Gene_locus Report for: bovin-pafa Bovine plasma PAF acetylhydrolase
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Cetartiodactyla: N E > Ruminantia: N E > Pecora: N E > Bovidae: N E > Bovinae: N E > Bos: N E > Bos taurus: N E A85-EsteraseD-FGH :
bovin-estd Bos taurus (Bovine) Esterase D .
ABHD6-Lip :
bovin-q1lz86 Bos taurus (Bovine) similar to abhydrolase domain containing 6 .
ABHD8 :
bovin-abhd8 Bos taurus (Bovine); Bos mutus (wild yak) abhydrolase domain-containing protein 8 (EC 3.-.-.-) .
ABHD10 :
bovin-ABHDA Bos taurus (Bovine); Bos mutus (wild yak) abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
bovin-q3sz73 Bos taurus (Bovine) abhydrolase domain containing 11 .
ABHD12-PHARC :
bovin-f1mps6 Bos taurus (Bovine) Uncharacterized protein ,
bovin-q08dw9 Bos taurus (Bovine), Bos mutus (wild Yak) abhydrolase domain containing protein 12 .
ABHD13-BEM46 :
bovin-a7mb66 Bos taurus (Bovine). Abhydrolase domain containing 13 .
ABHD16 :
bovin-ABHD16A Bos taurus (Bovine) Phosphatidylserine lipase ABHD16A HLA-B-associated transcript 5 BAT5 ,
bovin-ABHD16B Bos taurus (Bovine); Bos mutus (wild yak) Abhydrolase domain containing 16B .
ABHD17-depalmitoylase :
bovin-AB17A Bos taurus (Bovine) Abhydrolase domain-containing protein FAM108A ,
bovin-AB17C Bos taurus (Bovine) Abhydrolase domain-containing protein FAM108C1 .
ABHD18 :
bovin-f1n673 Bos taurus (Bovine). Uncharacterized protein .
abh_upf0017 :
bovin-abhd1 Bos taurus (Bovine) lung alpha/beta hydrolase 1 (Labh1-pending) hypothetical protein mgc127615 ,
bovin-abhd2 Bos taurus (Bovine) alpha/beta hydrolase domain containing protein 2 ,
bovin-abhd3 Bos taurus (Bovine) Abhydrolase domain-containing protein 3 ,
bovin-e1bkm2 Bos taurus (Bovine) Abhydrolase domain containing 15 .
ACHE :
bovin-ACHE Bos taurus protein for acetylcholinesterase T subunit .
Acidic_Lipase :
bovin-1lipg Bos taurus (Bovine) Gastric triacylglycerol lipase ,
bovin-e1ba50 Bos taurus (Bovine) Lipase ,
bovin-e1bnt1 Bos taurus (Bovine) Lipase LIPJ ,
bovin-f1msa3 Bos taurus (Bovine) Lipase LIPK ,
bovin-f1n110 Bos taurus (Bovine) Lipase .
ACPH_Peptidase_S9 :
bovin-acph Bos taurus (Bovine) Acylaminoacyl-peptidase .
Arb2_FAM172A :
bovin-a0a3q1nm09 Bos taurus (Bovine); Bos mutus (wild yak). Uncharacterized protein .
Arylacetamide_deacetylase :
bovin-aaad Bos taurus (Bovine); Bos mutus (Bovine, wild yak) Arylacetamide deacetylase ,
bovin-nceh1 Bos taurus (Bovine); Bos mutus Arylacetamide deacetylase-like 1 ,
bovin-g5e5g5 Bos taurus (Bovine). Uncharacterized protein ,
bovin-g5e5i3 Bos taurus (Bovine). Uncharacterized protein .
BCHE :
bovin-BCHE Bos taurus (Bovine), Bos mutus (wild yak) butyrylcholinesterase .
