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Family Report for: Haloalkane_dehalogenase-HLD1

Haloalkane_dehalogenase-HLD1



Relationship
Block X
Parent Family : Epoxide-hydrolase_like

Comment
Haloalkane dehalogenases (HLDs) are enzymes that catalyze the cleavage of carbon halogen bonds by a hydrolytic mechanism. The catalytic triad consists of the key nucleophile (Asp) the general base (His) and a catalytic acid (Asp or Glu). HLD where subdivided in three subfamily (Chovancova et al.) according to their substrate specificity and position of active site residues. Class one HLD1 (HLD-I) has catalytic triad Asp-His-Asp and halide-strabilizing residues Trp-Trp. Class two HLDII (HLD-II) has catalytic triad Asp-His-Glu and halide-stabilizing residues Asn-Trp. Class three HLDIII (HLD-III) has catalytic triad Asp-His-Asp and halide-strabilizing residues Asn-Trp. Also the reaction performed is different, the Renilla reniformis luciferase belongs to this family. In ESTHER as in HAMAP database class I and III are merged as they are close. OleB from bacterial hydrocarbon biosynthesis is a -lactone decarboxylase (Christenson et al.2017)

Database
Sequences
Interpro
|
IPR023489 (Haloalkane dehalogenase, subfamily 1)
PIRSF
|
Pdoc
|
PFam
|
PF00561 (Abhydrolase_1)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
12 more
    Title: Phylogenetic analysis of haloalkane dehalogenases
    Chovancova E, Kosinski J, Bujnicki JM, Damborsky J
    Ref: Proteins, 67:305, 2007 : PubMed

            

    Title: Evolving haloalkane dehalogenases
    Janssen DB
    Ref: Curr Opin Chemical Biology, 8:150, 2004 : PubMed

            

    Title: Repositioning the catalytic triad aspartic acid of haloalkane dehalogenase: effects on stability, kinetics, and structure
    Krooshof GH, Kwant EM, Damborsky J, Koca J, Janssen DB
    Ref: Biochemistry, 36:9571, 1997 : PubMed

            

Other Papers


Structure scheme for Haloalkane_dehalogenase-HLD1

Structures in Haloalkane_dehalogenase-HLD1 family (25)

Genes Proteins in Haloalkane_dehalogenase-HLD1 family (142)

Fragments of genes in Haloalkane_dehalogenase-HLD1 family (1)

Substrates of some enzymes in the Haloalkane_dehalogenase-HLD1 family (33)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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