Gene_locus Report for: bacsu-yjau

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Firmicutes: N E > Bacilli: N E > Bacillales: N E > Bacillaceae: N E > Bacillus: N E > Bacillus subtilis group: N E > Bacillus subtilis: N E

6_AlphaBeta_hydrolase : bacsu-cbxnp Bacillus subtilis carboxylesterase NA ou NP naproxen ester hydrolase CesA P96688, bacsu-ybfk Bacillus subtilis ybkf CesB, bacsu-yqjlBacillus subtilis hypothetical protein yqjl, baciu-a0a0d5d3y1Bacillus subtilis. Uncharacterized protein.
A85-IroE-IroD-Fes-Yiel : bacsu-YJCHBacillus subtilis yjch (and subsp. natto BEST195) protein, bacsu-YUIIBacillus subtilis (and subsp. natto BEST195) YUII protein.
Abhydrolase_7 : bacsu-YTAPBacillus subtilis ytap.
Acetyl-esterase_deacetylase : bacsu-CAH Bacillus subtilis cephalosporin c deacetylase (EC 3.1.1.41).
ACPH_Peptidase_S9 : bacsu-YTMABacillus subtilis putative peptidase, bacsu-yuxlBacillus subtilis probable peptidase yuxl (EC 3.4.21.-).
AlphaBeta_hydrolase : bacsu-YBDGBacillus subtilis ybdg protein, bacsu-ycgSBacillus subtilis gene ycgS, bacsu-yclEBacillus subtilis yclE BAA08999.1, bacsu-yqkdBacillus subtilis hypothetical protein yqkd, bacsu-YRAKBacillus subtilis hypothetical protein yrak, bacsu-YvaMBacillus subtilis gene yvaM RghR (rapG and rapH repressor).
CarbLipBact_1 : bacsu-YVAKBacillus subtilis, Bacillus amyloliquefaciens, Bacillus atrophaeus, Bacillus subtilis, YvaK protein Carboxylesterase.
Carbon-carbon_bond_hydrolase : bacsu-yugFBacillus subtilis gene yugF.
Carb_B_Bacteria : bacsu-pnbae Bacillus subtilis, Bacillus sp., EH84 para-nitrobenzyl esterase (pnbA) intracellular esterase B CarEW BS2 Bs2Est, bacsu-q4pns3Bacillus subtilis RRL-BB1. carboxylesterase, baciu-a0a0f0a5r4Bacillus subtilis; Bacillus licheniformis; Bacillus cereus. Carboxylic ester hydrolase.
Dienelactone_hydrolase : bacsu-yczhBacillus subtilis hypothetical 21.1 kda protein in sipu-kipi intergenic region.
Epoxide_hydrolase : bacsu-yfhMBacillus subtilis (and subsp. natto BEST195) yfhM Epoxide_hydrolase like Bsueh.
Haloperoxidase : bacsu-ydjpBacillus subtilis BAA22772.1 (and subsp. natto BEST195) peroxydase, bacsu-yisYBacillus subtilis (and subsp. natto BEST195) yisY Haloperoxidase like.
Hormone-sensitive_lipase_like : bacsu-brefe Bacillus subtilis brefeldin A esterase.
Hydrolase_RBBP9_YdeN : bacsu-YDEN Bacillus subtilis yden protein.
Lipase_2 : bacsu-lip Bacillus subtilis lipase (lipA) (EC 3.1.1.3) BSLA (triacylglycerol lipase), bacsu-LIPBBacillus subtilis, Bacillus sp., Bacillus megaterium, yfip (esterase) (EC 3.1.1.1) lipW estB lipA lipB lipJ.
LYsophospholipase_carboxylesterase : bacsu-MHQDBacillus subtilis yolf.
MenH_SHCHC : bacsu-ytxmBacillus subtilis, Bacillus sp. ytxm.
Monoglyceridelipase_lysophospholip : bacsu-YTPABacillus subtilis Bacilysocin biosynthesis protein ytpA.
Proline_iminopeptidase : bacsu-YBACBacillus subtilis, Bacillus sp. hypothetical 36.9 kda protein.
RsbQ-like : bacsu-yvfQ Bacillus subtilis yvfQ sigma factor sigb CAB08011.1 CAB15415.1 also regulation proteinRsbQ.
Thioesterase : bacsu-FENB Bacillus subtilis; Bacillus malacitensis; Bacillus [Brevibacterium] halotolerans fengycin synthetase, bacsu-ITUCBacillus subtilis; Bacillus amyloliquefaciens; Bacillus sp., Iturin a synthetase c, bacsu-MYCCBacillus subtilis mycc Mycosubtilin synthase subunit C Thioesterase domain, bacsu-PKSRBacillus subtilis polyketide synthase Thioesterase domain, bacsu-PPSEBacillus subtilis peptide synthetase orf5 Thioesterase domain, bacsu-q6yk39Bacillus subtilis Bacillus amyloliquefaciens; Bacillus velezensis; Mycobacterium abscessus; Bacillus sp., bacillomycin d synthetase c, bacsu-srf4 Bacillus subtilis csi16 Thioesterase domain, bacsu-srfac Bacillus subtilis surfactin synthetase subunit 3, bacsu-SRFCBacillus subtilis and Bacillus amyloliquefaciens putative surfactin synthetase (fragment), bacsu-SRFDBacillus subtilis, Bacillus sp. CY22, Bacillus amyloliquefaciens, srfD srfDB3 srfad putative thioesterase, bacsu-YUKLBacillus subtilis DHBF yukl protein yukk protein Thioesterase domain dimodular nonribosomal peptide synthetase.
yjfP_esterase-like : bacsu-YITVBacillus subtilis hypothetical protein yitv