Carboxypeptidase_S10 :
bovin-ppgb Bos taurus (Bovine) Lysosomal protective protein Cathepsin A Peptidase_S10 mgc128937 ,
bovin-q2nkz9 Bos taurus (Bovine) similar to serine carboxypeptidase 1 protein .
Carb_B_Chordata :
bovin-e1bn79 Bos taurus (Bovine) Bos mutus (Yak) cauxin ,
bovin-est8 Bos taurus (Bovine) Bos mutus (Yak) Carboxylesterase 4A (Carboxylesterase 8) UNQ440/PRO873 homolog ,
bovin-f1mi11 Bos taurus (Bovine) Bos mutus (Yak) Uncharacterized protein ,
bovin-q2kj30 Bos taurus (Bovine), Bos mutus (Yak) hypothetical protein ,
bovin-q3t0r6 Bos taurus (Bovine), Bos mutus (Yak) hypothetical protein mgc127393 ,
bovin-q5myb8 Bos taurus (Bovine) retinyl ester hydrolase type 1 breh1 .
CGI-58_ABHD5_ABHD4 :
bovin-abhd4 Bos taurus (Bovine) abhydrolase domain containing protein 4 Lyso-N-acylphosphatidylethanolamine lipase ,
bovin-q0vcc8 Bos taurus (Bovine) Abhydrolase domain containing 5 .
Cholesterol_esterase :
bovin-balip .
CIB-CCG1-interacting-factor-B :
bovin-abheb Bos taurus (Bovine) Abhydrolase domain-containing protein 14B ,
bovin-f1mr65 Bos taurus (Bovine) Uncharacterized protein .
CMBL :
bovin-f1n2i5 Bos taurus (Bovine); Bos indicus x Bos taurus (Hybrid cattle); Bos mutus (wild yak). Carboxymethylenebutenolidase homolog .
DPP4N_Peptidase_S9 :
bovin-a0jnh8 Bos taurus (Bovine) Dipeptidyl-peptidase 10 ,
bovin-a5d7b7 Bos taurus (Bovine) Uncharacterized protein ,
bovin-dpp4 Bos taurus (Bovine) dipeptidyl peptidase IV ,
bovin-dpp6 Bos taurus (Bovine) related protein) (dipeptidylpeptidase VI) (dppx) ,
bovin-e1bi31 Bos taurus (Bovine) Uncharacterized protein ,
bovin-f1n1l4 Bos taurus (Bovine) Uncharacterized protein .
Duf_676 :
bovin-e1bpw3 Bos taurus (Bovine) Uncharacterized protein ,
bovin-f1mcd9 Bos taurus (Bovine) Uncharacterized protein .
Duf_829 :
bovin-tmm53 Bos taurus (Bovine) Transmembrane protein 53 .
Epoxide_hydrolase :
bovin-q3zcj6 Bos taurus (Bovine) hypothetical protein mgc126963 .
FSH1 :
bovin-OVCA2 Bos taurus (Bovine); Bos mutus (wild yak) hypothetical protein mgc128661 .
Hepatic_Lipase :
bovin-q3sz79 Bos taurus (Bovine); Bos mutus grunniens (Wild yak) (Bos grunniens) lipase, hepatic .
Hormone-sensitive_lipase_like :
bovin-hslip Bos taurus (Bovine) 17.6 kda hormone-sensitive lipase (fragment) .
Kynurenine-formamidase :
bovin-e1bll5 Bos taurus (Bovine). N-formylkynurenine formamidase .
Lipase_3 :
bovin-e1bbv2 Bos taurus (Bovine); Bos mutus (wild yak) Uncharacterized protein .
Lipoprotein_Lipase :
bovin-lipli ,
bovin-LIPG Bos taurus; Bos mutus (wild yak) lipase G, endothelial type (LIPG) .
LYsophospholipase_carboxylesterase :
bovin-lypa1 Bos taurus (Bovine) lysophospholipase I .
Maspardin-ACP33-SPG21_like :
bovin-SPG21 Bos taurus (Bovine); Bos mutus (wild Yak) hypothetical protein acid cluster protein 33 ACP33 SPG21 maspardin .
