(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Ascomycota: NE > saccharomyceta: NE > Saccharomycotina: NE > Saccharomycetes: NE > Saccharomycetales: NE > Debaryomycetaceae: NE > Candida/Lodderomyces clade: NE > Candida [Debaryomycetaceae]: NE > Candida albicans: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Candida albicans SC5314: N, E.
Candida albicans WO-1: N, E.
Candida albicans P94015: N, E.
Candida albicans P37005: N, E.
Candida albicans GC75: N, E.
Candida albicans P57072: N, E.
Candida albicans P78048: N, E.
Candida albicans P37037: N, E.
Candida albicans 12C: N, E.
Candida albicans P87: N, E.
Candida albicans 19F: N, E.
Candida albicans L26: N, E.
Candida albicans P34048: N, E.
Candida albicans P57055: N, E.
Candida albicans P75063: N, E.
Candida albicans P76055: N, E.
Candida albicans P37039: N, E.
Candida albicans P75010: N, E.
Candida albicans P76067: N, E.
Candida albicans P75016: N, E.
Candida albicans Ca6: N, E.
Candida albicans P78042: N, E.
Candida albicans P60002: N, E.
Candida albicans Ca529L: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MKLSKSTLIATLALTATSTNALVVQNPFSNIQQALKLDLSYDKLTSKLTD TFEQGKANIISTIAKVMNEPLDGLTPEIKNIWLEMLMKFPNSITELNFKA PPKKGKITTQQFDFHVTDAQVPNHKLRIKSTPKDLGIDTVKQYSGYLDVV DEDKHFFYYFFESRNDPKNDPVILWLNGGPGCSSLTGLFFELGPSSIDKN LKPVYNPHSWNANASVIFLDQPINVGYSYSSQSVSNTIAAGKDVYAFLQL FFKNFPEYANLDFHIAGESYAGHYIPAFASEILTHPERNFNLTSVLIGNG LTDPLVQYEYYEPMACGEGGEPSVLEPEECDGMLNLLPRCLSLIESCYES GSVWSCVPATIYCNNGQMGPYQKTGRNVYDIRTMCEGSSLCYSQLEYIDQ YLNLPEVKKALGAEVDEYQSCNFDINRNFMFAGDWMKPYQKNVIDLLEKE LPVLIYAGDKDFICNWLGNQAWTNRLEWSGSKGFTKAPVKSWKVGKNAAG EVKNYKHFTFLRVFGGGHMVPYDQPENALDMVNRWISGDYKY
References
Title: Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome Chibana H, Oka N, Nakayama H, Aoyama T, Magee BB, Magee PT, Mikami Y Ref: Genetics, 170:1525, 2005 : PubMed
The size of the genome in the opportunistic fungus Candida albicans is 15.6 Mb. Whole-genome shotgun sequencing was carried out at Stanford University where the sequences were assembled into 412 contigs. C. albicans is a diploid basically, and analysis of the sequence is complicated due to repeated sequences and to sequence polymorphism between homologous chromosomes. Chromosome 7 is 1 Mb in size and the best characterized of the 8 chromosomes in C. albicans. We assigned 16 of the contigs, ranging in length from 7309 to 267,590 bp, to chromosome 7 and determined sequences of 16 regions. These regions included four gaps, a misassembled sequence, and two major repeat sequences (MRS) of >16 kb. The length of the continuous sequence attained was 949,626 bp and provided complete coverage of chromosome 7 except for telomeric regions. Sequence analysis was carried out and predicted 404 genes, 11 of which included at least one intron. A 7-kb indel, which might be caused by a retrotransposon, was identified as the largest difference between the homologous chromosomes. Synteny analysis revealed that the degree of synteny between C. albicans and Saccharomyces cerevisiae is too weak to use for completion of the genomic sequence in C. albicans.
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Title: The carboxypeptidase Y-encoding gene from Candida albicans and its transcription during yeast-to-hyphae conversion Mukhtar M, Logan DA, Kaufer NF Ref: Gene, 121:173, 1992 : PubMed
We have cloned and sequenced the gene (CPY1) encoding the carboxypeptidase Y (CPY) of Candida albicans. The gene contains an open reading frame comprising 542 amino acids (aa) with an M(r) of 61,104. The aa sequence shows 74% identity to the mature CPY aa sequence from Saccharomyces cerevisiae. The putative pre (signal) and pro sequences at the N terminus of the C. albicans protein, however, show significant divergence from the corresponding prepro sequence of the S. cerevisiae protein. Southern analysis of C. albicans genomic DNA suggested the presence of only one CPY-encoding gene. Northern analysis during yeast-to-hyphae conversion suggested that the CPY1 gene is transiently down-regulated on a transcriptional level during the early events of this developmental switch.
