LYsophospholipase_carboxylesterase
Relationship
Comment
PLP_Cesterase. Abhydrolase_2; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, but different of the family Monoglyceridelipase_lysophospholipase which is part of PF00561 AlphaBeta hydrolase.
For bacterial enzymes, this family correspond to family VI of the classification of Arpigny and Jaeger (1999) The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. Another closely related family of hydrolases: the ABHD17-depalmitoylase family contributes to the depalmitoylation of Ras-family GTPases and synaptic proteins. Burger et al. show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. SOBER1 is a protein deacetylase and not an acylprotein thioesterase. Family TE21 in ThYme database Database
Interpro : IPR003140 Phospholipase\/carboxylesterase\/thioesterase PLP_Cesterase PLipase\/COase\/thioEstase
PIRSF : PIRSF016033 esterase
Pdoc : No Pdoc
Pfam : PF02230 Abhydrolase_2
Prints : No Print
EC Number : 3.1.1.5
References (17)
| Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__ |
| Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC |
| Ref : Protein Science , : , 2021 |
| Abstract : Caswell_2021_Protein.Sci__ |
| ESTHER : Caswell_2021_Protein.Sci__ |
| PubMedSearch : Caswell_2021_Protein.Sci__ |
| PubMedID: 34921469 |
| Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360 |
| Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ |
| Ref : J Lipid Res , 60 :360 , 2019 |
| Abstract : Wepy_2019_J.Lipid.Res_60_360 |
| ESTHER : Wepy_2019_J.Lipid.Res_60_360 |
| PubMedSearch : Wepy_2019_J.Lipid.Res_60_360 |
| PubMedID: 30482805 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Protein depalmitoylases - Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| Author(s) : Won SJ , Cheung See Kit M , Martin BR |
| Ref : Crit Rev Biochem Mol Biol , 53 :83 , 2018 |
| Abstract : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| ESTHER : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| PubMedSearch : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| PubMedID: 29239216 |
| Title : A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors - Burger_2017_Nat.Commun_8_2201 |
| Author(s) : Burger M , Willige BC , Chory J |
| Ref : Nat Commun , 8 :2201 , 2017 |
| Abstract : Burger_2017_Nat.Commun_8_2201 |
| ESTHER : Burger_2017_Nat.Commun_8_2201 |
| PubMedSearch : Burger_2017_Nat.Commun_8_2201 |
| PubMedID: 29259199 |
| Gene_locus related to this paper: maize-b6t1C9 , arath-SOBR1 , arath-SOBRL , arath-AT5G20060 |
| Title : Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2) - Won_2016_ACS.Chem.Biol_11_3374 |
| Author(s) : Won SJ , Davda D , Labby KJ , Hwang SY , Pricer R , Majmudar JD , Armacost KA , Rodriguez LA , Rodriguez CL , Chong FS , Torossian KA , Palakurthi J , Hur ES , Meagher JL , Brooks CL, 3rd , Stuckey JA , Martin BR |
| Ref : ACS Chemical Biology , 11 :3374 , 2016 |
| Abstract : Won_2016_ACS.Chem.Biol_11_3374 |
| ESTHER : Won_2016_ACS.Chem.Biol_11_3374 |
| PubMedSearch : Won_2016_ACS.Chem.Biol_11_3374 |
| PubMedID: 27748579 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution - Ma_2013_Appl.Microbiol.Biotechnol_97_4897 |
| Author(s) : Ma J , Wu L , Guo F , Gu J , Tang X , Jiang L , Liu J , Zhou J , Yu H |
| Ref : Applied Microbiology & Biotechnology , 97 :4897 , 2013 |
| Abstract : Ma_2013_Appl.Microbiol.Biotechnol_97_4897 |
| ESTHER : Ma_2013_Appl.Microbiol.Biotechnol_97_4897 |
| PubMedSearch : Ma_2013_Appl.Microbiol.Biotechnol_97_4897 |
| PubMedID: 22987200 |
| Gene_locus related to this paper: rhos4-q3j2v1 |
| Title : Large-scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis - Filippova_2013_J.Biol.Chem_288_10522 |
| Author(s) : Filippova EV , Weston LA , Kuhn ML , Geissler B , Gehring AM , Armoush N , Adkins CT , Minasov G , Dubrovska I , Shuvalova L , Winsor JR , Lavis LD , Satchell KJ , Becker DP , Anderson WF , Johnson RJ |
| Ref : Journal of Biological Chemistry , 288 :10522 , 2013 |
| Abstract : Filippova_2013_J.Biol.Chem_288_10522 |
| ESTHER : Filippova_2013_J.Biol.Chem_288_10522 |
| PubMedSearch : Filippova_2013_J.Biol.Chem_288_10522 |
| PubMedID: 23430251 |
| Gene_locus related to this paper: fratt-q5ni32 |
| Title : Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases - Burger_2012_J.Lipid.Res_53_43 |
| Author(s) : Burger M , Zimmermann TJ , Kondoh Y , Stege P , Watanabe N , Osada H , Waldmann H , Vetter IR |
