099 protein, drome-CG17101Drosophila melanogaster (Fruit fly) cg17101 protein, drome-CG18284Drosophila melanogaster (Fruit fly) GH10507p cg18284 protein, drome-CG18301Drosophila melanogaster (Fruit fly) cg18301 protein, drome-CG18302Drosophila melanogaster (Fruit fly) cg18302 protein, drome-CG18530Drosophila melanogaster (Fruit fly) cg12294 protein, drome-CG31089Drosophila melanogaster (Fruit fly) cg31089 protein, drome-CG31091Drosophila melanogaster (Fruit fly) cg31089 protein, drome-lip1Drosophila melanogaster (Fruit fly) lipase 1. LIP1, drome-LIP2Drosophila melanogaster (Fruit fly) cg17116 protein, drome-lip3Drosophila melanogaster (Fruit fly) lipase 3. LIP3.
Carboxypeptidase_S10 : drome-CG3344Drosophila melanogaster (Fruit fly) cg3344 protein, drome-CG4572Drosophila melanogaster (Fruit fly) cg4572 protein, drome-CG32483Drosophila melanogaster (Fruit fly) lp20617p cg32483-pa, drome-Q9VJN0Drosophila melanogaster (Fruit fly) bg:ds00365.3 protein, drome-Q8IP31Drosophila melanogaster (Fruit fly) bg:ds00365.3 protein.
Carb_B_Arthropoda : drome-aes01Drosophila melanogaster (Fruit fly) alpha esterase (aE1), drome-aes02Drosophila melanogaster (Fruit fly) alpha esterase (aE2),CG2505 gh15053p, drome-aes03Drosophila melanogaster (Fruit fly) AT03093p alpha esterase (aE3), drome-aes04Drosophila melanogaster (Fruit fly) alpha esterase (aE4), drome-aes05Drosophila melanogaster (Fruit fly) gh12017p alpha esterase (aE5) CG1089-PA GH12017p, drome-aes06Drosophila melanogaster (Fruit fly) alpha esterase (aE6) gene GH20431p CG1108, drome-aes08Drosophila melanogaster (Fruit fly) alpha esterase (aE8) gene, partial cds, drome-aes09Drosophila melanogaster (Fruit fly) alpha esterase (aE9) gene cdna GH04929 CG1128, drome-aes10Drosophila melanogaster (Fruit fly) alpha esterase (aE10) gene, partial cds, drome-CG3841Drosophila melanogaster (Fruit fly) CG3841 AT14896p carboxylesterase homologous to este4 contigous to CG4382, drome-CG6018Drosophila melanogaster (Fruit fly) CG6018 carboxylesterase homologous to aes01, drome-CG6414Drosophila melanogaster (Fruit fly) CG6414 gene for a carboxylesterase, drome-CG7529Drosophila melanogaster (Fruit fly) CG7529 carboxylesterase gene, drome-CG9858Drosophila melanogaster CG9858 clt cricklet. related juvenile hormone esterase, drome-CG10175Drosophila melanogaster (Fruit fly) CG10175 carboxylesterase RE03380p, drome-est6pDrosophila melanogaster (Fruit fly) gene for carboxylesterase P lp12708p, drome-EST23aes07Drosophila melanogaster (Fruit fly) alpha esterase (aE7) gene CG1112, partial cds, drome-este4Drosophila melanogaster (Fruit fly) esterase este4 CG4757 clone GH05741 BcDNA, drome-este6 Drosophila melanogaster (Fruit fly) gene for carboxylesterase 6 and P the odorant degrading enzyme.
CGI-58_ABHD5_ABHD4 : drome-CG1882Drosophila melanogaster (Fruit fly) Pummelig (Puml) phospholipase.
DPP4N_Peptidase_S9 : drome-CG3744Drosophila melanogaster (Fruit fly) cg3744 protein, drome-CG9059Drosophila melanogaster (Fruit fly) cg9059 protein, drome-CG11034Drosophila melanogaster (Fruit fly) cg11034 protein, drome-CG11319Drosophila melanogaster (Fruit fly) cg11319 protein, drome-OMEDrosophila melanogaster (Fruit fly) putative omega protein (cg9370 protein) lp13067p.
Duf_676 : drome-CG32333Drosophila melanogaster (Fruit fly) cg32333 protein.
Duf_829 : drome-a1z6g9Drosophila melanogaster (Fruit fly) CG8245-RA, drome-q7k274Drosophila melanogaster (Fruit fly) LD15586p (CG3082-PA, isoform A) (CG3082-PC, isoform C) CG3082-PD, isoform D (RH35959p).
