human-PLA2G7
Homo sapiens (Human) plasma PAF acetylhydrolase Phospholipase A2 groupe 7 PLA2G7 PAFAH PAF-AH Lp-PLA(2)
Comment
The PLA2G7 (PAFAH) gene encodes platelet-activating factor (PAF) (Lipoprotein-associated phospholipase A2) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate. Plasma platelet-activating factor acetylhydrolase deficiency is inherited in an autosomal recessive manner (Stafforini et al., 1996) due to mutation of PLA2G7. Kruse et al. (2000) identified PLA2G7 variants on Chromosome 6p21.2 associated with atopy and asthma in a Caucasian population: the variant thr198 allele (I198T\; 601690.0002) was highly associated with total IgE (147050) concentrations in an atopic population and with asthma in an asthmatic population\; and the variant val379 allele (A379V\; 601690.0003) was found to be highly associated with specific sensitization in the atopic population and with asthma in an asthmatic population. (Previously named human-pafa. Other names: 1-alkyl-2-acetylglycerophosphocholine esterase 2-acetyl-1-alkylglycerophosphocholine esterase Group-VIIA phospholipase A2, gVIIA-PLA2, LDL-associated phospholipase A2, LDL-PLA(2), Lp-PLA2). A rationally designed mutant (W298H<\/A>) of plasma platelet-activating factor acetylhydrolase PLA2G7, which hydrolyzes the organophosphorus nerve agent soman is published by Kirby et al.<\/A> A positive correlation with PLA2G7 levels has been found in certain disease states, including cardiovascular disorders, dementia,4 diabetic macular edema5 and prostate cancer. Consequently, inhibitors of PLA2G7 have been clinically investigated in atherosclerosis and Alzheimer's disease. Alternative names: 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, Group-VIIA phospholipase A2 (gVIIA-PLA2), LDL-associated phospholipase A2 (LDL-PLA(2))
Relationship
Family : PAF-Acetylhydrolase
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
3D59 - Crystal structure of human plasma platelet activating factor acetylhydrolase
3D5E - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by paraoxon
3F96 - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Sarin
3F97 - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Soman
3F98 - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Tabun
3F9C - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Diisopropylfluorophosphate
5I8P - Crystal structure of human LP_PLA2 in complex with novel inhibitor
5I9I - Crystal structure of human LP_PLA2 in complex with Darapladib
5JAD - Compound binding to human Lipoprotein-associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening
5JAH - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAL - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAN - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAO - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAP - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAR - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAS - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAT - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5JAU - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening
5LP1 - Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a [1.1.1]bicyclopentane- containing inhibitor at 1.91 A resolution
5LYY - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3908555
5LZ2 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 3-cyano-N-cyclopropylbenzenesulfonamide
5LZ4 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3975283
5LZ5 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3983270
5LZ7 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2
5LZ8 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2
5LZ9 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2
5YE7 - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor
5YE8 - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor
5YE9 - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor
5YEA - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor
6M06 - Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M06-BWF Compound 5
6M07 - Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M07-BWO compound 8
6M08 - Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M08-BWO compound 7
No kinetic
3-cyano-N-cyclopropylbenzenesulfonamide
5LP1-71H
5LZ9-7BR
6M06-BWF
6M07-BWO
6M08-BWL
7BP-5LZ8
CHEMBL1610004-P9
CHEMBL351434
CHEMBL3792924
CHEMBL3793506
CHEMBL3908555
CHEMBL3924430
CHEMBL3975283
CHEMBL3983270
CHEMBL4069230
CHEMBL4075815
CHEMBL4076292
CHEMBL4076637
DFP
Darapladib
GTPL9797
JMN4
Paraoxon
Rilapladib
SB-222657
SCHEMBL20516363
Soman
WWL153
Sequence
Peptide
MVPPKLHVLF CLCGCLAVVY PFDWQYINPV AHMKSSAWVN KIQVLMAAAS FGQTKIPRGN GPYSVGCTDL MFDHTNKGTF LRLYYPSQDN DRLDTLWIPN KEYFWGLSKF LGTHWLMGNI LRLLFGSMTT PANWNSPLRP GEKYPLVVFS HGLGAFRTLY SAIGIDLASH GFIVAAVEHR DRSASATYYF KDQSAAEIGD KSWLYLRTLK QEEETHIRNE QVRQRAKECS QALSLILDID HGKPVKNALD LKFDMEQLKD SIDREKIAVI GHSFGGATVI QTLSEDQRFR CGIALDAWMF PLGDEVYSRI PQPLFFINSE YFQYPANIIK MKKCYSPDKE RKMITIRGSV HQNFADFTFA TGKIIGHMLK LKGDIDSNVA IDLSNKASLA FLQKHLGLHK DFDQWDCLIE GDDENLIPGT NINTTNQHIM LQNSSGIEKY N
References (99)