Title: The complete genome sequence of the gram-positive bacterium Bacillus subtilis
Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A and Danchin A <140 more author(s)> Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A (- 140)
Ref: Nature, 390:249, 1997 : PubMed
Abstract


ESTHER: Kunst_1997_Nature_390_249
PubMedSearch: Kunst 1997 Nature 390 249
PubMedID: 9384377
Gene_locus related to this paper: bacsu-CAH, bacsu-cbxnp, bacsu-lip, bacsu-LIPB, bacsu-PKSR, bacsu-pnbae, bacsu-PPSE, bacsu-srf4, bacsu-srfac, bacsu-YBAC, bacsu-YBDG, bacsu-ybfk, bacsu-ycgS, bacsu-yczh, bacsu-YDEN, bacsu-ydjp, bacsu-yfhM, bacsu-yisY, bacsu-YITV, bacsu-yjau, bacsu-YJCH, bacsu-MHQD, bacsu-yqjl, bacsu-yqkd, bacsu-YRAK, bacsu-YTAP, bacsu-YTMA, bacsu-YTPA, bacsu-ytxm, bacsu-yugF, bacsu-YUII, bacsu-YUKL, bacsu-YVAK, bacsu-YvaM, bacsu-yvfQ

Abstract

Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete large amounts of industrially important enzymes. Many of the genes are involved in the synthesis of secondary metabolites, including antibiotics, that are more typically associated with Streptomyces species. The genome contains at least ten prophages or remnants of prophages, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.



        

Title: A new Bacillus subtilis gene, med, encodes a positive regulator of comK
Ogura M, Ohshiro Y, Hirao S, Tanaka T
Ref: Journal of Bacteriology, 179:6244, 1997 : PubMed
Abstract


ESTHER: Ogura_1997_J.Bacteriol_179_6244
PubMedSearch: Ogura 1997 J.Bacteriol 179 6244
PubMedID: 9335269
Gene_locus related to this paper: bacsu-yjau

Abstract

Bacillus subtilis degR, a positive regulator of the production of degradative enzymes, is negatively regulated by the competence transcription factor ComK which is overproduced in mecA null mutants. We used transposon Tn10 to search for a mutation that reduced the repression level of degR caused by a mecA mutation. A new gene exerting positive regulation on comK was obtained and designated med (suppressor of mecA effect on degR). Sequence determination, Northern analysis, and primer extension analyses revealed that the med gene contained an open reading frame (ORF) composed of 317 codons and was transcribed into an approximately 1,250-nucleotide mRNA together with its short downstream gene. The expression of comK is positively regulated by factors such as ComK itself, ComS (SrfA)-MecA, DegU, SinR, and AbrB. Quantitative analyses using comK'-'lacZ, srfA-lacZ, degU'-'lacZ, and sinR'-'lacZ fusions showed that disruption of med caused a significant decrease in comK expression in both mecA+ and mecA strains, while expression of srfA, sinR, and degU was not affected by the mutation. An epistatic analysis revealed that overproduction of ComK resulted in alteration of med expression, suggesting a regulatory loop between comK and med. Several possible mechanisms for positive regulation of comK by Med are discussed.