Epoxide_hydrolase : drome-CG15101Drosophila melanogaster (Fruit fly) gh06241p JHEH1 epoxide hydrolase (EC 3.3.2.3), drome-CG15102Drosophila melanogaster (Fruit fly) JHEH2 epoxide hydrolase (EC 3.3.2.3), drome-CG15106Drosophila melanogaster (Fruit fly) epoxide hydrolase JHEH3 (EC 3.3.2.3).
FSH1 : drome-CG5412Drosophila melanogaster (Fruit fly); Drosophila ficusphila cg5412 protein (gh07367p).
Gliotactin : drome-glitaDrosophila melanogaster (Fruit fly) CG3903 mRNA for gliotactin.
Glutactin : drome-CG9287Drosophila melanogaster (Fruit fly) CG9287 homologous to glutactin gene, drome-CG9289Drosophila melanogaster (Fruit fly) CG9289 homologous to glutactin gene MIP25834p, drome-glutaDrosophila melanogaster (Fruit fly) glutactin GLT.
Hormone-sensitive_lipase_like : drome-CG11055Drosophila melanogaster (Fruit fly) ld36294p.
Insect_lipase : drome-CG1986Drosophila melanogaster (Fruit fly) gene lipase, drome-CG4267Drosophila melanogaster (Fruit fly) gene lipase, drome-CG4582Drosophila melanogaster (Fruit fly) gene lipase, drome-CG4979Drosophila melanogaster (Fruit fly) gene lipase, drome-CG5162Drosophila melanogaster (Fruit fly) gene lipase rh13728p CG5162, drome-CG5665Drosophila melanogaster (Fruit fly) gene lipase close to vitellogenine and yolk proteines?, drome-CG6271Drosophila melanogaster (Fruit fly) gene lipase, drome-CG6283Drosophila melanogaster (Fruit fly) gene lipase, drome-CG6295Drosophila melanogaster (Fruit fly) gene lipase, drome-CG6296Drosophila melanogaster (Fruit fly) gene lipase, drome-CG6431Drosophila melanogaster (Fruit fly) gene lipase, drome-CG6472Drosophila melanogaster (Fruit fly) Lipase domain-containing protein, drome-CG6675Drosophila melanogaster (Fruit fly) gene lipase at29263p, drome-CG7367Drosophila melanogaster (Fruit fly) drome-CG7367 gene lipase, drome-CG9966Drosophila melanogaster (Fruit fly) CG9966 CG31684 gene lipase, drome-CG10116Drosophila melanogaster (Fruit fly) gene close to Vitellogenine and yolk protein gh07181p, drome-CG10163Drosophila melanogaster (Fruit fly) cg10163 protein, drome-CG10357Drosophila melanogaster (Fruit fly) gene lipase, drome-CG13282Drosophila melanogaster (Fruit fly) gene lipase, drome-CG13562Drosophila melanogaster (Fruit fly) cg13562 protein, drome-CG14034Drosophila melanogaster (Fruit fly) gene lipase male accessory gland protein, drome-CG17191Drosophila melanogaster gene lipase, drome-CG17192Drosophila melanogaster gene lipase, drome-CG17292Drosophila melanogaster gene lipase, drome-CG18258Drosophila melanogaster (Fruit fly) gene lipase, drome-CG18641Drosophila melanogaster (Fruit fly) gene lipase.
Juvenile_hormone_esterase : drome-CG8424Drosophila melanogaster (Fruit fly) CG8424 gene for a carboxylesterase duplicated gene of juvenile hormone esterase, drome-CG8425Drosophila melanogaster (Fruit fly) CG8425 juvenile hormone esterase.
Kynurenine-formamidase : drome-CG9542 Drosophila melanogaster (Fruit fly) kynurenine formamidase cg9542 protein (rh42281p).
LIDHydrolase : drome-CG9186Drosophila melanogaster (Fruit fly) cg9186 protein.
Lipase_3 : drome-CG33174Drosophila melanogaster (Fruit fly) cg11102 CG33174 protein.
LYsophospholipase_carboxylesterase : drome-CG6567Drosophila melanogaster (Fruit fly) cg6567 protein.
Ndr_family : drome-GH02439Drosophila melanogaster (Fruit fly); D. ananassae; D. virilis; Drosophila willistoni; Drosophila yakuba D. pseudoobscura; D. persimilis gh19206p gh02439, drome-MESK2Drosophila melanogaster (Fruit fly) D. simulans; D. ficusphila; D. erecta; D. yakuba; D. sechellia; D. ananassae; D.virilis; D. willistoni; D. mojavensis; D. pseudoobscura, misexpression suppressor of ksr cg15668 protein.
