Gene_locus Report for: canfa-pafa Canis lupus familiaris (Dog) (Canis familiaris), plasma PAF acetylhydrolase
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Carnivora: N E > Caniformia: N E > Canidae: N E > Canis: N E > Canis lupus: N E > Canis lupus familiaris: N E A85-EsteraseD-FGH :
canfa-e2rcq9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
ABHD6-Lip :
canfa-e2qvk3 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
ABHD8 :
canlf-f1ptw2 Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 8 .
ABHD10 :
canlf-j9p8h1 Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
canlf-f1prs1 Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 11 .
ABHD12-PHARC :
canfa-f1pb79 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canlf-e2rjg6 Canis lupus familiaris (Dog) (Canis familiaris). Uncharacterized protein .
ABHD13-BEM46 :
canlf-j9nus1 Canis lupus familiaris (Dog) (Canis familiaris); Vulpes vulpes (Red fox). Abhydrolase domain containing 13 .
ABHD16 :
canlf-e2rq56 Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 16A ,
canlf-j9nwb1 Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 16B .
abh_upf0017 :
canfa-e2qzs6 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1p9d8 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1pke8 Canis lupus familiaris (Dog) (Canis familiaris); Vulpes vulpes (Red fox). Abhydrolase domain containing 15 ,
canfa-f1pvp4 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
ACHE :
canfa-ACHE Canis lupus familiaris (Dog) (Canis familiaris) acetylcholinesterase .
Acidic_Lipase :
canfa-1lipg ,
canfa-e2qsl3 Canis lupus familiaris (Dog) (Canis familiaris) Lipase ,
canfa-e2qw15 Canis lupus familiaris (Dog) (Canis familiaris) Lipase ,
canfa-e2r455 Canis lupus familiaris (Dog) (Canis familiaris) Lipase ,
canfa-e2rqf1 Canis lupus familiaris (Dog) (Canis familiaris) Lipase .
ACPH_Peptidase_S9 :
canfa-e2r7e8 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Arb2_FAM172A :
canlf-e2ree2 Canis lupus familiaris (Dog) (Canis familiaris); Vulpes vulpes (Red fox); Leptonychotes weddellii (Weddell seal). Family with sequence similarity 172 member A .
Arylacetamide_deacetylase :
canlf-e2r2h2 Canis lupus familiaris (Dog) (Canis familiaris). Arylacetamide deacetylase AADAC ,
canlf-f1p648 Canis lupus familiaris (Dog) (Canis familiaris). Uncharacterized protein ,
canlf-f1pw90 Canis lupus familiaris (Dog) (Canis familiaris). Uncharacterized protein ,
canlf-j9p8v6 Canis lupus familiaris (Dog) (Canis familiaris). . Arylacetamide deacetylase .
BCHE :
canfa-BCHE Canis lupus familiaris (Dog) (Canis familiaris) butylcholinesterase (BCHE) .
Carb_B_Chordata :
canfa-cauxin Canis familiaris (Dog) (Canis lupus familiaris) EST5A (EST7) cauxin (LOC445456) carboxylesterase-like urinary excreted protein ,
canfa-CESDD1 Canis familiaris (Dog) carboxylesterase d1 ,
canfa-f1p6w8 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Cholesterol_esterase :
canfa-f1phd0 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
CIB-CCG1-interacting-factor-B :
canfa-e2rlz9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-e2rm00 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
CMBL :
canlf-e2rf91 Canis lupus familiaris (Dog) (Canis familiaris). Carboxymethylenebutenolidase homolog .
DPP4N_Peptidase_S9 :
canfa-e2r8z1 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-e2rd94 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-e2rss9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1p683 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1pgw0 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1pp08 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Duf_676 :
canfa-f1ppp9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1ptf1 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Hepatic_Lipase :
canlf-f1pcc4 Canis lupus familiaris (Dog) (Canis familiaris). Lipase C, hepatic type .
Lipoprotein_Lipase :
canlf-e2r774 Canis lupus familiaris (Dog) (Canis familiaris). Lipase G, endothelial type ,
canlf-f1pf96 Canis lupus familiaris (Dog) (Canis familiaris). Lipoprotein lipase .
Maspardin-ACP33-SPG21_like :
canfa-e2qsz2 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Monoglyceridelipase_lysophospholip :
canlf-f6v865 Canis lupus familiaris (Dog) (Canis familiaris). Uncharacterized protein .
