(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Archaea: NE > Asgard group: NE > Candidatus Lokiarchaeota: NE > Lokiarchaeum: NE > Lokiarchaeum sp. GC14_75: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MVIIIIVNTNLRKAQGYSRRGVIKFKGIPYAEPPIGDLRFKEPIPKDSWS GVLDATEYGPIAPQPPPPDNDMGYIPRKQSEAECLTLNIGTSGIEGELRP VMVWIHGGGFVSGNGADFDGARLVLKGDVVVVTINYRLGPLGFLYIPGKT ANVGLLDQIIALKWVKDNIHIFGGDPDNITIFGESAGGISICALLTMPAA KGLFHKTIAQSGAVHPSDFTPSRRKEATEILMSNLDIKSDDIDELRRIPI KELIEADPTRKTIESGEILYMDMPVLGPVIEENTLPTHPLDKIRNGYAKE IELLIGSNLDEFKSWTAVLPKFSKVDEQVMYEQIYRYLNALGKDINKAEI LVRDYKNIKSKRNLGSTRELLDAICSDYAFRVPSIRFAELQSKFQPNTYM YLFNWKSPMFGGRFGACHALEVAFVFGRLPDKDFGLHPSKNKETETLSNN MMNAWISFARKGNPNHEGLPEWPQYSVDKRSTMVFHIESKVINAPYDKER VAWYKLFF
The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided support for the emergence of the eukaryotic host cell from within the archaeal domain of life, but the identity and nature of the putative archaeal ancestor remain a subject of debate. Here we describe the discovery of 'Lokiarchaeota', a novel candidate archaeal phylum, which forms a monophyletic group with eukaryotes in phylogenomic analyses, and whose genomes encode an expanded repertoire of eukaryotic signature proteins that are suggestive of sophisticated membrane remodelling capabilities. Our results provide strong support for hypotheses in which the eukaryotic host evolved from a bona fide archaeon, and demonstrate that many components that underpin eukaryote-specific features were already present in that ancestor. This provided the host with a rich genomic 'starter-kit' to support the increase in the cellular and genomic complexity that is characteristic of eukaryotes.
