Gene_Locus Report

Biblio print

Add to basket

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Gene_locus Report for: 9zzzz-EH82

uncultured organism EH82 EH76 Uncharacterized protein

Comment
EH82 promiscuous activity 14/96 substrates Martinez-Martinez et al. 2018 EH76 promiscuous activity 16/96 substrates EH82 two proteins. n-term not an alpha/beta hydrolase but SGNH lipase c-term identical to EH76 so in the paper the difference comes from the extra n-term


Relationship
Family|5_AlphaBeta_hydrolase
Block| X
Position in NCBI Life Tree|uncultured organism
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> unclassified sequences: N E > environmental samples: N E > uncultured organism: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
1 Genbank : SRA059294
Sequence
Graphical view for this peptide sequence: 9zzzz-EH82
Colored MSA for 5_AlphaBeta_hydrolase (raw)
MRTYVFADTGERIPYGVFVSSSVTMERKAPLVVALHGLGASQESMVRTSF
RAVELAEKGGYILVVPLGYNSSGWYGVQAGGSVQQQREYSEKDVMNVLAM
VRDEFNIDDDRIFLMGHSMGGAGTLHLGMKYPSIWAALAPIAPATAALDP
DSLASIRHMPVIIVQGDADTAVPVAVTRRWASKLRELQMTFRYIEIPGGD
HMGVIGTGMPDIFAFFEAHPKNHH
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MRTYVFADTGERIPYGVFVSSSVTMERKAPLVVALHGLGASQESMVRTSF
RAVELAEKGGYILVVPLGYNSSGWYGVQAGGSVQQQREYSEKDVMNVLAM
VRDEFNIDDDRIFLMGHSMGGAGTLHLGMKYPSIWAALAPIAPATAALDP
DSLASIRHMPVIIVQGDADTAVPVAVTRRWASKLRELQMTFRYIEIPGGD
HMGVIGTGMPDIFAFFEAHPKNHH


Reference
    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer