Zearalenone-hydrolase
Relationship
Comment
The mycotoxin zearalenone has been contaminating maize and other grains. Zearalenone is a macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene, a member of resorcinols; a potent estrogenic metabolite produced by some Giberella species. It has a role as a fungal metabolite and a mycoestrogen. It can be hydrolyzed and inactivated by the lactonase ZHD. Zearalenone differs from other quorum-sensing lactones Fruhauf et al. 2024 describe another family which differs from this previously isolated family. The second family is Zearalenone-hydrolase-fam2 familyDatabase
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (18)
| Title : Degradation mechanism for Zearalenone ring-cleavage by Zearalenone hydrolase RmZHD: A QM\/MM study - Zhou_2020_Sci.Total.Environ_709_135897 |
| Author(s) : Zhou J , Zhu L , Chen J , Wang W , Zhang R , Li Y , Zhang Q |
| Ref : Sci Total Environ , 709 :135897 , 2020 |
| Abstract : Zhou_2020_Sci.Total.Environ_709_135897 |
| ESTHER : Zhou_2020_Sci.Total.Environ_709_135897 |
| PubMedSearch : Zhou_2020_Sci.Total.Environ_709_135897 |
| PubMedID: 31887512 |
| Gene_locus related to this paper: 9euro-a0a0d2ilk1 |
| Title : The Trp183 is essential in lactonohydrolase ZHD detoxifying zearalenone and zearalenols - Zhou_2020_Biochem.Biophys.Res.Commun_522_986 |
| Author(s) : Zhou H , Li L , Zhan B , Wang S , Li J , Hu XJ |
| Ref : Biochemical & Biophysical Research Communications , 522 :986 , 2020 |
| Abstract : Zhou_2020_Biochem.Biophys.Res.Commun_522_986 |
| ESTHER : Zhou_2020_Biochem.Biophys.Res.Commun_522_986 |
| PubMedSearch : Zhou_2020_Biochem.Biophys.Res.Commun_522_986 |
| PubMedID: 31810602 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Theoretical Study on Zearalenol Compounds Binding with Wild Type Zearalenone Hydrolase and V153H Mutant - Liu_2018_Int.J.Mol.Sci_19_ |
| Author(s) : Liu Y , Wan Y , Zhu J , Yu Z , Tian X , Han J , Zhang Z , Han W |
| Ref : Int J Mol Sci , 19 : , 2018 |
| Abstract : Liu_2018_Int.J.Mol.Sci_19_ |
| ESTHER : Liu_2018_Int.J.Mol.Sci_19_ |
| PubMedSearch : Liu_2018_Int.J.Mol.Sci_19_ |
| PubMedID: 30231501 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Esterase activity inspired selection and characterization of zearalenone degrading bacteria Bacillus pumilus ES-21 - Wang_2017_Food.Control_77_57 |
| Author(s) : Wang G , Yu M , Dong F , Shi J , Xu J |
| Ref : Food Control , 77 :57 , 2017 |
| Abstract : Wang_2017_Food.Control_77_57 |
| ESTHER : Wang_2017_Food.Control_77_57 |
| PubMedSearch : Wang_2017_Food.Control_77_57 |
| PubMedID: |
| Title : Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana - Hui_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_515 |
| Author(s) : Hui R , Hu X , Liu W , Zheng Y , Chen Y , Guo RT , Jin J , Chen CC |
| Ref : Acta Crystallographica F Struct Biol Commun , 73 :515 , 2017 |
| Abstract : Hui_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_515 |
| ESTHER : Hui_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_515 |
| PubMedSearch : Hui_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_515 |
| PubMedID: 28876230 |
| Gene_locus related to this paper: xylba-a0a0d2h023 |
| Title : The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 A resolution - Qi_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_376 |
| Author(s) : Qi Q , Yang WJ , Zhou HJ , Ming DM , Sun KL , Xu TY , Hu XJ , Lv H |