Neuroligin : drome-b6idz4Drosophila melanogaster (Fruit fly) neuroligin 4 (Fruit fly) GH07829p, drome-CG13772Drosophila melanogaster (Fruit fly) Neuroligin 2 CG13772 Nlg2 dnl2, DNlg2, dnlg2 homologous to neuroligins rh63339p, drome-nlg3Drosophila melanogaster (Fruit fly) CG14597 gene, drome-dnlg1Drosophila melanogaste (Fruit fly) Neuroligin.
Neurotactin : drome-nrtacDrosophila melanogaster (Fruit fly) mRNA for neurotactin.
NLS3-Tex30 : drome-CG8233Drosophila melanogaster (Fruit fly) ld22513p (cg8233-pb) Reduction in Cnn dots 1, isoform ABC, IP01785p1.
OtherNon-catalytic_C : drome-CG4382Drosophila melanogaster (Fruit fly) CG4382 Non-catalytic protein homologous to este4 contigous to CG3841, drome-CG5397Drosophila melanogaster (Fruit fly) CG5397 carboxylesterase may be not active, drome-CG10339Drosophila melanogaster (Fruit fly) CG13564 carboxylesterase without Active Ser, drome-CG12869Drosophila melanogaster (Fruit fly) CG12869 gene for a carboxylesterase may be inactive.
Palmitoyl-protein_thioesterase : drome-CG4851Drosophila melanogaster (Fruit fly) gh17076p cg4851 protein PPT2, drome-CG12108Drosophila melanogaster (Fruit fly) cg12108 protein re03479p PPT1.
Pancreatic_lipase : drome-CG5966Drosophila melanogaster (Fruit fly) CG5966 gene lipase, drome-CG6847Drosophila melanogaster (Fruit fly) CG6847 gene lipase rh14406p.
PC-sterol_acyltransferase : drome-GH02384Drosophila melanogaster (Fruit fly) bcdna.gh02384 CG31683 CG18858.
Pectinacetylesterase-Notum : drome-q9vux3 Drosophila melanogaster (Fruit fly).
PGAP1 : drome-CG3160Drosophila melanogaster (Fruit fly) cg3160 sd04405p protein.
PPase_methylesterase_euk : drome-CG5068Drosophila melanogaster (Fruit fly) epoxide hydrolase (EC 3.3.2.3).
Prolylcarboxypeptidase : drome-CG2493Drosophila melanogaster (Fruit fly) cg2493 IP19978p protein, drome-CG3734Drosophila melanogaster, Drosophila simulans (Fruit fly) re36938p cg3734 protein, drome-CG3739Drosophila melanogaster (Fruit fly) cg3739 protein, drome-CG9953Drosophila melanogaster, Drosophila sechellia (Fruit fly) cg9953 protein rh04336p, drome-CG11626Drosophila melanogaster Drosophila sechellia Drosophila simulans Drosophila yakuba Drosophila erecta (Fruit fly) cg11626 protein, drome-CG18493Drosophila melanogaster (Fruit fly) re11624p cg18493-pa.
S9N_PPCE_Peptidase_S9 : drome-CG2528Drosophila melanogaster (Fruit fly) cg2528 protein, drome-CG5355Drosophila melanogaster (Fruit fly) cg5355 protein.
SERHL : drome-CG5707Drosophila melanogaster (Fruit fly) CG5707 protein, drome-CG5704Drosophila melanogaster (Fruit fly) CG5704 protein, drome-CG7632Drosophila melanogaster (Fruit fly) cg7632 protein (sd17025p), drome-CG11309Drosophila melanogaster (Fruit fly) cg11309 protein GH24315p, drome-CG15820Drosophila melanogaster (Fruit fly) sd08776p cg15820 protein, drome-CG15821Drosophila melanogaster (Fruit fly) CR15821 pseudogene! ip09622p, drome-CG15879Drosophila melanogaster (Fruit fly) cg15879 protein, drome-KRAKENDrosophila melanogaster (Fruit fly) probable serine hydrolase (EC 3.1.-.-) (kraken protein).
Thioesterase : drome-CG3523Drosophila melanogaster (Fruit fly)CG3523 bcdna:gh07626 protein, drome-CG3524Drosophila melanogaster V(2)K05816(Fruit fly) cg3524 protein only C-term domain, drome-CG17374Drosophila melanogaster (Fruit fly) ld12605p cg17374-pa.3.
Valacyclovir-hydrolase : drome-CG5377Drosophila melanogaster (Fruit fly) cg5377 protein.
Yolk-Protein_dipter : drome-1viteDrosophila melanogaster (Fruit fly) Vitellogenin I Precursor (yolk protein) YP1, drome-2viteDrosophila melanogaster (Fruit fly) Vitellogenin II precursor (yolk protein). YP2, drome-3viteDrosophila melanogaster (Fruit fly) Vitellogenin III precursor