| Title : Correlation of LP-PLA2 and MMP-9 with the occurrence of early neurological deterioration in patients with acute ischemic stroke - Yu_2024_Medicine.(Baltimore)_103_e38310 |
| Author(s) : Yu B , Shi G , Yang F , Xu W |
| Ref : Medicine (Baltimore) , 103 :e38310 , 2024 |
| Abstract : |
| PubMedSearch : Yu_2024_Medicine.(Baltimore)_103_e38310 |
| PubMedID: 38788013 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Bioinformatics Analysis Identifies PLA2G7 as a Key Antigen-Presenting Prognostic Related Gene Promoting Hepatocellular Carcinoma through the STAT1\/PD-L1 Axis - Guo_2024_Front.Biosci.(Landmark.Ed)_29_39 |
| Author(s) : Guo S , Yang Q |
| Ref : Front Biosci (Landmark Ed) , 29 :39 , 2024 |
| Abstract : |
| PubMedSearch : Guo_2024_Front.Biosci.(Landmark.Ed)_29_39 |
| PubMedID: 38287833 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma - Zhang_2024_J.Immunother.Cancer_12_e008094 |
| Author(s) : Zhang F , Liu W , Meng F , Jiang Q , Tang W , Liu Z , Lin X , Xue R , Zhang S , Dong L |
| Ref : J Immunother Cancer , 12 : , 2024 |
| Abstract : |
| PubMedSearch : Zhang_2024_J.Immunother.Cancer_12_e008094 |
| PubMedID: 38272562 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2\/STAT3 pathway - Yao_2023_PeerJ_11_e15639 |
| Author(s) : Yao J , Zhao Y |
| Ref : PeerJ , 11 :e15639 , 2023 |
| Abstract : |
| PubMedSearch : Yao_2023_PeerJ_11_e15639 |
| PubMedID: 37397012 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-Associated Phospholipase A2 Activity as Potential Biomarker of Vascular Dementia - Zuliani_2023_Antioxidants.(Basel)_12_597 |
| Author(s) : ZulianiZuliani G , Marsillach J , Trentini A , Rosta V , Cervellati C |
| Ref : Antioxidants (Basel) , 12 :597 , 2023 |
| Abstract : |
| PubMedSearch : Zuliani_2023_Antioxidants.(Basel)_12_597 |
| PubMedID: 36978845 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : PLA2G7\/PAF-AH as Potential Negative Regulator of the Wnt Signaling Pathway Mediates Protective Effects in BRCA1 Mutant Breast Cancer - Liao_2023_Int.J.Mol.Sci_24_882 |
| Author(s) : Liao Y , Badmann S , Kraus F , Topalov NE , Mayr D , Kolben T , Hester A , Beyer S , Mahner S , Jeschke U , Trillsch F , Czogalla B , Burges A |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Liao_2023_Int.J.Mol.Sci_24_882 |
| PubMedID: 36614323 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Changes and significance of serum monocyte chemoattractant protein-1 and Lp-PLA2 in patients with hypertension and coronary heart disease - Tian_2022_J.Pak.Med.Assoc_72_1114 |
| Author(s) : Tian Y , Fan Y , Chen L , Sun M |
| Ref : J Pak Med Assoc , 72 :1114 , 2022 |
| Abstract : |
| PubMedSearch : Tian_2022_J.Pak.Med.Assoc_72_1114 |
| PubMedID: 35751319 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke - Zhang_2022_Cardiovasc.Ther_2022_3328574 |
| Author(s) : Zhang S , Huang S , Hu D , Jiang F , Lv Y , Liu G |
| Ref : Cardiovasc Ther , 2022 :3328574 , 2022 |
| Abstract : |
| PubMedSearch : Zhang_2022_Cardiovasc.Ther_2022_3328574 |
| PubMedID: 36313479 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association Lp-PLA2 Gene Polymorphisms with Coronary Heart Disease - Ma_2022_Dis.Markers_2022_9775699 |
| Author(s) : Ma S , Ding L , Cai M , Chen L , Yan B , Yang J |
| Ref : Dis Markers , 2022 :9775699 , 2022 |
| Abstract : |
| PubMedSearch : Ma_2022_Dis.Markers_2022_9775699 |
| PubMedID: 35818585 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling - Li_2021_Anal.Chem_93_8161 |
| Author(s) : Li X , Chandra D , Letarte S , Adam GC , Welch J , Yang RS , Rivera S , Bodea S , Dow A , Chi A , Strulson CA , Richardson DD |
| Ref : Analytical Chemistry , 93 :8161 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Anal.Chem_93_8161 |
| PubMedID: 34032423 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme - Khan_2020_J.Inflamm.Res_13_1125 |
| Author(s) : Khan MI , Hariprasad G |
| Ref : J Inflamm Res , 13 :1125 , 2020 |
| Abstract : |
| PubMedSearch : Khan_2020_J.Inflamm.Res_13_1125 |
| PubMedID: 33364808 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Phospholipase A2 is an Inflammatory Predictor in Cardiovascular Diseases: Is there any Spacious Room to Prove the Causation? - Santoso_2020_Curr.Cardiol.Rev_16_3 |
| Author(s) : Santoso A , Heriansyah T , Rohman MS |
| Ref : Curr Cardiol Rev , 16 :3 , 2020 |
| Abstract : |
| PubMedSearch : Santoso_2020_Curr.Cardiol.Rev_16_3 |
| PubMedID: 31146670 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The rs1051931 G>A Polymorphism in the PLA2G7 Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population - Gu_2020_Front.Pediatr_8_338 |
| Author(s) : Gu X , Lin W , Xu Y , Che D , Tan Y , Lu Z , Pi L , Fu L , Zhou H , Jiang Z |
| Ref : Front Pediatr , 8 :338 , 2020 |
| Abstract : |
| PubMedSearch : Gu_2020_Front.Pediatr_8_338 |
| PubMedID: 32656171 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach - Huang_2020_J.Med.Chem_63_7052 |
| Author(s) : Huang F , Hu H , Wang K , Peng C , Xu W , Zhang Y , Gao J , Liu Y , Zhou H , Huang R , Li M , Shen J , Xu Y |
| Ref : Journal of Medicinal Chemistry , 63 :7052 , 2020 |
| Abstract : |
| PubMedSearch : Huang_2020_J.Med.Chem_63_7052 |
