Gene_locus Report for: astmx-w5k377

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Actinopterygii: N E > Actinopteri: N E > Neopterygii: N E > Teleostei: N E > Osteoglossocephalai: N E > Clupeocephala: N E > Otomorpha: N E > Ostariophysi: N E > Otophysi: N E > Characiphysae: N E > Characiformes: N E > Characoidei: N E > Characidae: N E > Characidae incertae sedis: N E > Astyanax clade: N E > Astyanax: N E > Astyanax mexicanus: N E

Title: The cavefish genome reveals candidate genes for eye loss
McGaugh SE, Gross JB, Aken B, Blin M, Borowsky R, Chalopin D, Hinaux H, Jeffery WR, Keene A and Warren WC <11 more author(s)> McGaugh SE, Gross JB, Aken B, Blin M, Borowsky R, Chalopin D, Hinaux H, Jeffery WR, Keene A, Ma L, Minx P, Murphy D, O'Quin KE, Retaux S, Rohner N, Searle SM, Stahl BA, Tabin C, Volff JN, Yoshizawa M, Warren WC (- 11)
Ref: Nat Commun, 5:5307, 2014 : PubMed
Abstract


ESTHER: McGaugh_2014_Nat.Commun_5_5307
PubMedSearch: McGaugh 2014 Nat.Commun 5 5307
PubMedID: 25329095
Gene_locus related to this paper: astmx-w5kyj0, astmx-w5l5v5, astmx-w5k377, astmx-w5kdz8, astmx-w5k5k8, astmx-w5kf08, astmx-w5lfx9, astmx-a0a3b1il55, astmx-w5k188, astmx-w5lig8, astmx-a0a3b1it79, astmx-a0a3b1kh87, astmx-w5kk92, astmx-w5kf44, astmx-a0a3b1ihb9, astmx-a0a3b1jet6, astmx-w5lug4, astmx-w5ln33, astmx-a0a3b1k1i9, astmx-w5l3f7

Abstract

Natural populations subjected to strong environmental selection pressures offer a window into the genetic underpinnings of evolutionary change. Cavefish populations, Astyanax mexicanus (Teleostei: Characiphysi), exhibit repeated, independent evolution for a variety of traits including eye degeneration, pigment loss, increased size and number of taste buds and mechanosensory organs, and shifts in many behavioural traits. Surface and cave forms are interfertile making this system amenable to genetic interrogation; however, lack of a reference genome has hampered efforts to identify genes responsible for changes in cave forms of A. mexicanus. Here we present the first de novo genome assembly for Astyanax mexicanus cavefish, contrast repeat elements to other teleost genomes, identify candidate genes underlying quantitative trait loci (QTL), and assay these candidate genes for potential functional and expression differences. We expect the cavefish genome to advance understanding of the evolutionary process, as well as, analogous human disease including retinal dysfunction.