Ndr_family :
canfa-e2rb70 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-f1p8b6 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-e2rmb9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Neuroligin :
canfa-2neur Canis lupus familiaris (Dog) (Canis familiaris) Neuroligin ,
canfa-3neur Canis lupus familiaris (Dog) (Canis familiaris) Neuroligin 3 .
NLS3-Tex30 :
canfa-e2qxs8 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-e2r9h4 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Palmitoyl-protein_thioesterase :
canfa-q5jzr0 Canis familiaris (Dog) palmitoyl-protein thioesterase 1 .
Pancreatic_lipase :
canfa-1plip .
PC-sterol_acyltransferase :
canfa-q6xpz3 Canis familiaris (Dog) lysosomal phospholipase a2 .
Pectinacetylesterase-Notum :
canfa-f1pw93 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
PGAP1 :
canfa-e2r8v9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Phospholipase :
canlf-e2qxh0 Canis lupus familiaris (Dog) (Canis familiaris). Phospholipase A1 member A ,
canlf-f1pg57 Canis lupus familiaris (Dog) (Canis familiaris). Lipase H ,
canlf-f1q111 Canis lupus familiaris (Dog) (Canis familiaris). Lipase I .
PPase_methylesterase_euk :
canfa-e2rkq0 Canis lupus familiaris (Dog) (Canis familiaris) Protein phosphatase methylesterase 1 .
Prolylcarboxypeptidase :
canfa-e2r5t3 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein ,
canfa-e2r6f6 Canis lupus familiaris (Dog) (Canis familiaris) Dipeptidyl peptidase 7 ,
canfa-f1pwk3 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
S9N_PPCE_Peptidase_S9 :
canfa-f1phx2 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
S9N_PREPL_Peptidase_S9 :
canfa-e2qsb1 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
SERHL :
canfa-f1ps07 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein .
Thyroglobulin :
canfa-q1ert3 Canis familiaris (Dog) thyroglobulin .
Valacyclovir-hydrolase :
canfa-e2rgi0 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Canis familiaris:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: canfa-pafa Colored MSA for PAF-Acetylhydrolase (raw)
MLPPKLHALFCLCSCLTLVHPIDWQDLNPVAHIRSSAWANKIQALMAAAS
IRQSRIPKGNGSYSVGCTDLMFDYTNKGTFLRLYYPSQEDDHSDTLWIPN
KEYFFGLSKYLGTPWLMGKILSFFFGSVTTPANWNSPLRTGEKYPLIVFS
HGLGAFRTIYSAIGIDLASHGFIVAAIEHRDGSASATYYFKDQSAAEIGN
KSWSYLQELKPGDEEIHVRNEQVQKRAKECSQALNLILDIDHGRPIKNVL
DLEFDVEQLKDSIDRDKIAVIGHSFGGATVLQALSEDQRFRCGIALDAWM
LPLDDAIYSRIPQPLFFINSERFQFPENIKKMKKCYSPDKERKMITIRGS
VHQNFADFTFTTGKIVGYIFTLKGDIDSNVAIDLCNKASLAFLQKHLGLR
KDFDQWDSLIEGKDENLMPGTNINITNEHDTLQNSPEAEKSNLD
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M L P P K L H A L F C L C S C L T L V H P I D W Q D L N P V A H I R S S A W A N K I Q A L M A A A S I R Q S R I P K G N G S Y S V G C T D L M F D Y T N K G T F L R L Y Y P S Q E D D H S D T L W I P N K E Y F F G L S K Y L G T P W L M G K I L S F F F G S V T T P A N W N S P L R T G E K Y P L I V F S H G L G A F R T I Y S A I G I D L A S H G F I V A A I E H R D G S A S A T Y Y F K D Q S A A E I G N K S W S Y L Q E L K P G D E E I H V R N E Q V Q K R A K E C S Q A L N L I L D I D H G R P I K N V L D L E F D V E Q L K D S I D R D K I A V I G H S F G G A T V L Q A L S E D Q R F R C G I A L D A W M L P L D D A I Y S R I P Q P L F F I N S E R F Q F P E N I K K M K K C Y S P D K E R K M I T I R G S V H Q N F A D F T F T T G K I V G Y I F T L K G D I D S N V A I D L C N K A S L A F L Q K H L G L R K D F D Q W D S L I E G K D E N L M P G T N I N I T N E H D T L Q N S P E A E K S N L D