| PubMedID: 32459096 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2: The story continues - Huang_2020_Med.Res.Rev_40_79 |
| Author(s) : Huang F , Wang K , Shen J |
| Ref : Med Res Rev , 40 :79 , 2020 |
| Abstract : |
| PubMedSearch : Huang_2020_Med.Res.Rev_40_79 |
| PubMedID: 31140638 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The association between the D166E polymorphism of the lipoprotein associated phospholipase A2 and risk of myocardial infarction - Zhang_2019_Eur.Rev.Med.Pharmacol.Sci_23_3960 |
| Author(s) : Zhang MM , Zhang CG , Yang CJ , Zhao P , Li YL |
| Ref : Eur Rev Med Pharmacol Sci , 23 :3960 , 2019 |
| Abstract : |
| PubMedSearch : Zhang_2019_Eur.Rev.Med.Pharmacol.Sci_23_3960 |
| PubMedID: 31115024 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis - Hu_2019_Biomed.Res.Int_2019_8642784 |
| Author(s) : Hu G , Liu D , Tong H , Huang W , Hu Y , Huang Y |
| Ref : Biomed Res Int , 2019 :8642784 , 2019 |
| Abstract : |
| PubMedSearch : Hu_2019_Biomed.Res.Int_2019_8642784 |
| PubMedID: 31236414 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 predicts cardiovascular events in dialyzed patients - De Mauri_2019_J.Nephrol_32_283 |
| Author(s) : De Mauri A , Vidali M , Chiarinotti D , Bellomo G , Rolla R |
| Ref : J Nephrol , 32 :283 , 2019 |
| Abstract : |
| PubMedSearch : De Mauri_2019_J.Nephrol_32_283 |
| PubMedID: 30168082 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population - Chi_2018_J.Thromb.Thrombolysis_46_125 |
| Author(s) : Chi Y , Shi C , Zhang X , Xi Y |
| Ref : J Thromb Thrombolysis , 46 :125 , 2018 |
| Abstract : |
| PubMedSearch : Chi_2018_J.Thromb.Thrombolysis_46_125 |
| PubMedID: 29728838 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The Prognostic Value of Lipoprotein-Associated Phospholipase A(2) in the Long-Term Care of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention - Yang_2018_Clin.Appl.Thromb.Hemost_24_822 |
| Author(s) : Yang L , Wang H , Zhang Y , Han T , Wang W |
| Ref : Clin Appl Thromb Hemost , 24 :822 , 2018 |
| Abstract : |
| PubMedSearch : Yang_2018_Clin.Appl.Thromb.Hemost_24_822 |
| PubMedID: 29121808 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor - Measom_2017_ACS.Med.Chem.Lett_8_43 |
| Author(s) : Measom ND , Down KD , Hirst DJ , Jamieson C , Manas ES , Patel VK , Somers DO |
| Ref : ACS Med Chem Lett , 8 :43 , 2017 |
| Abstract : |
| PubMedSearch : Measom_2017_ACS.Med.Chem.Lett_8_43 |
| PubMedID: 28105273 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between Lp-PLA2 and coronary heart disease in Chinese patients - Yang_2017_J.Int.Med.Res_45_159 |
| Author(s) : Yang L , Liu Y , Wang S , Liu T , Cong H |
| Ref : J Internal Medicine Res , 45 :159 , 2017 |
| Abstract : |
| PubMedSearch : Yang_2017_J.Int.Med.Res_45_159 |
| PubMedID: 28222638 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib - Yeo_2017_PLoS.One_12_e0182115 |
| Author(s) : Yeo A , Li L , Warren L , Aponte J , Fraser D , King K , Johansson K , Barnes A , Macphee C , Davies R , Chissoe S , Tarka E , O'Donoghue ML , White HD , Wallentin L , Waterworth D |
| Ref : PLoS ONE , 12 :e0182115 , 2017 |
| Abstract : |
| PubMedSearch : Yeo_2017_PLoS.One_12_e0182115 |
| PubMedID: 28753643 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis - Santoso_2017_Am.J.Cardiovasc.Dis_7_122 |
| Author(s) : Santoso A , Maulana R , Alzahra F , Maghfirah I , Putrinarita AD , Heriansyah T |
| Ref : Am J Cardiovasc Dis , 7 :122 , 2017 |
| Abstract : |
| PubMedSearch : Santoso_2017_Am.J.Cardiovasc.Dis_7_122 |
| PubMedID: 29348973 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure - Kim_2017_PLoS.One_12_e0173611 |
| Author(s) : Kim M , Yoo HJ , Jang HY , Lee SH , Lee JH |
| Ref : PLoS ONE , 12 :e0173611 , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_PLoS.One_12_e0173611 |
| PubMedID: 28334001 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association of Lp-PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population - Ni_2017_J.Biochem.Mol.Toxicol_31_ |
| Author(s) : Ni J , Gu H , Hu W , Zhou F , Zhu X , Wang K |
| Ref : J Biochem Mol Toxicol , 31 : , 2017 |
| Abstract : |
| PubMedSearch : Ni_2017_J.Biochem.Mol.Toxicol_31_ |
| PubMedID: 28960681 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 - Liu_2017_J.Med.Chem_60_10231 |
| Author(s) : Liu Q , Huang F , Yuan X , Wang K , Zou Y , Shen J , Xu Y |
| Ref : Journal of Medicinal Chemistry , 60 :10231 , 2017 |
| Abstract : |
| PubMedSearch : Liu_2017_J.Med.Chem_60_10231 |
| PubMedID: 29193967 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population - Haghdoost_2016_Iran.J.Neurol_15_80 |
| Author(s) : Haghdoost F , Gharzi M , Faez F , Hosseinzadeh E , Tajaddini M , Ra Ei L , Asgari F , Banihashemi M , Masjedi SS , Zandifar A , Haghjooy-Javanmard S |
| Ref : Iran Journal of Neurology , 15 :80 , 2016 |
| Abstract : |
| PubMedSearch : Haghdoost_2016_Iran.J.Neurol_15_80 |
| PubMedID: 27326362 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening - Woolford_2016_J.Med.Chem_59_5356 |
