Interpro : IPR000073 Alpha\/beta hydrolase fold-1 , IPR045889 Methylesterase\/Alpha-hydroxynitrile lyase
PIRSF : PIRSF037175 esterase\/lyase
Pdoc : No Pdoc
Pfam : PF00561 Abhydrolase_1
Prints : No Print
EC Number : 4.1.2.47
Title : Evolution of a Catalytic Mechanism - Rauwerdink_2016_Mol.Biol.Evol_33_971 |
Author(s) : Rauwerdink A , Lunzer M , Devamani T , Jones B , Mooney J , Zhang ZJ , Xu JH , Kazlauskas RJ , Dean AM |
Ref : Molecular Biology Evolution , 33 :971 , 2016 |
Abstract : Rauwerdink_2016_Mol.Biol.Evol_33_971 |
ESTHER : Rauwerdink_2016_Mol.Biol.Evol_33_971 |
PubMedSearch : Rauwerdink_2016_Mol.Biol.Evol_33_971 |
PubMedID: 26681154 |
Gene_locus related to this paper: 9zzzz-5TDX , hevbr-hnl |
Title : Uncovering divergent evolution of alpha\/beta-hydrolases: a surprising residue substitution needed to convert hydroxynitrile lyase into an esterase - Nedrud_2014_Chem.Sci_5_4265 |
Author(s) : Nedrud DM , Lin H , Lopez G , Padhi SK , Legatt GA , Kazlauskas RJ |
Ref : Chem Sci , 5 :4265 , 2014 |
Abstract : Nedrud_2014_Chem.Sci_5_4265 |
ESTHER : Nedrud_2014_Chem.Sci_5_4265 |
PubMedSearch : Nedrud_2014_Chem.Sci_5_4265 |
PubMedID: 25346843 |
Gene_locus related to this paper: hevbr-hnl , nicta-SABP2 |
Title : Hydroxynitrile lyases with alpha\/beta-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms - Andexer_2012_Chembiochem_13_1932 |
Author(s) : Andexer JN , Staunig N , Eggert T , Kratky C , Pohl M , Gruber K |
Ref : Chembiochem , 13 :1932 , 2012 |
Abstract : Andexer_2012_Chembiochem_13_1932 |
ESTHER : Andexer_2012_Chembiochem_13_1932 |
PubMedSearch : Andexer_2012_Chembiochem_13_1932 |
PubMedID: 22851196 |
Gene_locus related to this paper: arath-HNL |
Title : Emergent decarboxylase activity and attenuation of alpha\/beta-hydrolase activity during the evolution of methylketone biosynthesis in tomato - Auldridge_2012_Plant.Cell_24_1596 |
Author(s) : Auldridge ME , Guo Y , Austin MB , Ramsey J , Fridman E , Pichersky E , Noel JP |
Ref : Plant Cell , 24 :1596 , 2012 |
Abstract : Auldridge_2012_Plant.Cell_24_1596 |
ESTHER : Auldridge_2012_Plant.Cell_24_1596 |
PubMedSearch : Auldridge_2012_Plant.Cell_24_1596 |
PubMedID: 22523203 |
Gene_locus related to this paper: solha-e0ycs2 |
Title : Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions - Padhi_2010_Chem.Biol_17_863 |
Author(s) : Padhi SK , Fujii R , Legatt GA , Fossum SL , Berchtold R , Kazlauskas RJ |
Ref : Chemical Biology , 17 :863 , 2010 |
Abstract : Padhi_2010_Chem.Biol_17_863 |
ESTHER : Padhi_2010_Chem.Biol_17_863 |
PubMedSearch : Padhi_2010_Chem.Biol_17_863 |
PubMedID: 20797615 |
Gene_locus related to this paper: hevbr-hnl , nicta-SABP2 |
Title : Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha\/beta-hydrolase fold - Guterl_2009_J.Biotechnol_141_166 |
Author(s) : Guterl JK , Andexer JN , Sehl T , von Langermann J , Frindi-Wosch I , Rosenkranz T , Fitter J , Gruber K , Kragl U , Eggert T , Pohl M |
Ref : J Biotechnol , 141 :166 , 2009 |
Abstract : Guterl_2009_J.Biotechnol_141_166 |
ESTHER : Guterl_2009_J.Biotechnol_141_166 |
