(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Protostomia: NE > Ecdysozoa: NE > Nematoda: NE > Enoplea: NE > Dorylaimia: NE > Trichinellida: NE > Trichuridae: NE > Trichuris: NE > Trichuris suis: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MKTFLGVSCSQANILSAQLTLMTAFLGCLSTVSTQAFDGYHTVKVEQGFI KGRLWNITNRQVQVYLGIPYAEPPVGPLRFQKPLKKKPWEGDHIAFEYGP PCIQFMDFHEHDRFSGNNMKRQKEDCLYLNIFSPYEENADTLYPVIVWIH GGSLLAGSSDSGVDTEVALKNIVLKNVTLVTLNYRLGPLGFLSTSLSDAK GNFGIWDQIEALAWLQANIREFNGDPDMVTVMGESAGGSSASLLALSPVT KGLVHRAILMSGSITAGWAMQRFGVPNWNVENLYKYLTCEKKITSEESWA QAEATQDYGCNFMEQALQCDSTVTEKDVYECIKQKADFSNPLMRKAFTYE LGLGQVLIDGEIIPYNVNELLSNLSRVPILIGVADVEWAHKKAVFYGFKS YTSITEQIALEKAQMIVQQSFMPYFDNTLPNSTLKMIALVALHHYLVWND SGPPWDMTKFVQSLQRMESDIEFTAPMLKEIDLYLNNNQSVYLYSFEHVP SNDIVEEEWVNVNLFGLKRKVRTERKLPIKRAFHGLDHAFIFTEGYSSNI FFSYSDADYKVSDAWCRFITNFAKTGNPTPQPVHGVVWPPMELNHNGYLT IDWPLRVTETGARRWMHGDFWNDLIPTLASVVREPDESKYKTLNVDEQLQ LAAFRRAWWALWVLVAGIAVFLWIVIVCLVTQKCLDFRSRHYKNIIVADV
Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at approximately 140-fold coverage of adult male and female T. suis and approximately 80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