| Author(s) : Woolford AJ , Pero JE , Aravapalli S , Berdini V , Coyle JE , Day PJ , Dodson AM , Grondin P , Holding FP , Lee LY , Li P , Manas ES , Marino J, Jr. , Martin AC , McCleland BW , McMenamin RL , Murray CW , Neipp CE , Page LW , Patel VK , Potvain F , Rich S , Rivero RA , Smith K , Somers DO , Trottet L , Velagaleti R , Williams G , Xie R |
| Ref : Journal of Medicinal Chemistry , 59 :5356 , 2016 |
| Abstract : |
| PubMedSearch : Woolford_2016_J.Med.Chem_59_5356 |
| PubMedID: 27167608 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults - Millwood_2016_Int.J.Epidemiol_45_1588 |
| Author(s) : Millwood IY , Bennett DA , Walters RG , Clarke R , Waterworth D , Johnson T , Chen Y , Yang L , Guo Y , Bian Z , Hacker A , Yeo A , Parish S , Hill MR , Chissoe S , Peto R , Cardon L , Collins R , Li L , Chen Z |
| Ref : Int J Epidemiol , 45 :1588 , 2016 |
| Abstract : |
| PubMedSearch : Millwood_2016_Int.J.Epidemiol_45_1588 |
| PubMedID: 27301456 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema - Chen_2016_J.Med.Chem_59_2674 |
| Author(s) : Chen X , Wang K , Xu W , Ma Q , Chen M , Du L , Mo M , Wang Y , Shen J |
| Ref : Journal of Medicinal Chemistry , 59 :2674 , 2016 |
| Abstract : |
| PubMedSearch : Chen_2016_J.Med.Chem_59_2674 |
| PubMedID: 26927682 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction - Cahyaningtias_2016_Genes.Dis_3_289 |
| Author(s) : Cahyaningtias M , Rohman MS , Widodo , Wahjono Adi A , Yuda R , Indrayana Y , Putri JF , Rusdianto , Lukitasari M , Hendrawan D |
| Ref : Genes Dis , 3 :289 , 2016 |
| Abstract : |
| PubMedSearch : Cahyaningtias_2016_Genes.Dis_3_289 |
| PubMedID: 30258899 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A, and subsequent cardiovascular events and mortality among patients with coronary heart disease - Benderly_2016_Biomarkers__1 |
| Author(s) : Benderly M , Sapir B , Kalter-Leibovici O , Zimlichman R |
| Ref : Biomarkers , :1 , 2016 |
| Abstract : |
| PubMedSearch : Benderly_2016_Biomarkers__1 |
| PubMedID: 27097870 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) - Woolford_2016_J.Med.Chem_59_10738 |
| Author(s) : Woolford AJ , Day PJ , Beneton V , Berdini V , Coyle JE , Dudit Y , Grondin P , Huet P , Lee LY , Manas ES , McMenamin RL , Murray CW , Page LW , Patel VK , Potvain F , Rich SJ , Sang Y , Somers DO , Trottet L , Wan Z , Zhang X |
| Ref : Journal of Medicinal Chemistry , 59 :10738 , 2016 |
| Abstract : |
| PubMedSearch : Woolford_2016_J.Med.Chem_59_10738 |
| PubMedID: 27933945 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors - Liu_2016_J.Med.Chem_59_5115 |
| Author(s) : Liu Q , Chen X , Chen W , Yuan X , Su H , Shen J , Xu Y |
| Ref : Journal of Medicinal Chemistry , 59 :5115 , 2016 |
| Abstract : |
| PubMedSearch : Liu_2016_J.Med.Chem_59_5115 |
| PubMedID: 27078579 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Relationship between plasma phospholipase A2 concentrations and lipoprotein subfractions in patients with stable coronary artery disease - Xu_2015_Clin.Chim.Acta_446_195 |
| Author(s) : Xu RX , Zhang Y , Li XL , Li S , Guo YL , Dong Q , Liu G , Li JJ |
| Ref : Clinica Chimica Acta , 446 :195 , 2015 |
| Abstract : |
| PubMedSearch : Xu_2015_Clin.Chim.Acta_446_195 |
| PubMedID: 25934512 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Nonsynonymous polymorphisms in PLA2G7 gene are associated with the risk of coronary heart disease in a southern Chinese population - Hong_2015_Mamm.Genome_26_191 |
| Author(s) : Hong M , Zhang M , Lu X |
| Ref : Mamm Genome , 26 :191 , 2015 |
| Abstract : |
| PubMedSearch : Hong_2015_Mamm.Genome_26_191 |
| PubMedID: 25690150 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population - Karasawa_2015_Enzymes_38_117 |
| Author(s) : Karasawa K |
| Ref : Enzymes , 38 :117 , 2015 |
| Abstract : |
| PubMedSearch : Karasawa_2015_Enzymes_38_117 |
| PubMedID: 26612650 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors - Chen_2015_J.Med.Chem_58_8529 |
| Author(s) : Chen X , Xu W , Wang K , Mo M , Zhang W , Du L , Yuan X , Xu Y , Wang Y , Shen J |
| Ref : Journal of Medicinal Chemistry , 58 :8529 , 2015 |
| Abstract : |
| PubMedSearch : Chen_2015_J.Med.Chem_58_8529 |
| PubMedID: 26479945 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease - Maiolino_2015_J.Cardiovasc.Med.(Hagerstown)_16_29 |
| Author(s) : Maiolino G , Lenzini L , Pedon L , Cesari M , Seccia TM , Frigo AC , Rossitto G , Caroccia B , Rossi GP |
| Ref : J Cardiovasc Med (Hagerstown) , 16 :29 , 2015 |
| Abstract : |
| PubMedSearch : Maiolino_2015_J.Cardiovasc.Med.(Hagerstown)_16_29 |
| PubMedID: 24732951 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman - Kirby_2015_Biochim.Biophys.Acta_1854_1809 |
| Author(s) : Kirby SD , Norris J , Sweeney R , Bahnson BJ , Cerasoli DM |
| Ref : Biochimica & Biophysica Acta , 1854 :1809 , 2015 |
| Abstract : |
| PubMedSearch : Kirby_2015_Biochim.Biophys.Acta_1854_1809 |
| PubMedID: 26343853 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Associations of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms with circulating PAF-AH levels and risk of coronary heart disease or blood stasis syndrome in the Chinese Han population - Zheng_2014_Mol.Biol.Rep_41_7141 |
| Author(s) : Zheng GH , Xiong SQ , Chen HY , Mei LJ , Wang T |
| Ref : Mol Biol Rep , 41 :7141 , 2014 |
