Interpro : IPR002472 Palmitoyl protein thioesterase , IPR030295 Lysosomal thioesterase PPT2 , IPR030294 Palmitoyl-protein thioesterase 1
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF02089 Palm_thioest
Prints : PR00414
EC Number : 3.1.2.22
Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__ |
Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC |
Ref : Protein Science , : , 2021 |
Abstract : Caswell_2021_Protein.Sci__ |
ESTHER : Caswell_2021_Protein.Sci__ |
PubMedSearch : Caswell_2021_Protein.Sci__ |
PubMedID: 34921469 |
Title : Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration - Koster_2019_Front.Synaptic.Neurosci_11_25 |
Author(s) : Koster KP , Yoshii A |
Ref : Front Synaptic Neurosci , 11 :25 , 2019 |
Abstract : Koster_2019_Front.Synaptic.Neurosci_11_25 |
ESTHER : Koster_2019_Front.Synaptic.Neurosci_11_25 |
PubMedSearch : Koster_2019_Front.Synaptic.Neurosci_11_25 |
PubMedID: 31555119 |
Gene_locus related to this paper: human-PPT1 |
Title : Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle - Won_2018_ACS.Chem.Biol_13_1560 |
Author(s) : Won SJ , Martin BR |
Ref : ACS Chemical Biology , 13 :1560 , 2018 |
Abstract : Won_2018_ACS.Chem.Biol_13_1560 |
ESTHER : Won_2018_ACS.Chem.Biol_13_1560 |
PubMedSearch : Won_2018_ACS.Chem.Biol_13_1560 |
PubMedID: 29733200 |
Title : Infantile neuronal ceroid lipofuscinosis: follow-up on a Spanish series - Perez-Poyato_2012_Gene_499_297 |
Author(s) : Perez Poyato MS , Mila Recansens M , Ferrer Abizanda I , Domingo Jimenez R , Lopez Lafuente A , Cusi Sanchez V , Rodriguez-Revenga L , Coll Rosell MJ , Gort L , Poo Arguelles P , Pineda Marfa M |
Ref : Gene , 499 :297 , 2012 |
Abstract : Perez-Poyato_2012_Gene_499_297 |
ESTHER : Perez-Poyato_2012_Gene_499_297 |
PubMedSearch : Perez-Poyato_2012_Gene_499_297 |
PubMedID: 22387303 |
Gene_locus related to this paper: human-PPT1 |
Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342 |
Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ |
Ref : Nucleic Acids Research , 39 :D342 , 2011 |
Abstract : Cantu_2011_Nucleic.Acids.Res_39_D342 |
ESTHER : Cantu_2011_Nucleic.Acids.Res_39_D342 |
PubMedSearch : Cantu_2011_Nucleic.Acids.Res_39_D342 |
PubMedID: 21045059 |
Title : Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease - Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
Author(s) : Dawson G , Schroeder C , Dawson PE |
Ref : Biochemical & Biophysical Research Communications , 395 :66 , 2010 |
Abstract : Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
ESTHER : Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
PubMedSearch : Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
PubMedID: 20346914 |
Gene_locus related to this paper: human-PPT1 |
Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281 |
Author(s) : Cantu DC , Chen Y , Reilly PJ |
Ref : Protein Science , 19 :1281 , 2010 |
Abstract : Cantu_2010_Protein.Sci_19_1281 |
ESTHER : Cantu_2010_Protein.Sci_19_1281 |
PubMedSearch : Cantu_2010_Protein.Sci_19_1281 |
PubMedID: 20506386 |
Title : The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2 - Calero_2003_J.Biol.Chem_278_37957 |
Author(s) : Calero G , Gupta P , Nonato MC , Tandel S , Biehl ER , Hofmann SL , Clardy J |
Ref : Journal of Biological Chemistry , 278 :37957 , 2003 |
Abstract : Calero_2003_J.Biol.Chem_278_37957 |
ESTHER : Calero_2003_J.Biol.Chem_278_37957 |
PubMedSearch : Calero_2003_J.Biol.Chem_278_37957 |
PubMedID: 12855696 |
Gene_locus related to this paper: human-PPT2 |
Title : Adult neuronal ceroid lipofuscinosis with palmitoyl-protein thioesterase deficiency: first adult-onset patients of a childhood disease - van Diggelen_2001_Ann.Neurol_50_269 |
Author(s) : van Diggelen OP , Thobois S , Tilikete C , Zabot MT , Keulemans JL , van Bunderen PA , Taschner PE , Losekoot M , Voznyi YV |
Ref : Annals of Neurology , 50 :269 , 2001 |
Abstract : van Diggelen_2001_Ann.Neurol_50_269 |
ESTHER : van Diggelen_2001_Ann.Neurol_50_269 |
PubMedSearch : van Diggelen_2001_Ann.Neurol_50_269 |
PubMedID: 11506414 |
Gene_locus related to this paper: human-PPT1 |
Title : The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis - Bellizzi_2000_Proc.Natl.Acad.Sci.U.S.A_97_4573 |
