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Glutactin

Relationship

Family: Glutactin

Block: C

Parent Family: Non-catalytic_C

Comment

Insect specific protein. Glutactin has a signal peptide and an amino domain of greater than 500 residues that strongly resembles acetylcholine esterases and other serine esterases, but lacks the catalytically critical serine residue. It is located at embryonic basement membranes, particularly to the sequentially invaginated envelope of the central nervous system, muscle apodemes and dorsal median cell processes. Ectopic expression of Glutactin inhibits synapse formation by motor neurons that normally innervate M12 muscle. Only the N-terminal part of Glutactin is a member of the alpha/beta hydrolase family. The C-terminal part is not included in ESTHER

Database

Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (4)

Title : Wnt4 is a local repulsive cue that determines synaptic target specificity. - Inaki_2007_Curr.Biol_17_1574
Author(s) : Inaki M , Yoshikawa S , Thomas JB , Aburatani H , Nose A
Ref : Current Biology , 17 :1574 , 2007
Abstract : Inaki_2007_Curr.Biol_17_1574
ESTHER : Inaki_2007_Curr.Biol_17_1574
PubMedSearch : Inaki_2007_Curr.Biol_17_1574
PubMedID: 17764943

Title : The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties - Darboux_1996_EMBO.J_15_4835
Author(s) : Darboux I , Barthalay Y , Piovant M , Hipeau-Jacquotte R
Ref : EMBO Journal , 15 :4835 , 1996
Abstract : Darboux_1996_EMBO.J_15_4835
ESTHER : Darboux_1996_EMBO.J_15_4835
PubMedSearch : Darboux_1996_EMBO.J_15_4835
PubMedID: 8890157

Title : Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid - Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647
Author(s) : Krejci E , Duval N , Chatonnet A , Vincens P , Massoulie J
Ref : Proceedings of the National Academy of Sciences of the United States of America , 88 :6647 , 1991
Abstract : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647
ESTHER : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647
PubMedSearch : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647
PubMedID: 1862088

Title : Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases - Olson_1990_EMBO.J_9_1219
Author(s) : Olson PF , Fessler LI , Nelson RE , Sterne RE , Campbell AG , Fessler JH
Ref : EMBO Journal , 9 :1219 , 1990
Abstract : Olson_1990_EMBO.J_9_1219
ESTHER : Olson_1990_EMBO.J_9_1219
PubMedSearch : Olson_1990_EMBO.J_9_1219
PubMedID: 2108864
Gene_locus related to this paper: drome-gluta

No structure scheme yet for this family

Genes Proteins in Glutactin family (49)

Fragments of genes in Glutactin family (7)

No fragment of genes

No substrate

No Inhibitor