MEST-like :
bovin-q2hjm9 Bos taurus (Bovine) mesoderm-specific transcript Paternally-expressed gene 1 peg1 (fragment) .
Ndr_family :
bovin-ndr1 Bos taurus (Bovine) hypothetical protein mgc127533 ,
bovin-ndrg2 Bos taurus (Bovine) mgc128884 Protein NDRG2 ,
bovin-ndrg3 Bos taurus (Bovine) Protein NDRG3 ,
bovin-q0vck8 Bos taurus (Bovine) Uncharacterized protein .
Neuroligin :
bovin-2neur Bos taurus (Bovine), Bos mutus (Wild Yak) NLGN2 Neuroligin 2 ,
bovin-3neur Bos taurus (Bovine) similar to neuroligin 3 ,
bovin-g3mxp5 Bos taurus (Bovine) Bos mutus (Yak) Neuroligin-3 .
NLS3-Tex30 :
bovin-KANSL3 Bos taurus (Bovine) Bos Mutus (Yak) LOC618190 protein ,
bovin-TEX30 Bos taurus (Bovine), Bos mutus (Yak) Testis-expressed sequence 30 protein, C13orf27 homolog .
PAF-Acetylhydrolase :
bovin-paf2 Bos taurus (Bovine) (EC 3.1.1.47) (serine dependent phospholipase a2) .
Palmitoyl-protein_thioesterase :
bovin-ppt ,
bovin-ppt2 Bos taurus (Bovine) Lysosomal thioesterase PPT2 .
Pancreatic_lipase :
bovin-lipr2 Bos taurus (Bovine); Bos mutus (wild yak) Pancreatic lipase-related protein 2 Can hydrolyze both phospholipids and galactolipids ,
bovin-e1bjq9 Bos taurus (Bovine); Bos mutus (wild yak). Pancreatic lipase ,
bovin-f1mc21 Bos taurus (Bovine); Bos mutus (wild yak). Pancreatic lipase .
PC-sterol_acyltransferase :
bovin-lcat Bos taurus (Bovine) phosphatidylcholine-sterol acyltransferase ,
bovin-LPLA2 Bos taurus (Bovine) lysosomal phospholipase a2 ( lysophospholipase 3) .
Pectinacetylesterase-Notum :
bovin-f1mbd6 Bos taurus (Bovine) palmitoleoyl-protein carboxylesterase NOTUM .
PGAP1 :
bovin-e1bnq0 Bos taurus (Bovine) Uncharacterized protein ,
bovin-srac1 Bos taurus (Bovine) Protein SERAC1 .
Phospholipase :
bovin-q5e9h0 Bos taurus (Bovine) phospholipase a1 member a ,
bovin-f1mxa8 Bos taurus (Bovine). Lipase H .
PPase_methylesterase_euk :
bovin-ppme1 Bos taurus (Bovine) protein phosphatase methylesterase-1 .
Prolylcarboxypeptidase :
bovin-a6qnx2 Bos taurus (Bovine) DPP7 protein ,
bovin-q2ta14 Bos taurus (Bovine) hypothetical protein .
S9N_PPCE_Peptidase_S9 :
bovin-ppce Bos taurus (Bovine) (PE) .
SERHL :
bovin-f1n385 Bos taurus (Bovine); Bos mutus (wild yak) Uncharacterized protein .
Thioesterase :
bovin-fas Bos taurus (Bovine) oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14) .
Thyroglobulin :
bovin-thyro .