| Ref : Acta Crystallographica F Struct Biol Commun , 73 :376 , 2017 |
| Abstract : Qi_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_376 |
| ESTHER : Qi_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_376 |
| PubMedSearch : Qi_2017_Acta.Crystallogr.F.Struct.Biol.Commun_73_376 |
| PubMedID: 28695844 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Isolation and characterisation of enzymatic zearalenone hydrolysis reaction products - Vekiru_2016_World.Mycotoxin.J_9_353 |
| Author(s) : Vekiru E , Fruhauf S , Hametner C , Schatzmayr G , Krska R , Moll WD , Schuhmacher R |
| Ref : World Mycotoxin Journal , 9 :353 , 2016 |
| Abstract : Vekiru_2016_World.Mycotoxin.J_9_353 |
| ESTHER : Vekiru_2016_World.Mycotoxin.J_9_353 |
| PubMedSearch : Vekiru_2016_World.Mycotoxin.J_9_353 |
| PubMedID: |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : High-level expression of a ZEN-detoxifying gene by codon optimization and biobrick in Pichia pastoris - Xiang_2016_Microbiol.Res_193_48 |
| Author(s) : Xiang L , Wang Q , Zhou Y , Yin L , Zhang G , Ma Y |
| Ref : Microbiol Res , 193 :48 , 2016 |
| Abstract : Xiang_2016_Microbiol.Res_193_48 |
| ESTHER : Xiang_2016_Microbiol.Res_193_48 |
| PubMedSearch : Xiang_2016_Microbiol.Res_193_48 |
| PubMedID: 27825486 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea - Peng_2014_RSC.Adv_4_62321 |
| Author(s) : Peng W , Ko TP , Yang YY , Zheng YY , Chen CC , Zhu Z , Huang CH , Zeng YF , Huang JW , Wang AHJ , Liu JR , Guo RT |
| Ref : RSC Advances , 4 :62321 , 2014 |
| Abstract : Peng_2014_RSC.Adv_4_62321 |
| ESTHER : Peng_2014_RSC.Adv_4_62321 |
| PubMedSearch : Peng_2014_RSC.Adv_4_62321 |
| PubMedID: |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Zearalenone lactonohydrolase activity in Hypocreales and its evolutionary relationships within the epoxide hydrolase subset of a\/b-hydrolases - Popiel_2014_BMC.Microbiol_14_82 |
| Author(s) : Popiel D , Koczyk G , Dawidziuk A , Gromadzka K , Blaszczyk L , Chelkowski J |
| Ref : BMC Microbiol , 14 :82 , 2014 |
| Abstract : Popiel_2014_BMC.Microbiol_14_82 |
| ESTHER : Popiel_2014_BMC.Microbiol_14_82 |
| PubMedSearch : Popiel_2014_BMC.Microbiol_14_82 |
| PubMedID: 24708405 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Zearalenone detoxification by zearalenone hydrolase is important for the antagonistic ability of Clonostachys rosea against mycotoxigenic Fusarium graminearum - Kosawang_2014_Fungal.Biol_118_364 |
| Author(s) : Kosawang C , Karlsson M , Velez H , Rasmussen PH , Collinge DB , Jensen B , Jensen DF |
| Ref : Fungal Biol , 118 :364 , 2014 |
| Abstract : Kosawang_2014_Fungal.Biol_118_364 |
| ESTHER : Kosawang_2014_Fungal.Biol_118_364 |
| PubMedSearch : Kosawang_2014_Fungal.Biol_118_364 |
| PubMedID: 24742831 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Reduced contamination by the Fusarium mycotoxin zearalenone in maize kernels through genetic modification with a detoxification gene - Igawa_2007_Appl.Environ.Microbiol_73_1622 |
| Author(s) : Igawa T , Takahashi-Ando N , Ochiai N , Ohsato S , Shimizu T , Kudo T , Yamaguchi I , Kimura M |
| Ref : Applied Environmental Microbiology , 73 :1622 , 2007 |
| Abstract : Igawa_2007_Appl.Environ.Microbiol_73_1622 |
| ESTHER : Igawa_2007_Appl.Environ.Microbiol_73_1622 |
| PubMedSearch : Igawa_2007_Appl.Environ.Microbiol_73_1622 |
| PubMedID: 17209063 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : A model transgenic cereal plant with detoxification activity for the estrogenic mycotoxin zearalenone - Higa-Nishiyama_2005_Transgenic.Res_14_713 |