Title: Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster a-Esterase-7
Birner-Gruenberger R, Bickmeyer I, Lange J, Hehlert P, Hermetter A, Kollroser M, Rechberger GN, Kuhnlein RP
Ref: Insect Biochemistry & Molecular Biology, 42:220, 2012 : PubMed
Abstract


ESTHER: Birner-Gruenberger_2012_Insect.Biochem.Mol.Biol_42_220
PubMedSearch: Birner-Gruenberger 2012 Insect.Biochem.Mol.Biol 42 220
PubMedID: 22198472
Gene_locus related to this paper: drome-aes02, drome-aes05, drome-CG1882, drome-CG2059, drome-CG5355, drome-CG8425, drome-CG18815, drome-EST23aes07, drome-este6
Inhibitor(s) related to this paper: NBD-HE-HP

Abstract

Carboxylesterases constitute a large enzyme family in insects, which is involved in diverse functions such as xenobiotic detoxification, lipid metabolism and reproduction. Phylogenetically, many insect carboxylesterases are represented by multienzyme clades, which are encoded by evolutionarily ancient gene clusters such as the a-Esterase cluster. Much in contrast to the vital importance attributed to carboxylesterases in general, the in vivo function of individual a-Esterase genes is largely unknown. This study employs a functional proteomics approach to identify esterolytic enzymes of the vinegar fly Drosophila melanogaster fat body. One of the fat body carboxylesterases, a-Esterase-7, was selected for mutational analysis by gene targeting to generate a deletion mutant fly. Phenotypic characterization of a-Esterase-7 null mutants and transgenic flies, which overexpress a chimeric a-Esterase-7:EGFP gene, reveals important functions of a-Esterase-7 in insecticide tolerance, lipid metabolism and lifespan control. The presented first deletion mutant of any a-Esterase in the model insect D. melanogaster generated by gene targeting not only provides experimental evidence for the endogenous functions of this gene family. It also offers an entry point for in vivo structure-function analyses of a-Esterase-7, which is of central importance for naturally occurring insecticide resistance in wild populations of various dipteran insect species.



        

Title: The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases
Bannan BA, Van Etten J, Kohler JA, Tsoi Y, Hansen NM, Sigmon S, Fowler E, Buff H, Williams TS and Korey CA <2 more author(s)> Bannan BA, Van Etten J, Kohler JA, Tsoi Y, Hansen NM, Sigmon S, Fowler E, Buff H, Williams TS, Ault JG, Glaser RL, Korey CA (- 2)
Ref: Fly (Austin), 2:198, 2008 : PubMed
Abstract


ESTHER: Bannan_2008_Fly.(Austin)_2_198
PubMedSearch: Bannan 2008 Fly.(Austin) 2 198
PubMedID: 18719403
Gene_locus related to this paper: drome-CG4851, drome-CG12108, drome-CG18815