References
Title: Genome sequence, comparative analysis and haplotype structure of the domestic dogLindblad-Toh K , Wade CM , Mikkelsen TS , Karlsson EK , Jaffe DB , Kamal M , Clamp M , Chang JL , Kulbokas EJ, 3rd and Lander ES <224 more author(s)> Lindblad-Toh K , Wade CM , Mikkelsen TS , Karlsson EK , Jaffe DB , Kamal M , Clamp M , Chang JL , Kulbokas EJ, 3rd , Zody MC , Mauceli E , Xie X , Breen M , Wayne RK , Ostrander EA , Ponting CP , Galibert F , Smith DR , deJong PJ , Kirkness E , Alvarez P , Biagi T , Brockman W , Butler J , Chin CW , Cook A , Cuff J , Daly MJ , Decaprio D , Gnerre S , Grabherr M , Kellis M , Kleber M , Bardeleben C , Goodstadt L , Heger A , Hitte C , Kim L , Koepfli KP , Parker HG , Pollinger JP , Searle SM , Sutter NB , Thomas R , Webber C , Baldwin J , Abebe A , Abouelleil A , Aftuck L , Ait-Zahra M , Aldredge T , Allen N , An P , Anderson S , Antoine C , Arachchi H , Aslam A , Ayotte L , Bachantsang P , Barry A , Bayul T , Benamara M , Berlin A , Bessette D , Blitshteyn B , Bloom T , Blye J , Boguslavskiy L , Bonnet C , Boukhgalter B , Brown A , Cahill P , Calixte N , Camarata J , Cheshatsang Y , Chu J , Citroen M , Collymore A , Cooke P , Dawoe T , Daza R , Decktor K , DeGray S , Dhargay N , Dooley K , Dorje P , Dorjee K , Dorris L , Duffey N , Dupes A , Egbiremolen O , Elong R , Falk J , Farina A , Faro S , Ferguson D , Ferreira P , Fisher S , FitzGerald M , Foley K , Foley C , Franke A , Friedrich D , Gage D , Garber M , Gearin G , Giannoukos G , Goode T , Goyette A , Graham J , Grandbois E , Gyaltsen K , Hafez N , Hagopian D , Hagos B , Hall J , Healy C , Hegarty R , Honan T , Horn A , Houde N , Hughes L , Hunnicutt L , Husby M , Jester B , Jones C , Kamat A , Kanga B , Kells C , Khazanovich D , Kieu AC , Kisner P , Kumar M , Lance K , Landers T , Lara M , Lee W , Leger JP , Lennon N , Leuper L , LeVine S , Liu J , Liu X , Lokyitsang Y , Lokyitsang T , Lui A , MacDonald J , Major J , Marabella R , Maru K , Matthews C , McDonough S , Mehta T , Meldrim J , Melnikov A , Meneus L , Mihalev A , Mihova T , Miller K , Mittelman R , Mlenga V , Mulrain L , Munson G , Navidi A , Naylor J , Nguyen T , Nguyen N , Nguyen C , Nicol R , Norbu N , Norbu C , Novod N , Nyima T , Olandt P , O'Neill B , O'Neill K , Osman S , Oyono L , Patti C , Perrin D , Phunkhang P , Pierre F , Priest M , Rachupka A , Raghuraman S , Rameau R , Ray V , Raymond C , Rege F , Rise C , Rogers J , Rogov P , Sahalie J , Settipalli S , Sharpe T , Shea T , Sheehan M , Sherpa N , Shi J , Shih D , Sloan J , Smith C , Sparrow T , Stalker J , Stange-Thomann N , Stavropoulos S , Stone C , Stone S , Sykes S , Tchuinga P , Tenzing P , Tesfaye S , Thoulutsang D , Thoulutsang Y , Topham K , Topping I , Tsamla T , Vassiliev H , Venkataraman V , Vo A , Wangchuk T , Wangdi T , Weiand M , Wilkinson J , Wilson A , Yadav S , Yang S , Yang X , Young G , Yu Q , Zainoun J , Zembek L , Zimmer A , Lander ES (- 224) Ref: Nature, 438 :803, 2005 : PubMed Abstract ESTHER: Lindblad-Toh_2005_Nature_438_803 PubMedSearch: Lindblad-Toh 2005 Nature 438 803 PubMedID: 16341006 Gene_locus related to this paper: canfa-1lipg ,
