9pseu-NcmC
Saccharothrix syringae. NcmC
Comment
Off-loading Dieckmann cyclase, NcmC, that installs the tetramate head group in nocamycin, a hybrid polyketide\/nonribosomalpeptide natural product. A conserved thioesterase-like scaffold has been adapted to perform a new chemical reaction: heterocyclization. The catalytic triad for the cyclization reaction consists of Cys89, Asp116, and His254
Relationship
Molecular evidence
No mutation
No kinetic
No disease
Sequence
Peptide
MTAPRAWRPI AGGPPAGPLV LAVDFAATGR PEAAFADLVA RLDPGTEVWE SLQPPLGTET GMVAEDYVTR WEEEVRASGR RIGAVLGFCA GSAFAGELAV RLARSQPRSP RLVVFDPESP TTSTLYYQFR KVVESLAGVL GEQAAREALA EGTAAADRIG DVEGLGAELV RVFTAAGRAA CAAADLDDEF ADELTATYRS FVSYLVAAAA VDHVKCWSGA VAVSSATPTS GLNPLDPAAR AALVERELTF DVHHADLLRD PGVARAVARL LA
References
| Title : Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation - Cogan_2020_ACS.Chem.Biol_15_2783 |
| Author(s) : Cogan DP , Ly J , Nair SK |
| Ref : ACS Chemical Biology , 15 :2783 , 2020 |
| Abstract : Cogan_2020_ACS.Chem.Biol_15_2783 |
| ESTHER : Cogan_2020_ACS.Chem.Biol_15_2783 |
| PubMedSearch : Cogan_2020_ACS.Chem.Biol_15_2783 |
| PubMedID: 33017142 |
| Gene_locus related to this paper: 9pseu-NcmC |