| Abstract : |
| PubMedSearch : Zheng_2014_Mol.Biol.Rep_41_7141 |
| PubMedID: 25034894 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Changes in lipoprotein-Associated phospholipase A2 activity predict coronary events and partly account for the treatment effect of pravastatin: results from the Long-Term Intervention with Pravastatin in Ischemic Disease study - White_2013_J.Am.Heart.Assoc_2_e000360 |
| Author(s) : White HD , Simes J , Stewart RA , Blankenberg S , Barnes EH , Marschner IC , Thompson P , West M , Zeller T , Colquhoun DM , Nestel P , Keech AC , Sullivan DR , Hunt D , Tonkin A |
| Ref : J Am Heart Assoc , 2 :e000360 , 2013 |
| Abstract : |
| PubMedSearch : White_2013_J.Am.Heart.Assoc_2_e000360 |
| PubMedID: 24152981 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations - Song_2012_Pharmacogenomics.J_12_425 |
| Author(s) : Song K , Nelson MR , Aponte J , Manas ES , Bacanu SA , Yuan X , Kong X , Cardon L , Mooser VE , Whittaker JC , Waterworth DM |
| Ref : Pharmacogenomics J , 12 :425 , 2012 |
| Abstract : |
| PubMedSearch : Song_2012_Pharmacogenomics.J_12_425 |
| PubMedID: 21606947 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high risk coronary artery disease patients - Maiolino_2012_PLoS.One_7_e48171 |
| Author(s) : Maiolino G , Pedon L , Cesari M , Frigo AC , Wolfert RL , Barisa M , Pagliani L , Rossitto G , Seccia TM , Zanchetta M , Rossi GP |
| Ref : PLoS ONE , 7 :e48171 , 2012 |
| Abstract : |
| PubMedSearch : Maiolino_2012_PLoS.One_7_e48171 |
| PubMedID: 23118945 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Carriage of the V279F null allele within the gene encoding Lp-PLA(2) is protective from coronary artery disease in South Korean males - Jang_2011_PLoS.One_6_e18208 |
| Author(s) : Jang Y , Waterworth D , Lee JE , Song K , Kim S , Kim HS , Park KW , Cho HJ , Oh IY , Park JE , Lee BS , Ku HJ , Shin DJ , Lee JH , Jee SH , Han BG , Jang HY , Cho EY , Vallance P , Whittaker J , Cardon L , Mooser V |
| Ref : PLoS ONE , 6 :e18208 , 2011 |
| Abstract : |
| PubMedSearch : Jang_2011_PLoS.One_6_e18208 |
| PubMedID: 21490708 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis - Zheng_2011_Mol.Biol.Rep_38_4089 |
| Author(s) : Zheng GH , Chen HY , Xiong SQ , Chu JF |
| Ref : Mol Biol Rep , 38 :4089 , 2011 |
| Abstract : |
| PubMedSearch : Zheng_2011_Mol.Biol.Rep_38_4089 |
| PubMedID: 21107710 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein associated phospholipase A(2): role in atherosclerosis and utility as a biomarker for cardiovascular risk - Colley_2011_EPMA.J_2_27 |
| Author(s) : Colley KJ , Wolfert RL , Cobble ME |
| Ref : EPMA J , 2 :27 , 2011 |
| Abstract : |
| PubMedSearch : Colley_2011_EPMA.J_2_27 |
| PubMedID: 21654904 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population - Li_2011_Ann.Hum.Genet_75_605 |
| Author(s) : Li L , Qi L , Lv N , Gao Q , Cheng Y , Wei Y , Ye J , Yan X , Dang A |
| Ref : Ann Hum Genet , 75 :605 , 2011 |
| Abstract : |
| PubMedSearch : Li_2011_Ann.Hum.Genet_75_605 |
| PubMedID: 21834908 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome - Fan_2010_Hum.Reprod_25_1288 |
| Author(s) : Fan P , Liu Hw , Wang XS , Zhang F , Song Q , Li Q , Wu HM , Bai H |
| Ref : Hum Reprod , 25 :1288 , 2010 |
| Abstract : |
| PubMedSearch : Fan_2010_Hum.Reprod_25_1288 |
| PubMedID: 20185515 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry - Casas_2010_Circulation_121_2284 |
| Author(s) : Casas JP , Ninio E , Panayiotou A , Palmen J , Cooper JA , Ricketts SL , Sofat R , Nicolaides AN , Corsetti JP , Fowkes FG , Tzoulaki I , Kumari M , Brunner EJ , Kivimaki M , Marmot MG , Hoffmann MM , Winkler K , Marz W , Ye S , Stirnadel HA , Boekholdt SM , Khaw KT , Humphries SE , Sandhu MS , Hingorani AD , Talmud PJ |
| Ref : Circulation , 121 :2284 , 2010 |
| Abstract : |
| PubMedSearch : Casas_2010_Circulation_121_2284 |
| PubMedID: 20479152 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2: role in atherosclerosis and utility as a cardiovascular biomarker - Toth_2010_Expert.Rev.Cardiovasc.Ther_8_425 |
| Author(s) : Toth PP , McCullough PA , Wegner MS , Colley KJ |
| Ref : Expert Rev Cardiovasc Ther , 8 :425 , 2010 |
| Abstract : |
| PubMedSearch : Toth_2010_Expert.Rev.Cardiovasc.Ther_8_425 |
| PubMedID: 20222820 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : PLA2G7 gene polymorphisms and coronary heart disease risk: a meta-analysis - Wang_2010_Thromb.Res_126_498 |
| Author(s) : Wang Q , Hao Y , Mo X , Wang L , Lu X , Huang J , Cao J , Li H , Gu D |
| Ref : Thromb Res , 126 :498 , 2010 |
| Abstract : |
| PubMedSearch : Wang_2010_Thromb.Res_126_498 |
| PubMedID: 20926117 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study) - Hoffmann_2009_J.Thromb.Haemost_7_41 |
| Author(s) : Hoffmann MM , Winkler K , Renner W , Winkelmann BR , Seelhorst U , Wellnitz B , Boehm BO , Marz W |
| Ref : J Thromb Haemost , 7 :41 , 2009 |
| Abstract : |
| PubMedSearch : Hoffmann_2009_J.Thromb.Haemost_7_41 |
| PubMedID: 18983494 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study - Hou_2009_Hum.Genet_125_11 |
| Author(s) : Hou L , Chen S , Yu H , Lu X , Chen J , Wang L , Huang J , Fan Z , Gu D |
