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Family Report for: Valacyclovir-hydrolase


Block X
Parent Family : Abhydrolase_6

Biphenyl hydrolase-like; BPHL, Valacyclovirase, Mucin-associated antigen, MCNAA, Breast epithelial Mucin-associated antigen. Alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Valacyclovir (VACV) is the 5-prime valyl ester prodrug of acyclovir, an effective antiherpetic drug. VACV is relatively stable in gut lumen while very susceptible to intracellular enzymatic hydrolysis.

PF12697 (Abhydrolase_6)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

5 more
    Title: Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase
    Lai L, Xu Z, Zhou J, Lee KD, Amidon GL
    Ref: Journal of Biological Chemistry, 283:9318, 2008 : PubMed


    Title: Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL)
    Puente XS, Pendas AM, Lopez-Otin C
    Ref: Genomics, 51:459, 1998 : PubMed


    Title: Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds
    Puente XS, Lopez-Otin C
    Ref: Journal of Biological Chemistry, 270:12926, 1995 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Valacyclovir-hydrolase family (4)

Genes Proteins in Valacyclovir-hydrolase family (99)

Fragments of genes in Valacyclovir-hydrolase family (9)

Substrates of some enzymes in the Valacyclovir-hydrolase family (2)

Inhibitors of some enzymes in the Valacyclovir-hydrolase family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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