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Family Report for: PAF-Acetylhydrolase


Block X
Parent Family : PAF_acetylhydro-like

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2 (group-VIIA), responsible for inactivation of platelet-activating factor through cleavage of an acetyl group (PAF: Extracellular signaling lipid; ligand for G protein-coupled platelet activating factor (PAF) receptors). Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, (whose subunits are not alpha/beta hydrolases), the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). Both these last two forms are alpha/beta hydrolases and are included in this family. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene (human-PLA2G7). This family also contains microbial lipase homologue of PAF-AH_p_II. The first sructure known was Streptomyces exfoliatus lipase
1 Disease(s)

IPR005065 (PAF_Ac_hydrop_II), IPR016715 (Platelet-activating factor acetylhydrolase, eucaryote)
PF03403 (PAF-AH_p_II)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

2 more
    Title: Lipoprotein-associated phospholipase A2: The story continues
    Huang F, Wang K, Shen J
    Ref: Med Res Rev, 40:79, 2020 : PubMed


    Title: Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis
    Samanta U, Bahnson BJ
    Ref: Journal of Biological Chemistry, 283:31617, 2008 : PubMed


    Title: Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution
    Wei Y, Swenson L, Castro C, Derewenda U, Minor W, Arai H, Aoki J, Inoue K, Servin-Gonzalez L, Derewenda ZS
    Ref: Structure, 6:511, 1998 : PubMed


Other Papers

Structure scheme for PAF-Acetylhydrolase

Structures in PAF-Acetylhydrolase family (35)

Genes Proteins in PAF-Acetylhydrolase family (149)

Fragments of genes in PAF-Acetylhydrolase family (3)

Substrates of some enzymes in the PAF-Acetylhydrolase family (6)

Inhibitors of some enzymes in the PAF-Acetylhydrolase family (35)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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