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Family Report for: Hydrolase_RBBP9_YdeN


Block X
Retinoblastoma binding protein 9 is an aminopeptidase with a preference for removing aromatic amino acids in human cells (Tang et al.). Ser_hydrolase.Hydrolase_RBBP9/YdeN. Protein of unknown function DUF1234 (old Duf_1234). This family contains Bacillus subtilis yden protein and human retinoblastoma-binding protein 9 (RBBP-9) required for pancreatic neoplasia. Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family.

IPR010662 (Putative hydrolase RBBP9/YdeN DUF1234)
PF06821 (Ser_hydrolase)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

13 more
    Title: Mechanism-based traps enable protease and hydrolase substrate discovery
    Tang S, Beattie AT, Kafkova L, Petris G, Huguenin-Dezot N, Fiedler M, Freeman M, Chin JW
    Ref: Nature, 602:701, 2022 : PubMed


    Title: RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia
    Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M and Cheresh DA <2 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 107:2189, 2010 : PubMed


    Title: Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution
    Janda I, Devedjiev Y, Cooper D, Chruszcz M, Derewenda U, Gabrys A, Minor W, Joachimiak A, Derewenda ZS
    Ref: Acta Crystallographica D Biol Crystallogr, 60:1101, 2004 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Hydrolase_RBBP9_YdeN family (4)

Genes Proteins in Hydrolase_RBBP9_YdeN family (102)

Fragments of genes in Hydrolase_RBBP9_YdeN family (2)

No Substrate

Inhibitors of some enzymes in the Hydrolase_RBBP9_YdeN family (3)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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