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Hepatic_Lipase

Relationship

Family: Hepatic_Lipase

Block: L

Parent Family: No family

Comment

Pancreatic, hepatic and gastric/lingual lipase are closely related to each other and to lipoprotein lipase (EC: 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). Familial human hepatic lipase deficiency is a rare recessive disorder Two variants (S267F and T383M) are rare mutations found to date only in HL deficient subjects and their relatives. Of the six HL variants described to date, only S267F and T383M are associated with hyperlipidemia. human-LIPC. The disease is characterised by premature atherosclerosis and abnormal circulating lipoproteins

Database

Interpro : IPR000734 Lipase , IPR002333 Hepatic lipase , IPR016272 Lipase, LIPH-type , IPR013818 Lipase

PIRSF : No PIRSF

Pdoc : PDOC00110

Pfam : PF00151 Lipase

Prints : PR00821 , PR00824

EC Number : 3.1.1.3

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (2)

Title : Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies - Holmes_2011_Open.Access.Bioinformatics_2011_85
Author(s) : Holmes RS , Vandeberg JL , Cox LA
Ref : Open Access Bioinformatics , 2011 :85 , 2011
Abstract : Holmes_2011_Open.Access.Bioinformatics_2011_85
ESTHER : Holmes_2011_Open.Access.Bioinformatics_2011_85
PubMedSearch : Holmes_2011_Open.Access.Bioinformatics_2011_85
PubMedID: 22408368

Title : Human hepatic lipase mutations and polymorphisms - Hegele_1992_Hum.Mutat_1_320
Author(s) : Hegele RA , Tu L , Connelly PW
Ref : Hum Mutat , 1 :320 , 1992
Abstract : Hegele_1992_Hum.Mutat_1_320
ESTHER : Hegele_1992_Hum.Mutat_1_320
PubMedSearch : Hegele_1992_Hum.Mutat_1_320
PubMedID: 1301939

No structure scheme yet for this family

Genes Proteins in Hepatic_Lipase family (116)

Fragments of genes in Hepatic_Lipase family (68)

No fragment of genes

Substrates in Hepatic_Lipase family (8)

Inhibitors in Hepatic_Lipase family (1)