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bactn-BT4193

Bacteroides thetaiotaomicron, Bacteroides caccae, Bacteroides ovatus, Bacteroides sp.,Bacteroides xylanisolvens, dipeptidyl peptidase IV

Comment

The sequence is the one of the structure. Other strains: Bacteroides thetaiotaomicron (strain ATCC 29148 \/ DSM 2079 \/ NCTC 10582 \/ E50 \/ VPI-5482) Bacteroides caccae (ATCC 43185), Bacteroides ovatus (ATCC 8483\; SD CMC 3f\; SD CC 2a), Bacteroides sp. (D1\; 2_2_4\; 1_1_6\; 2_1_22\; 1_1_14\; D22\; 3_1_23\; D2),Bacteroides xylanisolvens (SD CC 1b\; XB1A). Dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 is able to decrease the active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Sitagliptin, has little effect on microbial DPP4. daurisoline-d4 (Dau-d4) is a selective microbial DPP4 inhibitor that improves glucose tolerance in diabetic mice.

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Bacteroides thetaiotaomicron

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MRKVSLALLL CLLCLAGMAQ GQKALDLKDI TSGRFRPENI QGVIPMPDGE HYTQMSADGT QIIKYSFRTG EKVEVIFDVN QARECDFKNF DSYQFSPDGD KLLIATRTTP IYRHSYTAVH YIYPLKRNDK GVTTNNIIER LSDGGPQQVP VFSPDGTMIA FVRDNNIFLV KLLYGNSESQ VTEDGKQNSV LNGIPDWVYE EEFGFNRALE FSADNTMIAF IRFDESEVPS YSFPMFAGEA PQITPLKDYP GEYTYKYPKA GYPNSKVEVR TYDIKSHVTR TMKLPIDADG YIPRIRFTKD ASKLAVMTLN RHQDRFDLYF ADPRSTLCKL VLRDESPYYI KENVFDNIKF YPETFSLLSE RDGFSHLYWY SMGGNLIKKV TNGKYEVKDF LGYDEADGSF YYTSNEESPL RKAVYKIDKK GKKLKLSQRE GTNTPLFSQS MKYYMNKFSN LDTPMLVTLN DNTGKTLKTL INNDQLKQTL SGYAIPQKEF FTFQTTDGVT LNGWMMKPAN FSTSKKYPVL MYQYSGPGSQ QVLDTWGISW ETYMASLGYI VVCVDGRGTG GRGEAFEKCT YLKIGVKEAK DQVETALYLG KQPYVDKDRI GIWGWSYGGY MTLMSMSEGT PVFKAGVAVA APTDWRFYDT IYTERFMRTP KENAEGYKES SAFTRADKLH GNLLLVHGMA DDNVHFQNCA EYAEHLVQLG KQFDMQVYTN RNHGIYGGNT RQHLYTRLTN FFLNNL

References

Title : Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target - Wang_2023_Science_381_eadd5787
Author(s) : Wang K , Zhang Z , Hang J , Liu J , Guo F , Ding Y , Li M , Nie Q , Lin J , Zhuo Y , Sun L , Luo X , Zhong Q , Ye C , Yun C , Zhang Y , Wang J , Bao R , Pang Y , Wang G , Gonzalez FJ , Lei X , Qiao J , Jiang C
Ref : Science , 381 :eadd5787 , 2023
Abstract : Wang_2023_Science_381_eadd5787
ESTHER : Wang_2023_Science_381_eadd5787
PubMedSearch : Wang_2023_Science_381_eadd5787
PubMedID: 37535747
Gene_locus related to this paper: bactn-BT4193

Title : A genomic view of the human-Bacteroides thetaiotaomicron symbiosis - Xu_2003_Science_299_2074
Author(s) : Xu J , Bjursell MK , Himrod J , Deng S , Carmichael LK , Chiang HC , Hooper LV , Gordon JI
Ref : Science , 299 :2074 , 2003
Abstract : Xu_2003_Science_299_2074
ESTHER : Xu_2003_Science_299_2074
PubMedSearch : Xu_2003_Science_299_2074
PubMedID: 12663928
Gene_locus related to this paper: bacth-BT1008 , bacth-BT1087 , bacth-BT1121 , bacth-BT1192 , bacth-BT1400 , bacth-BT1838 , bacth-BT2436 , bacth-BT3100 , bacth-BT4214 , bactn-BT0152 , bactn-BT0587 , bactn-BT1114 , bactn-BT1261 , bactn-BT2379 , bactn-BT2525 , bactn-BT3084 , bactn-BT3112 , bactn-BT3254 , bactn-BT3286 , bactn-BT3608 , bactn-BT4077 , bactn-BT4193 , bactn-q8a7t0