| Ref : Hum Genet , 125 :11 , 2009 |
| Abstract : |
| PubMedSearch : Hou_2009_Hum.Genet_125_11 |
| PubMedID: 19034521 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype - Li_2009_J.Clin.Pharm.Ther_34_447 |
| Author(s) : Li S , Stuart L , Zhang Y , Meduri GU , Umberger R , Yates CR |
| Ref : J Clin Pharm Ther , 34 :447 , 2009 |
| Abstract : |
| PubMedSearch : Li_2009_J.Clin.Pharm.Ther_34_447 |
| PubMedID: 19583678 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Effects of G994T in the Lp-PLA2 gene on the plasma oxidized LDL level and carotid intima-media thickness in Japanese: the Shimane study - Wang_2009_Am.J.Hypertens_22_742 |
| Author(s) : Wang T , Karino K , Yamasaki M , Zhang Y , Masuda J , Yamaguchi S , Shiwaku K , Nabika T |
| Ref : Am J Hypertens , 22 :742 , 2009 |
| Abstract : |
| PubMedSearch : Wang_2009_Am.J.Hypertens_22_742 |
| PubMedID: 19373214 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes - Samanta_2009_Biochem.Pharmacol_78_420 |
| Author(s) : Samanta U , Kirby SD , Srinivasan P , Cerasoli DM , Bahnson BJ |
| Ref : Biochemical Pharmacology , 78 :420 , 2009 |
| Abstract : |
| PubMedSearch : Samanta_2009_Biochem.Pharmacol_78_420 |
| PubMedID: 19394314 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein - Gardner_2008_J.Biol.Chem_283_17099 |
| Author(s) : Gardner AA , Reichert EC , Topham MK , Stafforini DM |
| Ref : Journal of Biological Chemistry , 283 :17099 , 2008 |
| Abstract : |
| PubMedSearch : Gardner_2008_J.Biol.Chem_283_17099 |
| PubMedID: 18434304 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development - Wilensky_2008_Nat.Med_14_1059 |
| Author(s) : Wilensky RL , Shi Y , Mohler ER, 3rd , Hamamdzic D , Burgert ME , Li J , Postle A , Fenning RS , Bollinger JG , Hoffman BE , Pelchovitz DJ , Yang J , Mirabile RC , Webb CL , Zhang L , Zhang P , Gelb MH , Walker MC , Zalewski A , Macphee CH |
| Ref : Nat Med , 14 :1059 , 2008 |
| Abstract : |
| PubMedSearch : Wilensky_2008_Nat.Med_14_1059 |
| PubMedID: 18806801 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets - Sutton_2008_Hum.Mol.Genet_17_1318 |
| Author(s) : Sutton BS , Crosslin DR , Shah SH , Nelson SC , Bassil A , Hale AB , Haynes C , Goldschmidt-Clermont PJ , Vance JM , Seo D , Kraus WE , Gregory SG , Hauser ER |
| Ref : Hum Mol Genet , 17 :1318 , 2008 |
| Abstract : |
| PubMedSearch : Sutton_2008_Hum.Mol.Genet_17_1318 |
| PubMedID: 18204052 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis - Samanta_2008_J.Biol.Chem_283_31617 |
| Author(s) : Samanta U , Bahnson BJ |
| Ref : Journal of Biological Chemistry , 283 :31617 , 2008 |
| Abstract : |
| PubMedSearch : Samanta_2008_J.Biol.Chem_283_31617 |
| PubMedID: 18784071 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Comprehensive evaluation of genetic and environmental factors influencing the plasma lipoprotein-associated phospholipase A2 activity in a Japanese population - Zhang_2007_Hypertens.Res_30_403 |
| Author(s) : Zhang SY , Shibata H , Karino K , Wang BY , Kobayashi S , Masuda J , Nabika T |
| Ref : Hypertens Res , 30 :403 , 2007 |
| Abstract : |
| PubMedSearch : Zhang_2007_Hypertens.Res_30_403 |
| PubMedID: 17587752 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training - Wootton_2007_Nutr.Metab.Cardiovasc.Dis_17_24 |
| Author(s) : Wootton PT , Flavell DM , Montgomery HE , World M , Humphries SE , Talmud PJ |
| Ref : Nutr Metab Cardiovasc Dis , 17 :24 , 2007 |
| Abstract : |
| PubMedSearch : Wootton_2007_Nutr.Metab.Cardiovasc.Dis_17_24 |
| PubMedID: 17174223 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men - Jang_2006_J.Clin.Endocrinol.Metab_91_3521 |
| Author(s) : Jang Y , Kim OY , Koh SJ , Chae JS , Ko YG , Kim JY , Cho H , Jeong TS , Lee WS , Ordovas JM , Lee JH |
| Ref : J Clinical Endocrinology Metab , 91 :3521 , 2006 |
| Abstract : |
| PubMedSearch : Jang_2006_J.Clin.Endocrinol.Metab_91_3521 |
| PubMedID: 16787988 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction - Liu_2006_J.Thromb.Haemost_4_1023 |
| Author(s) : Liu PY , Li YH , Wu HL , Chao TH , Tsai LM , Lin LJ , Shi GY , Chen JH |
| Ref : J Thromb Haemost , 4 :1023 , 2006 |
| Abstract : |
| PubMedSearch : Liu_2006_J.Thromb.Haemost_4_1023 |
| PubMedID: 16689754 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients - Sekuri_2006_Anadolu.Kardiyol.Derg_6_132 |
| Author(s) : Sekuri C , Cam FS , Tengiz I , Ercan E , Bayturan O , Berdeli A |
| Ref : Anadolu Kardiyol Derg , 6 :132 , 2006 |
| Abstract : |
| PubMedSearch : Sekuri_2006_Anadolu.Kardiyol.Derg_6_132 |
| PubMedID: 16766276 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese - Mashiba_2005_Circ.J_69_1466 |
| Author(s) : Mashiba J , Koike G , Kamiunten H , Ikeda M , Sunagawa K |
| Ref : Circ J , 69 :1466 , 2005 |
| Abstract : |
| PubMedSearch : Mashiba_2005_Circ.J_69_1466 |
| PubMedID: 16308493 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients - Ishihara_2004_J.Hum.Genet_49_302 |
| Author(s) : Ishihara M , Iwasaki T , Nagano M , Ishii J , Takano M , Kujiraoka T , Tsuji M , Hattori H , Emi M |
| Ref : J Hum Genet , 49 :302 , 2004 |
| Abstract : |