Valacyclovir-hydrolase :
bovin-q2kix6 Bos taurus (Bovine) Biphenyl hydrolase-like Serine hydrolase; breast epithelial mucin-associated antigen Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: bovin-pafa Colored MSA for PAF-Acetylhydrolase (raw)
MLPSKLHALFCLCTCLALVYPFDWQDLNPVAYIESPAWVSKIQALMAAAN
IGQSKIPRGNGSYSVGCTDLMFDYTNKGTFLRLYYPSQDDDHSDTLWIPN
KEYFLGLSKFLGTHWLVGKIMGLFFGSMTTPAAWNAHLRTGEKYPLIIFS
HGLGAFRTIYSAIGIDLASHGFIVAAVEHRDGSASSTYYFKDQSAVEIGN
KSWLYLRTLKRGEEEFPLRNEQLRQRAKECSQALSLILDIDHGRPVTNVL
DLEFDVEQLKDSIDRDKIAIIGHSFGGATVIQTLSEDQRFRCGIALDAWM
FPVGDEVYSRIPQPLFFINSERFQYPSNIIRMKKCFLPDRERKMITIRGS
VHQNFVDFTFATSKIIGYLFTLKGDIDSNVAISLSNKASLAFLQKHLGLQ
KDFDQWDSLVEGEDHNLIPGTNINTTNHQAILQNSTGIERPNLD
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M L P S K L H A L F C L C T C L A L V Y P F D W Q D L N P V A Y I E S P A W V S K I Q A L M A A A N I G Q S K I P R G N G S Y S V G C T D L M F D Y T N K G T F L R L Y Y P S Q D D D H S D T L W I P N K E Y F L G L S K F L G T H W L V G K I M G L F F G S M T T P A A W N A H L R T G E K Y P L I I F S H G L G A F R T I Y S A I G I D L A S H G F I V A A V E H R D G S A S S T Y Y F K D Q S A V E I G N K S W L Y L R T L K R G E E E F P L R N E Q L R Q R A K E C S Q A L S L I L D I D H G R P V T N V L D L E F D V E Q L K D S I D R D K I A I I G H S F G G A T V I Q T L S E D Q R F R C G I A L D A W M F P V G D E V Y S R I P Q P L F F I N S E R F Q Y P S N I I R M K K C F L P D R E R K M I T I R G S V H Q N F V D F T F A T S K I I G Y L F T L K G D I D S N V A I S L S N K A S L A F L Q K H L G L Q K D F D Q W D S L V E G E D H N L I P G T N I N T T N H Q A I L Q N S T G I E R P N L D
References
Title: Anti-inflammatory properties of a platelet-activating factor acetylhydrolaseTjoelker LW , Wilder C , Eberhardt C , Stafforini DM Ref: Nature, 374 :549, 1995 : PubMed Abstract ESTHER: Tjoelker_1995_Nature_374_549 PubMedSearch: Tjoelker 1995 Nature 374 549 PubMedID: 7700381 Gene_locus related to this paper: bovin-pafa ,
canfa-pafa ,
chick-pafa ,
human-PLA2G7 ,
mouse-pafa Abstract
Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid that activates cells involved in inflammation. The biological activity of PAF depends on its structural features, namely an ether linkage at the sn-1 position and an acetate group at the sn-2 position. The actions of PAF are abolished by hydrolysis of the acetyl residue, a reaction catalysed by PAF acetylhydrolase. There are at least two forms of this enzyme--one intracellular and another that circulates in plasma and is likely to regulate inflammation. Here we report the molecular cloning and characterization of the human plasma PAF acetylhydrolase. The unique sequence contains a Gly-Xaa-Ser-Xaa-Gly motif commonly found in lipases. Recombinant PAF acetylhydrolase has the substrate specificity and lipoprotein association of the native enzyme, and blocks inflammation in vivo: it markedly decreases vascular leakage in pleurisy and paw oedema, suggesting that PAF acetylhydrolase might be a useful therapy for severe acute inflammation.
Title: Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triadTjoelker LW , Eberhardt C , Unger J , Le Trong H , Zimmerman GA Ref: Journal of Biological Chemistry, 270 :25481, 1995 : PubMed Abstract Other Papers
Bos taurus (Bovine) Bos mutus (Yak) protein for bile-salt-activated lipase