Abstract

Palmitoylation is the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. The addition and removal of this modification is controlled by both palmitoyl acyl-transferases and thioesterases. Using bioinformatic analysis, we identified 22 DHHC family palmitoyl acyl-transferase homologs in the Drosophila genome. We used in situ hybridization,RT-PCR, and published FlyAtlas microarray data to characterize the expression patterns of all 22 fly homologs. Our results indicate that all are expressed genes, but several, including CG1407, CG4676, CG5620, CG6017/dHIP14, CG6618, CG6627 and CG17257 appear to be enriched in neural tissues suggesting that they are important for neural function. Furthermore, we have found that several may be expressed in a sex-specific manner with adult male specific expression of CG4483 and CG17195. Using tagged versions of the DHHC genes, we demonstrate that fly DHHC proteins are primarily located in either the Golgi Apparatus or Endoplasmic Reticulum in S2 cells, except for CG1407, which was found on the plasma membrane. We also characterized the subcellular localization and expression of the three known thioesterases: Palmitoyl-protein Thioesterase 1 (Ppt1), Palmitoyl-protein Thioesterase 2 (Ppt2)and Acyl-protein Thioesterase 1 (APT1). Our results indicate that Ppt1 and Ppt2 are the major lysosomal thioesterases while APT1 is the likely cytoplasmic thioesterase. Finally, in vivo rescue experiments show that Ppt2 expression cannot rescue the neural inclusion phenotypes associated with loss of Ppt1, further supporting distinct functions and substrates for these two thioesterases. These results will serve as the basis for a more complete understanding of the protein palmitoylome's normal cellular functions in the fly and will lead to further insights into the molecular etiology of diseases associated with the mis-regulation of palmitoylation.



        

Title: The genome sequence of Drosophila melanogaster
Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA and Venter JC <185 more author(s)> Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC (- 185)
Ref: Science, 287:2185, 2000 : PubMed
Abstract


ESTHER: Adams_2000_Science_287_2185
PubMedSearch: Adams 2000 Science 287 2185
PubMedID: 10731132
Gene_locus related to this paper: drome-1vite, drome-2vite, drome-3vite, drome-a1z6g9, drome-abhd2, drome-ACHE, drome-b6idz4, drome-BEM46, drome-CG5707, drome-CG5704, drome-CG1309, drome-CG1882, drome-CG1986, drome-CG2059, drome-CG2493, drome-CG2528, drome-CG2772, drome-CG3160, drome-CG3344, drome-CG3523, drome-CG3524, drome-CG3734, drome-CG3739, drome-CG3744, drome-CG3841, drome-CG4267, drome-CG4382, drome-CG4390, drome-CG4572, drome-CG4582, drome-CG4851, drome-CG4979, drome-CG5068, drome-CG5162, drome-CG5355, drome-CG5377, drome-CG5397, drome-CG5412, drome-CG5665, drome-CG5932, drome-CG5966, drome-CG6018, drome-CG6113, drome-CG6271, drome-CG6283, drome-CG6295, drome-CG6296, drome-CG6414, drome-CG6431, drome-CG6472, drome-CG6567, drome-CG6675, drome-CG6753, drome-CG6847, drome-CG7329, drome-CG7367, drome-CG7529, drome-CG7632, drome-CG8058, drome-CG8093, drome-CG8233, drome-CG8424, drome-CG8425, drome-CG9059, drome-CG9186, drome-CG9287, drome-CG9289, drome-CG9542, drome-CG9858, drome-CG9953, drome-CG9966, drome-CG10116, drome-CG10163, drome-CG10175, drome-CG10339, drome-CG10357, drome-CG10982, drome-CG11034, drome-CG11055, drome-CG11309, drome-CG11319, drome-CG11406, drome-CG11598, drome-CG11600, drome-CG11608, drome-CG11626, drome-CG11935, drome-CG12108, drome-CG12869, drome-CG13282, drome-CG13562, drome-CG13772, drome-CG14034, drome-nlg3, drome-CG14717, drome-CG15101, drome-CG15102, drome-CG15106, drome-CG15111, drome-CG15820, drome-CG15821, drome-CG15879, drome-CG17097, drome-CG17099, drome-CG17101, drome-CG17191, drome-CG17192, drome-CG17292, drome-CG18258, drome-CG18284, drome-CG18301, drome-CG18302, drome-CG18493, drome-CG18530, drome-CG18641, drome-CG18815, drome-CG31089, drome-CG31091, drome-CG32333, drome-CG32483, drome-CG33174, drome-dnlg1, drome-este4, drome-este6, drome-GH02384, drome-GH02439, drome-glita, drome-KRAKEN, drome-lip1, drome-LIP2, drome-lip3, drome-MESK2, drome-nrtac, drome-OME, drome-q7k274, drome-Q9VJN0, drome-Q8IP31, drome-q9vux3

Abstract

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.