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Family Report for: Ndr_family


Family Ndr_family
Block X
RTP/Drg1/Ndr1 genes are repressed by the proto-oncogenes N-myc and c-myc. Members of this family are found in wide variety of multicellular eukaryotes, including plants (ndr nothing to do with nodal-related genes) Ndr1 included in alpha/beta hydolase PF00561 now have a Pfam family PF03096. Shaw et al Proteins 2002 May 1;47(2):163-8 identified this family as alpha/beta hydrolase. Kalaydjieva et al. showed that human-NDRG1 is mutated in hereditary motor and sensory neuropathy-Lom. Bhaduri et al. showed that ratno-ndr4 (Bdm1) is associated with hot water epilepsy. Mitchelmore et al. showed that NDRG2 is upregulated in Alzheimer's disease. NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase as published by Dong et al. (obsolete subfamilies IPR030693 Protein NDRG1; IPR030690 Protein NDRG2; IPR030692 Protein NDRG3; IPR030695 Protein NDRG4)
2 Disease(s)

IPR004142 (NDRG)
PF03096 (Ndr)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

11 more
    Title: A review on the role of NDRG1 in different cancers
    Ghafouri-Fard S, Ahmadi Teshnizi S, Hussen BM, Taheri M, Sharifi G
    Ref: Mol Biol Rep, :, 2023 : PubMed


    Title: Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family
    Le N, Hufford TM, Park JS, Brewster RM
    Ref: FASEB Journal, 35:e21961, 2021 : PubMed


    Title: The Role of N-myc Downstream-Regulated Gene Family in Glioma Based on Bioinformatics Analysis
    Tang T, Wang H, Han Y, Huang H, Niu W, Fei M, Zhu Y
    Ref: DNA & Cell Biology, 40:949, 2021 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Ndr_family family (8)

Genes Proteins in Ndr_family family (258)

Fragments of genes in Ndr_family family (57)

No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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