Author(s) : Bellizzi JJ, 3rd , Widom J , Kemp C , Lu JY , Das AK , Hofmann SL , Clardy J |
Ref : Proc Natl Acad Sci U S A , 97 :4573 , 2000 |
Abstract : Bellizzi_2000_Proc.Natl.Acad.Sci.U.S.A_97_4573 |
ESTHER : Bellizzi_2000_Proc.Natl.Acad.Sci.U.S.A_97_4573 |
PubMedSearch : Bellizzi_2000_Proc.Natl.Acad.Sci.U.S.A_97_4573 |
PubMedID: 10781062 |
Gene_locus related to this paper: bovin-ppt , human-PPT1 |
Title : Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride - Das_2000_J.Biol.Chem_275_23847 |
Author(s) : Das AK , Bellizzi JJ, 3rd , Tandel S , Biehl E , Clardy J , Hofmann SL |
Ref : Journal of Biological Chemistry , 275 :23847 , 2000 |
Abstract : Das_2000_J.Biol.Chem_275_23847 |
ESTHER : Das_2000_J.Biol.Chem_275_23847 |
PubMedSearch : Das_2000_J.Biol.Chem_275_23847 |
PubMedID: 10801859 |
Gene_locus related to this paper: bovin-ppt2 , human-PPT1 |
Title : Mutations in the palmitoyl-protein thioesterase gene (PPT\; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits - Mitchison_1998_Hum.Mol.Genet_7_291 |
Author(s) : Mitchison HM , Hofmann SL , Becerra CH , Munroe PB , Lake BD , Crow YJ , Stephenson JB , Williams RE , Hofman IL , Taschner PE , Martin JJ , Philippart M , Andermann E , Andermann F , Mole SE , Gardiner RM , O'Rawe AM |
Ref : Hum Mol Genet , 7 :291 , 1998 |
Abstract : Mitchison_1998_Hum.Mol.Genet_7_291 |
ESTHER : Mitchison_1998_Hum.Mol.Genet_7_291 |
PubMedSearch : Mitchison_1998_Hum.Mol.Genet_7_291 |
PubMedID: 9425237 |
Gene_locus related to this paper: human-PPT1 |
Title : Molecular genetics of palmitoyl-protein thioesterase deficiency in the U.S - Das_1998_J.Clin.Invest_102_361 |
Author(s) : Das AK , Becerra CH , Yi W , Lu JY , Siakotos AN , Wisniewski KE , Hofmann SL |
Ref : Journal of Clinical Investigation , 102 :361 , 1998 |
Abstract : Das_1998_J.Clin.Invest_102_361 |
ESTHER : Das_1998_J.Clin.Invest_102_361 |
PubMedSearch : Das_1998_J.Clin.Invest_102_361 |
PubMedID: 9664077 |
Gene_locus related to this paper: human-PPT1 |
Title : A novel insertion mutation (A169i) in the CLN1 gene is associated with infantile neuronal ceroid lipofuscinosis in an Italian patient - Santorelli_1998_Biochem.Biophys.Res.Commun_245_519 |
Author(s) : Santorelli FM , Bertini E , Petruzzella V , Di Capua M , Calvieri S , Gasparini P , Zeviani M |
Ref : Biochemical & Biophysical Research Communications , 245 :519 , 1998 |
Abstract : Santorelli_1998_Biochem.Biophys.Res.Commun_245_519 |
ESTHER : Santorelli_1998_Biochem.Biophys.Res.Commun_245_519 |
PubMedSearch : Santorelli_1998_Biochem.Biophys.Res.Commun_245_519 |
PubMedID: 9571187 |
Gene_locus related to this paper: human-PPT1 |
Title : Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis - Crews_1996_Proc.Natl.Acad.Sci.U.S.A_93_4316 |
Author(s) : Crews CM , Lane WS , Schreiber SL |
Ref : Proc Natl Acad Sci U S A , 93 :4316 , 1996 |
Abstract : Crews_1996_Proc.Natl.Acad.Sci.U.S.A_93_4316 |
ESTHER : Crews_1996_Proc.Natl.Acad.Sci.U.S.A_93_4316 |
PubMedSearch : Crews_1996_Proc.Natl.Acad.Sci.U.S.A_93_4316 |
PubMedID: 8633062 |
Gene_locus related to this paper: human-PPT1 |
Title : Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase - Lu_1996_Proc.Natl.Acad.Sci.U.S.A_93_10046 |
Author(s) : Lu JY , Verkruyse LA , Hofmann SL |
Ref : Proc Natl Acad Sci U S A , 93 :10046 , 1996 |
Abstract : Lu_1996_Proc.Natl.Acad.Sci.U.S.A_93_10046 |
ESTHER : Lu_1996_Proc.Natl.Acad.Sci.U.S.A_93_10046 |
PubMedSearch : Lu_1996_Proc.Natl.Acad.Sci.U.S.A_93_10046 |
PubMedID: 8816748 |
Gene_locus related to this paper: human-PPT1 |
Title : Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis - Vesa_1995_Nature_376_584 |
Author(s) : Vesa J , Hellsten E , Verkruyse LA , Camp LA , Rapola J , Santavuori P , Hofmann SL , Peltonen L |
Ref : Nature , 376 :584 , 1995 |
Abstract : Vesa_1995_Nature_376_584 |
ESTHER : Vesa_1995_Nature_376_584 |
PubMedSearch : Vesa_1995_Nature_376_584 |
PubMedID: 7637805 |
Gene_locus related to this paper: human-PPT1 |
Structures (5)
Genes Proteins in Palmitoyl-protein_thioesterase family (59)
Fragments of genes in Palmitoyl-protein_thioesterase family (13)
Structures in Palmitoyl-protein_thioesterase family (5)Substrates in Palmitoyl-protein_thioesterase family (1)
Inhibitors in Palmitoyl-protein_thioesterase family (7)