(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Ascomycota: NE > Taphrinomycotina: NE > Taphrinomycotina incertae sedis: NE > Saitoella: NE > Saitoella complicata: NE > Saitoella complicata NRRL Y-17804: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MGSSTSHLEPSEPFTLSLGSQGSVTGLILGENHNVRRFAGIPYAKPPLGN LRWRKPVPLSLDHIYEGEVTGTPLDCREMRNVSPQPSYFLHGRKLGAIPD DKFSEDCLMVNIWTPNEEPPEDSGGWPVFAWIHGGWLQIGSPSHAIQDDP TELIDKDGGNLQAIVVSIGYRLNVFGFLSGLDEVKGNFGFWDQRLGLEWI RGHITHFGGDPENVTLGGLSAGAYSVHAQLNYELREDKDTDLLFQRVIMF SNAIPTQPKPYLEAKDQFGELCNIAGISRDNSPADQLDKLRQVPANELIK LISQMKQHTFRAVTDDEFIASTLAEEQQNGTFAARFAKKEIKIMIGEVEN EESVYAAINPPKSFSDFLAELANYYGPEVAKKLTTAYPPLPADASPEDCS TRFGKIVSDVQVRIPIRMLVNDLVNGGVDRTSILRYRISFRPSSFDNVFH TNMGVGHAFDAAVWWFGKRLGLTPSEEKAVKAWLVLLQKLIRGEQTDEWS CPTVRAYRQLQSDGTIAVKDDQQWGELLTLSETLRFRDDEVDMG
References
Title: The early diverging ascomycetous budding yeast Saitoella complicata has three histone deacetylases belonging to the Clr6, Hos2, and Rpd3 lineages Nishida H, Matsumoto T, Kondo S, Hamamoto M, Yoshikawa H Ref: J Gen Appl Microbiol, 60:7, 2014 : PubMed
We sequenced the genomic DNA and the transcribed RNA of the ascomycetous budding yeast Saitoella complicata, which belongs to the earliest lineage (Taphrinomycotina) of ascomycetes. We found 3 protein-coding regions similar to Clr6 of Schizosaccharomyces (a member of Taphrinomycotina). Clr6 has a structure similar to that of Rpd3 and Hos2 of Saccharomyces. These proteins belong to the class 1 histone deacetylase (HDAC) family. The phylogenetic tree showed that the Clr6, Hos2, and Rpd3 lineages are separated in fungal HDACs. Basidiomycetes have 3 proteins belonging to the Clr6, Hos2, and Rpd3 lineages. On the other hand, whereas ascomycetes except for Schizosaccharomyces have the Hos2 and Rpd3 homologs, and lack the Clr6 homolog, Schizosaccharomyces has the Clr6 and Hos2 homologs, and lacks the Rpd3 homolog. Interestingly, Pneumocystis and Saitoella have 3 proteins belonging to the Clr6, Hos2, and Rpd3 lineages. Thus, these fungi are the first ascomycete found to possess all 3 types. Our findings indicated that Taphrinomycotina has conserved the Clr6 protein, suggesting that the ancestor of Dikarya (ascomycetes and basidiomycetes) had 3 proteins belonging to the Clr6, Hos2, and Rpd3 lineages. During ascomycete evolution, Pezizomycotina and Saccharomycotina appear to have lost their Clr6 homologs and Schizosaccharomyces to have lost its Rpd3 homolog.
Title: Draft genome sequencing of the enigmatic yeast Saitoella complicata Nishida H, Hamamoto M, Sugiyama J Ref: J Gen Appl Microbiol, 57:243, 2011 : PubMed
