(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Protostomia: NE > Ecdysozoa: NE > Panarthropoda: NE > Arthropoda: NE > Mandibulata: NE > Pancrustacea: NE > Hexapoda: NE > Insecta: NE > Dicondylia: NE > Pterygota: NE > Neoptera: NE > Holometabola: NE > Diptera: NE > Nematocera: NE > Culicomorpha: NE > Culicoidea: NE > Culicidae: NE > Anophelinae: NE > Anopheles [genus]: NE > Cellia: NE > Pyretophorus: NE > gambiae species complex: NE > Anopheles coluzzii: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MYWSVKRRALKRIGRCTCAVVVLLFLVGFVILPIIFKYSYALQKSILFLT FITYPPNLDLKRPEKSGLYATRNFYVNHHDHEEDLEVNVAVWHVLPLDLV RRYAKELHVDERTIANKTLPTIDGTTSNGGSIVADEKHHAGDRYKGIEKV LRSDGFQLTDEKHQRDLFEETLRATTNDVVLYLHGNTASRGAPHRVELYQ MLRALNYHVIAIDYRGYGDSANLSPSELGVVYDALAVYQYITSITNNPVY LWGHSLGTGVSTHLLSLLTEMSLPGPKAVVLESPFNNIKEEICAHPFSKL YRHLPWFDYLISRPMYKNKLRFESDQHIAEFRQPVLILHAEDDLVVPFEL GYKLYRKALDTRGKSWGPIEFHRFEKSSHYGHKYICRAPNLPEIIVRFFH AYRDAQY
The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process.