| Ref : J Lipid Res , 53 :43 , 2012 |
| Abstract : Burger_2012_J.Lipid.Res_53_43 |
| ESTHER : Burger_2012_J.Lipid.Res_53_43 |
| PubMedSearch : Burger_2012_J.Lipid.Res_53_43 |
| PubMedID: 22052940 |
| Gene_locus related to this paper: human-LYPLAL1 |
| Title : Regulation and structure of YahD, a copper-inducible alpha\/beta serine hydrolase of Lactococcus lactis IL1403 - Martinez_2011_FEMS.Microbiol.Lett_314_57 |
| Author(s) : Martinez J , Mancini S , Tauberger E , Weise C , Saenger W , Solioz M |
| Ref : FEMS Microbiology Letters , 314 :57 , 2011 |
| Abstract : Martinez_2011_FEMS.Microbiol.Lett_314_57 |
| ESTHER : Martinez_2011_FEMS.Microbiol.Lett_314_57 |
| PubMedSearch : Martinez_2011_FEMS.Microbiol.Lett_314_57 |
| PubMedID: 21059179 |
| Gene_locus related to this paper: lacla-YAHD |
| Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342 |
| Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ |
| Ref : Nucleic Acids Research , 39 :D342 , 2011 |
| Abstract : Cantu_2011_Nucleic.Acids.Res_39_D342 |
| ESTHER : Cantu_2011_Nucleic.Acids.Res_39_D342 |
| PubMedSearch : Cantu_2011_Nucleic.Acids.Res_39_D342 |
| PubMedID: 21045059 |
| Title : Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study - Pesaresi_2010_Biochimie_92_1787 |
| Author(s) : Pesaresi A , Lamba D |
| Ref : Biochimie , 92 :1787 , 2010 |
| Abstract : Pesaresi_2010_Biochimie_92_1787 |
| ESTHER : Pesaresi_2010_Biochimie_92_1787 |
| PubMedSearch : Pesaresi_2010_Biochimie_92_1787 |
| PubMedID: 20850500 |
| Gene_locus related to this paper: pseae-PA3859 |
| Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281 |
| Author(s) : Cantu DC , Chen Y , Reilly PJ |
| Ref : Protein Science , 19 :1281 , 2010 |
| Abstract : Cantu_2010_Protein.Sci_19_1281 |
| ESTHER : Cantu_2010_Protein.Sci_19_1281 |
| PubMedSearch : Cantu_2010_Protein.Sci_19_1281 |
| PubMedID: 20506386 |
| Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| Author(s) : Jaeger KE , Eggert T |
| Ref : Curr Opin Biotechnol , 13 :390 , 2002 |
| Abstract : Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| ESTHER : Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| PubMedSearch : Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| PubMedID: 12323363 |
| Title : Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A - Devedjiev_2000_Structure_8_1137 |
| Author(s) : Devedjiev Y , Dauter Z , Kuznetsov SR , Jones TL , Derewenda ZS |
| Ref : Structure , 8 :1137 , 2000 |
| Abstract : Devedjiev_2000_Structure_8_1137 |
| ESTHER : Devedjiev_2000_Structure_8_1137 |
| PubMedSearch : Devedjiev_2000_Structure_8_1137 |
| PubMedID: 11080636 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177 |
| Author(s) : Arpigny JL , Jaeger KE |
| Ref : Biochemical Journal , 343 :177 , 1999 |
| Abstract : Arpigny_1999_Biochem.J_343_177 |
| ESTHER : Arpigny_1999_Biochem.J_343_177 |
| PubMedSearch : Arpigny_1999_Biochem.J_343_177 |
| PubMedID: 10493927 |
| Title : cDNA cloning and expression of a novel family of enzymes with calcium-independent phospholipase A2 and lysophospholipase activities - Portilla_1998_J.Am.Soc.Nephrol_9_1178 |
| Author(s) : Portilla D , Crew MD , Grant D , Serrero G , Bates LM , Dai G , Sasner M , Cheng J , Buonanno A |
| Ref : J Am Soc Nephrol , 9 :1178 , 1998 |
| Abstract : Portilla_1998_J.Am.Soc.Nephrol_9_1178 |
| ESTHER : Portilla_1998_J.Am.Soc.Nephrol_9_1178 |
| PubMedSearch : Portilla_1998_J.Am.Soc.Nephrol_9_1178 |
| PubMedID: 9644627 |
| Gene_locus related to this paper: rabit-lypla1 , rabit-O77820 , ratno-lypla1a |
| Title : Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha\/beta hydrolase with broad substrate specificity - Kim_1997_Structure_5_1571 |
| Author(s) : Kim KK , Song HK , Shin DH , Hwang KY , Choe S , Yoo OJ , Suh SW |
| Ref : Structure , 5 :1571 , 1997 |
| Abstract : Kim_1997_Structure_5_1571 |
| ESTHER : Kim_1997_Structure_5_1571 |
| PubMedSearch : Kim_1997_Structure_5_1571 |
| PubMedID: 9438866 |
| Gene_locus related to this paper: psefl-cxest |
Structures (27)
Genes Proteins in LYsophospholipase_carboxylesterase family (350)
Fragments of genes in LYsophospholipase_carboxylesterase family (14)
Structures in LYsophospholipase_carboxylesterase family (27)Substrates in LYsophospholipase_carboxylesterase family (20)
Inhibitors in LYsophospholipase_carboxylesterase family (24)