Gene_Locus Report
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Gene_locus Report for: 9acar-MT743247

Hyalomma marginatum isolate Morocco: Jorf ElMelha JEM3-D8 AChE1

Comment
JEM3-D8 MT743247, UIX27087 (WT dead at 8 ppm diazinon) ; JEM3-A500 (resistant, alive at 500 ppm diazinon) MT743248, UIX27088, (ATT (isoleucine) ->AGT (serine) at a residue that aligns between residue 49 (glutamate) and 50 (glycine) of the mature AChE protein of Torpedo


Relationship
Family|ACHE
Block| C
Position in NCBI Life Tree|Hyalomma marginatum
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Chelicerata: N E > Arachnida: N E > Acari: N E > Parasitiformes: N E > Ixodida: N E > Ixodoidea: N E > Ixodidae: N E > Hyalomminae: N E > Hyalomma: N E > Hyalomma marginatum: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
>3 Genbank links 1 more: MT743247, UIX27087, MT743248
Sequence
Peptide
Graphical view for this peptide sequence: 9acar-MT743247
Colored MSA for ACHE (raw) 
VVVETVNGPVRGFVARSPLGKSVGVFYGIPYARPPTGQRRFDRAEIIEEP
WTDVLDATVKPASCVQVLDTFYGNFSGSIMWNANTELSEDCLKLNVWTPG
EPSTAEPPLAVLVWIYGGGFYGGTSTLDIYDARTLVSEEDVIVVSMNYRV
ASLGFLSFGNETLPGNAGLHDQYLALRWVQENIACFGGDPNRVTLFGESA
GAVSVGLHVLSPLSKPLFHRVILQSGSPTAPWGFQDTDTARKEAKRLATA
LGCPDGLDQDTLDCLRRKNPEEIVLKEANNSGIVDFPFVPVVDGLFLPDT
PQALTDEGSFARNISVMLGSNLNEGSWFVQYFFGLPVTDERPEVTKENFT
AALESLDPSLRTTPLSEIMNMYTAGEIPSTSAEILKALDSIVGDYHFTCP
VVQWADVLTRAGIPVYEYVFAHRSSRNPWPEWMGVIHGEEMAFVFGQPLN
DTNGYSEEDKNLSRRLMR
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA
VVVETVNGPVRGFVARSPLGKSVGVFYGIPYARPPTGQRRFDRAEIIEEP
WTDVLDATVKPASCVQVLDTFYGNFSGSIMWNANTELSEDCLKLNVWTPG
EPSTAEPPLAVLVWIYGGGFYGGTSTLDIYDARTLVSEEDVIVVSMNYRV
ASLGFLSFGNETLPGNAGLHDQYLALRWVQENIACFGGDPNRVTLFGESA
GAVSVGLHVLSPLSKPLFHRVILQSGSPTAPWGFQDTDTARKEAKRLATA
LGCPDGLDQDTLDCLRRKNPEEIVLKEANNSGIVDFPFVPVVDGLFLPDT
PQALTDEGSFARNISVMLGSNLNEGSWFVQYFFGLPVTDERPEVTKENFT
AALESLDPSLRTTPLSEIMNMYTAGEIPSTSAEILKALDSIVGDYHFTCP
VVQWADVLTRAGIPVYEYVFAHRSSRNPWPEWMGVIHGEEMAFVFGQPLN
DTNGYSEEDKNLSRRLMR

Reference
    Title: Variation of diazinon and amitraz susceptibility of Hyalomma marginatum (Acari: Ixodidae) in the Rabat-Sale-Kenitra region of Morocco
    Elhachimi L, Van Leeuwen T, Dermauw W, Rogiers C, Valcarcel F, Olmeda AS, Khatat SE, Daminet S, Sahibi H, Duchateau L
    Ref: Ticks Tick Borne Dis, 13:101883, 2021 : PubMed

            


Other Papers

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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