Insect_Phospholipase
Relationship
Comment
Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids and is conserved in a wide range of organisms. Included in this family are Vespid venom allergen phospholipase A1. Vespid phospholipase A1 (vPLA1) is one of the primary venom components with local inflammatory effects.
In addition to causing allergic reactions, vPLA1 can hydrolyze the sn-1 fatty acids in phospholipids and convert them into their corresponding lyso compounds. vPLA1 may disrupt the phospholipid packing of biological membranes, causing severe hemolysis and leading to cardiac dysfunction and death in animals Database
Interpro : IPR000734 Lipase , IPR002334 Dol\/Ves 1 allergen , IPR013818 Lipase
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF00151 Lipase
Prints : PR00821 , PR00825
EC Number : 3.1.1.32
References (1)
| Title : Crystal structure of vespid phospholipase A1 reveals insights into the mechanism for cause of membrane dysfunction - Hou_2016_Insect.Biochem.Mol.Biol_68_79 |
| Author(s) : Hou MH , Chuang CY , Ko TP , Hu NJ , Chou CC , Shih YP , Ho CL , Wang AH |
| Ref : Insect Biochemistry & Molecular Biology , 68 :79 , 2016 |
| Abstract : Hou_2016_Insect.Biochem.Mol.Biol_68_79 |
| ESTHER : Hou_2016_Insect.Biochem.Mol.Biol_68_79 |
| PubMedSearch : Hou_2016_Insect.Biochem.Mol.Biol_68_79 |
| PubMedID: 26603193 |
| Gene_locus related to this paper: vesba-pa1 |
Structures (1)
Genes Proteins in Insect_Phospholipase family (17)
No fragment of genes
Structures in Insect_Phospholipase family (1)No substrate
No Inhibitor