| PubMedSearch : Ishihara_2004_J.Hum.Genet_49_302 |
| PubMedID: 15148590 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease - Ninio_2004_Hum.Mol.Genet_13_1341 |
| Author(s) : Ninio E , Tregouet D , Carrier JL , Stengel D , Bickel C , Perret C , Rupprecht HJ , Cambien F , Blankenberg S , Tiret L |
| Ref : Hum Mol Genet , 13 :1341 , 2004 |
| Abstract : |
| PubMedSearch : Ninio_2004_Hum.Mol.Genet_13_1341 |
| PubMedID: 15115767 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe - Abuzeid_2003_Atherosclerosis_168_283 |
| Author(s) : Abuzeid AM , Hawe E , Humphries SE , Talmud PJ |
| Ref : Atherosclerosis , 168 :283 , 2003 |
| Abstract : |
| PubMedSearch : Abuzeid_2003_Atherosclerosis_168_283 |
| PubMedID: 12801611 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients - Yamamoto_2003_Diabetes.Res.Clin.Pract_59_219 |
| Author(s) : Yamamoto I , Fujitsu J , Nohnen S , Igarashi T , Motomura T , Inaba M , Tsubakimori S , Azuma J |
| Ref : Diabetes Res Clin Pract , 59 :219 , 2003 |
| Abstract : |
| PubMedSearch : Yamamoto_2003_Diabetes.Res.Clin.Pract_59_219 |
| PubMedID: 12590019 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A simple assay for a human serum phospholipase A2 that is associated with high-density lipoproteins - Petrovic_2001_J.Lipid.Res_42_1706 |
| Author(s) : Petrovic N , Grove C , Langton PE , Misso NL , Thompson PJ |
| Ref : J Lipid Res , 42 :1706 , 2001 |
| Abstract : |
| PubMedSearch : Petrovic_2001_J.Lipid.Res_42_1706 |
| PubMedID: 11590228 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Evidence for the existence of the PAF acetylhydrolase mutation (Val279Phe) in non-Japanese populations: a preliminary study in Turkey, Azerbaijan, and Kyrgyzstan - Balta_2001_Thromb.Res_101_231 |
| Author(s) : Balta G , Gurgey A , Kudayarov DK , Tunc B , Altay C |
| Ref : Thromb Res , 101 :231 , 2001 |
| Abstract : |
| PubMedSearch : Balta_2001_Thromb.Res_101_231 |
| PubMedID: 11248283 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma - Kruse_2000_Am.J.Hum.Genet_66_1522 |
| Author(s) : Kruse S , Mao XQ , Heinzmann A , Blattmann S , Roberts MH , Braun S , Gao PS , Forster J , Kuehr J , Hopkin JM , Shirakawa T , Deichmann KA |
| Ref : American Journal of Human Genetics , 66 :1522 , 2000 |
| Abstract : |
| PubMedSearch : Kruse_2000_Am.J.Hum.Genet_66_1522 |
| PubMedID: 10733466 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group - Packard_2000_N.Engl.J.Med_343_1148 |
| Author(s) : Packard CJ , O'Reilly DS , Caslake MJ , McMahon AD , Ford I , Cooney J , Macphee CH , Suckling KE , Krishna M , Wilkinson FE , Rumley A , Lowe GD |
| Ref : N Engl J Med , 343 :1148 , 2000 |
| Abstract : |
| PubMedSearch : Packard_2000_N.Engl.J.Med_343_1148 |
| PubMedID: 11036120 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population - Yamada_2000_Atherosclerosis_150_209 |
| Author(s) : Yamada Y , Yoshida H , Ichihara S , Imaizumi T , Satoh K , Yokota M |
| Ref : Atherosclerosis , 150 :209 , 2000 |
| Abstract : |
| PubMedSearch : Yamada_2000_Atherosclerosis_150_209 |
| PubMedID: 10781653 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome - Xu_2000_Am.J.Kidney.Dis_36_42 |
| Author(s) : Xu H , Iijima K , Shirakawa T , Shiozawa S , Miwa M , Yamaoka K , Kawamura N , Nakamura H , Yoshikawa N |
| Ref : Am J Kidney Dis , 36 :42 , 2000 |
| Abstract : |
| PubMedSearch : Xu_2000_Am.J.Kidney.Dis_36_42 |
| PubMedID: 10873870 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma - Stafforini_1999_J.Clin.Invest_103_989 |
| Author(s) : Stafforini DM , Numao T , Tsodikov A , Vaitkus D , Fukuda T , Watanabe N , Fueki N , McIntyre TM , Zimmerman GA , Makino S , Prescott SM |
| Ref : J Clinical Investigation , 103 :989 , 1999 |
| Abstract : |
| PubMedSearch : Stafforini_1999_J.Clin.Invest_103_989 |
| PubMedID: 10194471 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy - Tanaka_1999_Am.J.Kidney.Dis_34_289 |
| Author(s) : Tanaka R , Iijima K , Xu H , Inoue Y , Murakami R , Shirakawa T , Nishiyama K , Miwa M , Shiozawa S , Nakamura H , Yoshikawa N |
| Ref : Am J Kidney Dis , 34 :289 , 1999 |
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| PubMedSearch : Tanaka_1999_Am.J.Kidney.Dis_34_289 |
| PubMedID: 10430976 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A genome-wide search for linkage to asthma. German Asthma Genetics Group - Wjst_1999_Genomics_58_1 |
| Author(s) : Wjst M , Fischer G , Immervoll T , Jung M , Saar K , Rueschendorf F , Reis A , Ulbrecht M , Gomolka M , Weiss EH , Jaeger L , Nickel R , Richter K , Kjellman NI , Griese M , von Berg A , Gappa M , Riedel F , Boehle M , van Koningsbruggen S , Schoberth P , Szczepanski R , Dorsch W , Silbermann M , Loesgen S , Scholz M , Bickeboller H , Wichmann HE |
| Ref : Genomics , 58 :1 , 1999 |
| Abstract : |
| PubMedSearch : Wjst_1999_Genomics_58_1 |
| PubMedID: 10333435 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men - Yamada_1998_Metabolism_47_177 |
| Author(s) : Yamada Y , Ichihara S , Fujimura T , Yokota M |
| Ref : Metabolism , 47 :177 , 1998 |
| Abstract : |
| PubMedSearch : Yamada_1998_Metabolism_47_177 |
| PubMedID: 9472966 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension - Yoshida_1998_Thromb.Haemost_80_372 |