canfa-2neur ,
canfa-3neur ,
canfa-ACHE ,
canfa-BCHE ,
canfa-cauxin ,
canfa-CESDD1 ,
canfa-e2qsb1 ,
canfa-e2qsl3 ,
canfa-e2qsz2 ,
canfa-e2qvk3 ,
canfa-e2qw15 ,
canfa-e2qxs8 ,
canfa-e2qzs6 ,
canfa-e2r5t3 ,
canfa-e2r6f6 ,
canfa-e2r7e8 ,
canfa-e2r8v9 ,
canfa-e2r8z1 ,
canfa-e2r9h4 ,
canfa-e2r455 ,
canfa-e2rb70 ,
canfa-e2rcq9 ,
canfa-e2rd94 ,
canfa-e2rgi0 ,
canfa-e2rkq0 ,
canfa-e2rlz9 ,
canfa-e2rm00 ,
canfa-e2rqf1 ,
canfa-e2rss9 ,
canfa-f1p6w8 ,
canfa-f1p8b6 ,
canfa-f1p9d8 ,
canfa-f1p683 ,
canfa-f1pb79 ,
canfa-f1pgw0 ,
canfa-f1phd0 ,
canfa-f1phx2 ,
canfa-f1pke8 ,
canfa-f1pp08 ,
canfa-f1ppp9 ,
canfa-f1ps07 ,
canfa-f1ptf1 ,
canfa-f1pvp4 ,
canfa-f1pw93 ,
canfa-f1pwk3 ,
canfa-pafa ,
canfa-q1ert3 ,
canfa-q5jzr0 ,
canfa-e2rmb9 ,
canlf-f6v865 ,
canlf-e2rjg6 ,
canlf-e2r2h2 ,
canlf-f1p648 ,
canlf-f1pw90 ,
canlf-j9p8v6 ,
canlf-f1pcc4 ,
canlf-e2qxh0 ,
canlf-e2r774 ,
canlf-f1pf96 ,
canlf-e2rq56 ,
canlf-j9nwb1 ,
canlf-f1ptw2 ,
canlf-j9p8h1 ,
canlf-e2ree2 ,
canlf-f1prs1 ,
canlf-j9nus1 ,
canlf-e2rf91 ,
canlf-f1pg57 ,
canlf-f1q111 Abstract
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
Title: Anti-inflammatory properties of a platelet-activating factor acetylhydrolaseTjoelker LW , Wilder C , Eberhardt C , Stafforini DM Ref: Nature, 374 :549, 1995 : PubMed Abstract ESTHER: Tjoelker_1995_Nature_374_549 PubMedSearch: Tjoelker 1995 Nature 374 549 PubMedID: 7700381 Gene_locus related to this paper: bovin-pafa ,
canfa-pafa ,
chick-pafa ,
human-PLA2G7 ,
mouse-pafa Abstract
Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid that activates cells involved in inflammation. The biological activity of PAF depends on its structural features, namely an ether linkage at the sn-1 position and an acetate group at the sn-2 position. The actions of PAF are abolished by hydrolysis of the acetyl residue, a reaction catalysed by PAF acetylhydrolase. There are at least two forms of this enzyme--one intracellular and another that circulates in plasma and is likely to regulate inflammation. Here we report the molecular cloning and characterization of the human plasma PAF acetylhydrolase. The unique sequence contains a Gly-Xaa-Ser-Xaa-Gly motif commonly found in lipases. Recombinant PAF acetylhydrolase has the substrate specificity and lipoprotein association of the native enzyme, and blocks inflammation in vivo: it markedly decreases vascular leakage in pleurisy and paw oedema, suggesting that PAF acetylhydrolase might be a useful therapy for severe acute inflammation.
Title: Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triadTjoelker LW , Eberhardt C , Unger J , Le Trong H , Zimmerman GA Ref: Journal of Biological Chemistry, 270 :25481, 1995 : PubMed Abstract Other Papers
Canis lupus familiaris (Dog) (Canis familiaris) lipase (gl)