PubMedSearch : Guterl_2009_J.Biotechnol_141_166 |
PubMedID: 19433222 |
Gene_locus related to this paper: arath-HNL , hevbr-hnl , manes-hnl |
Title : Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis - Yang_2008_Plant.Physiol_147_1034 |
Author(s) : Yang Y , Xu R , Ma CJ , Vlot AC , Klessig DF , Pichersky E |
Ref : Plant Physiol , 147 :1034 , 2008 |
Abstract : Yang_2008_Plant.Physiol_147_1034 |
ESTHER : Yang_2008_Plant.Physiol_147_1034 |
PubMedSearch : Yang_2008_Plant.Physiol_147_1034 |
PubMedID: 18467465 |
Gene_locus related to this paper: arath-MES17 , arath-AT4G16690 , arath-AT4G37150 , arath-MES6 , arath-MES7 , arath-MES3 , arath-MES1 , arath-MES18 , arath-MES10 , arath-MES19 |
Title : Reaction mechanism of hydroxynitrile lyases of the alpha\/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236 - Gruber_2004_J.Biol.Chem_279_20501 |
Author(s) : Gruber K , Gartler G , Krammer B , Schwab H , Kratky C |
Ref : Journal of Biological Chemistry , 279 :20501 , 2004 |
Abstract : Gruber_2004_J.Biol.Chem_279_20501 |
ESTHER : Gruber_2004_J.Biol.Chem_279_20501 |
PubMedSearch : Gruber_2004_J.Biol.Chem_279_20501 |
PubMedID: 14998991 |
Gene_locus related to this paper: hevbr-hnl |
Title : High-affinity salicylic acid-binding protein 2 is required for plant innate immunity and has salicylic acid-stimulated lipase activity - Kumar_2003_Proc.Natl.Acad.Sci.U.S.A_100_16101 |
Author(s) : Kumar D , Klessig DF |
Ref : Proc Natl Acad Sci U S A , 100 :16101 , 2003 |
Abstract : Kumar_2003_Proc.Natl.Acad.Sci.U.S.A_100_16101 |
ESTHER : Kumar_2003_Proc.Natl.Acad.Sci.U.S.A_100_16101 |
PubMedSearch : Kumar_2003_Proc.Natl.Acad.Sci.U.S.A_100_16101 |
PubMedID: 14673096 |
Gene_locus related to this paper: nicta-SABP2 |
Title : Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta - Lauble_2002_Protein.Sci_11_65 |
Author(s) : Lauble H , Miehlich B , Forster S , Kobler C , Wajant H , Effenberger F |
Ref : Protein Science , 11 :65 , 2002 |
Abstract : Lauble_2002_Protein.Sci_11_65 |
ESTHER : Lauble_2002_Protein.Sci_11_65 |
PubMedSearch : Lauble_2002_Protein.Sci_11_65 |
PubMedID: 11742123 |
Gene_locus related to this paper: manes-hnl |
Title : Molecular cloning of the full-length cDNA of (S)-hydroxynitrile lyase from Hevea brasiliensis. Functional expression in Escherichia coli and Saccharomyces cerevisiae and identification of an active site residue - Hasslacher_1996_J.Biol.Chem_271_5884 |
Author(s) : Hasslacher M , Schall M , Hayn M , Griengl H , Kohlwein SD , Schwab H |
Ref : Journal of Biological Chemistry , 271 :5884 , 1996 |
Abstract : Hasslacher_1996_J.Biol.Chem_271_5884 |
ESTHER : Hasslacher_1996_J.Biol.Chem_271_5884 |
PubMedSearch : Hasslacher_1996_J.Biol.Chem_271_5884 |
PubMedID: 8621461 |
Gene_locus related to this paper: hevbr-hnl |
Structures (57)
Genes Proteins in Hydroxynitrile_lyase family (219)
Fragments of genes in Hydroxynitrile_lyase family (30)
Structures in Hydroxynitrile_lyase family (57)Substrates in Hydroxynitrile_lyase family (17)
Inhibitors in Hydroxynitrile_lyase family (14)