Thiohydrolase
Relationship
Comment
Under construction: extracted from Xaa-Pro-like_dom. Penicillium sp. Chain-fusing Polyketide Gregatin A GrgF belongs to this family. Thioesterase DcsB: A polyketide cyclase that forms medium-ring Lactones. The nucleophile can be Ser as in beab2-j4wat9 (Beauveria bassiana (White muscardine disease fungus) thioesterase DcsB) or Cys as in pensq-GrgF (Penicillium sp. Chain-fusing Polyketide Gregatin A GrgF). The C115S mutant functions as a thioesterase, while losing the ability to perform chain fusion.Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (2)
| Title : A Polyketide Cyclase That Forms Medium-Ring Lactones - Gao_2021_J.Am.Chem.Soc_143_80 |
| Author(s) : Gao DW , Jamieson CS , Wang G , Yan Y , Zhou J , Houk KN , Tang Y |
| Ref : Journal of the American Chemical Society , 143 :80 , 2021 |
| Abstract : Gao_2021_J.Am.Chem.Soc_143_80 |
| ESTHER : Gao_2021_J.Am.Chem.Soc_143_80 |
| PubMedSearch : Gao_2021_J.Am.Chem.Soc_143_80 |
| PubMedID: 33351624 |
| Gene_locus related to this paper: beab2-j4wat9 |
| Title : Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A - Wang_2020_J.Am.Chem.Soc_142_8464 |
| Author(s) : Wang WG , Wang H , Du LQ , Li M , Chen L , Yu J , Cheng GG , Zhan MT , Hu QF , Zhang L , Yao M , Matsuda Y |
| Ref : Journal of the American Chemical Society , 142 :8464 , 2020 |
| Abstract : Wang_2020_J.Am.Chem.Soc_142_8464 |
| ESTHER : Wang_2020_J.Am.Chem.Soc_142_8464 |
| PubMedSearch : Wang_2020_J.Am.Chem.Soc_142_8464 |
| PubMedID: 32275405 |
| Gene_locus related to this paper: pensq-GrgF |
Structures (3)
Genes Proteins in Thiohydrolase family (182)
Fragments of genes in Thiohydrolase family (3)
Structures in Thiohydrolase family (3)Substrates in Thiohydrolase family (1)
No Inhibitor