| Author(s) : Yoshida H , Imaizumi T , Fujimoto K , Itaya H , Hiramoto M , Yoshimizu N , Fukushi K , Satoh K |
| Ref : Thromb Haemost , 80 :372 , 1998 |
| Abstract : |
| PubMedSearch : Yoshida_1998_Thromb.Haemost_80_372 |
| PubMedID: 9759612 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma - Ober_1998_Hum.Mol.Genet_7_1393 |
| Author(s) : Ober C , Cox NJ , Abney M , Di Rienzo A , Lander ES , Changyaleket B , Gidley H , Kurtz B , Lee J , Nance M , Pettersson A , Prescott J , Richardson A , Schlenker E , Summerhill E , Willadsen S , Parry R |
| Ref : Hum Mol Genet , 7 :1393 , 1998 |
| Abstract : |
| PubMedSearch : Ober_1998_Hum.Mol.Genet_7_1393 |
| PubMedID: 9700192 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children - Xu_1998_Kidney.Int_54_1867 |
| Author(s) : Xu H , Iijima K , Shiozawa S , Tanaka SS , Inoue Y , Shirakawa T , Nishiyama K , Miwa M , Nakamura H , Yoshikawa N |
| Ref : Kidney Int , 54 :1867 , 1998 |
| Abstract : |
| PubMedSearch : Xu_1998_Kidney.Int_54_1867 |
| PubMedID: 9853251 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation - Yamada_1997_Biochem.Biophys.Res.Commun_236_772 |
| Author(s) : Yamada Y , Yokota M |
| Ref : Biochemical & Biophysical Research Communications , 236 :772 , 1997 |
| Abstract : |
| PubMedSearch : Yamada_1997_Biochem.Biophys.Res.Commun_236_772 |
| PubMedID: 9245731 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->\;Phe) is a genetic risk factor for stroke - Hiramoto_1997_Stroke_28_2417 |
| Author(s) : Hiramoto M , Yoshida H , Imaizumi T , Yoshimizu N , Satoh K |
| Ref : Stroke , 28 :2417 , 1997 |
| Abstract : |
| PubMedSearch : Hiramoto_1997_Stroke_28_2417 |
| PubMedID: 9412624 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Systematic screening of the LDL-PLA2 gene for polymorphic variants and case-control analysis in schizophrenia - Bell_1997_Biochem.Biophys.Res.Commun_241_630 |
| Author(s) : Bell R , Collier DA , Rice SQ , Roberts GW , Macphee CH , Kerwin RW , Price J , Gloger IS |
| Ref : Biochemical & Biophysical Research Communications , 241 :630 , 1997 |
| Abstract : |
| PubMedSearch : Bell_1997_Biochem.Biophys.Res.Commun_241_630 |
| PubMedID: 9434759 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation - Svetlov_1996_Arch.Biochem.Biophys_327_113 |
| Author(s) : Svetlov SI , Howard KM , Miwa M , Flickinger BD , Olson MS |
| Ref : Archives of Biochemistry & Biophysics , 327 :113 , 1996 |
| Abstract : |
| PubMedSearch : Svetlov_1996_Arch.Biochem.Biophys_327_113 |
| PubMedID: 8615681 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins - Tew_1996_Arterioscler.Thromb.Vasc.Biol_16_591 |
| Author(s) : Tew DG , Southan C , Rice SQ , Lawrence MP , Li H , Boyd HF , Moores K , Gloger IS , Macphee CH |
| Ref : Arterioscler Thromb Vasc Biol , 16 :591 , 1996 |
| Abstract : |
| PubMedSearch : Tew_1996_Arterioscler.Thromb.Vasc.Biol_16_591 |
| PubMedID: 8624782 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase - Stafforini_1996_J.Clin.Invest_97_2784 |
| Author(s) : Stafforini DM , Satoh K , Atkinson DL , Tjoelker LW , Eberhardt C , Yoshida H , Imaizumi T , Takamatsu S , Zimmerman GA , McIntyre TM , Gray PW , Prescott SM |
| Ref : J Clinical Investigation , 97 :2784 , 1996 |
| Abstract : |
| PubMedSearch : Stafforini_1996_J.Clin.Invest_97_2784 |
| PubMedID: 8675689 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states - |
| Author(s) : Nadel JA |
| Ref : J Clinical Investigation , 97 :2689 , 1996 |
| PubMedID: 8675676 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Anti-inflammatory properties of a platelet-activating factor acetylhydrolase - Tjoelker_1995_Nature_374_549 |
| Author(s) : Tjoelker LW , Wilder C , Eberhardt C , Stafforini DM |
| Ref : Nature , 374 :549 , 1995 |
| Abstract : |
| PubMedSearch : Tjoelker_1995_Nature_374_549 |
| PubMedID: 7700381 |
| Gene_locus related to this paper: bovin-pafa , canfa-pafa , chick-pafa , human-PLA2G7 , mouse-pafa |
| Title : Presence of platelet-activating factor-acetylhydrolase in milk - Furukawa_1993_J.Lipid.Res_34_1603 |
| Author(s) : Furukawa M , Narahara H , Yasuda K , Johnston JM |
| Ref : J Lipid Res , 34 :1603 , 1993 |
| Abstract : |
| PubMedSearch : Furukawa_1993_J.Lipid.Res_34_1603 |
| PubMedID: 8228643 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Novel General Approach for the Assay and Inhibition of Hydrolytic Enzymes Utilizing Suicide-Inhibitory Bifunctionally Linked Substrates (SIBLINKS): Exemplified by a Phospholipase A2 Assay - Washburn_1990_J.Am.Chem.Soc_112_2040 |
| Author(s) : Washburn WN , Dennis |
| Ref : Journal of the American Chemical Society , 112 :2040 , 1990 |
| Abstract : |
| PubMedSearch : Washburn_1990_J.Am.Chem.Soc_112_2040 |
| PubMedID: |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children - Miwa_1988_J.Clin.Invest_82_1983 |
| Author(s) : Miwa M , Miyake T , Yamanaka T , Sugatani J , Suzuki Y , Sakata S , Araki Y , Matsumoto M |
| Ref : J Clinical Investigation , 82 :1983 , 1988 |
| Abstract : |
| PubMedSearch : Miwa_1988_J.Clin.Invest_82_1983 |
| PubMedID: 3198761 |
| Gene_locus related to this paper: human-PLA2G7 |