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Family Report for: Lipase_2


Family Lipase_2
Block X
Previously included in Fungal_triacylglycerol_lipase. This group of lipases has been called class 2 as they are not clearly related to other lipase families, and includes LipA and LipB from Bacillus subtilis and uncharacterised proteins from Caenorhabditis. Two other subfamilies described in: Arpigny and Jaeger (1999), Jaeger and Eggert (Family I.4 and Family I.7) are included in Lipase_2 (see classification). A novel type of hydrolase purified from Paucimonas revealed an unusual substrate specificity for amorphous poly((R)-3-hydroxyalkanoates PHA and no homologies to any other PHB depolymerase. A new family was built and extracted form Lipase_2 PHAZ7_phb_depolymerase (Arpigny_Jaeger Family IX)

IPR002918 (Lipase EstA/Esterase EstB)
PF01674 (Lipase_2)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

3 more
    Title: Structural basis of selection and thermostability of laboratory evolved Bacillus subtilis lipase
    Acharya P, Rajakumara E, Sankaranarayanan R, Rao NM
    Ref: Journal of Molecular Biology, 341:1271, 2004 : PubMed


    Title: Lipolytic enzymes LipA and LipB from Bacillus subtilis differ in regulation of gene expression, biochemical properties, and three-dimensional structure
    Eggert T, van Pouderoyen G, Dijkstra BW, Jaeger KE
    Ref: FEBS Letters, 502:89, 2001 : PubMed


    Title: A new type of thermoalkalophilic hydrolase of Paucimonas lemoignei with high specificity for amorphous polyesters of short chain-length hydroxyalkanoic acids
    Handrick R, Reinhardt S, Focarete ML, Scandola M, Adamus G, Kowalczuk M, Jendrossek D
    Ref: Journal of Biological Chemistry, 276:36215, 2001 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Lipase_2 family (26)

Genes Proteins in Lipase_2 family (179)

Fragments of genes in Lipase_2 family (7)

Substrates of some enzymes in the Lipase_2 family (22)

Inhibitors of some enzymes in the Lipase_2 family (2)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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