| Author(s) : Higa-Nishiyama A , Takahashi-Ando N , Shimizu T , Kudo T , Yamaguchi I , Kimura M |
| Ref : Transgenic Res , 14 :713 , 2005 |
| Abstract : Higa-Nishiyama_2005_Transgenic.Res_14_713 |
| ESTHER : Higa-Nishiyama_2005_Transgenic.Res_14_713 |
| PubMedSearch : Higa-Nishiyama_2005_Transgenic.Res_14_713 |
| PubMedID: 16245162 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Efficient decontamination of zearalenone, the mycotoxin of cereal pathogen, by transgenic yeasts through the expression of a synthetic lactonohydrolase gene - Takahashi-Ando_2005_Appl.Microbiol.Biotechnol_67_838 |
| Author(s) : Takahashi-Ando N , Tokai T , Hamamoto H , Yamaguchi I , Kimura M |
| Ref : Applied Microbiology & Biotechnology , 67 :838 , 2005 |
| Abstract : Takahashi-Ando_2005_Appl.Microbiol.Biotechnol_67_838 |
| ESTHER : Takahashi-Ando_2005_Appl.Microbiol.Biotechnol_67_838 |
| PubMedSearch : Takahashi-Ando_2005_Appl.Microbiol.Biotechnol_67_838 |
| PubMedID: 15630583 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae - Kim_2005_Mol.Microbiol_58_1102 |
| Author(s) : Kim YT , Lee YR , Jin J , Han KH , Kim H , Kim JC , Lee T , Yun SH , Lee YW |
| Ref : Molecular Microbiology , 58 :1102 , 2005 |
| Abstract : Kim_2005_Mol.Microbiol_58_1102 |
| ESTHER : Kim_2005_Mol.Microbiol_58_1102 |
| PubMedSearch : Kim_2005_Mol.Microbiol_58_1102 |
| PubMedID: 16262793 |
| Gene_locus related to this paper: gibze-q2vlj3 |
| Title : Metabolism of zearalenone by genetically modified organisms expressing the detoxification gene from Clonostachys rosea - Takahashi-Ando_2004_Appl.Environ.Microbiol_70_3239 |
| Author(s) : Takahashi-Ando N , Ohsato S , Shibata T , Hamamoto H , Yamaguchi I , Kimura M |
| Ref : Applied Environmental Microbiology , 70 :3239 , 2004 |
| Abstract : Takahashi-Ando_2004_Appl.Environ.Microbiol_70_3239 |
| ESTHER : Takahashi-Ando_2004_Appl.Environ.Microbiol_70_3239 |
| PubMedSearch : Takahashi-Ando_2004_Appl.Environ.Microbiol_70_3239 |
| PubMedID: 15184117 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Expression in cereal plants of genes that inactivate Fusarium mycotoxins - Higa_2003_Biosci.Biotechnol.Biochem_67_914 |
| Author(s) : Higa A , Kimura M , Mimori K , Ochiai-Fukuda T , Tokai T , Takahashi-Ando N , Nishiuchi T , Igawa T , Fujimura M , Hamamoto H , Usami R , Yamaguchi I |
| Ref : Biosci Biotechnol Biochem , 67 :914 , 2003 |
| Abstract : Higa_2003_Biosci.Biotechnol.Biochem_67_914 |
| ESTHER : Higa_2003_Biosci.Biotechnol.Biochem_67_914 |
| PubMedSearch : Higa_2003_Biosci.Biotechnol.Biochem_67_914 |
| PubMedID: 12784641 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Purification and characterization of a lactonase from Erwinia cypripedii 314B that hydrolyzes ( S)-5-oxo-2-tetrahydrofurancarboxylic acid - Mochizuki_2003_Arch.Microbiol_180_490 |
| Author(s) : Mochizuki K |
| Ref : Arch Microbiol , 180 :490 , 2003 |
| Abstract : Mochizuki_2003_Arch.Microbiol_180_490 |
| ESTHER : Mochizuki_2003_Arch.Microbiol_180_490 |
| PubMedSearch : Mochizuki_2003_Arch.Microbiol_180_490 |
| PubMedID: 14576976 |
| Gene_locus related to this paper: biooc-ZHD101 |
Structures (28)
Genes Proteins in Zearalenone-hydrolase family (34)
No fragment of genes
Structures in Zearalenone-hydrolase family (28)Substrates in Zearalenone-hydrolase family (3)
Inhibitors in Zearalenone-hydrolase family (2)